Does isoflurane or isoflurane plus hyperoxia induce apoptotic cell death?

Anesthesia and Analgesia

Volumn 117, Issue 4, 2013, Pages 1023-

  Kopp, Vincent J ^a   Jobson, Meghan ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HALOTHANE; ISOFLURANE; OXYGEN; REACTIVE OXYGEN METABOLITE; SEVOFLURANE;

ANESTHESIA; APOPTOSIS; ASTROCYTE; BRAIN CELL; BRAIN OXYGEN TENSION; CELL DEATH; HYPEROXIA; LETTER; NERVE CELL DIFFERENTIATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; OXYGEN BLOOD LEVEL; PRIORITY JOURNAL;

ANESTHETICS, INHALATION; ANIMALS; APOPTOSIS; CEREBRAL CORTEX; FEMALE; ISOFLURANE; MALE; NEURONS;

EID: 84884994443     PISSN: 00032999     EISSN: 15267598     Source Type: Journal    
DOI: 10.1213/ANE.0b013e3182a231b5     Document Type: Letter

References (10)

1. Istaphanous GK, Ward CG, Nan X, Hughes EA, McCann JC, McAuliffe JJ, Danzer SC, Loepke AW. Characterization and quantification of isoflurane-induced developmental apoptotic cell death in mouse cerebral cortex. Anesth Analg 2013;116:845-54
2. Semenza GL. Life with oxygen. Science 2007;318:62-4 (Pubitemid 47538005)
3. Tapia PC. Sublethal mitochondrial stress with an attendant stoichiometric augmentation of reactive oxygen species may precipitate many of the beneficial alterations in cellular physiology produced by caloric restriction, intermittent fasting, exercise and dietary phytonutrients: "Mitohormesis" for health and vitality. Med Hypotheses 2006;66:832-43 (Pubitemid 43181634)
4. Farrow KN, Lee KJ, Perez M, Schriewer JM, Wedgwood S, Lakshminrusimha S, Smith CL, Steinhorn RH, Schumacker PT. Brief hyperoxia increases mitochondrial oxidation and increases phosphodiesterase 5 activity in fetal pulmonary artery smooth muscle cells. Antioxid Redox Signal 2012;17:460-70
5. Tiede LM, Cook EA, Morsey B, Fox HS. Oxygen matters: tissue culture oxygen levels affect mitochondrial function and structure as well as responses to HIV viroproteins. Cell Death Dis 2011;2:e246
6. Felderhoff-Mueser U, Bittigau P, Sifringer M, Jarosz B, Korobowicz E, Mahler L, Piening T, Moysich A, Grune T, Thor F, Heumann R, Bührer C, Ikonomidou C. Oxygen causes cell death in the developing brain. Neurobiol Dis 2004;17:273-82 (Pubitemid 39345782)
7. Martin LJ. Mitochondrial and cell death mechanisms in neurodegenerative diseases. Pharmaceuticals (Basel) 2010;3:839-915
8. Bolaños JP, Almeida A, Stewart V, Peuchen S, Land JM, Clark JB, Heales SJ. Nitric oxide-mediated mitochondrial damage in the brain: mechanisms and implications for neurodegenerative diseases. J Neurochem 1997;68:2227-40 (Pubitemid 27218141)
9. Hanley PJ, Ray J, Brandt U, Daut J. Halothane, isoflurane and sevoflurane inhibit NADH:ubiquinone oxidoreductase (complex I) of cardiac mitochondria. J Physiol 2002;544:687-93 (Pubitemid 35355950)
10. Boscolo A, Starr JA, Sanchez V, Lunardi, DiGruccio MR, Ori C, Trimmer P, Bennett J, Jevtovic-Todorovic V. The abolishment of anesthesia induced cognitive impairment by timely protection of mitochondria in the developing rat brain: the importance of free radicals and mitochondrial integrity. Neurobiol Dis 2012;45:1031-41