-
1
-
-
77956537218
-
Primary myelofibrosis
-
In: Swerdlow SH, Campo E, Harris NL et al, editors, IARC Lyon: World Health Organization
-
Thiele J, Kvasnicka HM, Tefferi A, et al. Primary myelofibrosis. In: Swerdlow SH, Campo E, Harris NL et al, editors. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. IARC Lyon: World Health Organization, 2008:44-7.
-
(2008)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
, pp. 44-47
-
-
Thiele, J.1
Kvasnicka, H.M.2
Tefferi, A.3
-
2
-
-
63849328927
-
New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment
-
Cervantes F, Dupriez B, Pereira A, Passamonti F, Reilly JT, Morra E, et al. New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment. Blood. 2009;113(13):2895-901.
-
(2009)
Blood
, vol.113
, Issue.13
, pp. 2895-2901
-
-
Cervantes, F.1
Dupriez, B.2
Pereira, A.3
Passamonti, F.4
Reilly, J.T.5
Morra, E.6
-
3
-
-
84865263436
-
Improving survival trends in primary myelofibrosis: An international study
-
Cervantes F, Dupriez B, Passamonti F, Vannucchi AM, Morra E, Reilly JT, et al. Improving survival trends in primary myelofibrosis: an international study. J Clin Oncol. 2012;30(24):2981-7.
-
(2012)
J Clin Oncol
, vol.30
, Issue.24
, pp. 2981-2987
-
-
Cervantes, F.1
Dupriez, B.2
Passamonti, F.3
Vannucchi, A.M.4
Morra, E.5
Reilly, J.T.6
-
4
-
-
77950352432
-
A dynamic prognostic model to predict survival in primary myelofibrosis: A study by the IWGMRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment)
-
Passamonti F, Cervantes F, Vannucchi AM, Morra E, Rumi E, Pereira A, et al. A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWGMRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment). Blood. 2010;115(9):1703-8.
-
(2010)
Blood
, vol.115
, Issue.9
, pp. 1703-1708
-
-
Passamonti, F.1
Cervantes, F.2
Vannucchi, A.M.3
Morra, E.4
Rumi, E.5
Pereira, A.6
-
5
-
-
79551491928
-
Philadelphia-negative classical myeloproliferative neoplasms: Critical concepts and management recommendations from European LeukemiaNet
-
Barbui T, Barosi G, Birgegard G, Cervantes F, Finazzi G, Griesshammer M, et al. Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European LeukemiaNet. J Clin Oncol. 2011;29(6):761-70.
-
(2011)
J Clin Oncol
, vol.29
, Issue.6
, pp. 761-770
-
-
Barbui, T.1
Barosi, G.2
Birgegard, G.3
Cervantes, F.4
Finazzi, G.5
Griesshammer, M.6
-
6
-
-
34548240698
-
Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders
-
Levine RL, Pardanani A, Tefferi A, Gilliland DG. Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders. Nat Rev Cancer. 2007;7(9):673-83.
-
(2007)
Nat Rev Cancer
, vol.7
, Issue.9
, pp. 673-683
-
-
Levine, R.L.1
Pardanani, A.2
Tefferi, A.3
Gilliland, D.G.4
-
7
-
-
66349138550
-
The diagnosis and management of polycythemia vera, essential thrombocythemia, and primary myelofibrosis in the JAK2 V617F era
-
Zhan H, Spivak JL. The diagnosis and management of polycythemia vera, essential thrombocythemia, and primary myelofibrosis in the JAK2 V617F era. Clin Adv Hematol Oncol. 2009;7(5):334-42.
-
(2009)
Clin Adv Hematol Oncol
, vol.7
, Issue.5
, pp. 334-342
-
-
Zhan, H.1
Spivak, J.L.2
-
8
-
-
21344467318
-
Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
-
Jones AV, Kreil S, Zoi K, Waghorn K, Curtis C, Zhang L, et al. Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders. Blood. 2005; 106(6):2162-8.
-
(2005)
Blood
, vol.106
, Issue.6
, pp. 2162-2168
-
-
Jones, A.V.1
Kreil, S.2
Zoi, K.3
Waghorn, K.4
Curtis, C.5
Zhang, L.6
-
9
-
-
38349101871
-
Classification and diagnosis of myeloproliferative neoplasms: The 2008 World Health Organization criteria and point-of-care diagnostic algorithms
-
Tefferi A, Vardiman JW. Classification and diagnosis of myeloproliferative neoplasms: the 2008 World Health Organization criteria and point-of-care diagnostic algorithms. Leukemia. 2008;22(1):14-22.
