Cardiorenal syndrome: A cardiologist's perspective of pathophysiology

Clinical Journal of the American Society of Nephrology

Volumn 8, Issue 10, 2013, Pages 1800-1807

  Anand, Inder S ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGIPRESSIN; CANDESARTAN; DIURETIC AGENT; NEUROHORMONE; VALSARTAN;

ACUTE HEART FAILURE; ANEMIA; ARTERIOVENOUS FISTULA; ARTICLE; CARDIOLOGIST; CARDIORENAL SYNDROME; CENTRAL VENOUS PRESSURE; CLINICAL TRIAL (TOPIC); DIABETES MELLITUS; DISEASE CLASSIFICATION; EDEMA; HEART FAILURE; HEART LEFT VENTRICLE CONTRACTION; HEMODYNAMICS; HUMAN; HYPOTENSION; KIDNEY BLOOD FLOW; KIDNEY PERFUSION; MORBIDITY; MORTALITY; PERICARDIECTOMY; PREVALENCE; PROGNOSIS; RENAL GRAFT DYSFUNCTION; SODIUM RETENTION; SYSTEMIC VASCULAR RESISTANCE; UREMIA; VENOUS CONGESTION; WATER RETENTION;

CARDIO-RENAL SYNDROME; GLOMERULAR FILTRATION RATE; HEART FAILURE; HEMODYNAMICS; HUMANS; KIDNEY; PROGNOSIS; VENOUS PRESSURE;

EID: 84885236737     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.04090413     Document Type: Article

References (50)

