Cathepsin D activity and selectivity in the acidic conditions of a tumor microenvironment: Utilization in the development of a novel Cathepsin D substrate for simultaneous cancer diagnosis and therapy

Biochimie

Volumn 95, Issue 11, 2013, Pages 2010-2017

  Achour, Oussama ^a   Bridiau, Nicolas ^a   Kacem, Meriem ^a   Delatouche, Régis ^a   Bordenave Juchereau, Stéphanie ^a   Sannier, Frédéric ^a   Thiéry, Valérie ^a   Piot, Jean Marie ^a   Maugard, Thierry ^a   Arnaudin, Ingrid ^a  

^a UNIVERSITÉ DE LA ROCHELLE   (France)

Author keywords

Cathepsin D; Interfacial activation; Pro Cathepsin D; Substrate structure; Tumor microenvironment

Indexed keywords

AMPHOPHILE; CATHEPSIN D; PROCATHEPSIN D; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER DIAGNOSIS; CANCER THERAPY; CATALYSIS; CULTURE MEDIUM; ENZYME ACTIVITY; HYDROLYSIS; PH; PROTEIN STRUCTURE; TUMOR MICROENVIRONMENT;

2-(N-MORPHOLINO)ETHANESULFONIC ACID; 3-(N-MORPHOLINO)PROPANESULFONIC ACID; 7-METHOXYCOUMARIN-4-ACETYL; CATHEPSIN D; CD; DINITROPHENYL; DNP; INTERFACIAL ACTIVATION; MCA; MES; MOPS; PCD; PPCD; PRE-PRO-CATHEPSIN D; PRO-CATHEPSIN D; SA; SODIUM ACETATE; SUBSTRATE STRUCTURE; TME; TUMOR MICROENVIRONMENT;

CATALYSIS; CATHEPSIN D; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS; SUBSTRATE SPECIFICITY; TUMOR MICROENVIRONMENT;

EID: 84885058830     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2013.07.010     Document Type: Article

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