The IL-33-ST2L pathway is associated with coronary artery disease in a Chinese Han population

American Journal of Human Genetics

Volumn 93, Issue 4, 2013, Pages 652-660

  Tu, Xin ^a   Nie, Shaofang ^a   Liao, Yuhua ^a   Zhang, Hongsong ^a   Fan, Qian ^a   Xu, Chengqi ^a   Bai, Ying ^a   Wang, Fan ^b   Ren, Xiang ^a   Tang, Tingting ^a   Xia, Ni ^a   Li, Sisi ^a   Huang, Yuan ^a   Liu, Juan ^a   Yang, Qing ^a   Zhao, Yuanyuan ^a   Lv, Qiulun ^a   Li, Qingxian ^c   Li, Yue ^d   Xia, Yunlong ^e   Qian, Jin ^f   Li, Bin ^g   Wu, Gang ^h   Wu, Yanxia ⁱ   Yang, Yan ^j   Wang, Qing K ^a   Cheng, Xiang ^a   more..

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JINING MEDICAL UNIVERSITY   (China)

^d HARBIN MEDICAL UNIVERSITY   (China)

^e DALIAN MEDICAL UNIVERSITY   (China)

^f Suizhou Central Hospital   (China)

^g Xiangyang Central Hospital   (China)

^h RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

ⁱ WUHAN NO 1 HOSPITAL   (China)

^j WUHAN ASIA HEART HOSPITAL   (China)

more..

Author keywords

[No Author keywords available]

Indexed keywords

IL1RL1 PROTEIN; INTERLEUKIN 33; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHINESE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DNA SEQUENCE; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENOTYPE; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84885300949     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2013.08.009     Document Type: Article

References (51)

