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Volumn 14, Issue 1, 2013, Pages

Budesonide and formoterol effects on rhinovirus replication and epithelial cell cytokine responses

Author keywords

Asthma; Bronchial epithelial cells; Budesonide; Formoterol; Human rhinovirus

Indexed keywords

BETA1 INTERFERON; BUDESONIDE; FORMOTEROL; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 28; INTERLEUKIN 8; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; BRONCHODILATING AGENT; CYTOKINE; ETHANOLAMINE DERIVATIVE;

EID: 84884942387     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-14-98     Document Type: Article
Times cited : (39)

References (35)
  • 1
    • 23244457496 scopus 로고    scopus 로고
    • The role of rhinovirus in asthma exacerbations
    • 10.1016/j.jaci.2005.06.003, 16083778
    • Friedlander SL, Busse WW. The role of rhinovirus in asthma exacerbations. J Allergy Clin Immunol 2005, 116:267-273. 10.1016/j.jaci.2005.06.003, 16083778.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 267-273
    • Friedlander, S.L.1    Busse, W.W.2
  • 2
    • 0028990124 scopus 로고
    • Community study of role of viral infections in exacerbations of asthma in 9-11 year old children
    • 10.1136/bmj.310.6989.1225, 2549614, 7767192
    • Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ 1995, 310:1225-1229. 10.1136/bmj.310.6989.1225, 2549614, 7767192.
    • (1995) BMJ , vol.310 , pp. 1225-1229
    • Johnston, S.L.1    Pattemore, P.K.2    Sanderson, G.3    Smith, S.4    Lampe, F.5    Josephs, L.6
  • 3
    • 84860483484 scopus 로고    scopus 로고
    • The relationship between combination inhaled corticosteroid and long-acting beta-agonist use and severe asthma exacerbations in a diverse population
    • 10.1016/j.jaci.2011.12.974, 3340459, 22281166
    • Wells KE, Peterson EL, Ahmedani BK, Severson RK, Gleason-Comstock J, Williams LK. The relationship between combination inhaled corticosteroid and long-acting beta-agonist use and severe asthma exacerbations in a diverse population. J Allergy Clin Immunol 2012, 129:1274-1279. 10.1016/j.jaci.2011.12.974, 3340459, 22281166.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 1274-1279
    • Wells, K.E.1    Peterson, E.L.2    Ahmedani, B.K.3    Severson, R.K.4    Gleason-Comstock, J.5    Williams, L.K.6
  • 4
    • 69249222635 scopus 로고    scopus 로고
    • Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future
    • 10.1007/s00228-009-0682-z, 19557399
    • Chung KF, Caramori G, Adcock IM. Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future. Eur J Clin Pharmacol 2009, 65:853-871. 10.1007/s00228-009-0682-z, 19557399.
    • (2009) Eur J Clin Pharmacol , vol.65 , pp. 853-871
    • Chung, K.F.1    Caramori, G.2    Adcock, I.M.3
  • 5
    • 79953259899 scopus 로고    scopus 로고
    • Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps
    • 10.1186/1465-9921-12-38, 3082240, 21463522
    • Bateman ED, Harrison TW, Quirce S, Reddel HK, Buhl R, Humbert M, et al. Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps. Respir Res 2011, 12:38. 10.1186/1465-9921-12-38, 3082240, 21463522.
    • (2011) Respir Res , vol.12 , pp. 38
    • Bateman, E.D.1    Harrison, T.W.2    Quirce, S.3    Reddel, H.K.4    Buhl, R.5    Humbert, M.6
  • 6
    • 80053086068 scopus 로고    scopus 로고
    • Effect of different asthma treatments on risk of cold-related exacerbations
    • 10.1183/09031936.00186510, 21406510
    • Reddel HK, Jenkins C, Quirce S, Sears MR, Bateman ED, OByrne PM, et al. Effect of different asthma treatments on risk of cold-related exacerbations. Eur Respir J 2011, 38:584-593. 10.1183/09031936.00186510, 21406510.
    • (2011) Eur Respir J , vol.38 , pp. 584-593
    • Reddel, H.K.1    Jenkins, C.2    Quirce, S.3    Sears, M.R.4    Bateman, E.D.5    OByrne, P.M.6
  • 7
    • 33644987512 scopus 로고    scopus 로고
    • Cytokine-activated bronchial epithelial cell pro-inflammatory functions are effectively downregulated in vitro by ciclesonide
    • 10.1016/j.pupt.2005.05.006, 16084120
    • Silvestri M, Serpero L, Petecchia L, Sabatini F, Cerasoli F, Rossi GA. Cytokine-activated bronchial epithelial cell pro-inflammatory functions are effectively downregulated in vitro by ciclesonide. Pulm Pharmacol Ther 2006, 19:210-217. 10.1016/j.pupt.2005.05.006, 16084120.
