Expression and function of PEPT2 during transdifferentiation of alveolar epithelial cells

Life Sciences

Volumn 93, Issue 17, 2013, Pages 630-636

  Takano, Mikihisa ^a   Horiuchi, Taishi ^a   Sasaki, Yoshihiro ^a   Kato, Yuki ^a   Nagai, Junya ^a   Yumoto, Ryoko ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Alveolar epithelial cells; Gly Sar uptake; Oligopeptide transporter; PEPT2; Transdifferentiation

Indexed keywords

CEFADROXIL; MESSENGER RNA; PEPTIDE TRANSPORTER 2; COTRANSPORTER; HYDROGEN-COUPLED OLIGOPEPTIDE TRANSPORTER PEPT2;

ANIMAL CELL; ARTICLE; CELL TRANSDIFFERENTIATION; IC 50; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INTRACELLULAR TRANSPORT; LUNG ALVEOLUS EPITHELIUM; NONHUMAN; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION; LUNG; MALE; METABOLISM; PHYSIOLOGY; PRIMARY CELL CULTURE; RAT; TIME; TRANSPORT AT THE CELLULAR LEVEL;

RATTUS;

ANIMALS; BIOLOGICAL TRANSPORT; CEFADROXIL; CELL TRANSDIFFERENTIATION; EPITHELIAL CELLS; GENE EXPRESSION; HYDROGEN-ION CONCENTRATION; LUNG; MALE; PRIMARY CELL CULTURE; RATS; SYMPORTERS; TIME FACTORS;

EID: 84885173237     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2013.08.008     Document Type: Article

References (31)