-
(2008)
Leukemia
, vol.22
, Issue.1
, pp. 14-22
-
-
Tefferi, A.1
Vardiman, J.W.2
-
10
-
-
84885606352
-
Problems and pitfalls regarding WHOdefined diagnosis of early/prefibrotic primary myelofibrosis versus essential thrombocythemia
-
[Epub ahead of print]
-
Barbui T, Thiele J, Vannucchi AM, Tefferi A. Problems and pitfalls regarding WHOdefined diagnosis of early/prefibrotic primary myelofibrosis versus essential thrombocythemia. Leukemia. 2013. [Epub ahead of print]
-
(2013)
Leukemia
-
-
Barbui, T.1
Thiele, J.2
Vannucchi, A.M.3
Tefferi, A.4
-
11
-
-
79957611312
-
Essential thrombocythemia versus early primary myelofibrosis: A multicenter study to validate the WHO classification
-
Thiele J, Kvasnicka HM, Mullauer L, Buxhofer-Ausch V, Gisslinger B, Gisslinger H. Essential thrombocythemia versus early primary myelofibrosis: a multicenter study to validate the WHO classification. Blood. 2011;117(21):5710-8.
-
(2011)
Blood
, vol.117
, Issue.21
, pp. 5710-5718
-
-
Thiele, J.1
Kvasnicka, H.M.2
Mullauer, L.3
Buxhofer-Ausch, V.4
Gisslinger, B.5
Gisslinger, H.6
-
12
-
-
84864136100
-
Disease characteristics and clinical outcome in young adults with essential thrombocythemia versus early/prefibrotic primary myelofibrosis
-
Barbui T, Thiele J, Carobbio A, Passamonti F, Rumi E, Randi ML, et al. Disease characteristics and clinical outcome in young adults with essential thrombocythemia versus early/prefibrotic primary myelofibrosis. Blood. 2012;120(3):569-71.
-
(2012)
Blood
, vol.120
, Issue.3
, pp. 569-571
-
-
Barbui, T.1
Thiele, J.2
Carobbio, A.3
Passamonti, F.4
Rumi, E.5
Randi, M.L.6
-
13
-
-
80051803115
-
Survival and disease progression in essential thrombocythemia are significantly influenced by accurate morphologic diagnosis: An international study
-
Barbui T, Thiele J, Passamonti F, Rumi E, Boveri E, Ruggeri M, et al. Survival and disease progression in essential thrombocythemia are significantly influenced by accurate morphologic diagnosis: an international study. J Clin Oncol. 2011;29(23):3179-84.
-
(2011)
J Clin Oncol
, vol.29
, Issue.23
, pp. 3179-3184
-
-
Barbui, T.1
Thiele, J.2
Passamonti, F.3
Rumi, E.4
Boveri, E.5
Ruggeri, M.6
-
14
-
-
84859650006
-
Incidence and risk factors for bleeding in 1104 patients with essential thrombocythemia or prefibrotic myelofibrosis diagnosed according to the 2008 WHO criteria
-
Finazzi G, Carobbio A, Thiele J, Passamonti F, Rumi E, Ruggeri M, et al. Incidence and risk factors for bleeding in 1104 patients with essential thrombocythemia or prefibrotic myelofibrosis diagnosed according to the 2008 WHO criteria. Leukemia. 2012;26 (4):716-9.
-
(2012)
Leukemia
, vol.26
, Issue.4
, pp. 716-719
-
-
Finazzi, G.1
Carobbio, A.2
Thiele, J.3
Passamonti, F.4
Rumi, E.5
Ruggeri, M.6
-
15
-
-
34548042964
-
Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: Recommendations from an ad hoc international expert panel
-
Tefferi A, Thiele J, Orazi A, Kvasnicka HM, Barbui T, Hanson CA, et al. Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel. Blood. 2007;110(4):1092-7.
-
(2007)
Blood
, vol.110
, Issue.4
, pp. 1092-1097
-
-
Tefferi, A.1
Thiele, J.2
Orazi, A.3
Kvasnicka, H.M.4
Barbui, T.5
Hanson, C.A.6
-
16
-
-
84884918515
-
-
Incyte Corporation, Available from, Accessed 20 February
-
Incyte Corporation. Jakafi (R) (ruxolitinib) Full prescribing information. Available from: http://www.incyte.com/products/uspi_jaka fi.pdf. Accessed 20 February 2013.
-
(2013)
Jakafi (R) (ruxolitinib) Full prescribing information
-
-
-
17
-
-
77956696835
-
Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis
-
Verstovsek S, Kantarjian H, Mesa RA, Pardanani AD, Cortes-Franco J, Thomas DA, et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N Engl J Med. 2010;363(12): 1117-27.
-
(2010)
N Engl J Med
, vol.363
, Issue.12
, pp. 1117-1127
-
-
Verstovsek, S.1
Kantarjian, H.2
Mesa, R.A.3
Pardanani, A.D.4
Cortes-Franco, J.5
Thomas, D.A.6
-
18
-
-
84863393110
-
A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
-
Verstovsek S, Mesa RA, Gotlib J, Levy RS, Gupta V, DiPersio JF, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med. 2012;366(9):799-807.
