Genomic alterations in human umbilical cord-derived mesenchymal stromal cells call for stringent quality control before any possible therapeutic approach

Cytotherapy

Volumn 15, Issue 11, 2013, Pages 1362-1373

  Borghesi, Alessandro ^a   Avanzini, Maria Antonietta ^a   Novara, Francesca ^b   Mantelli, Melissa ^a   Lenta, Elisa ^a   Achille, Valentina ^a   Cerbo, Rosa Maria ^a   Tzialla, Chryssoula ^a   Longo, Stefania ^a   De Silvestri, Annalisa ^a   Zimmermann, Luc J I ^c   Manzoni, Paolo ^d   Zecca, Marco ^a   Spinillo, Arsenio ^a   Maccario, Rita ^a   Zuffardi, Orsetta ^b,e   Stronati, Mauro ^a  

^a FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d S ANNA HOSPITAL   (Italy)

^e C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

Author keywords

Array comparative genomic hybridization; Karyotype; Mesenchymal stromal cells; Umbilical cord

Indexed keywords

ALLELIC IMBALANCE; ARTICLE; CELL CLONE; CELL EXPANSION; CELL PROLIFERATION; CELL THERAPY; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; COPY NUMBER VARIATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MESENCHYMAL STROMA CELL; MOSAICISM; PRIORITY JOURNAL; QUALITY CONTROL; SENESCENCE; UMBILICAL CORD; UMBILICAL CORD DERIVED MESENCHYMAL STROMA CELL;

ARRAY COMPARATIVE GENOMIC HYBRIDIZATION; KARYOTYPE; MESENCHYMAL STROMAL CELLS; UMBILICAL CORD;

CELL AGING; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELL- AND TISSUE-BASED THERAPY; CELLS, CULTURED; COMPARATIVE GENOMIC HYBRIDIZATION; DNA COPY NUMBER VARIATIONS; GENES, P16; GENOMIC INSTABILITY; HUMANS; KARYOTYPE; MESENCHYMAL STROMAL CELLS; MICROSATELLITE REPEATS; UMBILICAL CORD;

EID: 84884922980     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1016/j.jcyt.2013.06.006     Document Type: Article

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