Successful testicular sperm retrieval in adolescents with Klinefelter syndrome treated with at least 1 year of topical testosterone and aromatase inhibitor

Fertility and Sterility

Volumn 100, Issue 4, 2013, Pages 970-974

  Mehta, Akanksha ^a   Bolyakov, Alexander ^a   Roosma, Jordan ^a   Schlegel, Peter N ^a   Paduch, Darius A ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

hormone replacement; Klinefelter syndrome; testicular sperm extraction; testosterone

Indexed keywords

ANASTROZOLE; FOLLITROPIN; LUTEINIZING HORMONE; TESTOSTERONE;

ADOLESCENCE; ADOLESCENT; ADULT; ANDROGEN THERAPY; ARTICLE; CASE STUDY; CLINICAL ARTICLE; COHORT ANALYSIS; CRYOPRESERVATION; FOLLITROPIN BLOOD LEVEL; FOLLOW UP; HUMAN; KLINEFELTER SYNDROME; MALE; MICROSURGERY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SPERM RETRIEVAL; SPERMATOZOON; SPERMATOZOON DENSITY; TESTICULAR SPERM EXTRACTION; TESTIS;

HORMONE REPLACEMENT; KLINEFELTER SYNDROME; TESTICULAR SPERM EXTRACTION; TESTOSTERONE;

ACADEMIC MEDICAL CENTERS; ADMINISTRATION, CUTANEOUS; ADOLESCENT; AROMATASE INHIBITORS; CRYOPRESERVATION; DRUG THERAPY, COMBINATION; HORMONE REPLACEMENT THERAPY; HUMANS; KLINEFELTER SYNDROME; MALE; NITRILES; RETROSPECTIVE STUDIES; SEMEN PRESERVATION; SPERM RETRIEVAL; SPERMATOGENESIS; TESTOSTERONE; TIME FACTORS; TREATMENT OUTCOME; TRIAZOLES;

EID: 84884906598     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2013.06.010     Document Type: Article

References (34)