-
(2012)
N Engl J Med
, vol.366
, Issue.9
, pp. 799-807
-
-
Verstovsek, S.1
Mesa, R.A.2
Gotlib, J.3
Levy, R.S.4
Gupta, V.5
DiPersio, J.F.6
-
19
-
-
84857837774
-
JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
-
Harrison C, Kiladjian JJ, Al-Ali HK, Gisslinger H, Waltzman R, Stalbovskaya V, et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med. 2012;366(9):787-98.
-
(2012)
N Engl J Med
, vol.366
, Issue.9
, pp. 787-798
-
-
Harrison, C.1
Kiladjian, J.J.2
Al-Ali, H.K.3
Gisslinger, H.4
Waltzman, R.5
Stalbovskaya, V.6
-
20
-
-
84875315406
-
Long-term outcome of ruxolitinib treatment in patients with myelofibrosis: Durable reductions in spleen volume, improvements in quality of life, and overall survival advantage in COMFORT-I
-
Abstract 800
-
Verstovsek S, Mesa RA, Gotlib J, Levy RS, Gupta V, DiPersio JF, et al. Long-term outcome of ruxolitinib treatment in patients with myelofibrosis: Durable reductions in spleen volume, improvements in quality of life, and overall survival advantage in COMFORT-I. Blood. 2012;120(21):Abstract 800.
-
(2012)
Blood
, vol.120
, Issue.21
-
-
Verstovsek, S.1
Mesa, R.A.2
Gotlib, J.3
Levy, R.S.4
Gupta, V.5
DiPersio, J.F.6
-
21
-
-
84875324859
-
Long-term safety, efficacy, and survival findings from Comfort-II, a phase 3 study comparing ruxolitinib with best available therapy (BAT) for the treatment of myelofibrosis (MF)
-
(Abstract 801)
-
Cervantes F, Kiladjian JJ, Niederwieser D, Sirulnik A, Stalbovskaya V, McQuity M, et al. Long-term safety, efficacy, and survival findings from Comfort-II, a phase 3 study comparing ruxolitinib with best available therapy (BAT) for the treatment of myelofibrosis (MF). Blood. 2012;120:(Abstract 801).
-
(2012)
Blood
, vol.120
-
-
Cervantes, F.1
Kiladjian, J.J.2
Niederwieser, D.3
Sirulnik, A.4
Stalbovskaya, V.5
McQuity, M.6
-
22
-
-
84859938727
-
Ruxolitinib provides reductions in splenomegaly across subgroups; An analysis of spleen response in the COMFORT-II study
-
Abstract 279
-
Harrison CN, Kiladjian JJ, Gisslinger H, Niederwieser D, Passamonti F, Waltzman RJ, et al. Ruxolitinib provides reductions in splenomegaly across subgroups; An analysis of spleen response in the COMFORT-II study. Blood. 2011;118:Abstract 279.
-
(2011)
Blood
, vol.118
-
-
Harrison, C.N.1
Kiladjian, J.J.2
Gisslinger, H.3
Niederwieser, D.4
Passamonti, F.5
Waltzman, R.J.6
-
23
-
-
84873108939
-
Preliminary safety and eficiacy from a phase II study of ruxolitinib in patients with primary and secondary myelofibrosis with platelets counts of 50-100 x 109/L
-
Abstract 597
-
Talpaz M, Hamburg SI, Jamieson K, Terebelo HR, Afrin L, Winton EF, et al. Preliminary safety and eficiacy from a phase II study of ruxolitinib in patients with primary and secondary myelofibrosis with platelets counts of 50-100 x 109/L. Haematologica. 2012;97:244 Abstract 597.
-
(2012)
Haematologica
, vol.97
, pp. 244
-
-
Talpaz, M.1
Hamburg, S.I.2
Jamieson, K.3
Terebelo, H.R.4
Afrin, L.5
Winton, E.F.6
-
24
-
-
84878233090
-
Expand: A phase 1b, open-label, dose-finding study of ruxolitinib in patients with myelofibrosis and baseline platelet counts between 5x109/L and 99x109/L
-
Abstract 177
-
Harrison CN, Gisslinger H, Miller CB, Kiladjian JJ, Atienza E, Stalbovskaya V, et al. Expand: a phase 1b, open-label, dose-finding study of ruxolitinib in patients with myelofibrosis and baseline platelet counts between 5x109/L and 99x109/L. Blood. 2012;120 (21):Abstract 177.
