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Volumn 7, Issue 9, 2013, Pages 7724-7733

Image-guided local delivery strategies enhance therapeutic nanoparticle uptake in solid tumors

Author keywords

cancer therapy; drug delivery; imaging guidance; magnetic nanoparticles; magnetic resonance imaging; tumor targeting

Indexed keywords

CANCER CHEMOTHERAPEUTICS; CANCER THERAPY; IMAGING GUIDANCE; LOCAL DRUG DELIVERY; MAGNETIC NANO-PARTICLES; NANOPARTICLE UPTAKES; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES; TUMOR TARGETING;

EID: 84884934303     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn4023119     Document Type: Article
Times cited : (51)

References (63)
  • 2
    • 46749142847 scopus 로고    scopus 로고
    • Magnetic Nanoparticles in MR Imaging and Drug Delivery
    • Sun, C.; Lee, J. S. H.; Zhang, M. Magnetic Nanoparticles in MR Imaging and Drug Delivery Adv. Drug Delivery Rev. 2008, 60, 1252-1265
    • (2008) Adv. Drug Delivery Rev. , vol.60 , pp. 1252-1265
    • Sun, C.1    Lee, J.S.H.2    Zhang, M.3
  • 5
    • 67349227159 scopus 로고    scopus 로고
    • Molecular Imaging of Pancreatic Cancer in an Animal Model Using Targeted Multifunctional Nanoparticles
    • Yang, L.; Mao, H.; Cao, Z.; Wang, Y. A.; Peng, X.; Wang, X.; Sajja, H. K.; Wang, L.; Duan, H.; Ni, C. et al. Molecular Imaging of Pancreatic Cancer in an Animal Model Using Targeted Multifunctional Nanoparticles Gastroenterology 2009, 136, 1514-1525 e1512
    • (2009) Gastroenterology , vol.136 , pp. 1514-1525
    • Yang, L.1    Mao, H.2    Cao, Z.3    Wang, Y.A.4    Peng, X.5    Wang, X.6    Sajja, H.K.7    Wang, L.8    Duan, H.9    Ni, C.10
  • 6
    • 51049090204 scopus 로고    scopus 로고
    • Nanoparticle Therapeutics: An Emerging Treatment Modality for Cancer
    • Davis, M. E.; Chen, Z. G.; Shin, D. M. Nanoparticle Therapeutics: An Emerging Treatment Modality for Cancer Nat. Rev. Drug Discovery 2008, 7, 771-782
    • (2008) Nat. Rev. Drug Discovery , vol.7 , pp. 771-782
    • Davis, M.E.1    Chen, Z.G.2    Shin, D.M.3
  • 9
    • 79953054576 scopus 로고    scopus 로고
    • The EPR Effect: Unique Features of Tumor Blood Vessels for Drug Delivery, Factors Involved, and Limitations and Augmentation of the Effect
    • 10.1016/j.addr.2010.04.009
    • Fang, J.; Nakamura, H.; Maeda, H. The EPR Effect: Unique Features of Tumor Blood Vessels for Drug Delivery, Factors Involved, and Limitations and Augmentation of the Effect Adv. Drug Delivery Rev. 2010, 10.1016/j.addr.2010.04. 009
    • (2010) Adv. Drug Delivery Rev.
    • Fang, J.1    Nakamura, H.2    Maeda, H.3
  • 12
    • 79959963318 scopus 로고    scopus 로고
    • Extravasation of Polymeric Nanomedicines across Tumor Vasculature
    • 10.1016/j.addr.2010.11.005
    • Danquah, M. K.; Zhang, X. A.; Mahato, R. I. Extravasation of Polymeric Nanomedicines across Tumor Vasculature Adv. Drug Delivery Rev. 2010, 10.1016/j.addr.2010.11.005
    • (2010) Adv. Drug Delivery Rev.
