Regulatory dendritic cell expression of MHCII and IL-10 are jointly requisite for induction of tolerance in a murine model of OVA-asthma

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 68, Issue 9, 2013, Pages 1126-1135

  Huang, H ^a   Dawicki, W ^b   Lu, M ^a   Nayyar, A ^a   Zhang, X ^a   Gordon, J R ^a,b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

asthma; CD80 CD86; IL 10; MHCII; tolerogenic dendritic cells

Indexed keywords

ALLERGEN; B7 ANTIGEN; CD86 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OVALBUMIN; TRANSCRIPTION FACTOR FOXP3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; ASTHMA; CHEMOTAXIS; CONTROLLED STUDY; DENDRITIC CELL; EOSINOPHILIA; FEMALE; GENE SILENCING; IMMUNOBIOLOGY; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TH2 CELL;

ASTHMA; CD80/CD86; IL-10; MHCII; TOLEROGENIC DENDRITIC CELLS;

ANIMALS; ASTHMA; CELL MOVEMENT; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION; GENES, MHC CLASS II; IMMUNE TOLERANCE; INTERLEUKIN-10; LUNG; LYMPH NODES; MICE; MICE, KNOCKOUT; OVALBUMIN; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, REGULATORY;

EID: 84884981649     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/all.12203     Document Type: Article

References (33)