    • (2006) Pulm Pharmacol Ther , vol.19 , pp. 210-217
    • Silvestri, M.1    Serpero, L.2    Petecchia, L.3    Sabatini, F.4    Cerasoli, F.5    Rossi, G.A.6
  • 8
    • 0141638486 scopus 로고    scopus 로고
    • Modulation of the constitutive or cytokine-induced bronchial epithelial cell functions in vitro by fluticasone propionate
    • 10.1016/S0165-2478(03)00142-1, 14556981
    • Sabatini F, Silvestri M, Sale R, Serpero L, Raynal ME, Di BP, et al. Modulation of the constitutive or cytokine-induced bronchial epithelial cell functions in vitro by fluticasone propionate. Immunol Lett 2003, 89:215-224. 10.1016/S0165-2478(03)00142-1, 14556981.
    • (2003) Immunol Lett , vol.89 , pp. 215-224
    • Sabatini, F.1    Silvestri, M.2    Sale, R.3    Serpero, L.4    Raynal, M.E.5    Di, B.P.6
  • 9
    • 0033946520 scopus 로고    scopus 로고
    • Experimental rhinovirus 16 infection increases intercellular adhesion molecule-1 expression in bronchial epithelium of asthmatics regardless of inhaled steroid treatment
    • 10.1046/j.1365-2222.2000.00854.x, 10848925
    • Grunberg K, Sharon RF, Hiltermann TJ, Brahim JJ, Dick EC, Sterk PJ, et al. Experimental rhinovirus 16 infection increases intercellular adhesion molecule-1 expression in bronchial epithelium of asthmatics regardless of inhaled steroid treatment. Clin Exp Allergy 2000, 30:1015-1023. 10.1046/j.1365-2222.2000.00854.x, 10848925.
    • (2000) Clin Exp Allergy , vol.30 , pp. 1015-1023
    • Grunberg, K.1    Sharon, R.F.2    Hiltermann, T.J.3    Brahim, J.J.4    Dick, E.C.5    Sterk, P.J.6
  • 10
    • 20844440294 scopus 로고    scopus 로고
    • Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection
    • 10.1152/ajplung.00397.2004, 15764644
    • Spurrell JC, Wiehler S, Zaheer RS, Sanders SP, Proud D. Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection. Am J Physiol Lung Cell Mol Physiol 2005, 289:L85-L95. 10.1152/ajplung.00397.2004, 15764644.
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.289
    • Spurrell, J.C.1    Wiehler, S.2    Zaheer, R.S.3    Sanders, S.P.4    Proud, D.5
  • 11
    • 0033146616 scopus 로고    scopus 로고
    • Rhinovirus replication causes RANTES production in primary bronchial epithelial cells
    • 10.1165/ajrcmb.20.6.3261, 10340941
    • Schroth MK, Grimm E, Frindt P, Galagan DM, Konno SI, Love R, et al. Rhinovirus replication causes RANTES production in primary bronchial epithelial cells. Am J Respir Cell Mol Biol 1999, 20:1220-1228. 10.1165/ajrcmb.20.6.3261, 10340941.
    • (1999) Am J Respir Cell Mol Biol , vol.20 , pp. 1220-1228
    • Schroth, M.K.1    Grimm, E.2    Frindt, P.3    Galagan, D.M.4    Konno, S.I.5    Love, R.6
  • 12
    • 33845945126 scopus 로고    scopus 로고
    • Modulation of the immune system by human rhinoviruses
    • 10.1159/000095993, 17016053
    • Kirchberger S, Majdic O, Stockl J. Modulation of the immune system by human rhinoviruses. Int Arch Allergy Immunol 2007, 142:1-10. 10.1159/000095993, 17016053.
    • (2007) Int Arch Allergy Immunol , vol.142 , pp. 1-10
    • Kirchberger, S.1    Majdic, O.2    Stockl, J.3
  • 13
    • 55249105235 scopus 로고    scopus 로고
    • The role of chemokines in virus-associated asthma exacerbations
    • 10.1007/s11882-008-0084-9, 18682112
    • Kallal LE, Lukacs NW. The role of chemokines in virus-associated asthma exacerbations. Curr Allergy Asthma Rep 2008, 8:443-450. 10.1007/s11882-008-0084-9, 18682112.
