Are adolescent boys with klinefelter syndrome androgen deficient? A longitudinal study of finnish 47,XXY boys

Pediatric Research

Volumn 59, Issue 6, 2006, Pages 854-859

  Wikström, Anne M ^a,d   Dunkel, Leo ^a,b   Wickman, Sanna ^a   Norjavaara, Ensio ^c   Ankarberg Lindgren, Carina ^c   Raivio, Taneli ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ESTRADIOL; FOLLITROPIN; GONADORELIN; GONADOTROPIN; LEPTIN; LUTEINIZING HORMONE; PROSTATE SPECIFIC ANTIGEN; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADOLESCENT; ANDROGEN DEFICIENCY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; FINLAND; FOLLITROPIN BLOOD LEVEL; FOLLOW UP; GONADOTROPIN BLOOD LEVEL; HORMONE SUBSTITUTION; HUMAN; KLINEFELTER SYNDROME; LONGITUDINAL STUDY; LUTEINIZING HORMONE BLOOD LEVEL; MALE; PRIORITY JOURNAL; PUBERTY; SCHOOL CHILD; TESTOSTERONE BLOOD LEVEL; BLOOD; GENETICS; KARYOTYPING; METABOLISM; PROSPECTIVE STUDY;

ADOLESCENT; ANDROGENS; FOLLICLE STIMULATING HORMONE; GONADOTROPIN-RELEASING HORMONE; HUMANS; KARYOTYPING; KLINEFELTER SYNDROME; LEPTIN; LUTEINIZING HORMONE; PROSPECTIVE STUDIES; PROSTATE-SPECIFIC ANTIGEN; PUBERTY; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE;

EID: 33746543213     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.pdr.0000219386.31398.c3     Document Type: Article

References (39)