    • Danquah, M.K.1    Zhang, X.A.2    Mahato, R.I.3
  • 13
    • 78049351925 scopus 로고    scopus 로고
    • A Reexamination of Active and Passive Tumor Targeting by Using Rod-Shaped Gold Nanocrystals and Covalently Conjugated Peptide Ligands
    • Huang, X.; Peng, X.; Wang, Y.; Wang, Y.; Shin, D. M.; El-Sayed, M. A.; Nie, S. A Reexamination of Active and Passive Tumor Targeting by Using Rod-Shaped Gold Nanocrystals and Covalently Conjugated Peptide Ligands ACS Nano 2010, 4, 5887-5896
    • (2010) ACS Nano , vol.4 , pp. 5887-5896
    • Huang, X.1    Peng, X.2    Wang, Y.3    Wang, Y.4    Shin, D.M.5    El-Sayed, M.A.6    Nie, S.7
  • 14
    • 77953412389 scopus 로고    scopus 로고
    • Understanding and Overcoming Major Barriers in Cancer Nanomedicine
    • Nie, S. Understanding and Overcoming Major Barriers in Cancer Nanomedicine Nanomedicine (London). 2010, 5, 523-528
    • (2010) Nanomedicine (London). , vol.5 , pp. 523-528
    • Nie, S.1
  • 15
    • 34848918210 scopus 로고    scopus 로고
    • Impact of Tumor-Specific Targeting on the Biodistribution and Efficacy of Sirna Nanoparticles Measured by Multimodality in Vivo Imaging
    • Bartlett, D. W.; Su, H.; Hildebrandt, I. J.; Weber, W. A.; Davis, M. E. Impact of Tumor-Specific Targeting on the Biodistribution and Efficacy of Sirna Nanoparticles Measured by Multimodality in Vivo Imaging Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 15549-15554
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 15549-15554
    • Bartlett, D.W.1    Su, H.2    Hildebrandt, I.J.3    Weber, W.A.4    Davis, M.E.5
  • 16
    • 33746172167 scopus 로고    scopus 로고
    • Antibody Targeting of Long-Circulating Lipidic Nanoparticles Does Not Increase Tumor Localization but Does Increase Internalization in Animal Models
    • Kirpotin, D. B.; Drummond, D. C.; Shao, Y.; Shalaby, M. R.; Hong, K.; Nielsen, U. B.; Marks, J. D.; Benz, C. C.; Park, J. W. Antibody Targeting of Long-Circulating Lipidic Nanoparticles Does Not Increase Tumor Localization but Does Increase Internalization in Animal Models Cancer Res. 2006, 66, 6732-6740
    • (2006) Cancer Res. , vol.66 , pp. 6732-6740
    • Kirpotin, D.B.1    Drummond, D.C.2    Shao, Y.3    Shalaby, M.R.4    Hong, K.5    Nielsen, U.B.6    Marks, J.D.7    Benz, C.C.8    Park, J.W.9
  • 17
    • 80054686286 scopus 로고    scopus 로고
    • Tumor Metastasis: Molecular Insights and Evolving Paradigms
    • Valastyan, S.; Weinberg, R. A. Tumor Metastasis: Molecular Insights and Evolving Paradigms Cell 2011, 147, 275-292
    • (2011) Cell , vol.147 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 20
    • 78649644675 scopus 로고    scopus 로고
    • Imaging in Interventional Oncology
    • Solomon, S. B.; Silverman, S. G. Imaging in Interventional Oncology Radiology 2010, 257, 624-640
    • (2010) Radiology , vol.257 , pp. 624-640
    • Solomon, S.B.1    Silverman, S.G.2
  • 21
    • 54249106758 scopus 로고    scopus 로고
    • MRI for Identification of Progression in Brain Tumors: From Morphology to Function
    • Weber, M. A.; Giesel, F. L.; Stieltjes, B. MRI for Identification of Progression in Brain Tumors: From Morphology to Function Expert Rev. Neurother. 2008, 8, 1507-1525
    • (2008) Expert Rev. Neurother. , vol.8 , pp. 1507-1525
    • Weber, M.A.1    Giesel, F.L.2    Stieltjes, B.3
  • 22
    • 33750317391 scopus 로고    scopus 로고
    • New Developments in MRI for Target Volume Delineation in Radiotherapy
    • Khoo, V. S.; Joon, D. L. New Developments in MRI for Target Volume Delineation in Radiotherapy. Br. J. Radiol. 2006, 79 (Spec No 1), S2-15.