-
(2012)
Blood
, vol.120
, Issue.21
-
-
Harrison, C.N.1
Gisslinger, H.2
Miller, C.B.3
Kiladjian, J.J.4
Atienza, E.5
Stalbovskaya, V.6
-
25
-
-
80054028202
-
Longterm outcome of treatment with ruxolitinib in myelofibrosis
-
Tefferi A, Litzow MR, Pardanani A. Longterm outcome of treatment with ruxolitinib in myelofibrosis. N Engl J Med. 2011;365(15):1455-7.
-
(2011)
N Engl J Med
, vol.365
, Issue.15
, pp. 1455-1457
-
-
Tefferi, A.1
Litzow, M.R.2
Pardanani, A.3
-
26
-
-
84858830416
-
SAR302503: Interim safety, efficacy and long-term impact on JAK2 V617F allele burden in a phase I/II study in patients with myelofibrosis
-
Abstract 3838
-
Pardanani A, Gotlib J, Jamieson C, Cortes JE, Talpaz M, Stone R, et al. SAR302503: Interim safety, efficacy and long-term impact on JAK2 V617F allele burden in a phase I/II study in patients with myelofibrosis. Blood. 2011;118(21):Abstract 3838.
-
(2011)
Blood
, vol.118
, Issue.21
-
-
Pardanani, A.1
Gotlib, J.2
Jamieson, C.3
Cortes, J.E.4
Talpaz, M.5
Stone, R.6
-
27
-
-
84878257414
-
A phase II randomized dose-ranging study of the JAK2-selective inhibitor SAR302503 in patients with intermediate-2 or high-risk primary myelofibrosis (MF), or post-essential thrombocythemia (ET) MF
-
Abstract 2837
-
Talpaz M, Jamieson C, Gabrail NY, Lebedinsky C, Gao G, Liu F, et al. A phase II randomized dose-ranging study of the JAK2-selective inhibitor SAR302503 in patients with intermediate-2 or high-risk primary myelofibrosis (MF), or post-essential thrombocythemia (ET) MF. Blood. 2012;120(21):Abstract 2837.
-
(2012)
Blood
, vol.120
, Issue.21
-
-
Talpaz, M.1
Jamieson, C.2
Gabrail, N.Y.3
Lebedinsky, C.4
Gao, G.5
Liu, F.6
-
28
-
-
84858848013
-
Results of a phase 2 study of pacritinib (SB1518), a novel oral JAK2 inhibitor, in patients with primary, post-polycythemia vera, and postessential thrombocythemia myelofibrosis
-
Abstract 282
-
Komrokji RS, Wadleigh M, Seymour JF, Roberts AW, To LB, Zhu HJ, et al. Results of a phase 2 study of pacritinib (SB1518), a novel oral JAK2 inhibitor, in patients with primary, post-polycythemia vera, and postessential thrombocythemia myelofibrosis. Blood. 2011;118(21):Abstract 282.
-
(2011)
Blood
, vol.118
, Issue.21
-
-
Komrokji, R.S.1
Wadleigh, M.2
Seymour, J.F.3
Roberts, A.W.4
To, L.B.5
Zhu, H.J.6
-
29
-
-
84875345485
-
Phase I/II study of CYT387, a JAK1/JAK2 inhibitor for the treatment of myelofibrosis
-
Abstract 178
-
Pardanani A, Gotlib J, Gupta V, Roberts AW, Wadleigh M, Sirhan S, et al. Phase I/II study of CYT387, a JAK1/JAK2 inhibitor for the treatment of myelofibrosis. Blood. 2012;120(21):Abstract 178.
-
(2012)
Blood
, vol.120
, Issue.21
-
-
Pardanani, A.1
Gotlib, J.2
Gupta, V.3
Roberts, A.W.4
Wadleigh, M.5
Sirhan, S.6
-
30
-
-
0036008494
-
Hypermethylation of the P15INK4b and P16INK4a in agnogenic myeloid metaplasia (AMM) and AMM in leukaemic transformation
-
Wang JC, Chen W, Nallusamy S, Chen C, Novetsky AD. Hypermethylation of the P15INK4b and P16INK4a in agnogenic myeloid metaplasia (AMM) and AMM in leukaemic transformation. Br J Haematol. 2002;116(3):582-6.
-
(2002)
Br J Haematol
, vol.116
, Issue.3
, pp. 582-586
-
-
Wang, J.C.1
Chen, W.2
Nallusamy, S.3
Chen, C.4
Novetsky, A.D.5
-
31
-
-
7644238051
-
RARbeta2 is a candidate tumor suppressor gene in myelofibrosis with myeloid metaplasia
-
Jones LC, Tefferi A, Idos GE, Kumagai T, Hofmann WK, Koeffler HP. RARbeta2 is a candidate tumor suppressor gene in myelofibrosis with myeloid metaplasia. Oncogene. 2004;23(47):7846-53.
