Effects of Chelator Modifications on 68Ga-Labeled [Tyr 3]Octreotide Conjugates

Molecular Imaging and Biology

Volumn 15, Issue 5, 2013, Pages 606-613

  Lin, Mai ^a   Welch, Michael J ^a   Lapi, Suzanne E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

68Ga; Tyr3 octreotide; Peptide; Positron emission tomography; Somatostatin receptor

Indexed keywords

1,4,7 TRIAZACYCLONONANE 1,4,7 TRIACETIC ACID; CHELATING AGENT; GADOTERIC ACID; GADOTERIC ACID GA 68; GALLIUM 68; OCTREOTIDE[3 TYROSINE]; SOMATOSTATIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CHELATION; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; DRUG UPTAKE; HYDROPHILICITY; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; ISOTOPE LABELING; MALE; MOLECULAR MECHANICS; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOCHEMISTRY; RAT; RECEPTOR BINDING; TISSUE DISTRIBUTION;

ANIMALS; CELL LINE, TUMOR; CHELATING AGENTS; ENDOCYTOSIS; MALE; MICE; MICE, NUDE; MICROSCOPY, FLUORESCENCE; OCTREOTIDE; ORGAN SPECIFICITY; ORGANOMETALLIC COMPOUNDS; RATS; RECEPTORS, SOMATOSTATIN; STAINING AND LABELING; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 84885304780     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-013-0627-x     Document Type: Article

References (36)