1. Bojesen A, Juul S, Gravholt CH 2003 Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study. J Clin Endocrinol Metab 88:622-626
2. Lanfranco F, Kamischke A, Zitzmann M, Nieschlag E 2004 Klinefelter's syndrome. Lancet 364:273-283
3. Ratcliffe S 1999 Long-term outcome in children of sex chromosome abnormalities. Arch Dis Child 80:192-195
4. Klinefelter HF NJr., Reifenstein EC Jr, Albright F 1942 Syndrome characterized by gynecomastia, aspermatogenesis without a-Leydigism and increased excretion of follicle-stimulating hormone. J Clin Endocrin 2:615-624
5. Wikstrom AM, Raivio T, Hadziselimovic F, Wikstrom S, Tuuri T, Dunkel L 2004 Klinefelter syndrome in adolescence: onset of puberty is associated with accelerated germ cell depletion. J Clin Endocrinol Metab 89:2263-2270
6. Laron Z, Hochman IH 1971 Small testes in prepubetal boys with Klinefelter's syndrome. J Clin Endocrinol Metab 32:671-672
7. Robinson A, Bender BG, Borelli JB, Puck MH, Salbenblatt JA, Winter JS 1986 Sex chromosomal aneuploidy: prospective and longitudinal studies. Birth Defects Orig Artic Ser 22:23-71
8. Salbenblatt JA, Bender BG, Puck MH, Robinson A, Faiman C, Winter JS 1985 Pituitary-gonadal function in Klinefelter syndrome before and during puberty. Pediatr Res 19:82-86
9. Topper E, Dickerman Z, Prager-Lewin R, Kaufman H, Maimon Z, Laron Z 1982 Puberty in 24 patients with Klinefelter syndrome. Eur J Pediatr 139:8-12
10. Smyth CM, Bremner WJ 1998 Klinefelter syndrome. Arch Intern Med 158:1309-1314
11. Myhre SA, Ruvalcaba RH, Johnson HR, Thuline HC, Kelley VC 1970 The effects of testosterone treatment in Klinefelter's syndrome. J Pediatr 76:267-276
12. Nielsen J, Pelsen B, Sorensen K 1988 Follow-up of 30 Klinefelter males treated with testosterone. Clin Genet 33:262-269
13. Sorensen K 1992 Physical and mental development of adolescent males with Klinefelter syndrome. Horm Res 37:55-61
14. Patwardhan AJ, Eliez S, Bender B, Linden MG, Reiss AL 2000 Brain morphology in Klinefelter syndrome: extra X chromosome and testosterone supplementation. Neurology 54:2218-2223
15. Simpson JL, de la Cruz F, Swerdloff RS, Samango-Sprouse C, Skakkebaek NE, Graham JM Jr, Hassold T, Aylstock M, Meyer-Bahlburg HF, Willard HF, Hall JG, Salameh W, Boone K, Staessen C, Geschwind D, Giedd J, Dobs AS, Rogol A, Brinton B, Paulsen CA 2003 Klinefelter syndrome: expanding the phenotype and identifying new research directions. Genet Med 5:460-468
16. Greulich WW, Pyle SL 1959 Radiographic Atlas of Skeletal Development of the Hand and Wrist, 2nd ed. Stanford University Press, Stanford, CA, pp 97-119
17. Tanner JM 1962 Growth at Adolescence; With a General Consideration of the Effects of Hereditary and Environmental Factors upon Growth and Maturation from Birth to Maturity, 2nd ed. Blackwell, Oxford, UK, pp 22-29
18. Hansen PF, With TK 1952 Clinical measurements of testes in boys and men. Acta Med Scand 266:457-465
19. Ankarberg-Lindgren C, Norjavaara E 2004 Changes of diurnal rhythm and levels of total and free testosterone secretion from pre to late puberty in boys: testis size of 3 ml is a transition stage to puberty. Eur J Endocrinol 151:747-757
20. Ankarberg Lindgren C 2005 Testosterone and 17β-oestradiol secretion in children and adolescents: assay development, levels for comparison and clinical applications. Göteborg Pediatric Growth Research Center, Department of Pediatrics. Sahlgrenska Academy at Göteborg University, Göteborg, Sweden, pp 46-52
21. Wickman S, Sipila I, Ankarberg-Lindgren C, Norjavaara E, Dunkel L 2001 A specific aromatase inhibitor and potential increase in adult height in boys with delayed puberty: a randomised controlled trial. Lancet 357:1743-1748
22. Raivio T, Dunkel L, Wickman S, Janne OA 2004 Serum androgen bioactivity in adolescence: a longitudinal study of boys with constitutional delay of puberty. J Clin Endocrinol Metab 89:1188-1192
23. Ankarberg C, Norjavaara E 1999 Diurnal rhythm of testosterone secretion before and throughout puberty in healthy girls: correlation with 17beta-estradiol and dehydroepiandrosterone sulfate. J Clin Endocrinol Metab 84:975-984
24. Norjavaara E, Ankarberg C, Albertsson-Wikland K 1996 Diurnal rhythm of 17 beta-estradiol secretion throughout pubertal development in healthy girls: evaluation by a sensitive radioimmunoassay. J Clin Endocrinol Metab 81:4095-4102
25. Dunkel L, Alfthan H, Stenman UH, Perheentupa J 1990 Gonadal control of pulsatile secretion of luteinizing hormone and follicle-stimulating hormone in prepubertal boys evaluated by ultrasensitive time-resolved immunofluorometric assays. J Clin Endocrinol Metab 70:107-114
26. Matthews JN, Altman DG, Campbell MJ, Royston P 1990 Analysis of serial measurements in medical research. BMJ 300:230-235
27. Ojajärvi P 1982 The adolescent Finnish child, a longitudinal study of the anthropometry, physical development and physiological changes during puberty. PhD Thesis, University of Helsinki, Helsinki, Finland, pp 1-140
28. Stewart DA, Bailey JD, Netley CT, Rovet J, Park E 1986 Growth and development from early to midadolescence of children with X and Y chromosome aneuploidy: the Toronto Study. Birth Defects Orig Artic Ser 22:119-182
29. Styne DM 2002 The Testes: Disorders of Sexual Differentiation and Puberty in the Male. In: Sperling MA (ed) Pediatric Endocrinology, 2nd ed. Saunders, Philadelphia, pp 598-599
30. Lahlou N, Fennoy I, Carel JC, Roger M 2004 Inhibin B and anti-Mullerian hormone, but not testosterone levels, are normal in infants with nonmosaic Klinefelter syndrome. J Clin Endocrinol Metab 89:1864-1868
31. Ross JL, Samango-Sprouse C, Lahlou N, Kowal K, Elder FF, Zinn A 2005 Early androgen deficiency in infants and young boys with 47,XXY Klinefelter syndrome. Horm Res 64:39-45
32. Vieira JG, Nishida SK, Pereira AB, Arraes RF, Verreschi IT 1994 Serum levels of prostate-specific antigen in normal boys throughout puberty. J Clin Endocrinol Metab 78:1185-1187
33. Randell EW, Diamandis EP, Ellis G 1996 Serum prostate-specific antigen measured in children from birth to age 18 years. Clin Chem 42:420-423
34. Juul A, Muller J, Skakkebaek NE 1997 Prostate specific antigen in boys with precocious puberty before and during gonadal suppression by GnRH agonist treatment. Eur J Endocrinol 136:401-405
35. Kim MR, Gupta MK, Travers SH, Rogers DG, Van Lente F, Faiman C 1999 Serum prostate specific antigen, sex hormone binding globulin and free androgen index as markers of pubertal development in boys. Clin Endocrinol (Oxf) 50:203-210
36. Wabitsch M, Blum WF, Muche R, Braun M, Hube F, Rascher W, Heinze E, Teller W, Hauner H 1997 Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest 100:808-813
37. Garcia-Mayor RV, Andrade MA, Rios M, Lage M, Dieguez C, Casanueva FF 1997 Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage. J Clin Endocrinol Metab 82:2849-2855
38. Blum WF, Englaro P, Hanitsch S, Juul A, Hertel NT, Muller J, Skakkebaek NE, Heiman ML, Birkett M, Attanasio AM, Kiess W, Rascher W 1997 Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab 82:2904-2910
39. Ankarberg-Lindgren C, Dahlgren J, Carlsson B, Rosberg S, Carlsson L, Wikland KA, Norjavaara E 2001 Leptin levels show diurnal variation throughout puberty in healthy children, and follow a gender-specific pattern. Eur J Endocrinol 145:43-51