-
(2004)
Oncogene
, vol.23
, Issue.47
, pp. 7846-7853
-
-
Jones, L.C.1
Tefferi, A.2
Idos, G.E.3
Kumagai, T.4
Hofmann, W.K.5
Koeffler, H.P.6
-
32
-
-
55049114480
-
Hypermethylation of CXCR4 promoter in CD34+ cells from patients with primary myelofibrosis
-
Bogani C, Ponziani V, Guglielmelli P, Desterke C, Rosti V, Bosi A, et al. Hypermethylation of CXCR4 promoter in CD34+ cells from patients with primary myelofibrosis. Stem Cells. 2008;26(8):1920-30.
-
(2008)
Stem Cells
, vol.26
, Issue.8
, pp. 1920-1930
-
-
Bogani, C.1
Ponziani, V.2
Guglielmelli, P.3
Desterke, C.4
Rosti, V.5
Bosi, A.6
-
33
-
-
50549085051
-
Epigenetic alteration of SOCS family members is a possible pathogenetic mechanism in JAK2 wild type myeloproliferative diseases
-
Teofili L, Martini M, Cenci T, Guidi F, Torti L, Giona F, et al. Epigenetic alteration of SOCS family members is a possible pathogenetic mechanism in JAK2 wild type myeloproliferative diseases. Int J Cancer. 2008;123(7):1586-92.
-
(2008)
Int J Cancer
, vol.123
, Issue.7
, pp. 1586-1592
-
-
Teofili, L.1
Martini, M.2
Cenci, T.3
Guidi, F.4
Torti, L.5
Giona, F.6
-
34
-
-
84856271833
-
Epigenetic abnormalities in myeloproliferative neoplasms: A target for novel therapeutic strategies
-
Mascarenhas J, Roper N, Chaurasia P, Hoffman R. Epigenetic abnormalities in myeloproliferative neoplasms: a target for novel therapeutic strategies. Clin Epigenetics. 2011;2(2):197-212.
-
(2011)
Clin Epigenetics
, vol.2
, Issue.2
, pp. 197-212
-
-
Mascarenhas, J.1
Roper, N.2
Chaurasia, P.3
Hoffman, R.4
-
35
-
-
57449114002
-
Enhanced histone deacetylase enzyme activity in primary myelofibrosis
-
Wang JC, Chen C, Dumlao T, Naik S, Chang T, Xiao YY, et al. Enhanced histone deacetylase enzyme activity in primary myelofibrosis. Leuk Lymphoma. 2008;49(12):2321-7.
-
(2008)
Leuk Lymphoma
, vol.49
, Issue.12
, pp. 2321-2327
-
-
Wang, J.C.1
Chen, C.2
Dumlao, T.3
Naik, S.4
Chang, T.5
Xiao, Y.Y.6
-
36
-
-
34447118173
-
Effects of chromatin-modifying agents on CD34+ cells from patients with idiopathic myelofibrosis
-
Shi J, Zhao Y, Ishii T, Hu W, Sozer S, Zhang W, et al. Effects of chromatin-modifying agents on CD34+ cells from patients with idiopathic myelofibrosis. Cancer Res. 2007;67(13):6417-24.
-
(2007)
Cancer Res
, vol.67
, Issue.13
, pp. 6417-6424
-
-
Shi, J.1
Zhao, Y.2
Ishii, T.3
Hu, W.4
Sozer, S.5
Zhang, W.6
-
37
-
-
70350233460
-
Correction of the abnormal trafficking of primary myelofibrosis CD34+ cells by treatment with chromatin-modifying agents
-
Wang X, Zhang W, Ishii T, Sozer S, Wang J, Xu M, et al. Correction of the abnormal trafficking of primary myelofibrosis CD34+ cells by treatment with chromatin-modifying agents. Cancer Res. 2009;69(19):7612-8.
-
(2009)
Cancer Res
, vol.69
, Issue.19
, pp. 7612-7618
-
-
Wang, X.1
Zhang, W.2
Ishii, T.3
Sozer, S.4
Wang, J.5
Xu, M.6
-
38
-
-
42349087790
-
The histone deacetylase inhibitor ITF2357 selectively targets cells bearing mutated JAK2(V617F)
-
Guerini V, Barbui V, Spinelli O, Salvi A, Dellacasa C, Carobbio A, et al. The histone deacetylase inhibitor ITF2357 selectively targets cells bearing mutated JAK2(V617F). Leukemia. 2008;22(4):740-7.
-
(2008)
Leukemia
, vol.22
, Issue.4
, pp. 740-747
-
-
Guerini, V.1
Barbui, V.2
Spinelli, O.3
Salvi, A.4
Dellacasa, C.5
Carobbio, A.6
-
39
-
-
84864024938
-
Phase I study of the oral histone deacetylase inhibitor SB939 in patients with advanced hematologic malignancies
-
Abstract 3292
-
Garcia-Manero G, Chuah C, Wilding G, Chang J, Verstovsek S, Faderl S, et al. Phase I study of the oral histone deacetylase inhibitor SB939 in patients with advanced hematologic malignancies. Blood. 2010;116: Abstract 3292.
