Regeneration and cardiotonic glycoside production in Digitalis davisiana Heywood (Alanya foxglove)

Plant Cell, Tissue and Organ Culture

Volumn 104, Issue 2, 2011, Pages 217-225

  Gurel, Ekrem ^a   Yucesan, Buhara ^a   Aglic, Esra ^a   Gurel, Songul ^b   Verma, Sandeep K ^a   Sokmen, Munevver ^c   Sokmen, Atalay ^c  

^a ABANT IZZET BAYSAL UNIVERSITY   (Turkey)

^b Sugar Institute   (Turkey)

^c KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Alanya foxglove; Digitalis davisiana; Digoxin; In vitro plants; Lanatoside C; Natural populations; Plant regeneration

Indexed keywords

CHEMOTHERAPY; DISEASES; SEED; SUGARS;

ALANYA FOXGLOVE; DIGITALIS DAVISIANA; DIGOXIN; IN-VITRO; NATURAL POPULATION; PLANT REGENERATION;

PLANTS (BOTANY);

DIGITALIS (GENUS); DIGITALIS DAVISIANA;

EID: 79151479483     PISSN: 01676857     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11240-010-9824-3     Document Type: Article

References (37)

1. Arrillaga I, Brisa MC, Segura J (1987) Somatic embryogenesis from hypocotyl callus cultures of Digitalis obscura L. Plant Cell Rep 6: 223-226.
2. Baytop T (1999) Türkiye'de Bitkilerle Tedavi (2nd edn). Nobel Ti{dotless}p Kitabevi, Istanbul (in Turkish).
3. Beale JM, Floss HG, Lehmann T, Luckner M (1988) Digitoxigenin-3β-O-(β-d-Fucopyranosyl-4-β-d-Glucopyranoside), the main cardenolide of somatic embryos of Digitalis lanata. Phytochemistry 27: 3143-3146.
4. Brisa MC, Segura J (1989) Morphogenic potential of mechanically isolated single cells from Digitalis obscura L. callus. Plant Cell Tiss Org 19: 129-139.
5. Cacho M, Moran M, Herrera MT, Tarrago JF, Corchete MP (1991) Morphogenesis in leaf, hypocotyl and root explants of Digitalis thapsi L. cultured in vitro. Plant Cell Tiss Org 25: 117-123.
6. Chee R, Pool R (1987) Improved inorganic media constitutents for in vitro shoot multiplication of Vitis. Sci Hortic Amsterdam 32: 85-95.
7. Davis PH (1978) Flora of Turkey and the East Aegean Islands, vol 6. Edinburg University Press, Edinburgh, pp 680-687.
8. Fernao C, Kreis W, Recio R, Braga de Oliveiras A (1997) Variation of cardenolides with growth in a Digitalis lanata Brazillian cultivar. Phytochemistry 45: 473-476.
9. Gamborg O, Miller R, Ojima K (1968) Nutrient requirement of suspensions cultures of soybean root cells. Exp Cell Res 50: 151-158.
10. Gavidia I, Segura J, Perez-Bermudez P (1993) Effects of giberellic acid on morphogenesis and cardenolide accumulation in juvenile and adult Digitalis obscura cultures. J Plant Physiol 142: 373-376.
11. Gavidia I, Agudoi LD, Perez-Bermudez P (1996) Selection and long-term cultures of high-yielding Digitalis obscura plants: RAPD markers for analysis of genetic stability. Plant Sci 121: 197-205.
12. Hagimori M, Matsumoto T, Obi Y (1982) Studies on the production of Digitalis cardenolides by plant tissue culture. II. Effect of light and plant growth substances on digitoxin formation by undifferentiated cells and shoot-forming cultures of Digitalis purpurea L. grown in liquid media. Plant Physiol 69: 653-656.
13. Huang L, Murashige T (1976) Plant tissue culture media: major constituents, their preparation and some application. TCA Manual 3: 539-548.
14. Kreis W, May U, Reinhard E (1986) UDP-glucose: Digitoxin 16′-O-glucosyltransferase from suspension-cultured Digitalis lanata cells. Plant Cell Rep 5: 442-445.
15. Kreis W, Hoelz H, May U, Reinhard E (1990) Storage of cardenolides in Digitalis lanata cells. Effect of dimethyl sulfoxide (DMSO) on cardenolide uptake and release. Plant Cell Tiss Organ 20: 191-199.