1. Brazeau P, Vale W, Burgus R et al (1973) Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 179:77-79
2. Reichlin S (1983) Somatostatin. N Engl J Med 309:1495-1501
3. Wang HL, Bogen C, Reisine T, Dichter M (1989) Somatostatin-14 and somatostatin-28 induce opposite effects on potassium currents in rat neocortical neurons. Proc Natl Acad Sci U S A 86:9616-9620
4. Bal CS, Gupta SK, Zaknun JJ (2010) Radiolabeled somatostatin analogs for radionuclide imaging and therapy in patients with gastroenteropancreatic neuroendocrine tumors. Trop Gastroenterol 31:87-95
5. Pawlikowski M, Melen-Mucha G (2004) Somatostatin analogs - from new molecules to new applications. Curr Opin Pharmacol 4:608-613
6. Pool SE, Krenning EP, Koning GA et al (2010) Preclinical and clinical studies of peptide receptor radionuclide therapy. Semin Nucl Med 40:209-218
7. Breeman WA, de Jong M, Kwekkeboom DJ et al (2001) Somatostatin receptor-mediated imaging and therapy: basic science, current knowledge, limitations and future perspectives. Eur J Nucl Med 28:1421-1429
8. Maecke HR, Hofmann M, Haberkorn U (2005) (68)Ga-labeled peptides in tumor imaging. J Nucl Med 46(Suppl 1):172S-178S
9. Kwekkeboom DJ, Mueller-Brand J, Paganelli G et al (2005) Overview of results of peptide receptor radionuclide therapy with 3 radiolabeled somatostatin analogs. J Nucl Med 46(Suppl 1):62S-66S
10. 111In-DTPAo] octreotide in patients. Eur J Nucl Med 28:1319-1325
11. 68Ga-DOTATOC-PET/CT on therapy management in patients with neuroendocrine tumors. Neuroendocrinology 91:101-109
12. 3-octreotide PET in comparison to CT and bone scintigraphy. J Nucl Med 50:1214-1221
13. Wadas TJ, Wong EH, Weisman GR, Anderson CJ (2010) Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease. Chem Rev 110:2858-2902
14. 111In] for SPECT, PET, and targeted therapeutic applications of somatostatin receptor (hsst2) expressing tumors. Bioconjug Chem 13:530-541
15. 3]-core. Bioconjug Chem 19:2409-2416
16. 111-labelled IgG. Eur J Nucl Med 17:305-309
17. Khaw BA, Klibanov A, O'Donnell SM et al (1991) Gamma imaging with negatively charge-modified monoclonal antibody: modification with synthetic polymers. J Nucl Med 32:1742-1751
18. Anderson CJ, Pajeau TS, Edwards WB, Sherman EL, Rogers BE, Welch MJ (1995) In vitro and in vivo evaluation of copper-64-octreotide conjugates. J Nucl Med 36:2315-2325
19. Sun X, Singh AN (2011) Multivalent bifunctional chelator scaffolds for gallium-68 based positron emission tomography imaging probe design: signal amplification via multivalency. Bioconjug Chem 22(8):1650-62
20. 111In] for SPECT, PET, and targeted therapeutic applications of somatostatin receptor (hsst2) expressing tumors. Bioconjug Chem 13:530-541
21. Lin M, Ranganathan D, Mori T et al (2012) Long-term evaluation of TiO(2)-based (68)Ge/(68)Ga generators and optimized automation of [(68)Ga]DOTATOC radiosynthesis. Appl Rad Isot 70:2539-2544
22. Liu Q, Cescato R, Dewi DA, Rivier J, Reubi JC, Schonbrunn A (2005) Receptor signaling and endocytosis are differentially regulated by somatostatin analogs. Mol Pharmacol 68:90-101
23. 3- octreotide: first results in patients with meningiomas. J Nucl Med 42:1053-1056
24. Hofman MS, Kong G, Neels OC, Eu P, Hong E, Hicks RJ (2012) High management impact of Ga-68 DOTATATE (GaTate) PET/CT for imaging neuroendocrine and other somatostatin expressing tumours. J Med imaging Radiat Oncol 56:40-47
25. 68Ga-DOTANOC somatostatin receptor PET/CT. Clin Nucl Med 37:892-894
26. Naji M, AL-N A (2012) (6)(8)Ga-labelled peptides in the management of neuroectodermal tumours. Eur J Nucl Med Mol Imaging 39(Suppl 1):S61-S67
27. Ambrosini V, Campana D, Tomassetti P, Fanti S (2012) (6)(8)Ga-labelled peptides for diagnosis of gastroenteropancreatic NET. Eur J Nucl Med Mol Imaging 39(Suppl 1):S52-S60
28. 18F- labelled derivative of the MMP inhibitor CGS 27023A for PET: radiosynthesis and initial small-animal PET studies. Appl Radiat Isot 67:606-610
29. Dawson RMC, Elliott DC, Elliott WH (1989) Data for Biochemical Research. 3rd ed.: Clarendon, New York
30. Sprague JE, Li WP, Liang K, Achilefu S, Anderson CJ (2006) In vitro and in vivo investigation of matrix metalloproteinase expression in metastatic tumor models. Nucl Med Biol 33:227-237
31. 111In- octreotide. J Nucl Med 41:1114-1119
32. Verwijnen SM, Sillevis Smith PA, Hoeben RC et al (2004) Molecular imaging and treatment of malignant gliomas following adenoviral transfer of the herpes simplex virus-thymidine kinase gene and the somatostatin receptor subtype 2 gene. Cancer Biother Radiopharm 19:111-120
33. Silbernagl S (1988) The renal handling of amino acids and oligopeptides. Physiol Rev 68:911-1007
34. Christensen EI, Gburek J (2004) Protein reabsorption in renal proximal tubule-function and dysfunction in kidney pathophysiology. Pediatr Nephrol (Berlin, Germany) 19:714-721
35. Vegt E, Eek A, Oyen WJ, de Jong M, Gotthardt M, Boerman OC (2010) Albumin-derived peptides efficiently reduce renal uptake of radiolabelled peptides. Eur J Nucl Med Mol Imaging 37(2)226-34
36. Vegt E, van Eerd JE, Eek A et al (2008) Reducing renal uptake of radiolabeled peptides using albumin fragments. J Nucl Med 49:1506-1511