-
(2010)
Blood
, vol.116
-
-
Garcia-Manero, G.1
Chuah, C.2
Wilding, G.3
Chang, J.4
Verstovsek, S.5
Faderl, S.6
-
40
-
-
79960163508
-
Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylami de (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile
-
Wang H, Yu N, Chen D, Lee KC, Lye PL, Chang JW, et al. Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylami de (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. J Med Chem. 2011;54(13):4694-720.
-
(2011)
J Med Chem
, vol.54
, Issue.13
, pp. 4694-4720
-
-
Wang, H.1
Yu, N.2
Chen, D.3
Lee, K.C.4
Lye, P.L.5
Chang, J.W.6
-
41
-
-
84864008019
-
Therapy with the histone deacetylase inhibitor pracinostat for patients with myelofibrosis
-
Quintas-Cardama A, Kantarjian H, Estrov Z, Borthakur G, Cortes J, Verstovsek S. Therapy with the histone deacetylase inhibitor pracinostat for patients with myelofibrosis. Leuk Res. 2012;36(9):1124-7.
-
(2012)
Leuk Res
, vol.36
, Issue.9
, pp. 1124-1127
-
-
Quintas-Cardama, A.1
Kantarjian, H.2
Estrov, Z.3
Borthakur, G.4
Cortes, J.5
Verstovsek, S.6
-
42
-
-
34548125345
-
The histone deacetylase inhibitor ITF2357 has antileukemic activity in vitro and in vivo and inhibits IL-6 and VEGF production by stromal cells
-
Golay J, Cuppini L, Leoni F, Mico C, Barbui V, Domenghini M, et al. The histone deacetylase inhibitor ITF2357 has antileukemic activity in vitro and in vivo and inhibits IL-6 and VEGF production by stromal cells. Leukemia. 2007;21(9):1892-900.
-
(2007)
Leukemia
, vol.21
, Issue.9
, pp. 1892-1900
-
-
Golay, J.1
Cuppini, L.2
Leoni, F.3
Mico, C.4
Barbui, V.5
Domenghini, M.6
-
43
-
-
77955168425
-
A pilot study of the histone-deacetylase inhibitor givinostat in patients with JAK2V617F positive chronic myeloproliferative neoplasms
-
Rambaldi A, Dellacasa CM, Finazzi G, Carobbio A, Ferrari ML, Guglielmelli P, et al. A pilot study of the histone-deacetylase inhibitor givinostat in patients with JAK2V617F positive chronic myeloproliferative neoplasms. Br J Haematol. 2010;150(4): 446-55.
-
(2010)
Br J Haematol
, vol.150
, Issue.4
, pp. 446-455
-
-
Rambaldi, A.1
Dellacasa, C.M.2
Finazzi, G.3
Carobbio, A.4
Ferrari, M.L.5
Guglielmelli, P.6
-
44
-
-
84866602529
-
A phase II study of the HDAC inhibitor givinostat in combination with hydroxyurea in patients with polycythemia vera resistant to hydroxyurea monotherapy
-
Abstract 1748
-
Rambaldi A, Finazzi G, Vannucchi AM, Martinelli V, Rodeghiero F, Nobile F, et al. A phase II study of the HDAC inhibitor givinostat in combination with hydroxyurea in patients with polycythemia vera resistant to hydroxyurea monotherapy. Blood. 2011; 118:Abstract 1748.
-
(2011)
Blood
, vol.118
-
-
Rambaldi, A.1
Finazzi, G.2
Vannucchi, A.M.3
Martinelli, V.4
Rodeghiero, F.5
Nobile, F.6
-
45
-
-
43049088775
-
Phase I study of oral LBH589, a novel deacetylase (DAC) inhibitor in advanced solid tumors and nonhodgkin's lymphoma
-
Abstract 3500
-
Prince HM, George D, Patnaik A, Mita M, Dugan M, Butterfoss D, et al. Phase I study of oral LBH589, a novel deacetylase (DAC) inhibitor in advanced solid tumors and nonhodgkin's lymphoma. J Clin Oncol. 2007; 25(18S):Abstract 3500.
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 S
-
-
Prince, H.M.1
George, D.2
Patnaik, A.3
Mita, M.4
Dugan, M.5
Butterfoss, D.6
-
46
-
-
39749143465
-
Phase IA/II study of oral LBH589, a novel deacetylase inhibitor (DACi), administered on 2 schedules, in patients with advanced hematologic malignancies
-
Abstract 907
-
Spencer A, Prince M, De Angelo DJ, Fischer T, Bhalla KN, Giles FJ, et al. Phase IA/II study of oral LBH589, a novel deacetylase inhibitor (DACi), administered on 2 schedules, in patients with advanced hematologic malignancies. Blood. 2007;110: Abstract 907.