1. J. He, D. Gu, X. Wu, K. Reynolds, X. Duan, C. Yao, J. Wang, C.S. Chen, J. Chen, and R.P. Wildman Major causes of death among men and women in China N. Engl. J. Med. 353 2005 1124 1134
2. V.L. Roger, A.S. Go, D.M. Lloyd-Jones, E.J. Benjamin, J.D. Berry, W.B. Borden, D.M. Bravata, S. Dai, E.S. Ford, C.S. Fox American Heart Association Statistics Committee and Stroke Statistics Subcommittee Heart disease and stroke statistics - 2012 update: a report from the American Heart Association Circulation 125 2012 188 197
3. S. Zdravkovic, A. Wienke, N.L. Pedersen, M.E. Marenberg, A.I. Yashin, and U. De Faire Heritability of death from coronary heart disease: a 36-year follow-up of 20 966 Swedish twins J. Intern. Med. 252 2002 247 254
4. S. Zdravkovic, A. Wienke, N.L. Pedersen, and U. de Faire Genetic influences on angina pectoris and its impact on coronary heart disease Eur. J. Hum. Genet. 15 2007 872 877
5. N.J. Samani, J. Erdmann, A.S. Hall, C. Hengstenberg, M. Mangino, B. Mayer, R.J. Dixon, T. Meitinger, P. Braund, H.E. Wichmann WTCCC and the Cardiogenics Consortium Genomewide association analysis of coronary artery disease N. Engl. J. Med. 357 2007 443 453
6. R. Clarke, J.F. Peden, J.C. Hopewell, T. Kyriakou, A. Goel, S.C. Heath, S. Parish, S. Barlera, M.G. Franzosi, S. Rust PROCARDIS Consortium Genetic variants associated with Lp(a) lipoprotein level and coronary disease N. Engl. J. Med. 361 2009 2518 2528
7. J. Erdmann, A. Grosshennig, P.S. Braund, I.R. König, C. Hengstenberg, A.S. Hall, P. Linsel-Nitschke, S. Kathiresan, B. Wright, D.A. Trégouët Italian Atherosclerosis, Thrombosis, and Vascular Biology Working Group Myocardial Infarction Genetics Consortium Wellcome Trust Case Control Consortium Cardiogenics Consortium New susceptibility locus for coronary artery disease on chromosome 3q22.3 Nat. Genet. 41 2009 280 282
8. S. Kathiresan, B.F. Voight, S. Purcell, K. Musunuru, D. Ardissino, P.M. Mannucci, S. Anand, J.C. Engert, N.J. Samani, H. Schunkert Myocardial Infarction Genetics Consortium Wellcome Trust Case Control Consortium Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants Nat. Genet. 41 2009 334 341
9. N. Soranzo, T.D. Spector, M. Mangino, B. Kühnel, A. Rendon, A. Teumer, C. Willenborg, B. Wright, L. Chen, and M. Li A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium Nat. Genet. 41 2009 1182 1190
10. J. Erdmann, C. Willenborg, J. Nahrstaedt, M. Preuss, I.R. König, J. Baumert, P. Linsel-Nitschke, C. Gieger, S. Tennstedt, and P. Belcredi Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23 Eur. Heart J. 32 2011 158 168
11. H. Schunkert, I.R. König, S. Kathiresan, M.P. Reilly, T.L. Assimes, H. Holm, M. Preuss, A.F. Stewart, M. Barbalic, C. Gieger Cardiogenics CARDIoGRAM Consortium Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease Nat. Genet. 43 2011 333 338
12. C.A. Disease Coronary Artery Disease (C4D) Genetics Consortium A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease Nat. Genet. 43 2011 339 344
13. F. Wang, C.Q. Xu, Q. He, J.P. Cai, X.C. Li, D. Wang, X. Xiong, Y.H. Liao, Q.T. Zeng, and Y.Z. Yang Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population Nat. Genet. 43 2011 345 349
14. X. Lu, L. Wang, S. Chen, L. He, X. Yang, Y. Shi, J. Cheng, L. Zhang, C.C. Gu, J. Huang Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Consortium Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease Nat. Genet. 44 2012 890 894
15. P. Deloukas, S. Kanoni, C. Willenborg, M. Farrall, T.L. Assimes, J.R. Thompson, E. Ingelsson, D. Saleheen, J. Erdmann, B.A. Goldstein CARDIoGRAMplusC4D Consortium DIAGRAM Consortium CARDIOGENICS Consortium MuTHER Consortium Wellcome Trust Case Control Consortium Large-scale association analysis identifies new risk loci for coronary artery disease Nat. Genet. 45 2013 25 33