1. Jencks SF, Williams MV, Coleman EA: Rehospitalizations among patients in the Medicare fee-for-service program. N Engl J Med 360: 1418-1428, 2009
2. Fonarow GC, Heywood JT: The confounding issue of comorbid renal insufficiency. Am J Med 119[Suppl 1]: S17-S25, 2006
3. Ronco C, McCullough P, Anker SD, Anand I, Aspromonte N, Bagshaw SM, Bellomo R, Berl T, Bobek I, Cruz DN, Daliento L, Davenport A, Haapio M, Hillege H, House AA, Katz N, Maisel A, Mankad S, Zanco P, Mebazaa A, Palazzuoli A, Ronco F, Shaw A, Sheinfeld G, Soni S, Vescovo G, Zamperetti N, Ponikowski P; Acute Dialysis Quality Initiative (ADQI) consensus group: Cardio-renal syndromes: Report from the consensus conference of the acute dialysis quality initiative. Eur Heart J 31: 703-711, 2010
4. Heywood JT, Fonarow GC, Costanzo MR, Mathur VS, Wigneswaran JR, Wynne J; ADHERE Scientific Advisory Committee and Investigators: High prevalence of renal dysfunction and its impact on outcome in 118,465 patients hospitalized with acute decompensated heart failure: A report from the ADHERE database. J Card Fail 13: 422-430, 2007
5. Gottlieb SS, Abraham W, Butler J, Forman DE, Loh E, Massie BM, O'connor CM, Rich MW, Stevenson LW, Young J, Krumholz HM: The prognostic importance of different definitions of worsening renal function in congestive heart failure. J Card Fail 8: 136-141, 2002
6. Smith GL, Vaccarino V, Kosiborod M, Lichtman JH, Cheng S, Watnick SG, Krumholz HM: Worsening renal function: What is a clinically meaningful change in creatinine during hospitalization with heart failure? J Card Fail 9: 13-25, 2003
7. Forman DE, Butler J, Wang Y, Abraham WT, O'Connor CM, Gottlieb SS, Loh E, Massie BM, Rich MW, Stevenson LW, Young JB, Krumholz HM: Incidence, predictors at admission, and impact of worsening renal function among patients hospitalized with heart failure. J Am Coll Cardiol 43: 61-67, 2004
8. Bagshaw SM, Cruz DN, Aspromonte N, Daliento L, Ronco F, Sheinfeld G, Anker SD, Anand I, Bellomo R, Berl T, Bobek I, Davenport A, Haapio M, Hillege H, House A, Katz N, Maisel A, Mankad S, McCullough P, Mebazaa A, Palazzuoli A, Ponikowski P, Shaw A, Soni S, Vescovo G, Zamperetti N, Zanco P, Ronco C; Acute Dialysis Quality Initiative Consensus Group: Epidemiology of cardio-renal syndromes: Workgroup statements from the 7th ADQI Consensus Conference. Nephrol Dial Transplant 25: 1406-1416, 2010
9. Shlipak MG, Smith GL, Rathore SS, Massie BM, Krumholz HM: Renal function, digoxin therapy, and heart failure outcomes: Evidence from the digoxin intervention group trial. J Am Soc Nephrol 15: 2195-2203, 2004
10. Hillege HL, Nitsch D, Pfeffer MA, Swedberg K, McMurray JJ, Yusuf S, Granger CB, Michelson EL, Ostergren J, Cornel JH, de Zeeuw D, Pocock S, van Veldhuisen DJ; Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) Investigators: Renal function as a predictor of outcome in a broad spectrum of patients with heart failure. Circulation 113: 671-678, 2006
11. Dries DL, Exner DV, Domanski MJ, Greenberg B, Stevenson LW: The prognostic implications of renal insufficiency in asymptomatic and symptomatic patients with left ventricular systolic dysfunction. J Am Coll Cardiol 35: 681-689, 2000
12. Anand IS, Bishu K, Rector TS, Ishani A, Kuskowski MA, Cohn JN: Proteinuria, chronic kidney disease, and the effect of an angiotensin receptor blocker in addition to an angiotensin-converting enzyme inhibitor in patients with moderate to severe heart failure. Circulation 120: 1577-1584, 2009
13. McAlister FA, Ezekowitz J, Tonelli M, Armstrong PW: Renal insufficiency and heart failure: Prognostic and therapeutic implications from a prospective cohort study. Circulation 109: 1004-1009, 2004
14. Ezekowitz J, McAlister FA, Humphries KH, Norris CM, Tonelli M, Ghali WA, Knudtson ML; APPROACH Investigators: The association among renal insufficiency, pharmacotherapy, and outcomes in 6,427 patients with heart failure and coronary artery disease. J Am Coll Cardiol 44: 1587-1592, 2004
15. McClellan WM, Flanders WD, Langston RD, Jurkovitz C, Presley R: Anemia and renal insufficiency are independent risk factors for death among patients with congestive heart failure admitted to community hospitals: A population-based study. J Am Soc Nephrol 13: 1928-1936, 2002
16. Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM: Secular trends in renal dysfunction and outcomes in hospitalized heart failure patients. J Card Fail 12: 257-262, 2006
17. Akhter MW, Aronson D, Bitar F, Khan S, Singh H, Singh RP, Burger AJ, Elkayam U: Effect of elevated admission serum creatinine and its worsening on outcome in hospitalized patients with decompensated heart failure. Am J Cardiol 94: 957-960, 2004
18. Butler J, Forman DE, Abraham WT, Gottlieb SS, Loh E, Massie BM, O'Connor CM, Rich MW, Stevenson LW, Wang Y, Young JB, Krumholz HM: Relationship between heart failure treatment and development of worsening renal function among hospitalized patients. Am Heart J 147: 331-338, 2004
19. Krumholz HM, Chen YT, Vaccarino V, Wang Y, Radford MJ, Bradford WD, Horwitz RI: Correlates and impact on outcomes of worsening renal function in patients. or 565 years of age with heart failure. Am J Cardiol 85: 1110-1113, 2000
20. Nohria A, Hasselblad V, Stebbins A, Pauly DF, Fonarow GC, Shah M, Yancy CW, Califf RM, Stevenson LW, Hill JA: Cardiorenal interactions: Insights from the ESCAPE trial. J Am Coll Cardiol 51: 1268-1274, 2008
21. Anand IS: Pathogenesis of anemia in cardiorenal disease. Rev Cardiovasc Med 6[Suppl 3]: S13-S21, 2005
22. Peters JP: The role of sodium in the production of edema. N Engl J Med 239: 353-362, 1948
