메뉴 건너뛰기




Volumn 23, Issue 2, 2010, Pages 429-436

Expression of α-, β- and γ-synuclein in colorectal cancer, and potential clinical significance in progression of the disease

Author keywords

Clinicopathological factors; Colorectal cancer; Expression; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; BETA SYNUCLEIN; GAMMA SYNUCLEIN; MESSENGER RNA;

EID: 76649098026     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or-00000652     Document Type: Article
Times cited : (22)

References (30)
  • 2
    • 0031763264 scopus 로고    scopus 로고
    • The synuclein family
    • Lavedan C: The synuclein family. Genome Res 8: 871-880, 1998.
    • (1998) Genome Res , vol.8 , pp. 871-880
    • Lavedan, C.1
  • 3
    • 0032102455 scopus 로고    scopus 로고
    • The synucleins: A family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
    • Clayton DF and George JM: The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends Neurosci 21: 249-254, 1998.
    • (1998) Trends Neurosci , vol.21 , pp. 249-254
    • Clayton, D.F.1    George, J.M.2
  • 7
    • 0037023699 scopus 로고    scopus 로고
    • Biophysical properties of the synucleins and their propensities to fibrillate: Inhibition of alpha-synuclein assembly by beta- and gamma-synucleins
    • Uversky VN, Li J, Souillac P, Millett IS, Doniach S, Jakes R, Goedert M and Fink AL: Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins. J Biol Chem 277: 11970-11978, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 11970-11978
    • Uversky, V.N.1    Li, J.2    Souillac, P.3    Millett, I.S.4    Doniach, S.5    Jakes, R.6    Goedert, M.7    Fink, A.L.8
  • 8
    • 0037426346 scopus 로고    scopus 로고
    • Beta-synuclein inhibits formation of alpha-synuclein protofibrils: A possible therapeutic strategy against Parkinson's disease
    • Park JY and Lansbury PT Jr: Beta-synuclein inhibits formation of alpha-synuclein protofibrils: a possible therapeutic strategy against Parkinson's disease. Biochemistry 42: 3696-3700, 2003.
    • (2003) Biochemistry , vol.42 , pp. 3696-3700
    • Park, J.Y.1    Lansbury Jr, P.T.2
  • 9
    • 0031045589 scopus 로고    scopus 로고
    • Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing
    • Ji H, Liu Y, Jia T, Wang M, Liu J, Xiao G, Joseph BK, Rosen C and Shi YE: Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing. Cancer Res 57: 759-764, 1997.
    • (1997) Cancer Res , vol.57 , pp. 759-764
    • Ji, H.1    Liu, Y.2    Jia, T.3    Wang, M.4    Liu, J.5    Xiao, G.6    Joseph, B.K.7    Rosen, C.8    Shi, Y.E.9
  • 10
    • 24744445401 scopus 로고    scopus 로고
    • Loss of epigenetic control of synuclein-γ gene as a molecular indicator of metastasis in a wide range of human cancers
    • Liu H, Liu W, Wu Y, Zhou Y, Xue R, Luo C, Wang L, Zhao W, Jiang JD and Liu J: Loss of epigenetic control of synuclein-γ gene as a molecular indicator of metastasis in a wide range of human cancers. Cancer Res 65: 7635-7643, 2005.
    • (2005) Cancer Res , vol.65 , pp. 7635-7643
    • Liu, H.1    Liu, W.2    Wu, Y.3    Zhou, Y.4    Xue, R.5    Luo, C.6    Wang, L.7    Zhao, W.8    Jiang, J.D.9    Liu, J.10
  • 13
    • 0033083049 scopus 로고    scopus 로고
    • Stimulation of breast cancer invasion and metastasis by synuclein-γ
    • Jia T, Liu YE, Liu J and Shi YE: Stimulation of breast cancer invasion and metastasis by synuclein-γ. Cancer Res 59: 742-747, 1999.
    • (1999) Cancer Res , vol.59 , pp. 742-747
    • Jia, T.1    Liu, Y.E.2    Liu, J.3    Shi, Y.E.4
  • 14
    • 0345304252 scopus 로고    scopus 로고
    • Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1
    • Gupta A, Inaba S, Wong OK, Fang G and Liu J: Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1. Oncogene 22: 7593-7599, 2003.
    • (2003) Oncogene , vol.22 , pp. 7593-7599
    • Gupta, A.1    Inaba, S.2    Wong, O.K.3    Fang, G.4    Liu, J.5
  • 15
    • 24744435804 scopus 로고    scopus 로고
    • Synuclein gamma inhibits the mitotic checkpoint function and promotes chromosomal instability of breast cancer cells
    • Inaba S, Li C, Shi YE, Song DQ, Jiang JD and Liu J: Synuclein gamma inhibits the mitotic checkpoint function and promotes chromosomal instability of breast cancer cells. Breast Cancer Res Treat 94: 25-35, 2005.
    • (2005) Breast Cancer Res Treat , vol.94 , pp. 25-35
    • Inaba, S.1    Li, C.2    Shi, Y.E.3    Song, D.Q.4    Jiang, J.D.5    Liu, J.6
  • 16
    • 0037144401 scopus 로고    scopus 로고
    • γ-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy rrug-induced apoptosis by modulating MAPK pathways
    • Pan ZZ, Bruening W, Giasson BI, Lee VM and Godwin AK: γ-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy rrug-induced apoptosis by modulating MAPK pathways. J Biol Chem 277: 35050-35060, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 35050-35060
    • Pan, Z.Z.1    Bruening, W.2    Giasson, B.I.3    Lee, V.M.4    Godwin, A.K.5
