Functional salivary gland regeneration by transplantation of a bioengineered organ germ

Nature Communications

Volumn 4, Issue , 2013, Pages

  Ogawa, Miho ^a,b   Oshima, Masamitsu ^a   Imamura, Aya ^a   Sekine, Yurie ^a   Ishida, Kentaro ^a   Yamashita, Kentaro ^a   Nakajima, Kei ^c   Hirayama, Masatoshi ^d   Tachikawa, Tetsuhiko ^e   Tsuji, Takashi ^a,b  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b Organ Technologies   (Japan)

^c TOKYO DENTAL COLLEGE   (Japan)

^d KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e SHOWA UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PILOCARPINE;

BIOENGINEERING; CANCER; DISEASE TREATMENT; INFECTIOUS DISEASE; MATURATION; MICROBIAL COMMUNITY; RADIATION EXPOSURE; SALIVA; TRANSPLANTATION;

ANIMAL EXPERIMENT; ARTICLE; BIOENGINEERING; INNERVATION; MORPHOGENESIS; MOUSE; MYOEPITHELIUM; NONHUMAN; ORTHOTOPIC TRANSPLANTATION; REGENERATION; SALIVA; SALIVARY GLAND; SALIVATION; SUBMANDIBULAR GLAND; XEROSTOMIA;

ANIMALS; CITRIC ACID; EMBRYO, MAMMALIAN; EMBRYONIC STEM CELLS; EPITHELIAL CELLS; GRAFT SURVIVAL; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; PILOCARPINE; RECOVERY OF FUNCTION; REGENERATION; STEM CELL TRANSPLANTATION; SUBMANDIBULAR GLAND; TISSUE ENGINEERING; TRANSPLANTATION, HOMOLOGOUS; XEROSTOMIA;

EID: 84885148267     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3498     Document Type: Article

References (35)

