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Volumn 22, Issue 2, 2013, Pages 296-302

To design novel lead molecules for the enzyme, AChE associated with Alzheimer's disease

Author keywords

Acetylcholinesterase; Alzheimer's disease (AD); Galantamine analogues; Lead molecules

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; GALANTAMINE; ZINC;

EID: 84884952540     PISSN: 0976044X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (16)

References (34)
  • 1
    • 0022558388 scopus 로고
    • New perspectives on Alzheimer's disease
    • Price, D.L., New perspectives on Alzheimer's disease, Neuroscience 9, 1986, 489-512.
    • (1986) Neuroscience , vol.9 , pp. 489-512
    • Price, D.L.1
  • 2
    • 0030767243 scopus 로고    scopus 로고
    • The cholinergic system in Alzheimer's disease
    • Kasa P, Rakonczay Z, Gulya K,. The cholinergic system in Alzheimer's disease, Prog. Neurobiology, 52, 1997, 511-535.
    • (1997) Prog. Neurobiology , vol.52 , pp. 511-535
    • Kasa, P.1    Rakonczay, Z.2    Gulya, K.3
  • 3
    • 0038043202 scopus 로고    scopus 로고
    • Bernardes, The asymmetric deformation of CH3 groups, was 1510cm-1 and the values
    • Carvalho I, Pupo MT, Borges A. D. L, Bernardes, The asymmetric deformation of CH3 groups, was 1510cm-1 and the values, L. S. C. Quím Nova, 26, 2003, 428-438.
    • (2003) L.S.C. Quím Nova , vol.26 , pp. 428-438
    • Carvalho, I.1    Pupo, M.T.2    Borges, A.D.L.3
  • 5
    • 0011162190 scopus 로고
    • Loss of central cholinergic neurons in Alzheimer's disease
    • Selective 1403
    • Davies P, Maloney A. J, loss of central cholinergic neurons in Alzheimer's disease, Lancet, 2, 1976, Selective 1403.
    • (1976) Lancet , vol.2
    • Davies, P.1    Maloney, A.J.2
  • 7
    • 0026440987 scopus 로고
    • Cortical biopsy in Alzheimer's disease: Diagnostic accuracy and Neurochemical, neuropath logical and cognitive correlations
    • DeKosky ST, Harbaugh RE, Schmitt FA, Bakay RA, Chui HC, Knopman DS, Cortical biopsy in Alzheimer's disease: diagnostic accuracy and Neurochemical, neuropath logical and cognitive correlations, Ann. Neurol. 32, 1992, 625-632.
    • (1992) Ann. Neurol , vol.32 , pp. 625-632
    • DeKosky, S.T.1    Harbaugh, R.E.2    Schmitt, F.A.3    Bakay, R.A.4    Chui, H.C.5    Knopman, D.S.6
  • 8
    • 0027741511 scopus 로고
    • Cholinergic therapy in dementia
    • Whitehouse PJ, Cholinergic therapy in dementia, Acta Neurol. 149, 1993, 42-45.
    • (1993) Acta Neurol , vol.149 , pp. 42-45
    • Whitehouse, P.J.1
  • 9
    • 0031041005 scopus 로고    scopus 로고
    • Drug treatments for Alzheimer's disease
    • Kelly CA, Harvey RJ, Cayton H, Drug treatments for Alzheimer's disease, Br. Med. J. 314, 1997, 693-694.
    • (1997) Br. Med. J , vol.314 , pp. 693-694
    • Kelly, C.A.1    Harvey, R.J.2    Cayton, H.3
  • 10
    • 0033668050 scopus 로고    scopus 로고
    • Galantamine: A review of its use in Alzheimer's disease
    • Scott LJ, Goa KL, Galantamine: a review of its use in Alzheimer's disease, Drugs, 60, 2000, 1095-1122.
    • (2000) Drugs , vol.60 , pp. 1095-1122
    • Scott, L.J.1    Goa, K.L.2
  • 11
    • 0032860308 scopus 로고    scopus 로고
    • Rivastigmine a brain region selective acetyl cholinesterase inhibitor for treating Alzheimer's disease: Review and current status
    • Gottwald MD, Rozanski RI, Rivastigmine a brain region selective acetyl cholinesterase inhibitor for treating Alzheimer's disease: review and current status, Expert Opin. Invest, Drugs, 8, 1999, 1673-1682.
    • (1999) Expert Opin. Invest Drugs , vol.8 , pp. 1673-1682
    • Gottwald, M.D.1    Rozanski, R.I.2