    • (2008) Curr Allergy Asthma Rep , vol.8 , pp. 443-450
    • Kallal, L.E.1    Lukacs, N.W.2
  • 14
    • 33646452550 scopus 로고    scopus 로고
    • Combination therapy: synergistic suppression of virus-induced chemokines in airway epithelial cells
    • 10.1165/rcmb.2005-0385OC, 16424382
    • Edwards MR, Johnson MW, Johnston SL. Combination therapy: synergistic suppression of virus-induced chemokines in airway epithelial cells. Am J Respir Cell Mol Biol 2006, 34:616-624. 10.1165/rcmb.2005-0385OC, 16424382.
    • (2006) Am J Respir Cell Mol Biol , vol.34 , pp. 616-624
    • Edwards, M.R.1    Johnson, M.W.2    Johnston, S.L.3
  • 15
    • 81355136055 scopus 로고    scopus 로고
    • Budesonide and formoterol reduce early innate anti-viral immune responses in vitro
    • 10.1371/journal.pone.0027898, 3220700, 22125636
    • Davies JM, Carroll ML, Li H, Poh AM, Kirkegard D, Towers M, et al. Budesonide and formoterol reduce early innate anti-viral immune responses in vitro. PLoS One 2011, 6:e27898. 10.1371/journal.pone.0027898, 3220700, 22125636.
    • (2011) PLoS One , vol.6
    • Davies, J.M.1    Carroll, M.L.2    Li, H.3    Poh, A.M.4    Kirkegard, D.5    Towers, M.6
  • 16
    • 0029912952 scopus 로고    scopus 로고
    • Oral prednisone therapy in experimental rhinovirus infections
    • 10.1016/S0091-6749(96)80077-7, 8655877
    • Gustafson LM, Proud D, Hendley JO, Hayden FG, Gwaltney JM. Oral prednisone therapy in experimental rhinovirus infections. J Allergy Clin Immunol 1996, 97:1009-1014. 10.1016/S0091-6749(96)80077-7, 8655877.
    • (1996) J Allergy Clin Immunol , vol.97 , pp. 1009-1014
    • Gustafson, L.M.1    Proud, D.2    Hendley, J.O.3    Hayden, F.G.4    Gwaltney, J.M.5
  • 17
    • 67651222099 scopus 로고    scopus 로고
    • Similar colds in subjects with allergic asthma and nonatopic subjects after inoculation with rhinovirus-16
    • 252, 10.1016/j.jaci.2009.05.030, 2737589, 19596142
    • DeMore JP, Weisshaar EH, Vrtis RF, Swenson CA, Evans MD, Morin A, et al. Similar colds in subjects with allergic asthma and nonatopic subjects after inoculation with rhinovirus-16. J Allergy Clin Immunol 2009, 124:245-52. 252, 10.1016/j.jaci.2009.05.030, 2737589, 19596142.
    • (2009) J Allergy Clin Immunol , vol.124 , pp. 245-252
    • DeMore, J.P.1    Weisshaar, E.H.2    Vrtis, R.F.3    Swenson, C.A.4    Evans, M.D.5    Morin, A.6
  • 18
    • 77249119309 scopus 로고    scopus 로고
    • Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma
    • 10.1038/mi.2009.109, 2884103, 19710636
    • Bochkov YA, Hanson KM, Keles S, Brockman-Schneider RA, Jarjour NN, Gern JE. Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma. Mucosal Immunol 2010, 3:69-80. 10.1038/mi.2009.109, 2884103, 19710636.
    • (2010) Mucosal Immunol , vol.3 , pp. 69-80
    • Bochkov, Y.A.1    Hanson, K.M.2    Keles, S.3    Brockman-Schneider, R.A.4    Jarjour, N.N.5    Gern, J.E.6
  • 19
    • 0028607508 scopus 로고
    • Complete sequence of the RNA genome of human rhinovirus 16, a clinically useful common cold virus belonging to the ICAM-1 receptor group
    • 10.1007/BF01702661, 7732663
    • Lee WM, Wang WS, Rueckert RR. Complete sequence of the RNA genome of human rhinovirus 16, a clinically useful common cold virus belonging to the ICAM-1 receptor group. Virus Genes 1995, 9:177-181. 10.1007/BF01702661, 7732663.
    • (1995) Virus Genes , vol.9 , pp. 177-181
    • Lee, W.M.1    Wang, W.S.2    Rueckert, R.R.3
  • 20
    • 20144375334 scopus 로고    scopus 로고
    • Quantitative and qualitative analysis of rhinovirus infection in bronchial tissues
    • 10.1164/rccm.200407-970OC, 15591468
    • Mosser AG, Vrtis R, Burchell L, Lee WM, Dick CR, Weisshaar E, et al. Quantitative and qualitative analysis of rhinovirus infection in bronchial tissues. Am J Respir Crit Care Med 2005, 171:645-651. 10.1164/rccm.200407-970OC, 15591468.
