Epithelioid angiomyolipoma of the kidney: Pathological features and clinical outcome in a series of consecutively resected tumors

Modern Pathology

Volumn 26, Issue 10, 2013, Pages 1355-1364

  He, Wenlei ^a   Cheville, John C ^b   Sadow, Peter M ^c   Gopalan, Anuradha ^a   Fine, Samson W ^a   Al Ahmadie, Hikmat A ^a   Chen, Ying Bei ^a   Oliva, Esther ^c   Russo, Paul ^a   Reuter, Victor E ^a   Tickoo, Satish K ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b MAYO CLINIC   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Epithelioid angiomyolipoma; PEComa; Renal angiomyolipoma

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; FEMALE; FOLLOW UP; GIANT CELL; HUMAN; KIDNEY EPITHELIOID ANGIOMYOLIPOMA; KIDNEY HEMANGIOMYOLIPOMA; MALE; MITOSIS RATE; NEPHRECTOMY; OUTCOME ASSESSMENT; PATHOLOGY; PRIORITY JOURNAL; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; ANGIOMYOLIPOMA; FEMALE; HUMANS; KIDNEY; KIDNEY NEOPLASMS; MALE; MIDDLE AGED; NEPHRECTOMY; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 84885022133     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2013.72     Document Type: Article

References (28)

1. Martignoni G, Amin MB. Angiomyolipoma, In: Eble JN, Sauter G, Epstein JI, Sesterhenn IA(eds) WHO Classification of Tumours. Pathology and Genetics. Tumours of the Urinary System and Male Genital Organs. IARC Press: Lyon, France; 2004, pp 65-67.
2. Fine SW, Reuter VE, Epstein JI, et al. Angiomyolipoma with epithelial cysts (AMLEC): a distinct cystic variant of angiomyolipoma. Am J Surg Pathol 2006;30: 593-599.
3. Martignoni G, Pea M, Bonetti F, et al. Oncocytoma-like angiomyolipoma. A clinicopathologic and immunohistochemical study of 2 cases. Arch Pathol Lab Med 2002;126: 610-612.
4. Matsuyama A, Hisaoka M, Ichikawa K, et al. Sclerosing variant of epithelioid angiomyolipoma. Pathol Int 2008;58: 306-310.
5. Amin MB. Epithelioid angiomyolipoma, In: Eble JN, Sauter G, Epstein JI, Sesterhenn IA (eds) WHO Classification of Tumours. Pathology and Genetics. Tumours of the Urinary System and Male Genital Organs. IARC Press: Lyon, France; 2004, pp 68-69.
6. Cibas ES, Goss GA, Kulke MH, et al. Malignant epithelioid angiomyolipoma ('sarcoma ex angiomyolipoma') of the kidney: a case report and review of the literature. Am J Surg Pathol 2001;25: 121-126.
7. Eble JN, Amin MB, Young RH. Epithelioid angiomyolipoma of the kidney: a report of five cases with a prominent and diagnostically confusing epithelioid smooth muscle component. Am J Surg Pathol 1997; 21: 1123-1130.
8. Faraji H, Nguyen BN, Mai KT. Renal epithelioid angiomyolipoma: a study of six cases and a metaanalytic study. Development of criteria for screening the entity with prognostic significance. Histopathology 2009;55: 525-534.
9. Martignoni G, Pea M, Rigaud G, et al. Renal angiomyolipoma with epithelioid sarcomatous transformation and metastases: demonstration of the same genetic defects in the primary and metastatic lesions. Am J Surg Pathol 2000;24: 889-894.
10. Pea M, Bonetti F, Martignoni G, et al. Apparent renal cell carcinomas in tuberous sclerosis are heterogeneous: the identification of malignant epithelioid angiomyolipoma. Am J Surg Pathol 1998;22: 180-187.
11. Aydin H, Magi-Galluzzi C, Lane BR, et al. Renal angiomyolipoma: clinicopathologic study of 194 cases with emphasis on the epithelioid histology and tuberous sclerosis association. Am J Surg Pathol 2009;33: 289-297.
12. Brimo F, Robinson B, Guo C, et al. Renal epithelioid angiomyolipoma with atypia: a series of 40 cases with emphasis on clinicopathologic prognostic indicators of malignancy. Am J Surg Pathol 2010;34: 715-722.
13. Nese N, Martignoni G, Fletcher CD, et al. Pure epithelioid PEComas (so-called epithelioid angiomyolipoma) of the kidney: a clinicopathologic study of 41 cases: detailed assessment of morphology and risk stratification. Am J Surg Pathol 2011;35: 161-176.
14. Mai KT, Perkins DG, Collins JP. Epithelioid cell variant of renal angiomyolipoma. Histopathology 1996; 28: 277-280.
15. Martignoni G, Pea M, Bonetti F, et al. Carcinomalike monotypic epithelioid angiomyolipoma in patients without evidence of tuberous sclerosis: a clinicopathologic and genetic study. Am J Surg Pathol 1998;22: 663-672.
16. Takahashi N, Kitahara R, Hishimoto Y, et al. Malignant transformation of renal angiomyolipoma. Int J Urol 2003;10: 271-273.
17. El-Hashemite N, Zhang H, Henske EP, et al. Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma. Lancet 2003;361: 1348-1349.
18. Delgado R, de Leon Bojorge B, Albores-Saavedra J. Atypical angiomyolipoma of the kidney: a distinct morphologic variant that is easily confused with a variety of malignant neoplasms. Cancer 1998;83: 1581-1592.
19. Stone CH, Lee MW, Amin MB, et al. Renal angiomyolipoma: further immunophenotypic characterization of an expanding morphologic spectrum. Arch Pathol Lab Med 2001;125: 751-758.
20. L'Hostis H, Deminiere C, Ferriere JM, et al. Renal angiomyolipoma: a clinicopathologic, immunohistochemical, and follow-up study of 46 cases. Am J Surg Pathol 1999;23: 1011-1020.
21. Henske EP, Neumann HP, Scheithauer BW, et al. Loss of heterozygosity in the tuberous sclerosis (TSC2) region of chromosome band 16p13 occurs in sporadic as well as TSC-associated renal angiomyolipomas. Genes Chromosomes Cancer 1995;13: 295-298.
22. Pan CC, Chung MY, Ng KF, et al. Constant allelic alteration on chromosome 16p (TSC2 gene) in perivascular epithelioid cell tumour (PEComa): genetic evidence for the relationship of PEComa with angiomyolipoma. J Pathol 2008;214: 387-393.
23. Martignoni G, Pea M, Reghellin D, et al. PEComas: the past, the present and the future. Virchows Arch 2008;452: 119-132.
24. Henske EP. Tuberous sclerosis and the kidney: from mesenchyme to epithelium, and beyond. Pediatr Nephrol 2005;20: 854-857.
25. Rakowski SK, Winterkorn EB, Paul E, et al. Renal manifestations of tuberous sclerosis complex: Incidence, prognosis, and predictive factors. Kidney Int 2006;70: 1777-1782.
26. Krischock L, Beach R, Taylor J. Sirolimus and tuberous sclerosis-associated renal angiomyolipomas. Arch Dis Child 2010;95: 391-392.
27. Micozkadioglu H, Koc Z, Ozelsancak R, et al. Rapamycin therapy for renal, brain, and skin lesions in a tuberous sclerosis patient. Ren Fail 2010;32: 1233-1236.
28. Sampson JR. Therapeutic targeting of mTOR in tuberous sclerosis. Biochem Soc Trans 2009;37: 259-264.