Brain activation patterns in women with acquired hypoactive sexual desire disorder and women with normal sexual function: A cross-sectional pilot study

Fertility and Sterility

Volumn 100, Issue 4, 2013, Pages

  Woodard, Terri L ^a   Nowak, Nicole T ^b   Balon, Richard ^c   Tancer, Manuel ^c   Diamond, Michael P ^d  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Brain activation patterns; female sexual dysfunction; functional neuroimaging; hypoactive sexual desire disorder (HSDD); sexual stimuli

Indexed keywords

ADULT; ARTICLE; BRAIN FUNCTION; CLINICAL ARTICLE; CLINICAL RESEARCH; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; FILM; HUMAN; HYPOACTIVE SEXUAL DESIRE DISORDER; INSULA; MIDDLE FRONTAL GYRUS; PARAHIPPOCAMPAL GYRUS; PILOT STUDY; PRECUNEUS; PREMENOPAUSE; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; SEXUAL FUNCTION; THALAMUS; VIDEORECORDING;

BRAIN ACTIVATION PATTERNS; FEMALE SEXUAL DYSFUNCTION; FUNCTIONAL NEUROIMAGING; HYPOACTIVE SEXUAL DESIRE DISORDER (HSDD); SEXUAL STIMULI;

ADULT; BRAIN; BRAIN MAPPING; BRAIN WAVES; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; EMOTIONS; FEMALE; HUMANS; LINEAR MODELS; MAGNETIC RESONANCE IMAGING; MALE; PHOTIC STIMULATION; PILOT PROJECTS; PREMENOPAUSE; SEX FACTORS; SEXUAL BEHAVIOR; SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL; VIDEO RECORDING; VISUAL PERCEPTION;

EID: 84884904234     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2013.05.041     Document Type: Article

References (65)