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 645-651
    • Mosser, A.G.1    Vrtis, R.2    Burchell, L.3    Lee, W.M.4    Dick, C.R.5    Weisshaar, E.6
  • 21
    • 0021971892 scopus 로고
    • Evidence for at least two dominant neutralization antigens on human rhinovirus 14
    • 254989, 2981332
    • Sherry B, Rueckert R. Evidence for at least two dominant neutralization antigens on human rhinovirus 14. J Virol 1985, 53:137-143. 254989, 2981332.
    • (1985) J Virol , vol.53 , pp. 137-143
    • Sherry, B.1    Rueckert, R.2
  • 22
    • 58149396790 scopus 로고    scopus 로고
    • Selection of housekeeping genes for real-time PCR in atopic human bronchial epithelial cells
    • 10.1183/09031936.00129107, 18417509
    • He JQ, Sandford AJ, Wang IM, Stepaniants S, Knight DA, Kicic A, et al. Selection of housekeeping genes for real-time PCR in atopic human bronchial epithelial cells. Eur Respir J 2008, 32:755-762. 10.1183/09031936.00129107, 18417509.
    • (2008) Eur Respir J , vol.32 , pp. 755-762
    • He, J.Q.1    Sandford, A.J.2    Wang, I.M.3    Stepaniants, S.4    Knight, D.A.5    Kicic, A.6
  • 23
    • 74849096564 scopus 로고    scopus 로고
    • The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis
    • 10.1513/pats.200907-072DP, 20008870
    • Holgate ST, Roberts G, Arshad HS, Howarth PH, Davies DE. The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis. Proc Am Thorac Soc 2009, 6:655-659. 10.1513/pats.200907-072DP, 20008870.
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 655-659
    • Holgate, S.T.1    Roberts, G.2    Arshad, H.S.3    Howarth, P.H.4    Davies, D.E.5
  • 24
    • 0034901163 scopus 로고    scopus 로고
    • Effects of formoterol and budesonide on GM-CSF and IL-8 secretion by triggered human bronchial epithelial cells
    • 10.1183/09031936.01.00073301, 11491146
    • Korn SH, Jerre A, Brattsand R. Effects of formoterol and budesonide on GM-CSF and IL-8 secretion by triggered human bronchial epithelial cells. Eur Respir J 2001, 17:1070-1077. 10.1183/09031936.01.00073301, 11491146.
    • (2001) Eur Respir J , vol.17 , pp. 1070-1077
    • Korn, S.H.1    Jerre, A.2    Brattsand, R.3
  • 25
    • 70350330313 scopus 로고    scopus 로고
    • Budesonide and formoterol inhibit inflammatory mediator production by bronchial epithelial cells infected with rhinovirus
    • 10.1111/j.1365-2222.2009.03307.x, 19549024
    • Skevaki CL, Christodoulou I, Spyridaki IS, Tiniakou I, Georgiou V, Xepapadaki P, et al. Budesonide and formoterol inhibit inflammatory mediator production by bronchial epithelial cells infected with rhinovirus. Clin Exp Allergy 2009, 39:1700-1710. 10.1111/j.1365-2222.2009.03307.x, 19549024.
    • (2009) Clin Exp Allergy , vol.39 , pp. 1700-1710
    • Skevaki, C.L.1    Christodoulou, I.2    Spyridaki, I.S.3    Tiniakou, I.4    Georgiou, V.5    Xepapadaki, P.6
  • 26
    • 42249100469 scopus 로고    scopus 로고
    • Effect of budesonide and formoterol on IL-6 and IL-8 release from primary bronchial epithelial cells
    • 10.1080/02770900801890372, 18415826
    • Strandberg K, Palmberg L, Larsson K. Effect of budesonide and formoterol on IL-6 and IL-8 release from primary bronchial epithelial cells. J Asthma 2008, 45:201-203. 10.1080/02770900801890372, 18415826.
    • (2008) J Asthma , vol.45 , pp. 201-203
    • Strandberg, K.1    Palmberg, L.2    Larsson, K.3
  • 27
    • 17144403499 scopus 로고    scopus 로고
    • Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus
    • 10.1084/jem.20041901, 2213100, 15781584
    • Wark PA, Johnston SL, Bucchieri F, Powell R, Puddicombe S, Laza-Stanca V, et al. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 2005, 201:937-947. 10.1084/jem.20041901, 2213100, 15781584.
