메뉴 건너뛰기




Volumn 30, Issue 5, 2013, Pages 2161-2170

Effects of γ-synuclein on the tumorigenicity and metastasis of colon cancer SW1116 cells in vitro and in vivo

Author keywords

synuclein; Colorectal cancer; In vitro; In vivo; Metastasis; Tumorigenicity

Indexed keywords

GAMMA SYNUCLEIN; SMALL INTERFERING RNA;

EID: 84885038888     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2688     Document Type: Article
Times cited : (7)

References (32)
  • 2
    • 67649891795 scopus 로고    scopus 로고
    • Current management of colorectal hepatic metastasis
    • Mayo SC and Pawlik TM: Current management of colorectal hepatic metastasis. Expert Rev Gastroenterol Hepatol 3: 131-144, 2009.
    • (2009) Expert Rev Gastroenterol Hepatol , vol.3 , pp. 131-144
    • Mayo, S.C.1    Pawlik, T.M.2
  • 3
    • 65349139422 scopus 로고    scopus 로고
    • Curable metastatic colorectal cancer: Recommended paradigms
    • Berri RN and Abdalla EK: Curable metastatic colorectal cancer: recommended paradigms. Curr Oncol Rep 11: 200-208, 2009.
    • (2009) Curr Oncol Rep , vol.11 , pp. 200-208
    • Berri, R.N.1    Abdalla, E.K.2
  • 5
    • 34547141894 scopus 로고    scopus 로고
    • Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
    • Mani SA, Yang J, Brooks M, et al: Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci USA 104: 10069-10074, 2007.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 10069-10074
    • Mani, S.A.1    Yang, J.2    Brooks, M.3
  • 6
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang J, Mani SA, Donaher JL, et al: Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117: 927-939, 2004.
    • (2004) Cell , vol.117 , pp. 927-939
    • Yang, J.1    Mani, S.A.2    Donaher, J.L.3
  • 7
    • 57149084065 scopus 로고    scopus 로고
    • Molecular and cellular biology of synucleins
    • Surguchov A: Molecular and cellular biology of synucleins. Int Rev Cell Mol Biol 270: 225-317, 2008.
    • (2008) Int Rev Cell Mol Biol , vol.270 , pp. 225-317
    • Surguchov, A.1
  • 9
    • 0031045589 scopus 로고    scopus 로고
    • Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing
    • Ji H, Liu YE, Jia T, et al: Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. Cancer Res 57: 759-764, 1997.
    • (1997) Cancer Res , vol.57 , pp. 759-764
    • Ji, H.1    Liu, Y.E.2    Jia, T.3
  • 10
    • 34548101128 scopus 로고    scopus 로고
    • Neuronal protein synuclein γ predicts poor clinical outcome in breast cancer
    • Guo J, Shou C, Meng L, et al: Neuronal protein synuclein γ predicts poor clinical outcome in breast cancer. Int J Cancer 121: 1296-1305, 2007.
    • (2007) Int J Cancer , vol.121 , pp. 1296-1305
    • Guo, J.1    Shou, C.2    Meng, L.3
  • 11
    • 65249187279 scopus 로고    scopus 로고
    • Synuclein-γ is closely involved in perineural invasion and distant metastasis in mouse models and is a novel prognostic factor in pancreatic cancer
    • Hibi T, Mori T, Fukuma M, et al: Synuclein-γ is closely involved in perineural invasion and distant metastasis in mouse models and is a novel prognostic factor in pancreatic cancer. Clin Cancer Res 15: 2864-2871, 2009.
    • (2009) Clin Cancer Res , vol.15 , pp. 2864-2871
    • Hibi, T.1    Mori, T.2    Fukuma, M.3
  • 12
    • 57349163599 scopus 로고    scopus 로고
    • Relationship of SNCG, S100A4, S100A9 and LCN2 gene expression and DNA methylation in bladder cancer
    • Dokun OY, Florl AR, Seifert HH, Wolff I and Schulz WA: Relationship of SNCG, S100A4, S100A9 and LCN2 gene expression and DNA methylation in bladder cancer. Int J Cancer 123: 2798-2807, 2008.
    • (2008) Int J Cancer , vol.123 , pp. 2798-2807
    • Dokun, O.Y.1    Florl, A.R.2    Seifert, H.H.3    Wolff, I.4    Schulz, W.A.5
  • 13
    • 24744445401 scopus 로고    scopus 로고
    • Loss of epigenetic control of synuclein-γ gene as a molecular indicator of metastasis in a wide range of human cancers
    • Liu H, Liu W, Wu Y, et al: Loss of epigenetic control of synuclein-γ gene as a molecular indicator of metastasis in a wide range of human cancers. Cancer Res 65: 7635-7643, 2005.
