Effects of TGF-β1 and VEGF-A transgenes on the osteogenic potential of bone marrow stromal cells in vitro and in vivo

Journal of Tissue Engineering

Volumn 3, Issue 1, 2012, Pages 1-12

  Kuroda, Shinji ^a   Sumner, Dale R ^b   Virdi, Amarjit S ^b  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Bone marrow; Gene transfer; TGF 1; Tissue engineering; VEGF A

Indexed keywords

BONE; CELL CULTURE; CELL ENGINEERING; GENE EXPRESSION; PHOSPHATASES; RNA; SCAFFOLDS (BIOLOGY);

BONE MARROW; BONE MARROW STROMAL CELLS; CELL-BE; CELL/B.E; IN-VITRO; OSTEOGENIC POTENTIAL; TGF-Β1; TISSUES ENGINEERINGS; TRANSGENE; VEGF-A;

GENE TRANSFER;

EID: 84885155689     PISSN: None     EISSN: 20417314     Source Type: Journal    
DOI: 10.1177/2041731412459745     Document Type: Article

References (53)

1. Caplan AI. Mesenchymal stem cells. J Orthop Res 1991; 9: 641-650.
2. Goshima J, Goldberg VM and Caplan AI. The osteogenic potential of culture-expanded rat marrow mesenchymal cells assayed in vivo in calcium phosphate ceramic blocks. Clin Orthop Relat Res 1991; 262: 298-311.
3. Ohgushi H, Goldberg VM and Caplan AI. Heterotopic osteogenesis in porous ceramics induced by marrow cells. J Orthop Res 1989; 7: 568-578.
4. Ohgushi H, Goldberg VM and Caplan AI. Repair of bone defects with marrow cells and porous ceramic. Experiments in rats. Acta Orthop Scand 1989; 60: 334-339.
5. Nakahara H, Bruder SP, Goldberg VM, et al. In vivo osteochondrogenic potential of cultured cells derived from the periosteum. Clin Orthop Relat Res 1990; 259: 223-232.
6. Lucas PA, Syftestad GT and Caplan AI. A water-soluble fraction from adult bone stimulates the differentiation of cartilage in explants of embryonic muscle. Differentiation 1988; 37: 47-52.
7. Nathanson MA and Hay ED. Analysis of cartilage differentiation from skeletal muscle grown on bone matrix. I. Ultrastructural aspects. Dev Biol 1980; 78: 301-331.
8. Bab I, Passi-Even L, Gazit D, et al. Osteogenesis in in vivo diffusion chamber cultures of human marrow cells. Bone Miner 1988; 4: 373-386.
9. Herbertson A and Aubin JE. Dexamethasone alters the subpopulation make-up of rat bone marrow stromal cell cultures. J Bone Miner Res 1995; 10: 285-294.
10. McCulloch CA, Strugurescu M, Hughes F, et al. Osteogenic progenitor cells in rat bone marrow stromal populations exhibit self-renewal in culture. Blood 1991; 77: 1906-1911.
11. Langer R and Vacanti JP. Tissue engineering. Science 1993; 260: 920-926.
12. Langer R. Drug delivery and targeting. Nature 1998; 392: 5-10.
13. Fu S and Liesveld J. Mobilization of hematopoietic stem cells. Blood Rev 2000; 14: 205-218.
14. Bonadio J. Tissue engineering via local gene delivery. J Mol Med 2000; 78: 303-311.
15. Bonadio J. Tissue engineering via local gene delivery: update and future prospects for enhancing the technology. Adv Drug Deliv Rev 2000; 44: 185-194.
16. Lew D, Parker SE, Latimer T, et al. Cancer gene therapy using plasmid DNA: pharmacokinetic study of DNA following injection in mice. Hum Gene Ther 1995; 6: 553-564.
17. Bonewald LF and Mundy GR. Role of transforming growth factor beta in bone remodeling: a review. Connect Tissue Res 1989; 23: 201-208.
18. Centrella M McCarthy TL and Canalis E. Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone. J Biol Chem 1987; 262: 2869-2874.
19. Robey PG, Young MF, Flanders KC, et al. Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro. J Cell Biol 1987; 105: 457-463.
20. Linkhart TA, Mohan S and Baylink DJ. Growth factors for bone growth and repair: IGF, TGF beta and BMP. Bone 1996; 19: 1S-12S.
21. Sandberg MM, Aro HT and Vuorio EI. Gene expression during bone repair. Clin Orthop Relat Res 1993; 289: 292-312.
22. Rosen D, Miller SC, DeLeon E, et al. Systemic administration of recombinant transforming growth factor beta 2 (rTGF-beta 2) stimulates parameters of cancellous bone formation in juvenile and adult rats. Bone 1994; 15: 355-359.
23. Joyce ME, Jingushi S and Bolander ME. Transforming growth factor-beta in the regulation of fracture repair. Orthop Clin North Am 1990; 21: 199-209.
24. Lind M, Schumacker B, Soballe K, et al. Transforming growth factor-beta enhances fracture healing in rabbit tibiae. Acta Orthop Scand 1993; 64: 553-556.
25. Leung DW, Cachianes G, Kuang WJ, et al. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246: 1306-1309.
26. Ferrara N, Leung DW, Cachianes G, et al. Purification and cloning of vascular endothelial growth factor secreted by pituitary folliculostellate cells. Methods Enzymol 1991; 198: 391-405.
27. Collin-Osdoby P. Role of vascular endothelial cells in bone biology. J Cell Biochem 1994; 55: 304-309.