    • (2006) Br. J. Radiol. , vol.79 , Issue.SPEC. 1 , pp. 2-15
    • Khoo, V.S.1    Joon, D.L.2
  • 24
    • 42549152143 scopus 로고    scopus 로고
    • Biodistribution, Clearance, and Biocompatibility of Iron Oxide Magnetic Nanoparticles in Rats
    • Jain, T. K.; Reddy, M. K.; Morales, M. A.; Leslie-Pelecky, D. L.; Labhasetwar, V. Biodistribution, Clearance, and Biocompatibility of Iron Oxide Magnetic Nanoparticles in Rats Mol. Pharm. 2008, 5, 316-327
    • (2008) Mol. Pharm. , vol.5 , pp. 316-327
    • Jain, T.K.1    Reddy, M.K.2    Morales, M.A.3    Leslie-Pelecky, D.L.4    Labhasetwar, V.5
  • 25
    • 33749610850 scopus 로고    scopus 로고
    • Simultaneous Imaging and R 2* Mapping Using a Radial Multi-Gradient-Echo (Rmge) Sequence
    • Winkelmann, S.; Schaeffter, T.; Weiss, S.; Eggers, H.; Doessel, O. Simultaneous Imaging and R 2* Mapping Using a Radial Multi-Gradient-Echo (Rmge) Sequence J. Magn. Reson. Imaging 2006, 24, 939-944
    • (2006) J. Magn. Reson. Imaging , vol.24 , pp. 939-944
    • Winkelmann, S.1    Schaeffter, T.2    Weiss, S.3    Eggers, H.4    Doessel, O.5
  • 26
    • 0027973923 scopus 로고
    • Theory of NMR Signal Behavior in Magnetically Inhomogeneous Tissues: The Static Dephasing Regime
    • Yablonskiy, D. A.; Haacke, E. M. Theory of NMR Signal Behavior in Magnetically Inhomogeneous Tissues: The Static Dephasing Regime Magn. Reson. Med. 1994, 32, 749-763
    • (1994) Magn. Reson. Med. , vol.32 , pp. 749-763
    • Yablonskiy, D.A.1    Haacke, E.M.2
  • 27
    • 0037260472 scopus 로고    scopus 로고
    • Steady-State Blood Volume Measurements in Experimental Tumors with Different Angiogenic Burdens a Study in Mice
    • Bremer, C.; Mustafa, M.; Bogdanov, A., Jr.; Ntziachristos, V.; Petrovsky, A.; Weissleder, R. Steady-State Blood Volume Measurements in Experimental Tumors with Different Angiogenic Burdens a Study in Mice Radiology 2003, 226, 214-220
    • (2003) Radiology , vol.226 , pp. 214-220
    • Bremer, C.1    Mustafa, M.2    Bogdanov Jr., A.3    Ntziachristos, V.4    Petrovsky, A.5    Weissleder, R.6
  • 28
    • 0036295196 scopus 로고    scopus 로고
    • Application of the Static Dephasing Regime Theory to Superparamagnetic Iron-Oxide Loaded Cells
    • Bowen, C. V.; Zhang, X.; Saab, G.; Gareau, P. J.; Rutt, B. K. Application of the Static Dephasing Regime Theory to Superparamagnetic Iron-Oxide Loaded Cells Magn. Reson. Med. 2002, 48, 52-61
    • (2002) Magn. Reson. Med. , vol.48 , pp. 52-61
    • Bowen, C.V.1    Zhang, X.2    Saab, G.3    Gareau, P.J.4    Rutt, B.K.5
  • 29
    • 58149302843 scopus 로고    scopus 로고
    • Development of Receptor Targeted Magnetic Iron Oxide Nanoparticles for Efficient Drug Delivery and Tumor Imaging
    • Yang, L.; Cao, Z.; Sajja, hK; Mao, H.; Wang, L.; Geng, H.; Xu, H.; Jiang, T.; Wood, W. C.; Nie, S. et al. Development of Receptor Targeted Magnetic Iron Oxide Nanoparticles for Efficient Drug Delivery and Tumor Imaging J. Biomed. Nanotechnol. 2008, 4, 439-449