    • (2005) Cancer Res , vol.65 , pp. 7635-7643
    • Liu, H.1    Liu, W.2    Wu, Y.3
  • 14
    • 33644867290 scopus 로고    scopus 로고
    • Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays
    • Sanchez-Carbayo M, Socci ND, Lozano J, Saint F and Cordon-Cardo C: Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays. J Clin Oncol 24: 778-789, 2006.
    • (2006) J Clin Oncol , vol.24 , pp. 778-789
    • Sanchez-Carbayo, M.1    Socci, N.D.2    Lozano, J.3    Saint, F.4    Cordon-Cardo, C.5
  • 15
    • 0037592405 scopus 로고    scopus 로고
    • Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas
    • Fung KM, Rorke LB, Giasson B, Lee VM and Trojanowski JQ: Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas. Acta Neuropathol 106: 167-175, 2003.
    • (2003) Acta Neuropathol , vol.106 , pp. 167-175
    • Fung, K.M.1    Rorke, L.B.2    Giasson, B.3    Lee, V.M.4    Trojanowski, J.Q.5
  • 16
    • 0034193239 scopus 로고    scopus 로고
    • Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary
    • Bruening W, Giasson BI, Klein-Szanto AJ, Lee VM, Trojanowski JQ and Godwin AK: Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary. Cancer 88: 2154-2163, 2000.
    • (2000) Cancer , vol.88 , pp. 2154-2163
    • Bruening, W.1    Giasson, B.I.2    Klein-Szanto, A.J.3    Lee, V.M.4    Trojanowski, J.Q.5    Godwin, A.K.6
  • 17
    • 76649098026 scopus 로고    scopus 로고
    • Expression of α-, β- And γ-synuclein in colorectal cancer, and potential clinical significance in progression of the disease
    • Ye Q, Wang TF, Peng YF, et al: Expression of α-, β- and γ-synuclein in colorectal cancer, and potential clinical significance in progression of the disease. Oncol Rep 23: 429-436, 2010.
    • (2010) Oncol Rep , vol.23 , pp. 429-436
    • Ye, Q.1    Wang, T.F.2    Peng, Y.F.3
  • 18
    • 54949151907 scopus 로고    scopus 로고
    • Aberrant expression and demethylation of γ-synuclein in colorectal cancer, correlated with progression of the disease
    • Ye Q, Zheng MH, Cai Q, et al: Aberrant expression and demethylation of γ-synuclein in colorectal cancer, correlated with progression of the disease. Cancer Sci 99: 1924-1932, 2008.
    • (2008) Cancer Sci , vol.99 , pp. 1924-1932
    • Ye, Q.1    Zheng, M.H.2    Cai, Q.3
  • 19
    • 0033083049 scopus 로고    scopus 로고
    • Stimulation of breast cancer invasion and metastasis by synuclein γ
    • Jia T, Liu YE, Liu J and Shi YE: Stimulation of breast cancer invasion and metastasis by synuclein γ. Cancer Res 59: 742-747, 1999.
    • (1999) Cancer Res , vol.59 , pp. 742-747
    • Jia, T.1    Liu, Y.E.2    Liu, J.3    Shi, Y.E.4
  • 20
    • 0037328249 scopus 로고    scopus 로고
    • Effect of γ-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells
    • Surgucheva IG, Sivak JM, Fini ME, Palazzo RE and Surguchov AP: Effect of γ-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells. Arch Biochem Biophys 410: 167-176, 2003.
    • (2003) Arch Biochem Biophys , vol.410 , pp. 167-176
    • Surgucheva, I.G.1    Sivak, J.M.2    Fini, M.E.3    Palazzo, R.E.4    Surguchov, A.P.5
  • 21
    • 0345304252 scopus 로고    scopus 로고
    • Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1
    • Gupta A, Inaba S, Wong OK, Fang G and Liu J: Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1. Oncogene 22: 7593-7599, 2003.
    • (2003) Oncogene , vol.22 , pp. 7593-7599
    • Gupta, A.1    Inaba, S.2    Wong, O.K.3    Fang, G.4    Liu, J.5
  • 22
    • 24744435804 scopus 로고    scopus 로고
    • Synuclein gamma inhibits the mitotic checkpoint function and promotes chromosomal instability of breast cancer cells
    • Inaba S, Li C, Shi YE, Song DQ, Jiang JD and Liu J: Synuclein gamma inhibits the mitotic checkpoint function and promotes chromosomal instability of breast cancer cells. Breast Cancer Res Treat 94: 25-35, 2005.
    • (2005) Breast Cancer Res Treat , vol.94 , pp. 25-35
    • Inaba, S.1    Li, C.2    Shi, Y.E.3    Song, D.Q.4    Jiang, J.D.5    Liu, J.6
  • 23
    • 34948870171 scopus 로고    scopus 로고