16. J.F. Peden, and M. Farrall Thirty-five common variants for coronary artery disease: the fruits of much collaborative labour Hum. Mol. Genet. 20 R2 2011 R198 R205
17. B.P. Prins, V. Lagou, F.W. Asselbergs, H. Snieder, and J. Fu Genetics of coronary artery disease: genome-wide association studies and beyond Atherosclerosis 225 2012 1 10
18. G.K. Hansson Inflammation, atherosclerosis, and coronary artery disease N. Engl. J. Med. 352 2005 1685 1695
19. R. Kleemann, S. Zadelaar, and T. Kooistra Cytokines and atherosclerosis: a comprehensive review of studies in mice Cardiovasc. Res. 79 2008 360 376
20. R. van Minkelen, S.B. Wettinger, M.C. de Visser, H.L. Vos, P.H. Reitsma, F.R. Rosendaal, R.M. Bertina, and C.J. Doggen Haplotypes of the interleukin-1 receptor antagonist gene, interleukin-1 receptor antagonist mRNA levels and the risk of myocardial infarction Atherosclerosis 203 2009 201 205
21. K.A. Blagodatskikh, M.A. Evdokimova, IuV. Agapkina, A.G. Nikitin, A.N. Brovkin, A.A. Pushkov, E.G. Blagodatskikh, O.Iu. Kudriasheva, V.S. Osmolovskaia, and L.O. Minushkina [Gene IL6 G(-174)C and gene IL10 G(-1082)A polymorphisms are associated with unfavourable outcomes in patients with acute coronary syndrome] Mol. Biol. (Mosk.) 44 2010 839 846
22. Y. Chen, H. Huang, S. Liu, L.A. Pan, B. Zhou, L. Zhang, and Z. Zeng IL-16 rs11556218 gene polymorphism is associated with coronary artery disease in the Chinese Han population Clin. Biochem. 44 2011 1041 1044
23. X. Zhang, F. Pei, M. Zhang, C. Yan, M. Huang, T. Wang, and Y. Han Interleukin-17A gene variants and risk of coronary artery disease: a large angiography-based study Clin. Chim. Acta 412 2011 327 331
24. L. Tiret, T. Godefroy, E. Lubos, V. Nicaud, D.A. Tregouet, S. Barbaux, R. Schnabel, C. Bickel, C. Espinola-Klein, O. Poirier AtheroGene Investigators Genetic analysis of the interleukin-18 system highlights the role of the interleukin-18 gene in cardiovascular disease Circulation 112 2005 643 650
25. A.M. Miller, D. Xu, D.L. Asquith, L. Denby, Y. Li, N. Sattar, A.H. Baker, I.B. McInnes, and F.Y. Liew IL-33 reduces the development of atherosclerosis J. Exp. Med. 205 2008 339 346
26. L. Shi, C. Li, C. Wang, Y. Xia, G. Wu, F. Wang, C. Xu, P. Wang, X. Li, and D. Wang Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population Hum. Genet. 126 2009 843 849
27. C. Xu, F. Wang, B. Wang, X. Li, C. Li, D. Wang, X. Xiong, P. Wang, Q. Lu, and X. Wang Minor allele C of chromosome 1p32 single nucleotide polymorphism rs11206510 confers risk of ischemic stroke in the Chinese Han population Stroke 41 2010 1587 1592
28. X. Cheng, L. Shi, S. Nie, F. Wang, X. Li, C. Xu, P. Wang, B. Yang, Q. Li, and Z. Pan The same chromosome 9p21.3 locus is associated with type 2 diabetes and coronary artery disease in a Chinese Han population Diabetes 60 2011 680 684
29. A. Kapur, R.J. Hall, I.S. Malik, A.C. Qureshi, J. Butts, M. de Belder, A. Baumbach, G. Angelini, A. de Belder, and K.G. Oldroyd Randomized comparison of percutaneous coronary intervention with coronary artery bypass grafting in diabetic patients. 1-year results of the CARDia (Coronary Artery Revascularization in Diabetes) trial J. Am. Coll. Cardiol. 55 2010 432 440
30. S. Ye, J. Willeit, F. Kronenberg, Q. Xu, and S. Kiechl Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis: a population-based, prospective study J. Am. Coll. Cardiol. 52 2008 378 384
31. G. Mancia, G. De Backer, A. Dominiczak, R. Cifkova, R. Fagard, G. Germano, G. Grassi, A.M. Heagerty, S.E. Kjeldsen, S. Laurent Management of Arterial Hypertension of the European Society of Hypertension European Society of Cardiology 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) J. Hypertens. 25 2007 1105 1187
32. S. John, N. Shephard, G.Y. Liu, E. Zeggini, M.Q. Cao, W.W. Chen, N. Vasavda, T. Mills, A. Barton, and A. Hinks Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites Am. J. Hum. Genet. 75 2004 54 64