    • (2005) J Exp Med , vol.201 , pp. 937-947
    • Wark, P.A.1    Johnston, S.L.2    Bucchieri, F.3    Powell, R.4    Puddicombe, S.5    Laza-Stanca, V.6
  • 28
    • 33748446393 scopus 로고    scopus 로고
    • Role of deficient type III interferon-lambda production in asthma exacerbations
    • 10.1038/nm1462, 16906156
    • Contoli M, Message SD, Laza-Stanca V, Edwards MR, Wark PA, Bartlett NW, et al. Role of deficient type III interferon-lambda production in asthma exacerbations. Nat Med 2006, 12:1023-1026. 10.1038/nm1462, 16906156.
    • (2006) Nat Med , vol.12 , pp. 1023-1026
    • Contoli, M.1    Message, S.D.2    Laza-Stanca, V.3    Edwards, M.R.4    Wark, P.A.5    Bartlett, N.W.6
  • 29
    • 67649210683 scopus 로고    scopus 로고
    • In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects
    • 10.1016/j.jaci.2009.03.010, 2744461, 19428098
    • Lopez-Souza N, Favoreto S, Wong H, Ward T, Yagi S, Schnurr D, et al. In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects. J Allergy Clin Immunol 2009, 123:1384-1390. 10.1016/j.jaci.2009.03.010, 2744461, 19428098.
    • (2009) J Allergy Clin Immunol , vol.123 , pp. 1384-1390
    • Lopez-Souza, N.1    Favoreto, S.2    Wong, H.3    Ward, T.4    Yagi, S.5    Schnurr, D.6
  • 30
    • 34548263714 scopus 로고    scopus 로고
    • IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations
    • 10.1016/j.jaci.2007.04.046, 17628646
    • Wark PA, Bucchieri F, Johnston SL, Gibson PG, Hamilton L, Mimica J, et al. IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations. J Allergy Clin Immunol 2007, 120:586-593. 10.1016/j.jaci.2007.04.046, 17628646.
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 586-593
    • Wark, P.A.1    Bucchieri, F.2    Johnston, S.L.3    Gibson, P.G.4    Hamilton, L.5    Mimica, J.6
  • 31
    • 77954524570 scopus 로고    scopus 로고
    • The ABCs of rhinoviruses, wheezing, and asthma
    • 10.1128/JVI.02290-09, 2897627, 20375160
    • Gern JE. The ABCs of rhinoviruses, wheezing, and asthma. J Virol 2010, 84:7418-7426. 10.1128/JVI.02290-09, 2897627, 20375160.
    • (2010) J Virol , vol.84 , pp. 7418-7426
    • Gern, J.E.1
  • 32
    • 84887020404 scopus 로고    scopus 로고
    • Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor kappaB and c-Jun N-terminal kinase activation
    • Papi A, Contoli M, Adcock IM, Bellettato C, Padovani A, Casolari P, et al. Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor kappaB and c-Jun N-terminal kinase activation. J Allergy Clin Immunol 2013, (in press) http://dx.doi.org/10.1016/j.jaci.2013.05.028.
    • (2013) J Allergy Clin Immunol
    • Papi, A.1    Contoli, M.2    Adcock, I.M.3    Bellettato, C.4    Padovani, A.5    Casolari, P.6
  • 33
    • 77954355316 scopus 로고    scopus 로고
    • Human monocytic cells direct the robust release of CXCL10 by bronchial epithelial cells during rhinovirus infection
    • 10.1111/j.1365-2222.2010.03546.x, 2909328, 20545701
    • Korpi-Steiner NL, Valkenaar SM, Bates ME, Evans MD, Gern JE, Bertics PJ. Human monocytic cells direct the robust release of CXCL10 by bronchial epithelial cells during rhinovirus infection. Clin Exp Allergy 2010, 40:1203-1213. 10.1111/j.1365-2222.2010.03546.x, 2909328, 20545701.
    • (2010) Clin Exp Allergy , vol.40 , pp. 1203-1213
    • Korpi-Steiner, N.L.1    Valkenaar, S.M.2    Bates, M.E.3    Evans, M.D.4    Gern, J.E.5    Bertics, P.J.6
  • 34
    • 34548713042 scopus 로고    scopus 로고
    • TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells
    • 2220044, 17617600
    • Kato A, Favoreto S, Avila PC, Schleimer RP. TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J Immunol 2007, 179:1080-1087. 2220044, 17617600.
    • (2007) J Immunol , vol.179 , pp. 1080-1087
    • Kato, A.1    Favoreto, S.2    Avila, P.C.3    Schleimer, R.P.4
  • 35


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