1. American Psychiatric Association Diagnostic criteria from DSM-IV-TR 2000 American Psychiatric Association Washington, DC
2. R.D. Hayes, L. Dennerstein, C.M. Bennett, and C.K. Fairley What is the "true" prevalence of female sexual dysfunctions and does the way we assess these conditions have an impact? J Sex Med 5 2008 777 787 (Pubitemid 351472187)
3. J.A. Simon Low sexual desire - is it all in her head? Pathophysiology, diagnosis, and treatment of hypoactive sexual desire disorder Postgrad Med 122 2010 128 136
4. S. Ogawa, T.M. Lee, A.S. Nayak, and P. Glynn Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields Magn Reson Med 14 1990 68 78 (Pubitemid 20243866)
5. K.K. Kwong, J.W. Belliveau, D.A. Chesler, I.E. Goldberg, R.M. Weisskoff, and B.P. Poncelet Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation Proc Natl Acad Sci USA 89 1992 5675 5679
6. P.T. Fox, and M.E. Raichle Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects Proc Natl Acad Sci USA 83 1986 1140 1144 (Pubitemid 16086428)
7. S. Ogawa, D.W. Tank, R. Menon, J.M. Ellermann, S.G. Kim, and H. Merkle Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging Proc Natl Acad Sci USA 89 1992 5951 5955
8. T.L. Woodard, and M.P. Diamond Contribution of imaging to our understanding of sexual function and dysfunction Adv Psychosom Med 29 2008 150 168
9. B.A. Arnow, L. Millheiser, A. Garrett, M. Lake Polan, G.H. Glover, and K.R. Hill Women with hypoactive sexual desire disorder compared to normal females: a functional magnetic resonance imaging study Neuroscience 158 2009 484 502
10. E.R. Gizewski, E. Krause, S. Karama, A. Baars, W. Senf, and M. Forsting There are differences in cerebral activation between females in distinct menstrual phases during viewing of erotic stimuli: a fMRI study Exp Brain Res 174 2006 101 108 (Pubitemid 44337551)
11. G.W. Jeong, K. Park, G. Youn, H.K. Kang, H.J. Kim, and J.J. Seo Assessment of cerebrocortical regions associated with sexual arousal in premenopausal and menopausal women by using BOLD-based functional MRI J Sex Med 2 2005 645 651 (Pubitemid 41742924)
12. S. Karama, A.R. Lecours, J.M. Leroux, P. Bourgouin, G. Beaudoin, and S. Joubert Areas of brain activation in males and females during viewing of erotic film excerpts Hum Brain Mapp 16 2002 1 13 (Pubitemid 34461646)
13. K.J. Park The role of functional MRI in neural assessment of female sexual dysfunction Current Sexual Health Reports 4 2007 33 40
14. F. Castelli, F. Happe, U. Frith, and C. Frith Movement and mind: a functional imaging study of perception and interpretation of complex intentional movement patterns Neuroimage 12 2000 314 325
15. F.H. Quirk, J.R. Heiman, R.C. Rosen, E. Laan, M.D. Smith, and M. Boolell Development of a sexual function questionnaire for clinical trials of female sexual dysfunction J Womens Health Gend Based Med 11 2002 277 289
16. L.R. Derogatis, R. Rosen, S. Leiblum, A. Burnett, and J. Heiman The Female Sexual Distress Scale (FSDS): initial validation of a standardized scale for assessment of sexually related personal distress in women J Sex Marital Ther 28 2002 317 330 (Pubitemid 34627829)
17. T.L. Woodard, K. Collins, M. Perez, R. Balon, M.E. Tancer, and M. Kruger What kind of erotic film clips should we use in female sex research? An exploratory study J Sex Med 5 2008 146 154
18. S.B. Eickhoff, A.R. Laird, C. Grefkes, L.E. Wang, K. Zilles, and P.T. Fox Coordinate-based activation likelihood estimation meta-analysis of neuroimaging data: a random-effects approach based on empirical estimates of spatial uncertainty Hum Brain Mapp 30 2009 2907 2926
19. J.L. Lancaster, M.G. Woldorff, L.M. Parsons, M. Liotti, C.S. Freitas, and L. Rainey Automated Talairach atlas labels for functional brain mapping Hum Brain Mapp 10 2000 120 131 (Pubitemid 30456920)
20. J.L. Lancaster, D. Tordesillas-Gutiérrez, M. Martinez, F. Salinas, A. Evans, and K. Zilles Bias between MNI and Talairach coordinates analyzed using the ICBM-152 brain template Hum Brain Mapp 28 2007 1194 1205 (Pubitemid 350077483)
21. K.J.H.A. Friston, K.J. Worsley, J.P. Poline, C.D. Frith, and R.S.J. Frackowiak Statistical parametric maps in functional imaging: a general linear approach Hum Brain Mapp 2 1994 189 210 (Pubitemid 124008664)
22. K. Park, H.K. Kang, J.J. Seo, H.J. Kim, S.B. Ryu, and G.W. Jeong Blood-oxygenation-level-dependent functional magnetic resonance imaging for evaluating cerebral regions of female sexual arousal response Urology 57 2001 1189 1194 (Pubitemid 32455605)
23. J.S. Archer, T.E. Love-Geffen, K.L. Herbst-Damm, D.A. Swinney, and J.R. Chang Effect of estradiol versus estradiol and testosterone on brain-activation patterns in postmenopausal women Menopause 13 2006 528 537
24. H.J. Kim, S.J. Eun, S.H. Cho, J.J. Seo, H.K. Kang, and K. Park Qualitative and quantitative measurement of brain activity associated with visual sexual arousal in males and females: 3.0 tesla functional MR imaging J Korean Radiol Soc 51 2004 179 190