  • 17
    • 0037592405 scopus 로고    scopus 로고
    • Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas
    • Fung KM, Rorke LB, Giasson B, Lee VM and Trojanowski JQ: Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas. Acta Neuropathol 106: 167-175, 2003.
    • (2003) Acta Neuropathol , vol.106 , pp. 167-175
    • Fung, K.M.1    Rorke, L.B.2    Giasson, B.3    Lee, V.M.4    Trojanowski, J.Q.5
  • 18
    • 0034193239 scopus 로고    scopus 로고
    • Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary
    • Bruening W, Giasson BI, Klein-Szanto AJ, Lee VM, Trojanowski JQ and Godwin AK: Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary. Cancer 88: 2154-2163, 2000.
    • (2000) Cancer , vol.88 , pp. 2154-2163
    • Bruening, W.1    Giasson, B.I.2    Klein-Szanto, A.J.3    Lee, V.M.4    Trojanowski, J.Q.5    Godwin, A.K.6
  • 20
    • 34447554584 scopus 로고    scopus 로고
    • Colorectal cancer: What has changed in diagnosis and treatment over the last 50 years?
    • Gennari L, Russo A and Rossetti C: Colorectal cancer: what has changed in diagnosis and treatment over the last 50 years? Tumori 93: 235-241, 2007.
    • (2007) Tumori , vol.93 , pp. 235-241
    • Gennari, L.1    Russo, A.2    Rossetti, C.3
  • 21
    • 26444615109 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition prevents colorectal cancer: From the bench to the bed side
    • Samoha S and Arber N: Cyclooxygenase-2 inhibition prevents colorectal cancer: from the bench to the bed side. Oncology 69: 33-37, 2005.
    • (2005) Oncology , vol.69 , pp. 33-37
    • Samoha, S.1    Arber, N.2
  • 22
    • 26944471722 scopus 로고    scopus 로고
    • Pre- and postoperative adjuvant therapy for locally advanced rectal cancer
    • McGartland LP, Mulcahy MF and Benson III AB: Pre- and postoperative adjuvant therapy for locally advanced rectal cancer. Clin Adv Hematol Oncol 2: 806-814, 2004.
    • (2004) Clin Adv Hematol Oncol , vol.2 , pp. 806-814
    • McGartland, L.P.1    Mulcahy, M.F.2    Benson III, A.B.3
  • 24
    • 0037328249 scopus 로고    scopus 로고
    • Effect of γ-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells
    • Surgucheva IG, Sivak JM, Fini ME, Palazzo RE and Surguchov AP: Effect of γ-synuclein overexpression on matrix metalloproteinases in retinoblastoma Y79 cells. Arch Biochem Biophys 410: 167-176, 2003.
    • (2003) Arch Biochem Biophys , vol.410 , pp. 167-176
    • Surgucheva, I.G.1    Sivak, J.M.2    Fini, M.E.3    Palazzo, R.E.4    Surguchov, A.P.5
  • 25
    • 34948870171 scopus 로고    scopus 로고
    • Involvement of RHO GTPases and ERK in synuclein-γ enhanced cancer cell motility
    • Pan ZZ, Bruening W and Godwin AK: Involvement of RHO GTPases and ERK in synuclein-γ enhanced cancer cell motility. Int J Oncol 29: 1201-1205, 2006.
    • (2006) Int J Oncol , vol.29 , pp. 1201-1205
    • Pan, Z.Z.1    Bruening, W.2    Godwin, A.K.3
  • 26
    • 33644867290 scopus 로고    scopus 로고
    • Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays
    • Sanchez-Carbayo M, Socci ND, Lozano J, Saint F and Cordon-Cardo C: Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays. Int J Oncol 24: 778-779, 2006.
    • (2006) Int J Oncol , vol.24 , pp. 778-779
    • Sanchez-Carbayo, M.1    Socci, N.D.2    Lozano, J.3    Saint, F.4    Cordon-Cardo, C.5
  • 28
    • 0035950270 scopus 로고    scopus 로고
    • Beta-Synuclein inhibits alpha-synuclein aggregation: A possible role as an anti-parkinsonian factor
    • Hashimoto M, Rockenstein E, Mante M, Mallory M and Masliah E: Beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor. Neuron 32: 213-223, 2001.
    • (2001) Neuron , vol.32 , pp. 213-223
    • Hashimoto, M.1    Rockenstein, E.2    Mante, M.3    Mallory, M.4    Masliah, E.5
  • 29
    • 0036670331 scopus 로고    scopus 로고
    • Development of a new treatment for Alzheimer's disease and Parkinson's disease using anti-aggregatory beta-synuclein-derived peptides
    • Windisch M, Hutter-Paier B, Rockenstein E, Hashimoto M, Mallory M and Masliah E: Development of a new treatment for Alzheimer's disease and Parkinson's disease using anti-aggregatory beta-synuclein-derived peptides. J Mol Neurosci 19: 63-69, 2002.
    • (2002) J Mol Neurosci , vol.19 , pp. 63-69
    • Windisch, M.1    Hutter-Paier, B.2    Rockenstein, E.3    Hashimoto, M.4    Mallory, M.5    Masliah, E.6
  • 30
    • 0141844595 scopus 로고    scopus 로고
    • Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: Cross-talk with alpha-synuclein and implication for Parkinson's disease
    • Da Costa CA, Masliah E and Checler F: Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease. J Biol Chem 278: 37330-37335, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 37330-37335
    • Da Costa, C.A.1    Masliah, E.2    Checler, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.