    • Involvement of RHO GTPases and ERK in synuclein-γ enhanced cancer cell motility
    • Pan ZZ, Bruening W and Godwin AK: Involvement of RHO GTPases and ERK in synuclein-γ enhanced cancer cell motility. Int J Oncol 29: 1201-1205, 2006.
    • (2006) Int J Oncol , vol.29 , pp. 1201-1205
    • Pan, Z.Z.1    Bruening, W.2    Godwin, A.K.3
  • 24
    • 34447554584 scopus 로고    scopus 로고
    • Colorectal cancer: What has changed in diagnosis and treatment over the last 50 years?
    • Gennari L, Russo A and Rossetti C: Colorectal cancer: what has changed in diagnosis and treatment over the last 50 years? Tumori 93: 235-241, 2007.
    • (2007) Tumori , vol.93 , pp. 235-241
    • Gennari, L.1    Russo, A.2    Rossetti, C.3
  • 25
    • 26444615109 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition prevents colorectal cancer: From the bench to the bed side
    • Samoha S and Arber N: Cyclooxygenase-2 inhibition prevents colorectal cancer: from the bench to the bed side. Oncology 69: 33-37, 2005.
    • (2005) Oncology , vol.69 , pp. 33-37
    • Samoha, S.1    Arber, N.2
  • 26
    • 0141606784 scopus 로고    scopus 로고
    • Down-regulation of γ-synuclein in human esophageal squamous cell carcinoma
    • Zhou CQ, Liu S, Xue LY, et al: Down-regulation of γ-synuclein in human esophageal squamous cell carcinoma. World J Gastroenterol 9: 1900-1903, 2003.
    • (2003) World J Gastroenterol , vol.9 , pp. 1900-1903
    • Zhou, C.Q.1    Liu, S.2    Xue, L.Y.3
  • 27
    • 0037144401 scopus 로고    scopus 로고
    • γ-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways
    • Pan ZZ, Bruening W, Giasson BI, Lee VM and Godwin AK: γ-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways. J Biol Chem 277: 35050-35060, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 35050-35060
    • Pan, Z.Z.1    Bruening, W.2    Giasson, B.I.3    Lee, V.M.4    Godwin, A.K.5
  • 28
    • 34047184198 scopus 로고    scopus 로고
    • Chaperoning of estrogen receptor and induction of mammary gland proliferation by neuronal protein synuclein gamma
    • Liu YE, Pu W, Jiang Y, Shi D, Dackour R and Shi YE: Chaperoning of estrogen receptor and induction of mammary gland proliferation by neuronal protein synuclein gamma. Oncogene 26: 2115-2125, 2007.
    • (2007) Oncogene , vol.26 , pp. 2115-2125
    • Liu, Y.E.1    Pu, W.2    Jiang, Y.3    Shi, D.4    Dackour, R.5    Shi, Y.E.6
  • 29
    • 3042702990 scopus 로고    scopus 로고
    • γ-synuclein, a novel heat-shock protein-associated chaperone, stimulates ligand-dependent estrogen receptor α signaling and mammary tumorigenesis
    • Jiang Y, Liu YE, Goldberg ID and Shi YE: γ-synuclein, a novel heat-shock protein-associated chaperone, stimulates ligand-dependent estrogen receptor α signaling and mammary tumorigenesis. Cancer Res 64: 4539-4546, 2004.
    • (2004) Cancer Res , vol.64 , pp. 4539-4546
    • Jiang, Y.1    Liu, Y.E.2    Goldberg, I.D.3    Shi, Y.E.4
  • 30
    • 33751252276 scopus 로고    scopus 로고
    • Cancer metastasis: Building a framework
    • Gupta GP and Massague J: Cancer metastasis: building a framework. Cell 127: 679-695, 2006.
    • (2006) Cell , vol.127 , pp. 679-695
    • Gupta, G.P.1    Massague, J.2
  • 31
    • 0038481970 scopus 로고    scopus 로고
    • The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited
    • Fidler IJ: The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 3: 453-458, 2003.
    • (2003) Nat Rev Cancer , vol.3 , pp. 453-458
    • Fidler, I.J.1
  • 32
    • 69949092197 scopus 로고    scopus 로고
    • Tumor cell-microenvironment interaction models coupled with clinical validation reveal CCL2 and SNCG as two predictors of colorectal cancer hepatic metastasis
    • Hu H, Sun L, Guo C, et al: Tumor cell-microenvironment interaction models coupled with clinical validation reveal CCL2 and SNCG as two predictors of colorectal cancer hepatic metastasis. Clin Cancer Res 15: 5485-5493, 2009.
    • (2009) Clin Cancer Res , vol.15 , pp. 5485-5493
    • Hu, H.1    Sun, L.2    Guo, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.