1. J.L. Barton, T. Berg, L. Didon, and M. Nord The pattern recognition receptor Nod1 activates CCAAT/enhancer binding protein β signalling in lung epithelial cells Eur Respir J 30 2007 214 222
2. C. Bosquillon Drug transporters in the lung - do they play a role in the biopharmaceutics of inhaled drugs? J Pharm Sci 99 2010 2240 2255
3. +/peptide cotransporter FASEB J 9 1995 1489 1496
4. M. Brandsch, I. Knütter, and E. Bosse-Doenecke Pharmaceutical and pharmacological importance of peptide transporters J Pharm Pharmacol 60 2008 543 585
5. H. Daniel, and G. Kottra The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology Pflugers Arch 447 2004 610 618
6. F. Döring, D. Dorn, U. Bachfischer, S. Amasheh, M. Herget, and H. Daniel Functional analysis of a chimeric mammalian peptide transporter derived from the intestinal and renal isoforms J Physiol 497 Pt 3 1996 773 779
7. 2 Exp Mol Pathol 22 1975 142 150
8. H. Fehrenbach Alveolar epithelial type II cell: defender of the alveolus revisited Respir Res 2 2001 33 46
9. N.H. Feng, H.I. Lin, J.S. Wang, S.T. Chou, H.K. Ma, S.A. Rooney, and J.F. Lu Differential expression of a V-type ATPase C subunit gene, Atp6v1c2, during culture of rat lung type II pneumocytes J Biomed Sci 12 2005 899 911
10. D.A. Groneberg, M. Nickolaus, J. Springer, F. Döring, H. Daniel, and A. Fischer Localization of the peptide transporter PEPT2 in the lung: implications for pulmonary oligopeptide uptake Am J Pathol 158 2001 707 714
11. D.A. Groneberg, P.R. Eynott, F. Döring, Q.T. Dinh, T. Oates, P.J. Barnes, K.F. Chung, H. Daniel, and A. Fischer Distribution and function of the peptide transporter PEPT2 in normal and cystic fibrosis human lung Thorax 57 2002 55 60
12. D.A. Groneberg, A. Fischer, K.F. Chung, and H. Daniel Molecular mechanisms of pulmonary peptidomimetic drug and peptide transport Am J Respir Cell Mol Biol 30 2004 251 260
13. M. Ikehata, R. Yumoto, K. Nakamura, J. Nagai, and M. Takano Comparison of albumin uptake in rat alveolar type II and type I-like epithelial cells in primary culture Pharm Res 25 2008 913 922
14. M. Ikehata, R. Yumoto, Y. Kato, J. Nagai, and M. Takano Mechanism of insulin uptake in rat alveolar type II and type I-like epithelial cells Biol Pharm Bull 32 2009 1765 1769
15. K. Inui, T. Terada, S. Masuda, and H. Saito Physiological and pharmacological implications of peptide transporters, PEPT1 and PEPT2 Nephrol Dial Transplant 15 2000 11 13
16. C. Jin, E. Zoidis, C. Ghirlanda, and C. Schmid Dexamethasone and cyclic AMP regulate sodium phosphate cotransporter (NaPi-IIb and Pit-1) mRNA and phosphate uptake in rat alveolar type II epithelial cells Lung 188 2010 51 61
17. M.A. Kamal, R.F. Keep, and D.E. Smith Role and relevance of PEPT2 in drug disposition, dynamics, and toxicity Drug Metab Pharmacokinet 23 2008 236 242
18. +/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1 Eur J Pharm Biopharm 59 2005 17 24
19. D. Meredith, and C.A. Boyd Dipeptide transport characteristics of the apical membrane of rat lung type II pneumocytes Am J Physiol 269 1995 L137 L143
20. S. Newstead Towards a structural understanding of drug and peptide transport within the proton-dependent oligopeptide transporter (POT) family Biochem Soc Trans 39 2011 1353 1358
21. K. Oda, R. Yumoto, J. Nagai, H. Katayama, and M. Takano Mechanism underlying insulin uptake in alveolar epithelial cell line RLE-6TN Eur J Pharmacol 672 2011 62 69
22. J.S. Patton, and P.R. Byron Inhaling medicines: delivering drugs to the body through the lungs Nat Rev Drug Discov 6 2007 67 74
23. H.B. Søndergaard, B. Brodin, and C.U. Nielsen hPEPT1 is responsible for uptake and transport of Gly-Sar in the human bronchial airway epithelial cell-line Calu-3 Pflugers Arch 456 2008 611 622
24. P.W. Swaan, T. Bensman, T.M. Bahadduri, M.W. Hall, A. Sarkar, S. Bao, C.M. Khantwal, S. Ekins, and D.L. Knoell Bacterial peptide recognition and immune activation facilitated by human peptide transporter PEPT2 Am J Respir Cell Mol Biol 39 2008 536 542
25. M. Takano, E. Kimura, S. Suzuki, J. Nagai, and R. Yumoto Human erythrocyte nucleoside transporter ENT1 functions at ice-cold temperatures Drug Metab Pharmacokinet 25 2010 351 360
26. T. Terada, H. Saito, M. Mukai, and K. Inui Recognition of β-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells Am J Physiol 273 1997 F706 F711
27. T. Terada, K. Sawada, H. Saito, Y. Hashimoto, and K. Inui Functional characteristics of basolateral peptide transporter in the human intestinal cell line Caco-2 Am J Physiol 276 1999 G1435 G1441
28. T. Terada, K. Sawada, T. Ito, H. Saito, Y. Hashimoto, and K. Inui Functional expression of novel peptide transporter in renal basolateral membranes Am J Physiol Renal Physiol 279 2000 F851 F857
29. B.D. Uhal Cell cycle kinetics in the alveolar epithelium Am J Physiol 272 1997 L1031 L1045
30. + exchanger in primary cultures of astrocytes from mouse cerebral cortex Brain Res 1044 2005 33 41
31. R. Yumoto, H. Nishikawa, M. Okamoto, H. Katayama, J. Nagai, and M. Takano Clathrin-mediated endocytosis of FITC-albumin in alveolar type II epithelial cell line RLE-6TN Am J Physiol Lung Cell Mol Physiol 290 2006 L946 L955