Changes in IL-17 and TGF-β1 levels in serum and bronchoalveolar lavage fluid and their clinical significance among children with asthma

Chinese Journal of Contemporary Pediatrics

Volumn 15, Issue 8, 2013, Pages 604-608

  Jiang, Kun ^a   Chen, He Bin ^a   Wang, Ying ^a   Lin, Jia Hui ^a   Hu, Yan ^a   Fang, Yu Rong ^a  

^a Wuhan Children's Hospital   (China)

Author keywords

Asthma; Child; Interleukin 17; Transforming growth factor beta 1

Indexed keywords

INTERLEUKIN 17; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; ASTHMA; CONTROLLED STUDY; DISEASE SEVERITY; EOSINOPHIL; EPITHELIUM CELL; HUMAN; LUNG LAVAGE; MACROPHAGE; MAJOR CLINICAL STUDY; NEUTROPHIL; PROTEIN BLOOD LEVEL;

ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INTERLEUKIN-17; MALE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84885057329     PISSN: 10088830     EISSN: None     Source Type: Journal    
DOI: 10.7499/j.issn.1008-8830.2013.08.002     Document Type: Article

References (8)

1. Tanaka S, Yoshimoto T, Naka T, Nakae S, Iwakura Y, Cua D, et al . Natural occurring IL-17 producing T cells regulate the initial phase of neutrophil mediated airway responses[J]. J Immunol, 2009, 183(11): 7523-7530.
2. Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B. IL-33-activated dendritic cells are critical for allergic airway inflammation[J]. Eur J Immunol, 2011, 41(6): 1675-1686.
3. Bettelli E, Korn T, Oukka M, Kuchroo VK. Induction and effector functions of T (H) 17 cells[J]. Nature, 2008, 453(7198): 1051-1057.
4. Bajoriuniene I, Malakauskas K, Lavinskiene S, Jeroch J, Gasiuniene E, Vitkauskiene A, et al. Response of peripheral blood Th17 cells to inhaled dermatophagoides pteronyssinus in patients with allergic rhinitis and asthma[J]. Lung, 2012, 190(5): 487-495.
5. Minshall EM, Leung DY, Martin RJ, Song YL, Cameron L, Ernst P, et al. Eosinophil associated TGF-beta1 mRNA expression and airway fibrosis in bronchial asthma[J]. Am Respir Cell Mol Biol, 1997, 17(3): 326-333.
6. Wilson RH, Whitehead GS, Nakano H, Free ME, Kolls JK, Cook DN. Allergic sensitization through the airway primes Th-17- dependent neutrophilia and airway hyperresponsiveness[J]. Am J Respir Crit Care Med, 2009, 180(8): 720-730.
7. Linden A. Interleukin-17 and airway remodeling[J]. Pulm Pharmacol Ther, 2006, 19(1): 47-50.
8. Al-Alwan LA, Chang Y, Baglole CJ, Risse PA, Halayko AJ, Martin JG, et al. Autocrine-regulated airway smooth muscle cell migration is dependent on IL-17-induced growth-related oncogenes[J]. J Allergy Clin Immunol, 2012, 130(4): 977-985.