HLA-peptide multimer selection of adenovirus-specific T cells for adoptive T-cell therapy

Journal of Immunotherapy

Volumn 36, Issue 8, 2013, Pages 423-431

  Chakupurakal, Geothy ^a   Onion, David ^a   Bonney, Sarah ^a   Cobbold, Mark ^b   Mautner, Vivien ^a   Moss, Paul ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b Medical School   (United Kingdom)

Author keywords

adenovirus; immunotherapy; multimer; stem cell transplantation; T cell; tetramer

Indexed keywords

CD27 ANTIGEN; CD28 ANTIGEN; CD45RA ANTIGEN; CD45RO ANTIGEN; CD57 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR7; EPITOPE; GAMMA INTERFERON; HLA A ANTIGEN; HLA ANTIGEN CLASS 1; HLA B ANTIGEN; L SELECTIN; POLYMER; TETRAMER;

ADENOVIRUS; ADOPTIVE TRANSFER; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENVIRONMENTAL FACTOR; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; IN VITRO STUDY; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

ADENOVIRIDAE INFECTIONS; ANTIGENS, CD; ANTIGENS, VIRAL; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELL SEPARATION; CELLS, CULTURED; FLOW CYTOMETRY; HLA-A1 ANTIGEN; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; IMMUNOTHERAPY, ADOPTIVE; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; PEPTIDE FRAGMENTS; PROTEIN BINDING; RECEPTORS, CCR7; T-LYMPHOCYTE SUBSETS; VIRUS REPLICATION;

EID: 84885054136     PISSN: 15249557     EISSN: 15374513     Source Type: Journal    
DOI: 10.1097/CJI.0b013e3182a8029e     Document Type: Article

References (43)