1. Vissink, a., Burlage, F. R., Spijkervet, F. K. L., Jansma, J. & Coppes, R. P. Prevention and treatment of the consequences of head and neck radiotherapy. Crit. Rev. Oral Biol. Med. 14, 213-225 (2003).
2. Vissink, A., Jansma, J., Spijkervet, F. K. L., Burlage, F. R. & Coppes, R. P. Oral sequelae of head and neck radiotherapy. Crit. Rev. Oral Biol. Med. 14, 199-212 (2003).
3. Okumura, K., Shinohara, M. & Endo, F. Capability of tissue stem cells to organize into salivary rudiments. Stem Cells Int. 2012, 502136 (2012).
4. Denny, P. C. & Denny, P. A. Dynamics of parenchymal cell division, differentiation, and apoptosis in the young adult female mouse submandibular gland. Anat. Rec. 254, 408-417 (1999).
5. Avery, J K. Oral development and histology 292-330 (Thieme Press, 2002).
6. Tucker, A. S. Salivary gland development. Semin. Cell. Dev. Biol. 18, 237-244 (2007).
7. Jaskoll, T. & Melnick, M. Embryonic salivary gland branching morphogenesis. Madame Curie 13-14 (2004).
8. Atkinson, J. C., Grisius, M. & Massey, W. Salivary hypofunction and xerostomia: Diagnosis and treatment. Dent. Clin. North Am. 49, 309-326 (2005).
9. Hayashi, Y., Arakaki, R. & Ishimaru, N. Salivary gland and autoimmunity. J. Med. Invest. 56, 185-191 (2009).
10. Ship, J. A., Pillemer, S. R. & Baum, B. J. Xerostomia and the geriatric patient. J. Am. Geriatr. Soc. 50, 535-543 (2002).
11. Edgar, M., Dawes, C. & Mullane, O. D. Saliva and Oral Health 3rd edn (British Dental Association, 2004).
12. Fox, P. C. Salivary enhancement therapies. Caries Res. 38, 241-246 (2004).
13. Nakamura, T. et al. M3 muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice. J. Physiol 558, 561-575 (2004).
14. Kagami, H., Wang, S. & Hai, B. Restoring the function of salivary glands. Oral Dis. 14, 15-24 (2008).
15. Copelan, E. A. Hematopoietic stem-cell transplantation. N. Engl. J. Med. 354, 1813-1826 (2006).
16. Segers, V. F. M. & Lee, R. T. Stem-cell therapy for cardiac disease. Nature 451, 937-942 (2008).
17. Wang, X. et al. The origin and liver repopulating capacity of murine oval cells. Proc. Natl Acad. Sci. USA 100, 11881-11888 (2003).
18. Takahashi, S., Schoch, E. & Walker, N. I. Origin of acinar cell regeneration after atrophy of the rat parotid induced by duct obstruction. Int. J. Exp. Pathol. 79, 293-301 (1998).
19. Feng, J., Van Der Zwaag, M., Stokman, M. a., Van Os, R. & Coppes, R. P. Isolation and characterization of human salivary gland cells for stem cell transplantation to reduce radiation-induced hyposalivation. Radiother. Oncol. 92, 466-471 (2009).
20. Lombaert, I. M. a. et al. Rescue of salivary gland function after stem cell transplantation in irradiated glands. PLoS ONE 3, e2063 (2008).
21. Sumita, Y. et al. Bone marrow-Derived cells rescue salivary gland function in mice with head and neck irradiation. Int. J. Biochem. Cell Biol. 43, 80-87 (2011).
22. Purnell, B. The complete guide to organ repair. Science 322, 1489 (2008).
23. Ikeda, E. & Tsuji, T. Growing bioengineered teeth from single cells: Potential for dental regenerative medicine. Exp. Opin. Biol. Ther. 8, 735-744 (2008).
24. Sasai, Y. et al. Next-generation regenerative medicine: Organogenesis from stem cells in 3D culture. Cell Stem Cell 12, 520-530 (2013).
25. Nakao, K. et al. The development of a bioengineered organ germ method. Nat. Methods 4, 227-230 (2007).
26. Ikeda, E., Morita, R., Nakao, K., Ishida, K. & Nakamura, T. Fully functional bioengineered tooth replacement as an organ replacement therapy. Proc. Natl Acad. Sci. USA 106, 13475-13480 (2009).
27. Toyoshima, K. et al. Fully functional hair follicle regeneration through the rearrangement of stem cells and their niches. Nat. Commun. 3, 784 (2012).
28. Matsuo, R., Yamamoto, T., Yoshitaka, K. & Morimoto, T. Neural substrates for reflex salivation induced by taste, mechanical, and thermal stimulation of the oral region in decerebrate rats. Jap. J. Physiol. 39, 349-357 (1989).
29. Yamamoto, K. et al. Atrophic change of tongue papilla in 44 patients with Sjogren syndrome. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 107, 801-805 (2009).
30. Lin, C.-y. et al. Cell therapy for salivary gland regeneration. J. Dent. Res. 90, 341-346 (2011).
31. Proctor, Gordon B. & Guy, H. Carpenter, Regulation of salivary gland function by autonomic nerves. Auton. Neurosci. 133, 3-18 (2007).
32. Knox, S. M. et al. Parasympathetic stimulation improves epithelial organ regeneration. Nat. Commun. 4, 1494 (2013).
33. Ishikawa, Y. et al. Identification of AQP5 in lipid rafts and its translocation to apical membranes by activation of M3 mAChRs in interlobular ducts of rat parotid gland. Am. J. Physiol. Cell Physiol. 289, C1303-c1311 (2005).
34. Bengel, F. M. et al. Effect of sympathetic reinnervation on cardiac performance after heart transplantation. N. Engl. J. Med. 731-738 (2001).
35. Luukko, K., Kvinnsland, I. H. & Kettunen, P. Tissue interactions in the regulation of axon pathfinding during tooth morphogenesis. Dev. Dyn. 234, 482-488 (2005).