  • 12
    • 0025778840 scopus 로고
    • Atomic structure of acetyl cholinesterase from Torpedo California: A prototypic acetylcholinebinding protein Silman I
    • Sussman JL, Harel M, Frolow F, Oefner C, Goldman A, Toker L, Atomic structure of acetyl cholinesterase from Torpedo California: a prototypic acetylcholinebinding protein Silman I Science, 253, 1991, 872-879.
    • (1991) Science , vol.253 , pp. 872-879
    • Sussman, J.L.1    Harel, M.2    Frolow, F.3    Oefner, C.4    Goldman, A.5    Toker, L.6
  • 13
    • 0034681279 scopus 로고    scopus 로고
    • Properties of water molecules in the active site gorge of acetyl cholinesterase from computer simulation
    • Koellner G, Kryger G, Millard CB, Silman I, Sussman JL, Steiner T, Properties of water molecules in the active site gorge of acetyl cholinesterase from computer simulation, J. Mol. Biol., 296, 2000, 713-735.
    • (2000) J. Mol. Biol , vol.296 , pp. 713-735
    • Koellner, G.1    Kryger, G.2    Millard, C.B.3    Silman, I.4    Sussman, J.L.5    Steiner, T.6
  • 15
    • 0033103478 scopus 로고    scopus 로고
    • Structure of acetyl cholinesterase complexes with E2020 (Aricept): Implications for the design of new anti-Alzheimer drugs
    • Kryger G, Silman I, Sussman JL, Structure of acetyl cholinesterase complexes with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs, Structure, 7, 1999, 297-307.
    • (1999) Structure , vol.7 , pp. 297-307
    • Kryger, G.1    Silman, I.2    Sussman, J.L.3
  • 16
    • 0033522370 scopus 로고    scopus 로고
    • "Back door" opening implied by the crystal structure of a carbamoylated Acetyl cholinesterase
    • Bartolucci C, Perola E, Cellai L, Brufani M and Lamba D, "Back door" opening implied by the crystal structure of a carbamoylated Acetyl cholinesterase, Biochemistry, 38, 1999, 5714-5719.
    • (1999) Biochemistry , vol.38 , pp. 5714-5719
    • Bartolucci, C.1    Perola, E.2    Cellai, L.3    Brufani, M.4    Lamba, D.5
  • 17
    • 0032105342 scopus 로고    scopus 로고
    • Cholinergic foundations of Alzheimer's disease therapy
    • Giacobin E, Cholinergic foundations of Alzheimer's disease therapy, J. Physiol., Paris 92, 1998, 283-287.
    • (1998) J. Physiol. Paris , vol.92 , pp. 283-287
    • Giacobin, E.1
  • 19
    • 0025280479 scopus 로고
    • Galantamine hydro bromide in a long-term treatment of Alzheimer's disease
    • Thomsen T., Bickel U., Fischer J. P. and Kewitz H, Galantamine hydro bromide in a long-term treatment of Alzheimer's disease. Dementia 1, 1990, 46-51.
    • (1990) Dementia , vol.1 , pp. 46-51
    • Thomsen, T.1    Bickel, U.2    Fischer, J.P.3    Kewitz, H.4
  • 21
    • 0031593615 scopus 로고    scopus 로고
    • Clinical experience with Donepezil (Aricept) in the UK
    • Wilkinson D, Clinical experience with Donepezil (Aricept) in the UK, J. neural Transmission, 54, 1998, 311-315.
    • (1998) J. neural Transmission , vol.54 , pp. 311-315
    • Wilkinson, D.1
  • 22
    • 0001047396 scopus 로고
    • Alkaloids of Galan thus woronowi. II. Isolation of new alkaloid
    • Proskurnina NF and Yakovleva A P, Alkaloids of Galan thus woronowi. II. Isolation of new alkaloid, J. gen. Chemistry, 22, 1952, 1899-1902.
    • (1952) J. gen. Chemistry , vol.22 , pp. 1899-1902
    • Proskurnina, N.F.1    Yakovleva, A.P.2
  • 23
    • 0000118267 scopus 로고
    • Cholinesterase inhibition by Galantamine and lycoramine
    • Irwin RL and Smith HJ, Cholinesterase inhibition by Galantamine and lycoramine, Biochemical Pharmacy, 3, 1960, 147-148.
    • (1960) Biochemical Pharmacy , vol.3 , pp. 147-148
    • Irwin, R.L.1    Smith, H.J.2