33. D.J. Schaid, J.C. Guenther, G.B. Christensen, S. Hebbring, C. Rosenow, C.A. Hilker, S.K. McDonnell, J.M. Cunningham, S.L. Slager, M.L. Blute, and S.N. Thibodeau Comparison of microsatellites versus single-nucleotide polymorphisms in a genome linkage screen for prostate cancer-susceptibility Loci Am. J. Hum. Genet. 75 2004 948 965
34. M. Shimizu, A. Matsuda, K. Yanagisawa, T. Hirota, M. Akahoshi, N. Inomata, K. Ebe, K. Tanaka, H. Sugiura, and K. Nakashima Functional SNPs in the distal promoter of the ST2 gene are associated with atopic dermatitis Hum. Mol. Genet. 14 2005 2919 2927
35. H.J. Cordell Detecting gene-gene interactions that underlie human diseases Nat. Rev. Genet. 10 2009 392 404
36. C. Moussion, N. Ortega, and J.P. Girard The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'? PLoS ONE 3 2008 e3331
37. J. Schmitz, A. Owyang, E. Oldham, Y. Song, E. Murphy, T.K. McClanahan, G. Zurawski, M. Moshrefi, J. Qin, and X. Li IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines Immunity 23 2005 479 490
38. M. Komai-Koma, D. Xu, Y. Li, A.N. McKenzie, I.B. McInnes, and F.Y. Liew IL-33 is a chemoattractant for human Th2 cells Eur. J. Immunol. 37 2007 2779 2786
39. S. Drube, S. Heink, S. Walter, T. Löhn, M. Grusser, A. Gerbaulet, L. Berod, J. Schons, A. Dudeck, and J. Freitag The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells Blood 115 2010 3899 3906
40. T. Pecaric-Petkovic, S.A. Didichenko, S. Kaempfer, N. Spiegl, and C.A. Dahinden Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33 Blood 113 2009 1526 1534
41. P. Valent Interleukin-33: a regulator of basophils Blood 113 2009 1396 1397
42. M.D. Smithgall, M.R. Comeau, B.R. Yoon, D. Kaufman, R. Armitage, and D.E. Smith IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK cells Int. Immunol. 20 2008 1019 1030
43. D. Xu, H.R. Jiang, P. Kewin, Y. Li, R. Mu, A.R. Fraser, N. Pitman, M. Kurowska-Stolarska, A.N. McKenzie, I.B. McInnes, and F.Y. Liew IL-33 exacerbates antigen-induced arthritis by activating mast cells Proc. Natl. Acad. Sci. USA 105 2008 10913 10918
44. F.Y. Liew, N.I. Pitman, and I.B. McInnes Disease-associated functions of IL-33: the new kid in the IL-1 family Nat. Rev. Immunol. 10 2010 103 110
45. M.A. Sedhom, M. Pichery, J.R. Murdoch, B. Foligné, N. Ortega, S. Normand, K. Mertz, D. Sanmugalingam, L. Brault, and T. Grandjean Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice Gut 2012 10.1136/gutjnl-2011-301785 Published online November 21, 2012
46. J.E. McLaren, D.R. Michael, R.C. Salter, T.G. Ashlin, C.J. Calder, A.M. Miller, F.Y. Liew, and D.P. Ramji IL-33 reduces macrophage foam cell formation J. Immunol. 185 2010 1222 1229
47. S. Demyanets, V. Konya, S.P. Kastl, C. Kaun, S. Rauscher, A. Niessner, R. Pentz, S. Pfaffenberger, K. Rychli, and C.E. Lemberger Interleukin-33 induces expression of adhesion molecules and inflammatory activation in human endothelial cells and in human atherosclerotic plaques Arterioscler. Thromb. Vasc. Biol. 31 2011 2080 2089
48. Y.S. Choi, H.J. Choi, J.K. Min, B.J. Pyun, Y.S. Maeng, H. Park, J. Kim, Y.M. Kim, and Y.G. Kwon Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide production Blood 114 2009 3117 3126
49. S. Aoki, M. Hayakawa, H. Ozaki, N. Takezako, H. Obata, N. Ibaraki, T. Tsuru, S. Tominaga, and K. Yanagisawa ST2 gene expression is proliferation-dependent and its ligand, IL-33, induces inflammatory reaction in endothelial cells Mol. Cell. Biochem. 335 2010 75 81
50. A. Tsapaki, A. Zaravinos, S. Apostolakis, K. Voudris, K. Vogiatzi, G.E. Kochiadakis, and D.A. Spandidos Genetic variability of the distal promoter of the ST2 gene is associated with angiographic severity of coronary artery disease J. Thromb. Thrombolysis 30 2010 365 371
51. M. Kabesch, M. Schedel, D. Carr, B. Woitsch, C. Fritzsch, S.K. Weiland, and E. von Mutius IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma J. Allergy Clin. Immunol. 117 2006 269 274