    • (2008) J. Biomed. Nanotechnol. , vol.4 , pp. 439-449
    • Yang, L.1    Cao, Z.2    Sajja, H.3    Mao, H.4    Wang, L.5    Geng, H.6    Xu, H.7    Jiang, T.8    Wood, W.C.9    Nie, S.10
  • 30
    • 44649184953 scopus 로고    scopus 로고
    • Overview of Drug Delivery and Alternative Methods to Electroporation
    • Hui, S. W. Overview of Drug Delivery and Alternative Methods to Electroporation Methods Mol. Biol. 2008, 423, 91-107
    • (2008) Methods Mol. Biol. , vol.423 , pp. 91-107
    • Hui, S.W.1
  • 32
    • 78650459132 scopus 로고    scopus 로고
    • The Basis of Electrochemotherapy
    • Mir, L. M.; Orlowski, S. The Basis of Electrochemotherapy Methods Mol. Med. 2000, 37, 99-117
    • (2000) Methods Mol. Med. , vol.37 , pp. 99-117
    • Mir, L.M.1    Orlowski, S.2
  • 33
    • 0027385319 scopus 로고
    • Bleomycin, an Apoptosis-Mimetic Drug That Induces Two Types of Cell Death Depending on the Number of Molecules Internalized
    • Tounekti, O.; Pron, G.; Belehradek, J., Jr.; Mir, L. M. Bleomycin, an Apoptosis-Mimetic Drug That Induces Two Types of Cell Death Depending on the Number of Molecules Internalized Cancer Res. 1993, 53, 5462-5469
    • (1993) Cancer Res. , vol.53 , pp. 5462-5469
    • Tounekti, O.1    Pron, G.2    Belehradek Jr., J.3    Mir, L.M.4
  • 34
    • 0028916569 scopus 로고
    • Relationships between DNA Fragmentation, Chromatin Condensation, and Changes in Flow Cytometry Profiles Detected during Apoptosis
    • Tounekti, O.; Belehradek, J., Jr.; Mir, L. M. Relationships between DNA Fragmentation, Chromatin Condensation, and Changes in Flow Cytometry Profiles Detected During Apoptosis Exp. Cell Res. 1995, 217, 506-516
    • (1995) Exp. Cell Res. , vol.217 , pp. 506-516
    • Tounekti, O.1    Belehradek Jr., J.2    Mir, L.M.3
  • 35
    • 0023697540 scopus 로고
    • Combining Chemotherapy with Biological Response Modifiers in Treatment of Cancer
    • Mitchell, M. S. Combining Chemotherapy with Biological Response Modifiers in Treatment of Cancer J. Natl. Cancer Inst. 1988, 80, 1445-1450
    • (1988) J. Natl. Cancer Inst. , vol.80 , pp. 1445-1450
    • Mitchell, M.S.1
  • 36
    • 76749119408 scopus 로고    scopus 로고
    • Irreversible Electroporation Therapy in the Liver: Longitudinal Efficacy Studies in a Rat Model of Hepatocellular Carcinoma
    • Guo, Y.; Zhang, Y.; Klein, R.; Nijm, G. M.; Sahakian, A. V.; Omary, R. A.; Yang, G-Y; Larson, A. C. Irreversible Electroporation Therapy in the Liver: Longitudinal Efficacy Studies in a Rat Model of Hepatocellular Carcinoma Cancer Res. 2010, 70, 1555-1563
    • (2010) Cancer Res. , vol.70 , pp. 1555-1563
    • Guo, Y.1    Zhang, Y.2    Klein, R.3    Nijm, G.M.4    Sahakian, A.V.5    Omary, R.A.6    Yang, G.-Y.7    Larson, A.C.8
  • 37
    • 77955159783 scopus 로고    scopus 로고