  • 24
    • 0025339542 scopus 로고
    • Selective inhibition of human AChE by Galantamine in vitro and in vivo
    • Thomsen T, Kewitz H, Selective inhibition of human AChE by Galantamine in vitro and in vivo. Life Sciences, 46, 1990, 1553-1558.
    • (1990) Life Sciences , vol.46 , pp. 1553-1558
    • Thomsen, T.1    Kewitz, H.2
  • 25
    • 0030023684 scopus 로고    scopus 로고
    • Maelicke A (Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting lignads
    • Schrattenholz A, Pereira EF, Roth U, Weber KH, Albuquerque EX, Maelicke A (Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting lignads, Mol Pharmacology, 49, 1996,1-6.
    • (1996) Mol Pharmacology , vol.49 , pp. 1-6
    • Schrattenholz, A.1    Pereira, E.F.2    Roth, U.3    Weber, K.H.4    Albuquerque, E.X.5
  • 27
    • 0033813557 scopus 로고    scopus 로고
    • Allosteric modulation of nicotinic receptors as a treatment strategy for Alzheimer's disease
    • Maelicke A, Allosteric modulation of nicotinic receptors as a treatment strategy for Alzheimer's disease, Dement Geriatric Cogn Disord, 11, 2000, 11-18.
    • (2000) Dement Geriatric Cogn Disord , vol.11 , pp. 11-18
    • Maelicke, A.1
  • 28
    • 0034720816 scopus 로고    scopus 로고
    • Galantamine USA-1Study Group Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension
    • Raskind MA, Peskind ER, Wessel T, Yuan W, Galantamine USA-1Study Group Galantamine in AD: a 6-month randomized, placebo-controlled trial with a 6-month extension, Neurology, 54, 2000, 2261-2268.
    • (2000) Neurology , vol.54 , pp. 2261-2268
    • Raskind, M.A.1    Peskind, E.R.2    Wessel, T.3    Yuan, W.4
  • 29
    • 0034720864 scopus 로고    scopus 로고
    • Lilienfeld, Ding CA 5-Month, randomized, placebocontrolled trial of Galantamine in AD, The Galantamine USA-10 Study Group
    • Tariot PN, Solomon PR, Morris JC, Kershaw P, Lilienfeld, Ding CA 5-Month, randomized, placebocontrolled trial of Galantamine in AD, The Galantamine USA-10 Study Group. Neurology 54: 2000, 2269-2276.
    • (2000) Neurology , vol.54 , pp. 2269-2276
    • Tariot, P.N.1    Solomon, P.R.2    Morris, J.C.3    Kershaw, P.4
  • 30
    • 0034627263 scopus 로고    scopus 로고
    • Efficacy and safety of Galantamine in patients with mild to moderate Alzheimer's disease: Multicentre randomized controlled trial Galantamine International-1
    • Wilcock GK, Lilienfeld S, Gaens E (Efficacy and safety of Galantamine in patients with mild to moderate Alzheimer's disease: multicentre randomized controlled trial, Galantamine International-1 Study Group Br Med J, 321, 2000, 1445-1449.
    • (2000) Study Group Br Med J , vol.321 , pp. 1445-1449
    • Wilcock, G.K.1    Lilienfeld, S.2    Gaens, E.3
  • 33
    • 0031587286 scopus 로고    scopus 로고
    • Amyloid-cholinesterase interactionsImplications for Alzheimer's disease
    • Alvarez A, Opazo C, Alarcòn R, Garrido J, Inestrosa NC, Amyloid-cholinesterase interactionsImplications for Alzheimer's disease, J. Mol. Biol., 272, 1997,348-361.
    • (1997) J. Mol. Biol , vol.272 , pp. 348-361
    • Alvarez, A.1    Opazo, C.2    Alarcòn, R.3    Garrido, J.4    Inestrosa, N.C.5
  • 34
    • 0025079538 scopus 로고
    • Coyle JT Effects of different doses of Galantamine, a long-acting acetylChE inhibitor, on memory in mice
    • Sweeney JE, Bachman ES, Coyle JT Effects of different doses of Galantamine, a long-acting acetylChE inhibitor, on memory in mice, Psychopharmacology, 102, 1990, 191-200.
    • (1990) Psychopharmacology , vol.102 , pp. 191-200
    • Sweeney, J.E.1    Bachman, E.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.