23. Peters JP: The problem of cardiac edema. Am J Med 12: 66-76, 1952
24. Schrier RW: Pathogenesis of sodium and water retention in highoutput and low-output cardiac failure, nephrotic syndrome, cirrhosis, and pregnancy (1). N Engl J Med 319: 1065-1072, 1988
25. Michell AR: Effective blood volume: An effective concept or a modern myth. Perspect Biol Med 39: 471-490, 1996
26. Bayliss J, Norell M, Canepa-Anson R, Sutton G, Poole-Wilson P: Untreated heart failure: Clinical and neuroendocrine effects of introducing diuretics. Br Heart J 57: 17-22, 1987
27. Anand IS, Ferrari R, Kalra GS, Wahi PL, Poole-Wilson PA, Harris PC: Edema of cardiac origin. Studies of body water and sodium, renal function, hemodynamic indexes, and plasma hormones in untreated congestive cardiac failure. Circulation 80: 299-305, 1989
28. Anand IS, Ferrari R, Kalra GS, Wahi PL, Poole-Wilson PA, Harris PC: Pathogenesis of edema in constrictive pericarditis. Studies of body water and sodium, renal function, hemodynamics, and plasma hormones before and after pericardiectomy. Circulation 83: 1880-1887, 1991
29. Anand IS, Chandrashekhar Y, Ferrari R, Sarma R, Guleria R, Jindal SK, Wahi PL, Poole-Wilson PA, Harris P: Pathogenesis of congestive state in chronic obstructive pulmonary disease. Studies of body water and sodium, renal function, hemodynamics, and plasma hormones during edema and after recovery. Circulation 86: 12-21, 1992
30. Anand IS, Chandrashekhar Y, Ferrari R, Poole-Wilson PA, Harris PC: Pathogenesis of oedema in chronic severe anaemia: Studies of body water and sodium, renal function, haemodynamic variables, and plasma hormones. Br Heart J 70: 357-362, 1993
31. Anand IS, Florea VG: High output cardiac failure. Curr Treat Options Cardiovasc Med 3: 151-159, 2001
32. Anand IS, Chugh SS: Mechanisms and management of renal dysfunction in heart failure. Curr Opin Cardiol 12: 251-258, 1997
33. Carmines PK, Perry MD, Hazelrig JB, Navar LG: Effects of preglomerular and postglomerular vascular resistance alterations on filtration fraction. Kidney Int Suppl 20: S229-S232, 1987
34. Harris P: Evolution and the cardiac patient. Cardiovasc Res 17: 313-319, 1983
35. Rothe CF: Reflex control of veins and vascular capacitance. Physiol Rev 63: 1281-1342, 1983
36. de Man FS, Handoko ML, Guignabert C, Bogaard HJ, Vonk Noordegraaf A: Neurohormonal axis in patients with pulmonary arterial hypertension: Friend or foe? Am J Respir Crit Care Med 187: 14-19, 2013
37. Firth JD, Raine AE, Ledingham JG: Raised venous pressure: A direct cause of renal sodium retention in oedema? Lancet 1: 1033-1035, 1988
38. Damman K, van Deursen VM, Navis G, Voors AA, van Veldhuisen DJ, Hillege HL: Increased central venous pressure is associated with impaired renal function and mortality in a broad spectrum of patients with cardiovascular disease. J Am Coll Cardiol 53: 582-588, 2009
39. Mullens W, Abrahams Z, Francis GS, Sokos G, Taylor DO, Starling RC, Young JB, Tang WH: Importance of venous congestion for worsening of renal function in advanced decompensated heart failure. J Am Coll Cardiol 53: 589-596, 2009
40. Bradley SE, Bradley GP: The effect of increased intra-abdominal pressure on renal function in man. J Clin Invest 26: 1010-1022, 1947
41. Mullens W, Abrahams Z, Skouri HN, Francis GS, Taylor DO, Starling RC, Paganini E, Tang WH: Elevated intra-abdominal pressure in acute decompensated heart failure: A potential contributor to worsening renal function? J Am Coll Cardiol 51: 300-306, 2008
42. Winton FR: The influence of venous pressure on the isolated mammalian kidney. J Physiol 72: 49-61, 1931
43. Braam B, Cupples WA, Joles JA, Gaillard C: Systemic arterial and venous determinants of renal hemodynamics in congestive heart failure. Heart Fail Rev 17: 161-175, 2012
44. Gottschalk CW, Mylle M: Micropuncture study of pressures in proximal tubules and peritubular capillaries of the rat kidney and their relation to ureteral and renal venous pressures. Am J Physiol 185: 430-439, 1956
45. Bart BA, Goldsmith SR, Lee KL, Givertz MM, O'Connor CM, Bull DA, Redfield MM, Deswal A, Rouleau JL, LeWinter MM, Ofili EO, Stevenson LW, Semigran MJ, Felker GM, Chen HH, Hernandez AF, Anstrom KJ, McNulty SE, Velazquez EJ, Ibarra JC, Mascette AM, Braunwald E; Heart Failure Clinical Research Network: Ultrafiltration in decompensated heart failure with cardiorenal syndrome. N Engl J Med 367: 2296-2304, 2012
46. Colombo PC, Banchs JE, Celaj S, Talreja A, Lachmann J, Malla S, DuBois NB, Ashton AW, Latif F, Jorde UP, Ware JA, LeJemtel TH: Endothelial cell activation in patients with decompensated heart failure. Circulation 111: 58-62, 2005
47. Ganda A, Onat D, Demmer RT, Wan E, Vittorio TJ, Sabbah HN, Colombo PC: Venous congestion and endothelial cell activation in acute decompensated heart failure. Curr Heart Fail Rep 7: 66-74, 2010
48. Niebauer J, Volk HD, Kemp M, Dominguez M, Schumann RR, Rauchhaus M, Poole-Wilson PA, Coats AJ, Anker SD: Endotoxin and immune activation in chronic heart failure: A prospective cohort study. Lancet 353: 1838-1842, 1999
49. Massie BM, O'Connor CM, Metra M, Ponikowski P, Teerlink JR, Cotter G, Weatherley BD, Cleland JG, Givertz MM, Voors A, DeLucca P, Mansoor GA, Salerno CM, Bloomfield DM, Dittrich HC; PROTECT Investigators and Committees: Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure. N Engl J Med 363: 1419-1428, 2010
50. Butler J, Geisberg C, Howser R, Portner PM, Rogers JG, Deng MC, Pierson RN 3rd: Relationship between renal function and left ventricular assist device use. Ann Thorac Surg 81: 1745-1751, 2006