-
(2007)
Blood
, vol.110
-
-
Spencer, A.1
Prince, M.2
De Angelo, D.J.3
Fischer, T.4
Bhalla, K.N.5
Giles, F.J.6
-
47
-
-
84884913983
-
Phase I pharmacokinetic and pharmacodynamic study of once-weekly IV LBH589
-
Abstract 702
-
Sharma S, Vogelzang NJ, Beck J, Patnaik A, Mita M, Dugan M, et al. Phase I pharmacokinetic and pharmacodynamic study of once-weekly IV LBH589. Eur J Cancer. 2007;5(4):107: Abstract 702.
-
(2007)
Eur J Cancer
, vol.5
, Issue.4
, pp. 107
-
-
Sharma, S.1
Vogelzang, N.J.2
Beck, J.3
Patnaik, A.4
Mita, M.5
Dugan, M.6
-
48
-
-
79958761494
-
A phase II trial of panobinostat, an orally available deacetylase inhibitor (DACi), in patients with primary myelofibrosis (PMF), post essential thrombocythemia (ET), and post polycythemia vera (PV) myelofibrosis
-
Abstract 630
-
DeAngelo DJ, Tefferi A, Fiskus W, Mesa RA, Paley CS, Wadleigh M, et al. A phase II trial of panobinostat, an orally available deacetylase inhibitor (DACi), in patients with primary myelofibrosis (PMF), post essential thrombocythemia (ET), and post polycythemia vera (PV) myelofibrosis. Blood. 2010;116:Abstract 630.
-
(2010)
Blood
, vol.116
-
-
DeAngelo, D.J.1
Tefferi, A.2
Fiskus, W.3
Mesa, R.A.4
Paley, C.S.5
Wadleigh, M.6
-
49
-
-
84875032119
-
A phase I study of panobinostat (LBH589) in patients with primary myelofibrosis (PMF) and post-polycythaemia vera/essential thrombocythaemia myelofibrosis (post-PV/ET MF)
-
Mascarenhas J, Lu M, Li T, Petersen B, Hochman T, Najfeld V, et al. A phase I study of panobinostat (LBH589) in patients with primary myelofibrosis (PMF) and post-polycythaemia vera/essential thrombocythaemia myelofibrosis (post-PV/ET MF). Br J Haematol. 2013;161(1):68-75.
-
(2013)
Br J Haematol
, vol.161
, Issue.1
, pp. 68-75
-
-
Mascarenhas, J.1
Lu, M.2
Li, T.3
Petersen, B.4
Hochman, T.5
Najfeld, V.6
-
50
-
-
84866629631
-
Improved efficacy upon combined JAK1/2 and pan-deacetylase inhibition using ruxolitinib (INC424) and panobinostat (LBH589) in preclinical mouse models of JAK2V617-F-driven disease
-
Abstract 798
-
Baffert F, Evrot E, Ebel N, Roelli C, Andraos R, Qian Z, et al. Improved efficacy upon combined JAK1/2 and pan-deacetylase inhibition using ruxolitinib (INC424) and panobinostat (LBH589) in preclinical mouse models of JAK2V617-F-driven disease. Blood. 2011;118: Abstract 798.
-
(2011)
Blood
, vol.118
-
-
Baffert, F.1
Evrot, E.2
Ebel, N.3
Roelli, C.4
Andraos, R.5
Qian, Z.6
-
51
-
-
84866633871
-
Role of additional novel therapies in myeloproliferative neoplasms
-
Fiskus W, Ganguly S, Kambhampati S, Bhalla KN. Role of additional novel therapies in myeloproliferative neoplasms. Hematol Oncol Clin North Am. 2012;26(5):959-80.
-
(2012)
Hematol Oncol Clin North Am
, vol.26
, Issue.5
, pp. 959-980
-
-
Fiskus, W.1
Ganguly, S.2
Kambhampati, S.3
Bhalla, K.N.4
-
52
-
-
25844519550
-
HSP90 and the chaperoning of cancer
-
Whitesell L, Lindquist SL. HSP90 and the chaperoning of cancer. Nat Rev Cancer. 2005;5(10):761-72.
-
(2005)
Nat Rev Cancer
, vol.5
, Issue.10
, pp. 761-772
-
-
Whitesell, L.1
Lindquist, S.L.2
-
53
-
-
73949136283
-
Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells
-
Wang Y, Fiskus W, Chong DG, Buckley KM, Natarajan K, Rao R, et al. Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells. Blood. 2009;114(24): 5024-33.
