Prescribing patterns of hydrocortisone in septic shock: A single-center experience of how surviving sepsis guidelines are interpreted and translated into bedside practice

Critical Care Medicine

Volumn 41, Issue 10, 2013, Pages 2310-2317

  Contrael, Katlynd M ^a,b   Killian, Alley J ^a,b   Gregg, Sara R ^c   Buchman, Timothy G ^d   Coopersmith, Craig M ^d  

^a EMORY UNIVERSITY HOSPITAL   (United States)

^b MERCER UNIVERSITY   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

corticosteroids; hydrocortisone; sepsis; shock; Surviving Sepsis Campaign

Indexed keywords

ADRENALIN; DOPAMINE; HYDROCORTISONE; NORADRENALIN; PHENYLEPHRINE; VASOPRESSIN;

ARTICLE; CLINICAL PRACTICE; CORTICOSTEROID THERAPY; DISEASE DURATION; FLUID RESUSCITATION; HUMAN; INTENSIVE CARE UNIT; INTENSIVIST; MAJOR CLINICAL STUDY; MEDICAL RECORD REVIEW; PRACTICE GUIDELINE; PRESCRIPTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEPTIC SHOCK; TREATMENT RESPONSE;

ACADEMIC MEDICAL CENTERS; ANTI-INFLAMMATORY AGENTS; ATTITUDE OF HEALTH PERSONNEL; DECISION MAKING; GEORGIA; HUMANS; HYDROCORTISONE; INTENSIVE CARE UNITS; MEDICAL AUDIT; PHYSICIAN'S PRACTICE PATTERNS; PRACTICE GUIDELINES AS TOPIC; RETROSPECTIVE STUDIES; SHOCK, SEPTIC; VASOCONSTRICTOR AGENTS;

EID: 84884904287     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31828cef29     Document Type: Article

References (26)

1. Sprung CL, Caralis PV, Marcial EH, et al: The effects of high-dose corticosteroids in patients with septic shock. A prospective, controlled study. N Engl J Med 1984; 311:1137-1143 (Pubitemid 14012580)
2. Bone RC, Fisher CJ Jr, Clemmer TP, et al: A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 1987; 317:653-658 (Pubitemid 17138189)
3. Marik PE: Critical illness-related corticosteroid insufficiency. Chest 2009; 135:181-193
4. Marik PE, Pastores SM, Annane D, et al; American College of Critical Care Medicine: Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 2008; 36:1937-1949
5. Annane D, Sébille V, Charpentier C, et al: Effect of treatment with low doses of hydrocortisone and fluorocortisone on mortality in patients with septic shock. JAMA 2002; 288:862-871
6. Briegel J, Forst H, Haller M, et al: Stress doses of hydrocortisone reverse hyperdynamic septic shock: A prospective, randomized, double- blind, single-center study. Crit Care Med 1999; 27:723-732 (Pubitemid 29218204)
7. Bollaert PE, Charpentier C, Levy B, et al: Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med 1998; 26:645-650 (Pubitemid 28201409)
8. Sprung CL, Annane D, Keh D, et al; CORTICUS Study Group: Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008; 358:111-124
9. Annane D, Bellissant E, Bollaert PE, et al: Corticosteroids in the treatment of severe sepsis and septic shock in adults: A systematic review. JAMA 2009; 301:2362-2375
10. Sligl WI, Milner DA Jr, Sundar S, et al: Safety and efficacy of corticosteroids for the treatment of septic shock: A systematic review and meta-analysis. Clin Infect Dis 2009; 49:93-101
11. Patel GP, Balk RA: Systemic steroids in severe sepsis and septic shock. Am J Respir Crit Care Med 2012; 185:133-139
12. Surviving Sepsis website. Available at: http://www.survivingsepsis.org/ Pages/default.aspx. Accessed October 20, 2012
13. Dellinger RP, Carlet JM, Masur H, et al; Surviving Sepsis Campaign Management Guidelines Committee: Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004; 32:858-873 (Pubitemid 38344143)
14. Dellinger RP, Levy MM, Carlet JM, et al; International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical- Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases; European Society of Intensive Care Medicine; European Respiratory Society; International Sepsis Forum; Japanese Association for Acute Medicine; Japanese Society of Intensive Care Medicine; Society of Critical Care Medicine; Society of Hospital Medicine; Surgical Infection Society; World Federation of Societies of Intensive and Critical Care Medicine: Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008; 36:296-327
15. Dellinger RP, Levy MM, Rhodes A, et al; Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup: Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012. Crit Care Med 2013; 41:580-637
16. Levy MM, Dellinger RP, Townsend SR, et al; Surviving Sepsis Campaign: The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med 2010; 38:367-374
17. Oppert M, Schindler R, Husung C, et al: Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock. Crit Care Med 2005; 33:2457-2464 (Pubitemid 41682095)
18. Yildiz O, Doganay M, Aygen B, et al: Physiological-dose steroid therapy in sepsis [ISRCTN36253388]. Crit Care 2002; 6:251-259
19. Carpenter DL, Gregg SR, Owens DS, et al: Patient-care time allocation by nurse practitioners and physician assistants in the intensive care unit. Crit Care 2012; 16:R27
20. Rivers E, Nguyen B, Havstad S, et al; Early Goal-Directed Therapy Collaborative Group: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345:1368-1377
21. Guyatt GH, Oxman AD, Vist GE, et al; GRADE Working Group: GRADE: An emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008; 336:924-926 (Pubitemid 351632017)
22. Needham DM: Patient safety, quality of care, and knowledge translation in the intensive care unit. Respir Care 2010; 55:922-928
23. Cabana MD, Rand CS, Powe NR, et al: Why don't physicians follow clinical practice guidelines? A framework for improvement. JAMA 1999; 282:1458-1465 (Pubitemid 29493800)
24. Ilan R, Fowler RA, Geerts R, et al: Knowledge translation in critical care: Factors associated with prescription of commonly recommended best practices for critically ill patients. Crit Care Med 2007; 35:1696-1702 (Pubitemid 46985872)
25. Black MD, Schorr C, Levy MM: Knowledge translation and the multifaceted intervention in the intensive care unit. Crit Care Med 2012; 40:1324-1328
26. Brunkhorst FM, Engel C, Ragaller M, et al; German Sepsis Competence Network (SepNet): Practice and perception-A nationwide survey of therapy habits in sepsis. Crit Care Med 2008; 36:2719-2725