28. Harada S, Nagy JA, Sullivan KA, et al. Induction of vascular endothelial growth factor expression by prostaglandin E2 and E1 in osteoblasts. J Clin Invest 1994; 93: 2490-2496.
29. Saadeh PB, Mehrara BJ, Steinbrech DS, et al. Transforming growth factor-beta1 modulates the expression of vascular endothelial growth factor by osteoblasts. Am J Physiol 1999; 277: C628-C637.
30. McMahon JM, Conroy S, Lyons M, et al. Gene transfer into rat mesenchymal stem cells: a comparative study of viral and nonviral vectors. Stem Cells Dev 2006; 15: 87-96.
31. Mazur W, Ali NM, Grinstead WC, et al. Lipofectin-mediated versus adenovirus-mediated gene transfer in vitro and in vivo: comparison of canine and porcine model systems. Coron Artery Dis 1994; 5: 779-786.
32. Ochiya T, Takahama Y, Nagahara S, et al. New delivery system for plasmid DNA in vivo using atelocollagen as a carrier material: the minipellet. Nat Med 1999; 5: 707-710.
33. Shea LD, Smiley E, Bonadio J, et al. DNA delivery from polymer matrices for tissue engineering. Nat Biotechnol 1999; 17: 551-554.
34. Bonadio J, Smiley E, Patil P, et al. Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration. Nat Med 1999; 5: 753-759.
35. Heberden C, Denis I, Pointillart A, et al. TGF-beta and calcitriol. Gen Pharmacol 1998; 30: 145-151.
36. Mayr-Wohlfart U, Waltenberger J, Hausser H, et al. Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts. Bone 2002; 30: 472-477.
37. Midy V and Plouet J. Vasculotropin/vascular endothelial growth factor induces differentiation in cultured osteoblasts. Biochem Biophys Res Commun 1994; 199: 380-386.
38. Spinella-Jaegle S, Roman-Roman S, Faucheu C, et al. Opposite effects of bone morphogenetic protein-2 and transforming growth factor-beta1 on osteoblast differentiation. Bone 2001; 29: 323-330.
39. Goad DL, Rubin J, Wang H, et al. Enhanced expression of vascular endothelial growth factor in human SaOS-2 osteoblast- like cells and murine osteoblasts induced by insulinlike growth factor I. Endocrinology 1996; 137: 2262-2268.
40. Holderfield MT and Hughes CC. Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis. Circ Res 2008; 102: 637-652.
41. Bi LX, Simmons DJ and Mainous E. Expression of BMP-2 by rat bone marrow stromal cells in culture. Calcif Tissue Int 1999; 64: 63-68.
42. Green E, Todd B and Heath D. Mechanism of glucocorticoid regulation of alkaline phosphatase gene expression in osteoblast-like cells. Eur J Biochem 1990; 188: 147-153.
43. Ter Brugge PJ and Jansen JA. In vitro osteogenic differentiation of rat bone marrow cells subcultured with and without dexamethasone. Tissue Eng 2002; 8: 321-331.
44. Canalis E and Delany AM. Mechanisms of glucocorticoid action in bone. Ann N Y Acad Sci 2002; 966: 73-81.
45. Luppen CA. Leclerc N. Noh T. et al. Brief bone morphogenetic protein 2 treatment of glucocorticoid-inhibited MC3T3-E1 osteoblasts rescues commitment-associated cell cycle and mineralization without alteration of Runx 2. J Biol Chem 2003; 278: 44995-45003.
46. Luppen CA, Smith E, Spevak L, et al. Bone morphogenetic protein-2 restores mineralization in glucocorticoid-inhibited MC3T3-E1 osteoblast cultures. J Bone Miner Res 2003; 18: 1186-1197.
47. Chen TL, Cone CM and Feldman D. Glucocorticoid modulation of cell proliferation in cultured osteoblast-like bone cells: differences between rat and mouse. Endocrinology 1983; 112: 1739-1745.
48. Chevalley T, Strong DD, Mohan S, et al. Evidence for a role for insulin-like growth factor binding proteins in glucocorticoid inhibition of normal human osteoblast-like cell proliferation. Eur J Endocrinol 1996; 134: 591-601.
49. Smith E, Redman RA, Logg CR, et al. Glucocorticoids inhibit developmental stage-specific osteoblast cell cycle. Dissociation of cyclin A-cyclin-dependent kinase 2 from E2F4-p130 complexes. J Biol Chem 2000; 275: 19992-20001.
50. Weinstein RS, Jilka RL, Parfitt AM, et al. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest 1998; 102: 274-282.
51. Delany AM, Gabbitas BY and Canalis E. Cortisol downregulates osteoblast alpha 1 (I) procollagen mRNA by transcriptional and posttranscriptional mechanisms. J Cell Biochem 1995; 57: 488-494.
52. Chang DJ, Ji C, Kim KK, et al. Reduction in transforming growth factor beta receptor I expression and transcription factor CBFa1 on bone cells by glucocorticoid. J Biol Chem 1998; 273: 4892-4896.
53. Harris SE, Bonewald LF, Harris MA, et al. Effects of transforming growth factor beta on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts. J Bone Miner Res 1994; 9: 855-863.