Hypoxia inhibits cellular senescence to restore the therapeutic potential of old human endothelial progenitor cells via the hypoxia-inducible factor-1α-TWIST-p21 Axis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 33, Issue 10, 2013, Pages 2407-2414

  Lee, Sang Hun ^a,b   Lee, Jun Hee ^a,b   Yoo, So Young ^a,b   Hur, Jin ^c   Kim, Hyo Soo ^c,d   Kwon, Sang Mo ^a,b  

^a Pusan National University   (South Korea)

^b Soonchunhyang University   (South Korea)

^c National Research Laboratory for Cardiovascular Stem Cell Niche   (South Korea)

^d Seoul National University Hospital   (South Korea)

Author keywords

aging; anoxia; progenitor cells; tissues; transplantation

Indexed keywords

CYTOKINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN P21; SMALL INTERFERING RNA;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CAPILLARY DENSITY; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSPLANTATION; CELLULAR SENESCENCE; CONTROLLED STUDY; ENDOTHELIAL PROGENITOR CELL; EX VIVO STUDY; HINDLIMB; HUMAN; HUMAN CELL; HYPOXIA; LIMB ISCHEMIA; MODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SECRETION (PROCESS); SENESCENCE;

AGING; ANOXIA; PROGENITOR CELLS; TISSUES; TRANSPLANTATION;

ANGIOGENIC PROTEINS; ANIMALS; CELL AGING; CELL CYCLE; CELL HYPOXIA; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; HINDLIMB; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ISCHEMIA; MICE; MUSCLE, SKELETAL; NEOVASCULARIZATION, PHYSIOLOGIC; NUCLEAR PROTEINS; RECOVERY OF FUNCTION; REGIONAL BLOOD FLOW; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STEM CELLS; TIME FACTORS; TRANSFECTION; TWIST TRANSCRIPTION FACTOR;

EID: 84885030781     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.113.301931     Document Type: Article

References (29)

1. Asahara T, Murohara T, Sullivan A, Silver M, Van Der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997;275:964-967
2. Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, Silver M, Kearne M, Magner M, Isner JM. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res. 1999;85:221-228
3. Naiyer AJ, Jo DY, Ahn J, Mohle R, Peichev M, Lam G, Silverstein RL, Moore MA, Rafii S. Stromal derived factor-1-induced chemokinesis of cord blood CD34(+) cells (long-Term culture-initiating cells) through endothelial cells is mediated by E-selectin. Blood. 1999;94:4011-4019
4. Isner JM, Asahara T. Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization. J Clin Invest. 1999;103:1231-1236
5. Rafii S, Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nature Med. 2003;9:702-712
6. Dzau VJ, Gnecchi M, Pachori AS, Morello F, Melo LG. Therapeutic potential of endothelial progenitor cells in cardiovascular diseases. Hypertension. 2005;46:7-18
7. Armitage M, Nooney J, Evans S. Recent concerns surrounding hrt. Clin Endocrinol. 2003;59:145-155
8. Loomans CJ, De Koning EJ, Staal FJ, Rookmaaker MB, Verseyden C, De Boer HC, Verhaar MC, Braam B, Rabelink TJ, van Zonneveld AJ. Endothelial progenitor cell dysfunction: A novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes. 2004;53:195-199
9. Tepper OM, Galiano RD, Capla JM, Kalka C, Gagne PJ, Jacobowitz GR, Levine JP, Gurtner GC. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation. 2002;106:2781-2786
10. Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, Finkel T. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med. 2003;348:593-600
11. Vasa M, Fichtlscherer S, Aicher A, Adler K, Urbich C, Martin H, Zeiher AM, Dimmeler S. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res. 2001;89:E1-7
12. Imanishi T, Hano T, Nishio I. Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity. J Hypertens. 2005;23:1699-1706
13. Shi AW, Gu N, Liu XM, Wang X, Peng YZ. Ginsenoside rg1 enhances endothelial progenitor cell angiogenic potency and prevents senescence in vitro. J Int Med Res. 2011;39:1306-1318
14. Yang MH, Wu MZ, Chiou SH, Chen PM, Chang SY, Liu CJ, Teng SC, Wu KJ. Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol. 2008;10:295-305
15. Prabhu S, Ignatova A, Park ST, Sun XH. Regulation of the expression of cyclin-dependent kinase inhibitor p21 by e2a and id proteins. Mol Cell Biol. 1997;17:5888-5896
16. el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell. 1993;75:817-825
17. Kawamura T, Suzuki J, Wang YV, Menendez S, Morera LB, Raya A, Wahl GM, Izpisúa Belmonte JC. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature. 2009;460:1140-1144
18. Tsai CC, Chen YJ, Yew TL, Chen LL, Wang JY, Chiu CH, Hung SC. Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIF-TWIST. Blood. 2011;117:459-469
19. Harrison JS, Rameshwar P, Chang V, Bandari P. Oxygen saturation in the bone marrow of healthy volunteers. Blood. 2002;99:394
20. Akita T, Murohara T, Ikeda H, Sasaki K, Shimada T, Egami K, Imaizumi T. Hypoxic preconditioning augments efficacy of human endothelial progenitor cells for therapeutic neovascularization. Lab Invest. 2003;83:65-73
21. Fujita T, Shirasawa T, Maruyama N. Expression and structure of senescence marker protein-30 (smp30) and its biological significance. Mech Ageing Dev. 1999;107:271-280
22. Hung SC, Chen NJ, Hsieh SL, Li H, Ma HL, Lo WH. Isolation and characterization of size-sieved stem cells from human bone marrow. Stem Cells. 2002;20:249-258
23. Wagner W, Ho AD. Mesenchymal stem cell preparations-comparing apples and oranges. Stem Cell Rev. 2007;3:239-248
24. Murasawa S, Llevadot J, Silver M, Isner JM, Losordo DW, Asahara T. Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells. Circulation. 2002;106:1133-1139
25. Thum T, Bauersachs J. Endothelial progenitor cells as potential drug targets. Curr Drug Targets Cardiovasc Haematol Disord. 2005;5:277-286
26. Serakinci N, Guldberg P, Burns JS, Abdallah B, Schrødder H, Jensen T, Kassem M. Adult human mesenchymal stem cell as a target for neoplastic transformation. Oncogene. 2004;23:5095-5098
27. Welford SM, Bedogni B, Gradin K, Poellinger L, Broome Powell M, Giaccia AJ. Hif1alpha delays premature senescence through the activation of mif. Genes Dev. 2006;20:3366-3371
28. Takubo K, Goda N, Yamada W, Iriuchishima H, Ikeda E, Kubota Y, Shima H, Johnson RS, Hirao A, Suematsu M, Suda T. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell. 2010;7:391-402
29. Yang DG, Liu L, Zhou SH. Microrna alterations in senescent endothelial progenitor cells induced by remnant-like lipoproteins. Chin Med J. 2012;125:3479-3484