1. A.M. Wikstrom, T. Raivio, F. Hadziselimovic, S. Wikstrom, T. Tuuri, and L. Dunkel Klinefelter syndrome in adolescence: onset of puberty is associated with accelerated germ cell depletion J Clin Endocrinol Metab 89 2004 2263 2270 (Pubitemid 38619862)
2. A.M. Wikstrom, L. Dunkel, S. Wickman, E. Norjavaara, C. Ankarberg-Lindgren, and T. Raivio Are adolescent boys with Klinefelter syndrome androgen deficient? A longitudinal study of Finnish 47, XXY boys Pediatr Res 59 2006 854 859 (Pubitemid 44297642)
3. Z. Laron, Z. Dickerman, R. Zamir, and A. Galatzer Paternity in Klinefelter's syndrome - a case report Arch Androl 8 1982 149 151 (Pubitemid 12061642)
4. G. Terzoli, F. Lalatta, A. Lobbiani, G. Simoni, and G. Colucci Fertility in a 47, XXY patients: assessment of biological paternity by deoxyribonucleic acid fingerprinting Fertil Steril 58 1992 821 822
5. P.N. Schlegel Nonobstructive azoospermia: a revolutionary surgical approach and results Semin Reprod Med 27 2009 165 170
6. D.A. Paduch, A. Bolyakov, P. Cohen, and A. Travis Reproduction in men with Klinefelter syndrome: the past, the present, and the future Semin Reprod Med 27 2009 137 148
7. M.N. Damani, R. Mittal, and R.D. Oates Testicular tissue extraction in a young male with 47, XXY Klinefelter's syndrome: potential strategy for preservation of fertility Fertil Steril 76 2001 1054 1056 (Pubitemid 33031339)
8. V. de Sanctis, and S. Ciccone Fertility preservation in adolescents with Klinefelter's syndrome Pediatr Endocrinol Rev 8 Suppl 1 2010 178 181
9. C.P. Houk, A. Rogol, and P.A. Lee Fertility in men with Klinefleter syndrome Pediatr Endocrinol Rev 8 Suppl 1 2010 182 186
10. G. Forti, G. Corona, L. Vignozzi, C. Krausz, and M. Maggi Klinefelter's syndrome: a clinical and therapeutical update Sex Dev 4 2010 249 258
11. A. Mehta, and D.A. Paduch Klinefelter Syndrome: an argument for early and aggressive hormonal and fertility management Fertil Steril 98 2012 274 283
12. R. Ramasamy, J.A. Ricci, G.D. Palermo, L.V. Gosden, Z. Rosenwaks, and P.N. Schlegel Successful fertility treatment for Klinefelter's syndrome J Urol 182 2009 1108 1113
13. J.D. Schiff, G.D. Palermo, L.L. Veeck, M. Goldstein, Z. Rosenwaks, and P.N. Schlegel Success of testicular sperm extraction [corrected] and intracytoplasmic sperm injection in men with Klinefelter syndrome J Clin Endocrinol Metab 90 2005 6263 6267 (Pubitemid 41606554)
14. H. Okada, K. Goda, Y. Yamamoto, N. Sofikitis, I. Miyagawa, and Y. Mio Age as a limiting factor for successful sperm retrieval in patients with nonmosaic Klinefelter's syndrome Fertil Steril 84 2005 1662 1664 (Pubitemid 41785660)
15. K. Ferhi, R. Avakian, J.F. Griveau, and F. Guille Age as only predictive factor for successful sperm recovery in patients with Klinefelter's syndrome Andrologia 41 2009 84 87
16. M. Emre Bakircioglu, H.F. Erden, T. Kaplancan, N. Ciray, F. Bener, and M. Bahceci Aging may adversely affect testicular sperm recovery in patients with Klinefelter syndrome Urology 68 2006 1082 1086 (Pubitemid 44750125)
17. A. Bojesen, S. Juul, and C.H. Gravholt Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study J Clin Endocrinol Metab 88 2003 622 626 (Pubitemid 36207801)
18. P.N. Schlegel Testicular sperm extraction: microdissection improves sperm yield with minimal tissue excision Hum Reprod 14 1999 131 135 (Pubitemid 29046327)
19. R. Ramasamy, J.E. Reifsnyder, C. Bryson, N. Zaninovic, D. Liotta, and C.A. Cook Role of tissue digestion and extensive sperm search after microdissection testicular sperm extraction Fertil Steril 96 2011 299 302
20. D. van Saen, I. Gies, J. de Schepper, H. Tournaye, and E. Goossens Can pubertal boys with Klinefelter syndrome benefit from spermatogonial stem cell banking? Hum Reprod 27 2012 323 330
21. A.A. Dabaja, and P.N. Schlegel Microdissection testicular sperm extraction: an update Asian J Androl 15 2013 35 39
22. G.G. t'Sjoen, V.A. Giagulli, H. Delva, P. Crabbe, D. de Bacquer, and J.M. Kaufman Comparative assessment in young and elderly men of the gonadotropin response to aromatase inhibition J Clin Endocrinol Metab 90 2005 5717 5722 (Pubitemid 41415481)
23. G. Raven, F.H. de Jong, J.M. Kaufman, and W. de Ronde In men, peripheral estradiol levels directly reflect the action of estrogens at the hypothalamo-pituitary level to inhibit gonadotropin secretion J Clin Endocrinol Metab 91 2006 3324 3328 (Pubitemid 44402098)
24. J. Nielsen, B. Pelsen, and K. Sorensen Follow-up of 30 Klinefelter males treated with testosterone Clin Genet 44 1988 262 269
25. J. Nielsen, and B. Pelsen Follow-up 20 years later of 34 Klinefelter males with karyotype 47, XXY and 16 hypogonadal males with karyotype 46, XY Hum Genet 77 1987 188 192 (Pubitemid 17160067)
26. A.D. Rogol, and N. Tartaglia Considerations for androgen therapy in children and adolescents with Klinefelter syndrome (47, XXY) Pediatr Endocrinol Rev 8 Suppl 1 2010 145 150
27. K.A. Groth, N.E. Skakkebaek, C.H. Gravholt, and A. Bojesen Clinical review: Klinefelter syndrome - a clinical update J Clin Endocrinol Metab 98 2013 2012 2382
28. P.J. Simm, and M. Zacharin The psychosocial impact of Klinefelter syndrome - a 10 year review J Pediatr Endocrinol Metab 19 2006 499 505 (Pubitemid 43772793)
29. C. Wang Long-term testosterone gel (Androgel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men J Clin Endocrinol Metab 89 2004 2085 2098 (Pubitemid 38619836)
30. P. Bouloux Testim 1% testosterone gel for the treatment of male hypogonadism Clin Ther 27 2005 286 298 (Pubitemid 40692747)
31. M.S. Wosnitzer, and D.A. Paduch Endocrinological issues and hormonal manipulation in children and men with Klinefelter syndrome Am J Med Genet C Semin Med Genet 163 2013 16 26
32. M. Hero, E. Norjavaara, and L. Dunkel Inhibition of estrogen biosynthesis with a potent aromatase inhibitor increases predicted adult height in boys with idiopathic short stature: a randomized controlled trial J Clin Endocrinol Metab 90 2005 6396 6402 (Pubitemid 41759291)
33. M. Hero, S. Wickman, and L. Dunkel Treatment with the aromatase inhibitor letrozole during adolescence increases near-final height in boys with constitutional delay of puberty Clin Endocrinol (Oxf) 64 2006 510 513
34. S. Wickman, I. Sipila, C. Ankarberg-Lindgren, E. Norjavaara, and L. Dunkel A specific aromatase inhibitor and potential increase in adult height in boys with delayed puberty: a randomised controlled trial Lancet 357 2001 1743 1748 (Pubitemid 32524203)