    • MR Imaging to Assess Immediate Response to Irreversible Electroporation for Targeted Ablation of Liver Tissues: Preclinical Feasibility Studies in a Rodent Model
    • Zhang, Y.; Guo, Y.; Ragin, A. B.; Lewandowski, R. J.; Yang, G-Y; Nijm, G. M.; Sahakian, A. V.; Omary, R. A.; Larson, A. C. MR Imaging to Assess Immediate Response to Irreversible Electroporation for Targeted Ablation of Liver Tissues: Preclinical Feasibility Studies in a Rodent Model Radiology 2010, 256, 424-432
    • (2010) Radiology , vol.256 , pp. 424-432
    • Zhang, Y.1    Guo, Y.2    Ragin, A.B.3    Lewandowski, R.J.4    Yang, G.-Y.5    Nijm, G.M.6    Sahakian, A.V.7    Omary, R.A.8    Larson, A.C.9
  • 38
    • 84860645692 scopus 로고    scopus 로고
    • Radioembolization in the Treatment of Unresectable Liver Tumors: Experience across a Range of Primary Cancers
    • Coldwell, D.; Sangro, B.; Salem, R.; Wasan, H.; Kennedy, A. Radioembolization in the Treatment of Unresectable Liver Tumors: Experience across a Range of Primary Cancers Am. J. Clin. Oncol. 2012, 35, 167-177
    • (2012) Am. J. Clin. Oncol. , vol.35 , pp. 167-177
    • Coldwell, D.1    Sangro, B.2    Salem, R.3    Wasan, H.4    Kennedy, A.5
  • 42
    • 53449102984 scopus 로고    scopus 로고
    • Four-Dimensional Transcatheter Intraarterial Perfusion (Trip)-MRI for Monitoring Liver Tumor Embolization in Vx2 Rabbits
    • Wang, D.; Virmani, S.; Tang, R.; Szolc-Kowalska, B.; Woloschak, G.; Omary, R. A.; Larson, A. C. Four-Dimensional Transcatheter Intraarterial Perfusion (Trip)-MRI for Monitoring Liver Tumor Embolization in Vx2 Rabbits Magn. Reson. Med. 2008, 60, 970-975
    • (2008) Magn. Reson. Med. , vol.60 , pp. 970-975
    • Wang, D.1    Virmani, S.2    Tang, R.3    Szolc-Kowalska, B.4    Woloschak, G.5    Omary, R.A.6    Larson, A.C.7
  • 44
    • 42949105448 scopus 로고    scopus 로고
    • Diffusion-Weighted Propeller MRI for Quantitative Assessment of Liver Tumor Necrotic Fraction and Viable Tumor Volume in Vx2 Rabbits
    • Deng, J.; Virmani, S.; Young, J.; Harris, K.; Yang, G. Y.; Rademaker, A.; Woloschak, G.; Omary, R. A.; Larson, A. C. Diffusion-Weighted Propeller MRI for Quantitative Assessment of Liver Tumor Necrotic Fraction and Viable Tumor Volume in Vx2 Rabbits J. Magn. Reson. Imaging 2008, 27, 1069-1076
    • (2008) J. Magn. Reson. Imaging , vol.27 , pp. 1069-1076
    • Deng, J.1    Virmani, S.2    Young, J.3    Harris, K.4    Yang, G.Y.5    Rademaker, A.6    Woloschak, G.7    Omary, R.A.8    Larson, A.C.9
  • 45
    • 34548691483 scopus 로고    scopus 로고
    • Liver Tumors: Monitoring Embolization in Rabbits with Vx2 Tumors - Transcatheter Intraarterial First-Pass Perfusion MR Imaging
    • Wang, D.; Bangash, A. K.; Rhee, T. K.; Woloschak, G. E.; Paunesku, T.; Salem, R.; Omary, R. A.; Larson, A. C. Liver Tumors: Monitoring Embolization in Rabbits with Vx2 Tumors-Transcatheter Intraarterial First-Pass Perfusion MR Imaging Radiology 2007, 245, 130-139