1. Tebruegge M, Curtis N. Adenovirus infection in the immunocompromised host. Adv Exp Med Biol. 2010;659: 153-174.
2. Saquib R, Melton LB, Chandrakantan A, et al. Disseminated adenovirus infection in renal transplant recipients: the role of cidofovir and intravenous immunoglobulin. Transpl Infect Dis. 2010;12:77-83.
3. La Rosa AM, Champlin RE, Mirza N, et al. Adenovirus infections in adult recipients of blood and marrow transplants. Clin Infect Dis. 2001;32:871-876. (Pubitemid 32524820)
4. Ohrmalm L, Lindblom A, Omar H, et al. Evaluation of a surveillance strategy for early detection of adenovirus by PCR of peripheral blood in hematopoietic SCT recipients: incidence and outcome. Bone Marrow Transplant. 2010;46:267-272.
5. Walls T, Hawrami K, Ushiro-Lumb I, et al. Adenovirus infection after pediatric bone marrow transplantation: is treatment always necessary? Clin Infect Dis. 2005;40: 1244-1249. (Pubitemid 40570232)
6. Feuchtinger T, Lucke J, Hamprecht K, et al. Detection of adenovirus-specific T cells in children with adenovirus infection after allogeneic stem cell transplantation. Br J Haematol. 2005;128:503-509. (Pubitemid 40283168)
7. Chakrabarti S, Mautner V, Osman H, et al. Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery. Blood. 2002; 100:1619-1627. (Pubitemid 34925137)
8. Symeonidis N, Jakubowski A, Pierre-Louis S, et al. Invasive adenoviral infections in T-cell-depleted allogeneic hematopoietic stem cell transplantation: high mortality in the era of cidofovir. Transpl Infect Dis. 2007;9:108-113. (Pubitemid 46669079)
9. Mahr JA, Gooding LR. Immune evasion by adenoviruses. Immunol Rev. 1999;168:121-130. (Pubitemid 29276677)
10. Onion D, Patel P, Pineda RG, et al. Antivector and tumor immune responses following adenovirus-directed enzyme prodrug therapy for the treatment of prostate cancer. Hum Gene Ther. 2009;20:1249-1258.
11. Hutnick NA, Carnathan D, Demers K, et al. Adenovirusspecific human T cells are pervasive, polyfunctional, and crossreactive. Vaccine. 2010;28:1932-1941.
12. Flomenberg P, Piaskowski V, Truitt RL, et al. Characterization of human proliferative T cell responses to adenovirus. J Infect Dis. 1995;171:1090-1096.
13. Leen AM, Christin A, Khalil M, et al. Identification of hexonspecific CD4 and CD8 T-cell epitopes for vaccine and immunotherapy. J Virol. 2008;82:546-554. (Pubitemid 350309169)
14. Guillaume P, Dojcinovic D, Luescher IF. Soluble MHCpeptide complexes: tools for the monitoring of T cell responses in clinical trials and basic research. Cancer Immun. 2009;9:7.
15. Olive M, Eisenlohr L, Flomenberg N, et al. The adenovirus capsid protein hexon contains a highly conserved human CD4+ T-cell epitope. Hum Gene Ther. 2002;13:1167-1178. (Pubitemid 34746697)
16. Onion D, Crompton LJ, Milligan DW, et al. The CD4+ T-cell response to adenovirus is focused against conserved residues within the hexon protein. J Gen Virol. 2007;88(pt 9):2417-2425. (Pubitemid 47323886)
17. Cobbold M, Khan N, Pourgheysari B, et al. Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramers. J Exp Med. 2005;202:379-386. (Pubitemid 41126955)
18. Leen AM, Sili U, Savoldo B, et al. Fiber-modified adenoviruses generate subgroup cross-reactive, adenovirus-specific cytotoxic T lymphocytes for therapeutic applications. Blood. 2004;103:1011-1019. (Pubitemid 38129564)
19. Myers GD, Bollard CM, Wu MF, et al. Reconstitution of adenovirus-specific cell-mediated immunity in pediatric patients after hematopoietic stem cell transplantation. Bone Marrow Transplant. 2007;39:677-686. (Pubitemid 46813584)
20. Tang J, Olive M, Pulmanausahakul R, et al. Human CD8+ cytotoxic T cell responses to adenovirus capsid proteins. Virology. 2006;350:312-322. (Pubitemid 43928100)
21. Zhu F, Xu H, Tsao A, et al. Generation of cytotoxic T-cell lines using overlapping pentadecapeptides derived from conserved regions of the adenovirus hexon protein. J Gen Virol. 2010;91(pt 6):1577-1589.
22. Zandvliet ML, Falkenburg JH, van Liempt E, et al. Combined CD8+ and CD4+ adenovirus hexon-specific T cells associated with viral clearance after stem cell transplantation as treatment for adenovirus infection. Haematologica. 2010;95: 1943-1951.
23. Altman JD, Moss PA, Goulder PJ, et al. Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996;274:94-96. (Pubitemid 26332731)
24. Murakami P, McCaman MT. Quantitation of adenovirus DNA and virus particles with the PicoGreen fluorescent Dye. Anal Biochem. 1999;274:283-288. (Pubitemid 29489500)
25. Saunders AE, Johnson P. Modulation of immune cell signalling by the leukocyte common tyrosine phosphatase, CD45. Cell Signal. 2010;22:339-348.
26. Forster R, Davalos-Misslitz AC, Rot A. CCR7 and its ligands: balancing immunity and tolerance. Nat Rev Immunol. 2008;8:362-371. (Pubitemid 351595218)
27. Peggs KS, Allison JP. Co-stimulatory pathways in lymphocyte regulation: the immunoglobulin superfamily. Br J Haematol. 2005;130:809-824. (Pubitemid 43899722)
28. Brenchley JM, Karandikar NJ, Betts MR, et al. Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood. 2003;101:2711-2720. (Pubitemid 36857634)
29. Chakupurakal G. Preclinical Studies of Adenovirus-specific TCells for Adoptive Transfer to Haemopoietic Stem Cell Transplant Recipients. Birmingham: PhD Thesis Birmingham: School for Cancer Sciences, College for Medical and Dental Sciences; 2011.
30. Cebecauer M, Guillaume P, Hozak P, et al. Soluble MHCpeptide complexes induce rapid death of CD8+ CTL. J Immunol. 2005;174:6809-6819. (Pubitemid 40705644)
31. Chakrabarti S. Adenovirus infections after hematopoietic stem cell transplantation: still unravelling the story. Clin Infect Dis. 2007;45:966-968. (Pubitemid 47580343)
32. Leen AM, Sili U, Vanin EF, et al. Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells. Blood. 2004;104: 2432-2440. (Pubitemid 39331844)
33. Unsoeld H, Pircher H. Complex memory T-cell phenotypes revealed by coexpression of CD62L and CCR7. J Virol. 2005;79:4510-4513. (Pubitemid 40388388)
34. Debes GF, Bonhagen K, Wolff T, et al. CC chemokine receptor 7 expression by effector/memory CD4+ T cells depends on antigen specificity and tissue localization during influenza A virus infection. J Virol. 2004;78:7528-7535. (Pubitemid 38915899)
35. Gattinoni L, Lugli E, Ji Y, et al. A human memory T cell subset with stem cell-like properties. Nat Med. 2011;17:1290-1297.
36. van Lier RA, ten Berge IJ, Gamadia LE. Human CD8(+) T-cell differentiation in response to viruses. Nat Rev Immunol. 2003;3:931-939.
37. Appay V, Dunbar PR, Callan M, et al. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med. 2002;8:379-385. (Pubitemid 34407033)
38. Heemskerk B, van Vreeswijk T, Veltrop-Duits LA, et al. Adenovirus-specific CD4+ T cell clones recognizing endogenous antigen inhibit viral replication in vitro through cognate interaction. J Immunol. 2006;177:8851-8859. (Pubitemid 44893852)
39. Feuchtinger T, Matthes-Martin S, Richard C, et al. Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation. Br J Haematol. 2006;134:64-76. (Pubitemid 43830030)
40. Roddie C, Peggs KS. Donor lymphocyte infusion following allogeneic hematopoietic stem cell transplantation. Expert Opin Biol Ther. 2011;11:473-487.
41. Karlsson H, Brewin J, Kinnon C, et al. Generation of trispecific cytotoxic T cells recognizing cytomegalovirus, adenovirus, and Epstein-Barr virus: an approach for adoptive immunotherapy of multiple pathogens. J Immunother. 2007; 30:544-556. (Pubitemid 46988088)
42. Neudorfer J, Schmidt B, Huster KM, et al. Reversible HLA multimers (Streptamers) for the isolation of human cytotoxic T lymphocytes functionally active against tumor-and virusderived antigens. J Immunol Methods. 2007;320:119-131. (Pubitemid 46349106)
43. Abu-Ghosh A, Goldman S, Slone V, et al. Immunological reconstitution and correlation of circulating serum inflammatory mediators/cytokines with the incidence of acute graftversus-host disease during the first 100 days following unrelated umbilical cord blood transplantation. Bone Marrow Transplant. 1999;24:535-544. (Pubitemid 29423634)