Calcium and magnesium elimination enhances accumulation of cardenolides in callus cultures of endemic Digitalis species of Turkey

Plant Physiology and Biochemistry

Volumn 73, Issue , 2013, Pages 139-143

  Sahin, G ^a   Verma, S K ^a   Gurel, E ^a  

^a ABANT IZZET BAYSAL UNIVERSITY   (Turkey)

Author keywords

Calcium; Cardenolides accumulation; Digitalis cariensis Boiss. ex Jaub. et Spach; Digitalis davisiana Heywood; Digitalis lamarckii Ivanina; Digitalis trojana Ivanina; Magnesium

Indexed keywords

CALCIUM; CARDENOLIDE; DIGITALIS; INDOLEACETIC ACID; LANATOSIDE C; MAGNESIUM; PLANT EXTRACT; THIDIAZURON;

ARTICLE; BIOSYNTHESIS; CARDENOLIDES ACCUMULATION; CHEMISTRY; CULTURE MEDIUM; DIGITALIS CARIENSIS BOISS. EX JAUB. ET SPACH; DIGITALIS DAVISIANA HEYWOOD; DIGITALIS LAMARCKII IVANINA; DIGITALIS TROJANA IVANINA; GENETICS; GROWTH, DEVELOPMENT AND AGING; INDOLE-3-ACETIC ACID; LAN C; MAGNESIUM DEFICIENCY; METABOLISM; METHODOLOGY; MULTIPLE SCLEROSIS; MURASHIGE AND SKOOG; PLANT GROWTH; SEEDLING; SOMATIC EMBRYOGENESIS; SPECIES DIFFERENCE; TDZ; TURKEY (REPUBLIC);

CALCIUM; CARDENOLIDES ACCUMULATION; DIGITALIS CARIENSIS BOISS. EX JAUB. ET SPACH; DIGITALIS DAVISIANA HEYWOOD; DIGITALIS LAMARCKII IVANINA; DIGITALIS TROJANA IVANINA; IAA; INDOLE-3-ACETIC ACID; LAN C; LANATOSIDE C; MAGNESIUM; MS; MURASHIGE AND SKOOG; TDZ; THIDIAZURON;

CALCIUM; CARDENOLIDES; CULTURE MEDIA; DIGITALIS; HYPOCOTYL; MAGNESIUM; MAGNESIUM DEFICIENCY; PLANT EXTRACTS; PLANT SOMATIC EMBRYOGENESIS TECHNIQUES; SEEDLING; SPECIES SPECIFICITY; TURKEY;

EID: 84884956157     PISSN: 09819428     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plaphy.2013.09.007     Document Type: Article

References (40)