    • (2007) Radiology , vol.245 , pp. 130-139
    • Wang, D.1    Bangash, A.K.2    Rhee, T.K.3    Woloschak, G.E.4    Paunesku, T.5    Salem, R.6    Omary, R.A.7    Larson, A.C.8
  • 50
    • 67649756658 scopus 로고    scopus 로고
    • Society of Interventional Radiology Position Statement on Chemoembolization of Hepatic Malignancies
    • Brown, D. B.; Geschwind, J. F.; Soulen, M. C.; Millward, S. F.; Sacks, D. Society of Interventional Radiology Position Statement on Chemoembolization of Hepatic Malignancies J. Vasc. Interventional Radiol. 2009, 20, S317-323
    • (2009) J. Vasc. Interventional Radiol. , vol.20 , pp. 317-323
    • Brown, D.B.1    Geschwind, J.F.2    Soulen, M.C.3    Millward, S.F.4    Sacks, D.5
  • 51
    • 0036237822 scopus 로고    scopus 로고
    • Randomized Controlled Trial of Transarterial Lipiodol Chemoembolization for Unresectable Hepatocellular Carcinoma
    • Lo, C-M; Ngan, H.; Tso, W-K; Liu, C-L; Lam, C-M; Poon, RT-P; Fan, S-T; Wong, J. Randomized Controlled Trial of Transarterial Lipiodol Chemoembolization for Unresectable Hepatocellular Carcinoma Hepatology 2002 May 1, 35, 1164-1171
    • (2002) Hepatology , vol.35 , pp. 1164-1171
    • Lo, C.-M.1    Ngan, H.2    Tso, W.-K.3    Liu, C.-L.4    Lam, C.-M.5    Poon, R.-P.6    Fan, S.-T.7    Wong, J.8
  • 52
    • 0037129704 scopus 로고    scopus 로고
    • Arterial Embolisation or Chemoembolisation versus Symptomatic Treatment in Patients with Unresectable Hepatocellular Carcinoma: A Randomised Controlled Trial
    • Llovet, J. M.; Real, M. I.; Montaña, X.; Planas, R.; Coll, S.; Aponte, J.; Ayuso, C.; Sala, M.; Muchart, J.; Solà, R. et al. Arterial Embolisation or Chemoembolisation versus Symptomatic Treatment in Patients with Unresectable Hepatocellular Carcinoma: A Randomised Controlled Trial Lancet 2002, 359, 1734-1739
    • (2002) Lancet , vol.359 , pp. 1734-1739
    • Llovet, J.M.1    Real, M.I.2    Montaña, X.3    Planas, R.4    Coll, S.5    Aponte, J.6    Ayuso, C.7    Sala, M.8    Muchart, J.9    Solà, R.10
  • 53
    • 79953048071 scopus 로고    scopus 로고
    • Tumor Delivery of Macromolecular Drugs Based on the Epr Effect
    • Torchilin, V. Tumor Delivery of Macromolecular Drugs Based on the Epr Effect Adv. Drug Delivery Rev. 2011, 63, 131-135
    • (2011) Adv. Drug Delivery Rev. , vol.63 , pp. 131-135
    • Torchilin, V.1
  • 54
    • 9144237067 scopus 로고    scopus 로고
    • Synthesis of Monodisperse Iron Oxide Nanocrystals by Thermal Decomposition of Iron Carboxylate Salts
    • Yu, W. W.; Falkner, J. C.; Yavuz, C. T.; Colvin, V. L. Synthesis of Monodisperse Iron Oxide Nanocrystals by Thermal Decomposition of Iron Carboxylate Salts Chem. Commun. (Cambridge). 2004, 2306-2307
    • (2004) Chem. Commun. (Cambridge). , pp. 2306-2307