16. Kubalakova M, Irena S, Novak FJ (1987) Stability of lanatoside C content in the in vitro propagated Digitalis lanata clones. Biol Plant 29: 7-9.
17. Kuberski C, Scheibner H, Steup C, Diettrich B, Luckner M (1984) Embryogenesis and cardenolide formation in tissue cultures of Digitalis lanata. Phytochemistry 23: 1407-1412.
18. Lapena L, Perez-Bermudez P, Segura J (1988) Morphogenesis in hypocotyl cultures of Digitalis obscura influence of carbohydrate levels and sources. Plant Sci 57: 247-252.
19. Linsmaier E, Skoog F (1965) Organic growth factor requirements of tobacco tissue cultures. Physiol Plant 18: 100-127.
20. Lopez-Lazaro M (2007) Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved. Expert Opin Ther Tar 11: 1043-1053.
21. Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15: 473-505.
22. Newman R, Yang P, Pawlus A (2008) Cardiac glycosides as novel cancer therapeutic agents. Mol Interv 8: 36-49.
23. Perez-Alonso N, Wilken D, Gerth A, Jahn A, Nitzsche H, Kerns G, Cappote-Perez A, Jimenez E (2009) Cardiotonic glycosides from biomass of Digitalis purpurea L. cultured in temporary immersion systems. Plant Cell Tiss Org 99: 151-156.
24. Perez-Bermudez P, Cornejo MJ, Seguara J (1983) In vitro propagation of Digitalis obscura L. Plant Sci Lett 30: 77-82.
25. Perez-Bermudez P, Cornejo MJ, Segura J (1985) A morphogenetic role for ethylene in hypocotyl cultures of Digitalis obscura L. Plant Cell Rep 4: 188-190.
26. Pozueta-Romea J, Houlne G, Canas G, Schantz R, Chamarro J (2001) Enhanced regeneration of tomato and pepper seddling explants for Agrobacterium-mediated transformation. Plant Cell Tiss Org 67: 173-180.
27. Pradel H, Dumke-Lehmann UD, Diettrich B, Luckner M (1997) Hairy root cultures of Digitalis lanata. Secondary metabolism and plant regeneration. J Plant Physiol 151: 209-215.
28. Roca-Perez L, Isabel G, Perez-Bermudez P, Rafae LB (2005) Relationships among soil characteristics, plant macronutrients and cardenolide accumulation in natural populations of Digitalis obscura. J Plant Nutr Soil Sci 168: 774-780.
29. Roca-Perez L, Boluda R, Perez-Bermudez P (2006) Seasonal variation in nutrient status of foxglove leaves. J Plant Nutr 29: 1077-1084.
30. Sales E, Segura J, Arrillaga I (2003) Agrobacterium tumefaciens-mediated genetic transformation of the cardenolide-producing plant Digitalis minor L. Planta Med 69: 143-147.
31. Schenk R, Hildebrandt A (1972) Medium and techniques for induction and growth of monocotyledonous and dicotyledonous plant cell cultures. Can J Bot 50: 199-204.
32. Turker A, Yucesan B, Gurel E (2009a) In vitro regeneration of Achillea millefolium L. from shoot-tips and root segments of seedlings. J Plant Biochem Biot 18: 61-69.
33. Turker A, Yucesan B, Gurel E (2009b) Plant regeneration via adventitious shoot development from cultured leaf explants of purple loosestrife (Lythrum salicaria L.): A medicinal wetland plant. Biol Plant 54: 750-754.
34. Vela S, Gavidia I, Perez-Bermudez P, Segura J (1991) Micropropagation of juvenile and adult Digitalis obscura and cardenolide content of clonally propagated plants. In Vitro Cell Dev-Pl 27: 143-146.
35. Wiegrebe H, Wichtl M (1993) High-performance liquid chromatographic determination of cardenolides in Digitalis leaves after solid-phase extraction. J Chromatogr A 630: 402-407.
36. Yeh J, Hunag W, Kan S, Wang P (2001) Inhibitory effects of Digitalis on the proliferation of androgen dependent and independent prostate cancer cells. J Urol 166: 1937-1942.
37. Yucesan B, Turker A, Gurel E (2007) TDZ-induced high frequency plant regeneration through multiple shoot formation in witloof chicory (Cichorium intybus L.). Plant Cell Tiss Org 91: 243-250.