REG1A expression is an independent factor predictive of poor prognosis in patients with non-small cell lung cancer

Lung Cancer

Volumn 60, Issue 1, 2008, Pages 98-104

  Minamiya, Yoshihiro ^a   Kawai, Hideki ^a   Saito, Hajime ^a   Ito, Manabu ^a   Hosono, Yukiko ^a   Motoyama, Satoru ^a   Katayose, Yoshihisa ^a   Takahashi, Naoko ^a   Ogawa, Jun ichi ^a  

^a AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Non small cell lung cancer; Prognosis; Regenerating gene I alpha

Indexed keywords

AGED; ARTICLE; CANCER SURVIVAL; CONFIDENCE INTERVAL; CORRELATION ANALYSIS; FEMALE; GENE; GENE EXPRESSION; HAZARD RATIO; HUMAN; IMMUNOHISTOCHEMISTRY; LOG RANK TEST; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NUCLEOTIDE SEQUENCE; PREDICTIVE VALIDITY; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; REAL TIME POLYMERASE CHAIN REACTION; REGENERATING GENE 1 ALPHA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL RATE; TUMOR CELL;

ADULT; AGED; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LITHOSTATHINE; LUNG NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; RNA, MESSENGER; SURVIVAL RATE;

EID: 41149091820     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2007.09.012     Document Type: Article

References (18)

1. Terazono K., Yamamoto H., Takasawa S., Shiga K., Yonemura Y., Tochino Y., et al. A novel gene activated in regenerating islets. J Biol Chem 263 (1988) 2111-2114
2. Dusetti N.J., Frigerio J.M., Fox M.F., Swallow D.M., Dagorn J.C., and Iovanna J.L. Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene. Genomics 19 (1994) 108-114
3. Broekaert D., Eyckerman S., Lavens D., Verhee A., Waelput W., Vandekerckhove J., et al. Comparison of leptin- and interleukin-6-regulated expression of the rPAP gene family: evidence for differential co-regulatory signals. Eur Cytokine Netw 13 (2002) 78-85
4. Zhang Y.W., Ding L.S., and Lai M.D. Reg gene family and human diseases. World J Gastroenterol 9 (2003) 2635-2641
5. Watanabe T., Yonekura H., Terazono K., Yamamoto H., and Okamoto H. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J Biol Chem 265 (1990) 7432-7439
6. Takasawa S., and Okamoto H. Pancreatic beta-cell death, regeneration and insulin secretion: roles of poly(ADP-ribose) polymerase and cyclic ADP-ribose. Int J Exp Diabetes Res 3 (2002) 79-96
7. Sekikawa A., Fukui H., Fujii S., Nanakin A., Kanda N., Uenoyama Y., et al. Possible role of REG Ialpha protein in ulcerative colitis and colitic cancer. Gut 54 (2005) 1437-1444
8. Sekikawa A., Fukui H., Fujii S., Takeda J., Nanakin A., Hisatsune H., et al. REG Ialpha protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer. Gastroenterology 128 (2005) 642-653
9. Cavard C., Terris B., Grimber G., Christa L., Audard V., Radenen-Bussiere B., et al. Overexpression of regenerating islet-derived 1 alpha and 3 alpha genes in human primary liver tumors with beta-catenin mutations. Oncogene 25 (2006) 599-608
10. Dhar D.K., Udagawa J., Ishihara S., Otani H., Kinoshita Y., Takasawa S., et al. Expression of regenerating gene I in gastric adenocarcinomas: correlation with tumor differentiation status and patient survival. Cancer 100 (2004) 1130-1136
11. Yonemura Y., Sakurai S., Yamamoto H., Endou Y., Kawamura T., Bandou E., et al. REG gene expression is associated with the infiltrating growth of gastric carcinoma. Cancer 98 (2003) 1394-1400
12. Macadam R.C., Sarela A.I., Farmery S.M., Robinson P.A., Markham A.F., and Guillou P.J. Death from early colorectal cancer is predicted by the presence of transcripts of the REG gene family. Br J Cancer 83 (2000) 188-195
13. Harada K., Zen Y., Kanemori Y., Chen T.C., Chen M.F., Yeh T.S., et al. Human REG I gene is up-regulated in intrahepatic cholangiocarcinoma and its precursor lesions 1. Hepatology 33 (2001) 1036-1042
14. Motoyama S., Sugiyama T., Ueno Y., Okamoto H., Takasawa S., Nanjo H., et al. REG I expression predicts long-term survival among locally advanced thoracic squamous cell esophageal cancer patients treated with neoadjuvant chemoradiotherapy followed by esophagectomy. Ann Surg Oncol 13 (2006) 1724-1731
15. Naruke T., Suemasu K., and Ishikawa S. Lymph node mapping and curability at various levels of metastasis in resected lung cancer. J Thorac Cardiovasc Surg 76 (1978) 832-839
16. Rechreche H., Montalto G., Mallo G.V., Vasseur S., Marasa L., Soubeyran P., et al. Iovanna JL. pap, reg Ialpha and reg Ibeta mRNAs are concomitantly up-regulated during human colorectal carcinogenesis. Int J Cancer 81 (1999) 688-694
17. Yoshino N., Ishihara S., Rumi M.A., Ortega-Cava C.F., Yuki T., Kazumori H., et al. Interleukin-8 regulates expression of Reg protein in Helicobacter pylori-infected gastric mucosa. Am J Gastroenterol 100 (2005) 2157-2166
18. Kostanova-Poliakova D., and Sabova L. Anti-apoptotic proteins-targets for chemosensitization of tumor cells and cancer treatment. Neoplasma 52 (2005) 441-449