1. Baytop T. Türkiye'de Bitkilerle Tedavi 1999, Nobel Tip Kitabevi, Istanbul. second ed.
2. Yeh J., Hunag W., Kan S., Wang P. Inhibitory effects of Digitalis on the proliferation of androgen dependent and independent prostate cancer cells. J.Urol. 2001, 166:1937-1942.
3. Lopez-Lazaro M. Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved. Expert Opin. Ther. Targets 2007, 11:1043-1053.
4. Newman R., Yang P., Pawlus A. Cardiac glycosides as novel cancer therapeutic agents. Mol. Interv. 2008, 8:36-49.
5. Gurel E., Yucesan B., Aglic E., Gurel S., Verma S.K., Sokmen M., Sokmen A. Regeneration and cardiotonic glycoside production in Digitalis davisiana Heywood (Alanya Foxglove). Plant Cell Tissue Organ Cult. 2011, 104:217-225.
6. Eisenbeiβ M., Kreis W., Reinhard E. Cardenolide biosynthesis in light- and dark-grown Digitalis lanata shoot cultures. Plant Physiol. Biochem. 1999, 37:13-23.
7. Gavidia I., Perez-Bermudez P. Digitalis obscura cardenolides*. Effect of macronutrient concentration and N source on growth and productivity of shoot-tip cultures. Phytochemistry 1997, 46:273-278.
8. Hagimori M., Matsumoto T., Obi Y. Effects of mineral salts, initial pH and precursors on digitoxin formation by shoot forming cultures of Digitalis purpurea L. grown in liquid media. Agric. Biol. Chem. 1983, 47:565-571.
9. Seitz H.U., Gartner D. Enzymes in cardenolide-accumulating shoot cultures of Digitalis purpurea L. Plant Cell Tissue Organ Cult. 1994, 38:337-344.
10. Corchete P., Sanchez J.M., Cacho M., Moran M., Fernández-Tárrago J. Cardenolide content in suspension cell cultures derived from leaf and root callus of Digitalis thapsi L. Plant Physiol. 1990, 137:196-200.
11. Corchete P., Jimenez M.A., Morán M., Cacho M., Fernández-Tárrago J. Effect of calcium, manganese and lithium on growth and cardenolide content in cell suspension cultures of Digitalis thapsi L. Plant Cell Rep. 1991, 10:394-396.
12. Cacho M., Morán M., Fernández-Tárrago J., Corchete P. Calcium restriction induces cardenolide accumulation in cell suspension cultures of Digitalis thapsi L. Plant Cell Rep. 1995, 14:786-789.
13. Paranhos A., Fernández-Tarrago J., Corchete P. Relationship between active oxygen species and cardenolide production in cell cultures of Digitalis thapsi: effect of calcium restriction. New Phytol. 1999, 141:51-60.
14. Davis P.H. Flora of Turkey and the East Aegean Islands 1978, Edinburg University, Edinburgh.
15. Verma S.K., Sahin G., Yucesan B., Sahbaz N., Eker I., Gurel S., Gurel E. Direct somatic embryogenesis from hypocotyl segments of Digitalis trojana Ivan and subsequent plant regeneration. Ind. Crop Prod. 2012, 40:76-80.
16. Tanker M., Kurucu S., Tarhan O. Türkiye'de Yetişen Digitalis Türlerinin Kalbe Etkili Glikozitlerinin Teknik Ölçüde Elde Edilmesi imkanlarinin ve Maliyet Unsurlarinin Saptanmasi. Doǧa TU Tip ve Ecz. D 1988, 7:173-182.
17. Bourgaud F., Gravot A., Milesi S., Gontier E. Production of plant secondary metabolites: a historical perspective. Plant Sci. 2001, 161:839-851.
18. Ramachandra R.S., Ravishankar G.A. Plant cell cultures: chemical factories of secondary metabolites. Biotech. Adv. 2002, 20:101-153.
19. Khan T.A., Mazid M., Mohammad F. Status of secondary plant products under abiotic stress: an overview. J.Stress Physiol. Biochem. 2011, 7:75-98.
20. Gavidia I., Perez-Bermudez P. Cardenolides of Digitalis obscura: the effect of phosphate and manganese on growth and productivity of shoot-tip cultures. Phytochemistry 1997, 45:81-85.
21. Troufflard S., Mullen W., Larson T.R., Graham I.A., Crozier A., Amtmann A., Armengaud P. Potassium deficiency induces the biosynthesis of oxylipins and glucosinolates in Arabidopsis thaliana. BMC Plant Biol. 2010, 10:172-185.
22. Payne J., Hamill J.D., Robins R.J., Rhodes M.J.C. Production of hyoscyamine by "Hairy Root" cultures of Datura stramonium. Planta Med. 1987, 53:474-478.
23. Vázquez-Flota F., Moreno-Valenzuela O., Miranda-Ham M.L., Coello-Coello J., Loyola-Vargas V.M. Catharanthine and ajmalicine synthesis in Catharanthus roseus hairy root cultures. Plant Cell Tissue Organ Cult. 1994, 38:273-279.
24. Rokem J.S., Goldberg J. Secondary metabolites from plant cell suspension cultures: methods for yield improvement. Advances in Biotechnological Processes 1985, 241-274. Alan R Liss, New York. A. Mizrahi, A.L. van Wezel (Eds.).
25. Ikeda Y., Fujii Y., Yamazaki M. Determination of lanatoside C and Digoxin in Digitalis lanata by HPLC and its application to analysis of the fermented leaf powder. Nat. Prod. 1992, 55:748-752.
26. Merillon J.M., Liu D., Hughet F., Chenieux J.C., Rideau M. Effects of calcium entry blockers and calmodulin inhibitors on cytokinin-enhanced alkaloid accumulation in Catharanthus roseus cell cultures. Plant Physiol. Biochem. 1991, 29:289-296.
27. Cacho M., Morán M., Corchete P., Fernández-Tárrago J. Influence of medium composition on the accumulation of flavonolignans in cultured cells of Silybum marianum (L.) Gaertn. Plant Sci. 1999, 144:63-68.
28. Indrayanto G., Rahayu R., Rahman A., Noerani P.E. Effect of calcium, strontium and magnesium ions on the formation of phytosteroids in callus cultures of Agave amaniensis. Planta Med. 1993, 59:97-98.
29. Graves J.M.H., Smith W.K. Transformation of pregnenolone and progesterone by cultured plant cells. Nature 1967, 214:1248-1249.
30. Hirotoni M., Furuya T. Restoration of cardenolide synthesis in redifferentiated shoots from callus cultures of Digitalis purpurea. Phytochem 1977, 16:610-611.
31. Lui J.H.C., Staba E.J. Effect of precursors on serially propagated Digitalis lanata leaf and root cultures. Phytochemistry 1979, 18:1913-1916.
32. + and hypersensitive responses in tobacco. Plant Physiol. 1990, 92:215-221.
33. Inmaculada Y. Copper in plants. Braz. J. Plant Physiol. 2005, 17:145-156.
34. Tian D., Traw M.B., Chen J.Q., Kreitman M., Bergelson J. Fitness costs of R-gene-mediated resistance in Arabidopsis thaliana. Nature 2003, 423:74-77.
35. Zavala J.A., Baldwin I.T. Fitness benefits of trypsin proteinase inhibitor expression in Nicotiana attenuata are greater than their costs when plants are attacked. BMC Ecol. 2004, 4:11-15.
36. Vögeli U., Chappell J. Induction of sesquiterpene-cyclase and suppression of squalene synthetase activities in plant cell cultures treated with fungal elicitors. Plant Physiol. 1988, 88:1291-1296.
37. Gerschenzon J. Changes in the levels of plant secondary metabolites under water and nutrient stress. Phytochemical Adaptations to Stress 1983, 273-299. Plenum Press, New York. B.N. Timmermann, C. Steelink, F.A. Loewus (Eds.).
38. Murthy K.S., Smith T.A., Bould C. The relation between the putrescine content and potassium status of black currant leaves. Ann. Bot. 1971, 35:687-695.
39. Murashige T., Skoog F. Arevised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol. Plant 1962, 15:473-497.
40. Wiegrebe H., Wichtl M. High-performance liquid chromatographic determination of cardenolides in Digitalis leaves after solid-phase extraction. J.Chromatogr. A 1993, 630:402-407.