    • Yu, W.W.1    Falkner, J.C.2    Yavuz, C.T.3    Colvin, V.L.4
  • 55
    • 53549097639 scopus 로고    scopus 로고
    • Reexamining the Effects of Particle Size and Surface Chemistry on the Magnetic Properties of Iron Oxide Nanocrystals: New Insights into Spin Disorder and Proton Relaxivity
    • Duan, H.; Kuang, M.; Wang, X.; Wang, Y.; Mao, H.; Nie, S. Reexamining the Effects of Particle Size and Surface Chemistry on the Magnetic Properties of Iron Oxide Nanocrystals: New Insights into Spin Disorder and Proton Relaxivity J. Phys. Chem. C 2008, 112, 8127-8131
    • (2008) J. Phys. Chem. C , vol.112 , pp. 8127-8131
    • Duan, H.1    Kuang, M.2    Wang, X.3    Wang, Y.4    Mao, H.5    Nie, S.6
  • 56
    • 23044437968 scopus 로고    scopus 로고
    • Description and Technical Pitfalls of a Hepatoma Model and of Intra-Arterial Injection of Radiolabelled Lipiodol in the Rat
    • Garin, E.; Denizot, B.; Roux, J.; Noiret, N.; Lepareur, N.; Moreau, M.; Mesba, H.; Laurent, J. F.; Herry, J. Y.; Bourguet, P. et al. Description and Technical Pitfalls of a Hepatoma Model and of Intra-Arterial Injection of Radiolabelled Lipiodol in the Rat Lab. Anim. 2005, 39, 314-320
    • (2005) Lab. Anim. , vol.39 , pp. 314-320
    • Garin, E.1    Denizot, B.2    Roux, J.3    Noiret, N.4    Lepareur, N.5    Moreau, M.6    Mesba, H.7    Laurent, J.F.8    Herry, J.Y.9    Bourguet, P.10
  • 58
    • 33646401788 scopus 로고    scopus 로고
    • Recist Revisited: A Review of Validation Studies on Tumour Assessment
    • Therasse, P.; Eisenhauer, E. A.; Verweij, J. Recist Revisited: A Review of Validation Studies on Tumour Assessment Eur. J. Cancer 2006, 42, 1031-1039
    • (2006) Eur. J. Cancer , vol.42 , pp. 1031-1039
    • Therasse, P.1    Eisenhauer, E.A.2    Verweij, J.3
  • 62
    • 78650205375 scopus 로고    scopus 로고
    • Highly Malignant Intra-hepatic Metastatic Hepatocellular Carcinoma in Rats
    • Guo, Y.; Klein, R.; Omary, R. A.; Yang, G. Y.; Larson, A. C. Highly Malignant Intra-hepatic Metastatic Hepatocellular Carcinoma in Rats Am. J. Transl. Res. 2010, 3, 114-120
    • (2010) Am. J. Transl. Res. , vol.3 , pp. 114-120
    • Guo, Y.1    Klein, R.2    Omary, R.A.3    Yang, G.Y.4    Larson, A.C.5
  • 63
    • 77952584926 scopus 로고    scopus 로고
    • Reducing Non-specific Binding and Uptake of Nanoparticles and Improving Cell Targeting with an Antifouling Peo-B-Pgammamps Copolymer Coating
    • Chen, H.; Wang, L.; Yeh, J.; Wu, X.; Cao, Z.; Wang, Y. A.; Zhang, M.; Yang, L.; Mao, H. Reducing Non-specific Binding and Uptake of Nanoparticles and Improving Cell Targeting with an Antifouling Peo-B-Pgammamps Copolymer Coating Biomaterials 2010, 31, 5397-5407
    • (2010) Biomaterials , vol.31 , pp. 5397
    • Chen, H.1    Wang, L.2    Yeh, J.3    Wu, X.4    Cao, Z.5    Wang, Y.A.6    Zhang, M.7    Yang, L.8    Mao, H.9


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