Synthesis and structure-activity relationship of 2-phenyliminochromene derivatives as inhibitors for aldo-keto reductase (AKR) 1B10

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 21, 2013, Pages 6378-6384

  Endo, Satoshi ^a   Hu, Dawei ^b   Suyama, Miho ^a   Matsunaga, Toshiyuki ^a   Sugimoto, Kenji ^b   Matsuya, Yuji ^b   El Kabbani, Ossama ^c   Kuwata, Kazuo ^d   Hara, Akira ^d   Kitade, Yukio ^d   Toyooka, Naoki ^b  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c MONASH UNIVERSITY   (Australia)

^d GIFU UNIVERSITY   (Japan)

Author keywords

AKR1B10; Aldose reductase; Aldose reductase like protein; Molecular docking; Structure activity relationship

Indexed keywords

2 (4 BROMOPHENYLIMINO) 7 HYDROXY 2H CHROMENE 3 CARBOXYLIC ACID PYRIDIN 2 YLAMIDE; 2 (4 METHOXYPHENYLIMINO) 7 HYDROXY N (PYRIDIN 2 YL) 2H CHROMENE 3 CARBOXAMIDE; 2 PHENYLIMINOCHROMENE DERIVATIVE; 4 [7 HYDROXY 3 (PYRIDIN 2 YLCARBAMOYL) CHROMEN 2 YLIDENEAMINO]BENZOIC ACID; 4 METHOXY GROUP; 6 HYDROXY 2 (4 METHOXYPHENYLIMINO) 2H CHROMENE 3 CARBOXYLIC ACID PYRIDIN 2 YLAMIDE; 7 HYDROXY 2 (4 HYDROXYPHENYLIMINO) 2H CHROMENE 3 CARBOXYLIC ACID PYRIDIN 2 YLAMIDE; 7 HYDROXY 2 (4 IODOPHENYLIMINO) 2H CHROMENE 3 CARBOXYLIC ACID PYRIDIN 2 YLAMIDE; 7 HYDROXY 2 (4 METHOXPHENYLINO) 2H CHROMENE 3 CARBOXYLIC ACID ISOBUTYLAMIDE; 7 HYDROXY 2 (4 METHOXYPHENYLIMINO) 2 H CHROMENE 3 CARBOXYLIC ACID BUTYLAMIDE; 7 HYDROXY 2 (4 METHOXYPHENYLIMINO) 2H CHROMENE 3 CARBOXYLIC ACID (2 HYDROXYETHYL)AMIDE; 7 HYDROXY 2 (4 METHOXYPHENYLIMINO) 2H CHROMENE 3 CARBOXYLIC ACID BENZYLAMIDE; 7 HYDROXY 2 (4 METHOXYPHENYLIMINO) 2H CHROMENE 3 CARBOXYLIC ACID CYCLOHEXYLAMIDE; 7 HYDROXY 2 (4 METHOXYPHENYLIMINO) 2H CHROMENE 3 CARBOXYLIC ACID ISOPROPYLAMIDE; 7 HYDROXY 2 4 TOLYLIMINO 2H CHROMENE 3 CARBOXYLIC ACID PYRIDIN 2 YLAMIDE; 7 HYDROXY 2 PHENYLIMINO 2H CHROMENE 3 CARBOXYLIC ACID PYRIDIN 2 YLAMIDE; 8 HYDROXY 2 (4 METHOXYPHENYLIMINO) 2H CHROMENE 3 CARBOXYLIC ACID PYRIDIN 2 YLAMIDE; [4 [7 HYDROXY 3 (PYRIDIN 2 YLCARBAMOYL)CHROMEN 2 YLIDENEAMINO]PHENYL]ACETIC ACID; ALDOKETO REDUCTASE 1B10; ALDOKETO REDUCTASE 1B10 INHIBITOR; ANTINEOPLASTIC AGENT; BENZYLAMIDE DERIVATIVE; CHEMICAL COMPOUND; ENZYME INHIBITOR; HISTIDINE; HYDROGEN; HYDROXYL GROUP; OXIDOREDUCTASE; TYROSINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CATALYSIS; CHEMICAL INTERACTION; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROGEN BOND; MOLECULAR DOCKING; NONHUMAN; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

AKR; AKR1B10; ALDO-KETO REDUCTASE; ALDOSE REDUCTASE; ALDOSE REDUCTASE-LIKE PROTEIN; FBS; FETAL BOVINE SERUM; MOLECULAR DOCKING; SAR; STRUCTURE-ACTIVITY RELATIONSHIP;

ALDEHYDE REDUCTASE; BENZAMIDES; BENZOPYRANS; BINDING SITES; CATALYTIC DOMAIN; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; KINETICS; MOLECULAR DOCKING SIMULATION; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84885181859     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.08.059     Document Type: Article

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