1. Zygmunt B, Veldhoen M,. T helper cell differentiation. More than just cytokines. Adv Immunol 2011; 109: 159-196.
2. Taga K, Mostowski H, Tosato G,. Human interleukin-10 can directly inhibit T-cell growth. Blood 1993; 81: 2964-2971.
3. Sakaguchi S, Yamaguchi T, Nomura T, Ono M,. Regulatory T cells and immune tolerance. Cell 2008; 133: 775-787.
4. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A,. Interleukin-10 and the interleukin-10 receptor. Ann Rev Immunol 2001; 19: 683-765.
5. Steinbrink K, Graulich E, Kubsch S, Knop J, Enk AH,. CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity. Blood 2002; 99: 2468-2476.
6. Steinbrink K, Wolfl M, Jonuleit H, Knop J, Enk AH,. Induction of tolerance by IL-10-treated dendritic cells. J Immunol 1997; 159: 4772-4780.
7. Koya T, Matsuda H, Takeda K, Matsubara S, Miyahara N, Balhorn A, et al. IL-10-treated dendritic cells decrease airway hyperresponsiveness and airway inflammation in mice. J Allergy Clin Immunol 2007; 119: 1241-1250.
8. van Scott MR, Justice JP, Bradfield JF, Enright E, Sigounas A, Sur S,. IL-10 reduces Th2 cytokine production and eosinophilia but augments airway reactivity in allergic mice. Am J Physiol Lung Cell Mol Physiol 2000; 278: L667-L674.
9. Fu CL, Chuang YH, Chau LY, Chiang BL,. Effects of adenovirus-expressing IL-10 in alleviating airway inflammation in asthma. J Gene Med 2006; 8: 1393-1399.
10. - effector T cells. J Immunol 2010; 185: 5003-5010.
11. Li X, Yang A, Huang H, Zhang X, Town J, Davis B, et al. Induction of type 2 T helper cell allergen tolerance by IL-10-differentiated regulatory dendritic cells. Am J Respir Cell Mol Biol 2010; 42: 190-199.
12. Lu M, Dawicki W, Zhang X, Huang H, Nayyar A, Gordon JR,. Therapeutic induction of tolerance by IL-10-differentiated dendritic cells in a mouse model of house dust mite-asthma. Allergy 2011; 66: 612-620.
13. Henry E, Desmet CJ, Garze V, Fievez L, Bedoret D, Heirman C, et al. Dendritic cells genetically engineered to express IL-10 induce long-lasting antigen-specific tolerance in experimental asthma. J Immunol 2008; 181: 7230-7242.
14. -, dendritic cells tolerize Th2 responses via contact-dependent and -independent mechanisms, and reverse airway hyperresponsiveness, Th2, and eosinophil responses in a mouse model of asthma. J Immunol 2005; 175: 1516-1522.
15. Papp Z, Middleton DM, Rontved CM, Foldvari M, Gordon JR, Baca-Estrada ME,. Transtracheal administration of interleukin-12 induces neutrophil responses in the murine lung. J Interferon Cytokine Res 2000; 20: 191-195.
16. Schneider AM, Li F, Zhang X, Gordon JR,. Induction of pulmonary allergen-specific IgA responses or airway hyperresponsiveness in the absence of allergic lung disease following sensitization with limiting doses of ovalbumin-alum. Cell Immunol 2001; 212: 101-109.
17. Vijayaraghavan R, Schaper M, Thompson R, Stock MF, Boylstein LA, Luo JE, et al. Computer assisted recognition and quantitation of the effects of airborne chemicals acting at different areas of the respiratory tract in mice. Arch Toxicol 1994; 68: 490-499.
18. Vijayaraghavan R, Schaper M, Thompson R, Stock MF, Alarie Y,. Characteristic modifications of the breathing pattern of mice to evaluate the effects of airborne chemicals on the respiratory tract. Arch Toxicol 1993; 67: 478-490.
19. Nayyar A, Dawicki W, Huang H, Lu M, Zhang X, Gordon JR,. Induction of prolonged asthma tolerance by IL-10-differentiated dendritic cells: differential impact on airway hyperresponsiveness and the Th2 immunoinflammatory response. J Immunol 2012; 189: 72-79.
20. Yoffey J, Courtice F,. Lymphatics, Lymph and the Lymphomyeloid Complex. London, New York: Academic Press, 1970.
21. Lassailly F, Griessinger E, Bonnet D,. "Microenvironmental contaminations" induced by fluorescent lipophilic dyes used for noninvasive in vitro and in vivo cell tracking. Blood 2010; 115: 5347-5354.
22. Mocellin S, Marincola F, Rossi CR, Nitti D, Lise M,. The multifaceted relationship between IL-10 and adaptive immunity: putting together the pieces of a puzzle. Cytokine Growth Factor Rev 2004; 15: 61-76.
23. + T cells. J Exp Med 1996; 184: 19-29.
24. Makela MJ, Kanehiro A, Dakhama A, Borish L, Joetham A, Tripp R, et al. The failure of interleukin-10-deficient mice to develop airway hyperresponsiveness is overcome by respiratory syncytial virus infection in allergen-sensitized/challenged mice. Am J Respir Crit Care Med 2002; 165: 824-831.
25. Sakaguchi S, Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T,. Regulatory T cells: how do they suppress immune responses? Int Immunol 2009; 21: 1105-1111.
26. Garritsen HS, Macke L, Meyring W, Hannig H, Pagelow U, Wormann B, et al. Efficient generation of clinical-grade genetically modified dendritic cells for presentation of multiple tumor-associated proteins. Transfusion 2010; 50: 831-842.
27. Steinman RM,. The control of immunity and tolerance by dendritic cell. Pathol Biol (Paris) 2003; 51: 59-60.
28. Golovina TN, Mikheeva T, Suhoski MM, Aqui NA, Tai VC, Shan X, et al. CD28 costimulation is essential for human T regulatory expansion and function. J Immunol 2008; 181: 2855-2868.
29. Weaver TA, Charafeddine AH, Kirk AD,. Costimulation blockade: towards clinical application. Front Biosci 2008; 13: 2120-2139.
30. Quezada SA, Jarvinen LZ, Lind EF, Noelle RJ,. CD40/CD154 interactions at the interface of tolerance and immunity. Annu Rev Immunol 2004; 22: 307-328.
31. Scalapino KJ, Daikh DI,. CTLA-4: a key regulatory point in the control of autoimmune disease. Immunol Rev 2008; 223: 143-155.
32. Hochweller K, Anderton SM,. Kinetics of costimulatory molecule expression by T cells and dendritic cells during the induction of tolerance versus immunity in vivo. Eur J Immunol 2005; 35: 1086-1096.
33. Steinman RM, Turley S, Mellman I, Inaba K,. The induction of tolerance by dendritic cells that have captured apoptotic cells. J Exp Med 2000; 191: 411-416.