MicroRNA-223 promotes the growth and invasion of glioblastoma cells by targeting tumor suppressor PAX6

Oncology Reports

Volumn 30, Issue 5, 2013, Pages 2263-2269

  Huang, Bai Sheng ^a   Luo, Qi Zhi ^a   Han, Yang ^a   Li, Xiao Bo ^b   Cao, Li Jun ^c   Wu, Li Xiang ^a  

^a Central South University   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Glioblastoma; Invasion; MicroRNAs; PAX6

Indexed keywords

GELATINASE A; GELATINASE B; LUCIFERASE; MICRORNA 223; TRANSCRIPTION FACTOR PAX6; TUMOR SUPPRESSOR PROTEIN; VASCULOTROPIN A;

3' UNTRANSLATED REGION; ARTICLE; CELL CYCLE G1 PHASE; CELL INVASION; CELL VIABILITY; FETUS; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; TISSUE MICROARRAY; TUMOR CELL LINE; TUMOR GROWTH; TUMOR INVASION;

BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; EYE PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; GLIOBLASTOMA; HOMEODOMAIN PROTEINS; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICRORNAS; NEOPLASM INVASIVENESS; PAIRED BOX TRANSCRIPTION FACTORS; REPRESSOR PROTEINS;

EID: 84885070945     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2683     Document Type: Article

References (31)

1. Preusser M, de Ribaupierre S, Wohrer A, et al: Current concepts and management of glioblastoma. Ann Neurol 70: 9-21, 2011.
2. Qu S, Yao Y, Shang C, et al: MicroRNA-330 is an oncogenic factor in glioblastoma cells by regulating SH3GL2 gene. PloS One 7: e46010, 2012.
3. Lages E, Ipas H, Guttin A, Nesr H, Berger F and Issartel JP: MicroRNAs: molecular features and role in cancer. Front Biosci 17: 2508-2540, 2012.
4. Chang HT, Li SC, Ho MR, et al: Comprehensive analysis of microRNAs in breast cancer. BMC Genomics 13 (Suppl 7): S18, 2012.
5. Chen PS, Su JL and Hung MC: Dysregulation of microRNAs in cancer. J Biomed Sci 19: 90, 2012.
6. Liu H: MicroRNAs in breast cancer initiation and progression. Cell Mol Life Sci 69: 3587-3599, 2012.
7. Li G, Cai M, Fu D, et al: Heat shock protein 90B1 plays an oncogenic role and is a target of microRNA-223 in human osteosarcoma. Cell Physiol Biochem 30: 1481-1490, 2012.
8. Wu L, Li H, Jia CY, et al: MicroRNA-223 regulates FOXO1 expression and cell proliferation. FEBS Lett 586: 1038-1043, 2012.
9. Li X, Zhang Y, Zhang H, et al: miRNA-223 promotes gastric cancer invasion and metastasis by targeting tumor suppressor EPB41L3. Mol Cancer Res 9: 824-833, 2011.
10. Li J, Guo Y, Liang X, et al: MicroRNA-223 functions as an oncogene in human gastric cancer by targeting FBXW7/hCdc4. J Cancer Res Clin Oncol 138: 763-774, 2012.
11. Kang W, Tong JH, Chan AW, et al: Stathmin1 plays oncogenic role and is a target of microRNA-223 in gastric cancer. PloS One 7: e33919, 2012.
12. Zhao S, Deng Y, Liu Y, et al: MicroRNA-153 is tumor suppressive in glioblastoma stem cells. Mol Biol Rep 40: 2789-2798, 2013.
13. Zhang QQ, Xu H, Huang MB, et al: MicroRNA-195 plays a tumor-suppressor role in human glioblastoma cells by targeting signaling pathways involved in cellular proliferation and invasion. Neuro Oncol 14: 278-287, 2012.
14. Yue X, Wang P, Xu J, et al: MicroRNA-205 functions as a tumor suppressor in human glioblastoma cells by targeting VEGF-A. Oncol Rep 27: 1200-1206, 2012.
15. Lin J, Teo S, Lam DH, Jeyaseelan K and Wang S: MicroRNA-10b pleiotropically regulates invasion, angiogenicity and apoptosis of tumor cells resembling mesenchymal subtype of glioblastoma multiforme. Cell Death Dis 3: e398, 2012.
16. Fang X, Yoon JG, Li L, et al: The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis. BMC Genomics 12: 11, 2011.
17. Li Y, Guessous F, Zhang Y, et al: MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res 69: 7569-7576, 2009.
18. Mayes DA, Hu Y, Teng Y, et al: PAX6 suppresses the invasiveness of glioblastoma cells and the expression of the matrix metalloproteinase-2 gene. Cancer Res 66: 9809-9817, 2006.
19. Zhou YH, Wu X, Tan F, et al: PAX6 suppresses growth of human glioblastoma cells. J Neurooncol 71: 223-229, 2005.
20. Chen KC, Hsi E, Hu CY, Chou WW, Liang CL and Juo SH: MicroRNA-328 may influence myopia development by mediating the PAX6 gene. Invest Ophthalmol Vis Sci 53: 2732-2739, 2012.
21. Arocho A, Chen B, Ladanyi M and Pan Q: Validation of the 2-DeltaDeltaCt calculation as an alternate method of data analysis for quantitative PCR of BCR-ABL P210 transcripts. Diagn Mol Pathol 15: 56-61, 2006.
22. Jiang X, Yue J, Lu H, et al: Inhibition of filamin-A reduces cancer metastatic potential. Int J Biol Sci 9: 67-77, 2013.
23. Zhou YH, Hu Y, Mayes D, et al: PAX6 suppression of glioma angiogenesis and the expression of vascular endothelial growth factor A. J Neurooncol 96: 191-200, 2010.
24. Li L, Li B, Zhang H, et al: Lentiviral vector-mediated PAX6 overexpression promotes growth and inhibits apoptosis of human retinoblastoma cells. Invest Ophthalmol Vis Sci 52: 8393-8400, 2011.
25. Zong X, Yang H, Yu Y, et al: Possible role of Pax-6 in promoting breast cancer cell proliferation and tumorigenesis. BMB Rep 44: 595-600, 2011.
26. Chang JY, Hu Y, Siegel E, Stanley L and Zhou YH: PAX6 increases glioma cell susceptibility to detachment and oxidative stress. J Neurooncol 84: 9-19, 2007.
27. Sivak JM, West-Mays JA, Yee A, Williams T and Fini ME: Transcription factors Pax6 and AP-2α interact to coordinate corneal epithelial repair by controlling expression of matrix metalloproteinase gelatinase B. Mol Cell Biol 24: 245-257, 2004.
28. Zhang W, Fulci G, Buhrman JS, et al: Bevacizumab with angiostatin-armed oHSV increases antiangiogenesis and decreases bevacizumab-induced invasion in U87 glioma. Mol Ther 20: 37-45, 2012.
29. Qiu JF, Zhang ZQ, Wang Y and You J: Lentivirus-mediated RNAi knockdown of VEGFA in RKO colorectal cancer cells decreases tumor formation and growth in vitro and in vivo. Int J Clin Exp Pathol 5: 290-298, 2012.
30. Chen CH, Lai JM, Chou TY, et al: VEGFA upregulates FLJ10540 and modulates migration and invasion of lung cancer via PI3K/AKT pathway. PloS One 4: e5052, 2009.
31. de Chevigny A, Core N, Follert P, et al: miR-7a regulation of Pax6 controls spatial origin of forebrain dopaminergic neurons. Nat Neurosci 15: 1120-1126, 2012.