-
(2009)
Blood
, vol.114
, Issue.24
, pp. 5024-5033
-
-
Wang, Y.1
Fiskus, W.2
Chong, D.G.3
Buckley, K.M.4
Natarajan, K.5
Rao, R.6
-
54
-
-
82555173115
-
Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells
-
Fiskus W, Verstovsek S, Manshouri T, Rao R, Balusu R, Venkannagari S, et al. Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells. Clin Cancer Res. 2011;17(23):7347-58.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.23
, pp. 7347-7358
-
-
Fiskus, W.1
Verstovsek, S.2
Manshouri, T.3
Rao, R.4
Balusu, R.5
Venkannagari, S.6
-
55
-
-
84865735256
-
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy
-
Koppikar P, Bhagwat N, Kilpivaara O, Manshouri T, Adli M, Hricik T, et al. Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy. Nature. 2012;489(7414):155-9.
-
(2012)
Nature
, vol.489
, Issue.7414
, pp. 155-159
-
-
Koppikar, P.1
Bhagwat, N.2
Kilpivaara, O.3
Manshouri, T.4
Adli, M.5
Hricik, T.6
-
56
-
-
2342559981
-
The TOR pathway: A target for cancer therapy
-
Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer. 2004;4(5):335-48.
-
(2004)
Nat Rev Cancer
, vol.4
, Issue.5
, pp. 335-348
-
-
Bjornsti, M.A.1
Houghton, P.J.2
-
57
-
-
80052184481
-
Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis
-
Guglielmelli P, Barosi G, Rambaldi A, Marchioli R, Masciulli A, Tozzi L, et al. Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis. Blood. 2011;118(8):2069-76.
-
(2011)
Blood
, vol.118
, Issue.8
, pp. 2069-2076
-
-
Guglielmelli, P.1
Barosi, G.2
Rambaldi, A.3
Marchioli, R.4
Masciulli, A.5
Tozzi, L.6
-
58
-
-
84873138749
-
mTOR inhibitors alone and in combination with JAK2 inhibitors effectively inhibit cells of myeloproliferative neoplasms
-
Bogani C, Bartalucci N, Martinelli S, Tozzi L, Guglielmelli P, Bosi A, et al. mTOR inhibitors alone and in combination with JAK2 inhibitors effectively inhibit cells of myeloproliferative neoplasms. PLoS One. 2013;8(1):e54826.
-
(2013)
PLoS One
, vol.8
, Issue.1
-
-
Bogani, C.1
Bartalucci, N.2
Martinelli, S.3
Tozzi, L.4
Guglielmelli, P.5
Bosi, A.6
-
59
-
-
84877670562
-
-
Fiskus W, Verstovsek S, Manshouri T, Smith JE, Peth K, Abhyankar S, et al. Mol Cancer Ther. 2013;12(5):577-88.
-
(2013)
Mol Cancer Ther
, vol.12
, Issue.5
, pp. 577-588
-
-
Fiskus, W.1
Verstovsek, S.2
Manshouri, T.3
Smith, J.E.4
Peth, K.5
Abhyankar, S.6
-
60
-
-
84858668231
-
The Dynamic International Prognostic Scoring System for myelofibrosis predicts outcomes after hematopoietic cell transplantation
-
Scott BL, Gooley TA, Sorror ML, Rezvani AR, Linenberger ML, Grim J, et al. The Dynamic International Prognostic Scoring System for myelofibrosis predicts outcomes after hematopoietic cell transplantation. Blood. 2012;119(11):2657-64.
-
(2012)
Blood
, vol.119
, Issue.11
, pp. 2657-2664
-
-
Scott, B.L.1
Gooley, T.A.2
Sorror, M.L.3
Rezvani, A.R.4
Linenberger, M.L.5
Grim, J.6
-
61
-
-
73949084969
-
Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: A prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation
-
Kroger N, Holler E, Kobbe G, Bornhauser M, Schwerdtfeger R, Baurmann H, et al. Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. Blood. 2009;114 (26):5264-70.
-
(2009)
Blood
, vol.114
, Issue.26
, pp. 5264-5270
-
-
Kroger, N.1
Holler, E.2
Kobbe, G.3
Bornhauser, M.4
Schwerdtfeger, R.5
Baurmann, H.6
-
62
-
-
84865174824
-
Allogeneic hematopoietic cell transplantation for myelofibrosis in the era of JAK inhibitors
-
Gupta V, Hari P, Hoffman R. Allogeneic hematopoietic cell transplantation for myelofibrosis in the era of JAK inhibitors. Blood. 2012;120(7):1367-79.
-
(2012)
Blood
, vol.120
, Issue.7
, pp. 1367-1379
-
-
Gupta, V.1
Hari, P.2
Hoffman, R.3
|