25. J. Redouté, S. Stoléru, M.C. Grégoire, N. Costes, L. Cinotti, and F. Lavenne Brain processing of visual sexual stimuli in human males Hum Brain Mapp 11 2000 162 177
26. S. Stoléru, M.C. Grégoire, D. Gérard, J. Decety, E. Lafarge, and L. Cinotti Neuroanatomical correlates of visually evoked sexual arousal in human males Arch Sex Behav 28 1999 1 21 (Pubitemid 29100828)
27. L. Michels, U. Mehnert, S. Boy, B. Schurch, and S. Kollias The somatosensory representation of the human clitoris: an fMRI study Neuroimage 49 2010 177 184
28. B.R. Komisaruk, and B. Whipple Functional MRI of the brain during orgasm in women Annu Rev Sex Res 16 2005 62 86 (Pubitemid 43836775)
29. B.R. Komisaruk, B. Whipple, A. Crawford, W.-C. Liu, A. Kalnin, and K. Mosier Brain activation during vaginocervical self-stimulation and orgasm in women with complete spinal cord injury: fMRI evidence of mediation by the vagus nerves Brain Res 1024 2004 77 88 (Pubitemid 39286716)
30. H.D. Critchley, P. Rotshtein, Y. Nagai, J. O'Doherty, C.J. Mathias, and R.J. Dolan Activity in the human brain predicting differential heart rate responses to emotional facial expressions Neuroimage 24 2005 751 762 (Pubitemid 40094557)
31. B. Komisaruk, C. Beyer-Flores, and B. Whipple The science of orgasm 2006 Johns Hopkins University Press Baltimore
32. S. Zola-Morgan, and L.R. Squire The neuropsychology of memory: parallel findings in humans and nonhuman primates Ann NY Acad Sci 608 1990 434 450
33. J.E. LeDoux Emotional memory systems in the brain Behav Brain Res 58 1993 69 79
34. R. Basson Women's sexual dysfunction: revised and expanded definitions CMAJ 172 2005 1327 1333 (Pubitemid 40745076)
35. J.D. Bremner, M. Vythilingam, E. Vermetten, S.M. Southwick, T. McGlashan, and A. Nazeer MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder Am J Psychiatry 160 2003 924 932 (Pubitemid 41079578)
36. J.D. Schmahmann, and D. Caplan Cognition, emotion and the cerebellum Brain 129 2006 290 292
37. J.D. Schmahmann The role of the cerebellum in cognition and emotion: personal reflections since 1982 on the dysmetria of thought hypothesis, and its historical evolution from theory to therapy Neuropsychol Rev 20 2010 236 260
38. B.M. Turner, S. Paradiso, C.L. Marvel, R. Pierson, L.L. Boles Ponto, and R.D. Hichwa The cerebellum and emotional experience Neuropsychologia 45 2007 1331 1341 (Pubitemid 46072903)
39. M. Beauregard, J. Levesque, and P. Bourgouin Neural correlates of conscious self-regulation of emotion J Neurosci 21 2001 RC165
40. H. Garavan, J. Pankiewicz, A. Bloom, J.K. Cho, L. Sperry, and T.J. Ross Cue-induced cocaine craving: neuroanatomical specificity for drug users and drug stimuli Am J Psychiatry 157 2000 1789 1798
41. A. Tsujimura, Y. Miyagawa, K. Fujita, Y. Matsuoka, T. Takahashi, and T. Takao Brain processing of audiovisual sexual stimuli inducing penile erection: a positron emission tomography study J Urol 176 2006 679 683 (Pubitemid 43927891)
42. D.A. Gusnard, E. Akbudak, G.L. Shulman, and M.E. Raichle Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function Proc Natl Acad Sci USA 98 2001 4259 4264 (Pubitemid 32249932)
43. S.C. Johnson, L.C. Baxter, L.S. Wilder, J.G. Pipe, J.E. Heiserman, and G.P. Prigatano Neural correlates of self-reflection Brain 125 2002 1808 1814
44. W.H.J.V. Masters Human sexual inadequacy 1970 Little, Brown New York
45. Y. Miyagawa, A. Tsujimura, K. Fujita, Y. Matsuoka, T. Takahashi, and T. Takao Differential brain processing of audiovisual sexual stimuli in men: comparative positron emission tomography study of the initiation and maintenance of penile erection during sexual arousal Neuroimage 36 2007 830 842 (Pubitemid 46907631)
46. C.S. Weston Another major function of the anterior cingulate cortex: the representation of requirements Neurosci Biobehav Rev 36 2012 90 110
47. D. Ebert, and K.P. Ebmeier The role of the cingulate gyrus in depression: from functional anatomy to neurochemistry Biol Psychiatry 39 1996 1044 1050 (Pubitemid 26191353)
48. S.L. Rauch, M.A. Jenike, N.M. Alpert, L. Baer, H.C. Breiter, and C.R. Savage Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography Arch Gen Psychiatry 51 1994 62 70 (Pubitemid 24028999)
49. M. Yucel, S.J. Wood, A. Fornito, J. Riffkin, D. Velakoulis, and C. Pantelis Anterior cingulate dysfunction: implications for psychiatric disorders? J Psychiatry Neurosci 28 2003 350 354 (Pubitemid 37211277)
50. S. Hamann, R.A. Herman, C.L. Nolan, and K. Wallen Men and women differ in amygdala response to visual sexual stimuli Nat Neurosci 7 2004 411 416 (Pubitemid 38429182)
51. A. Ferretti, M. Caulo, C. Del Gratta, R. Di Matteo, A. Merla, and F. Montorsi Dynamics of male sexual arousal: distinct components of brain activation revealed by fMRI Neuroimage 26 2005 1086 1096 (Pubitemid 40806487)
52. A.K. Anderson, K. Christoff, D. Panitz, E. De Rosa, and J.D.E. Gabrieli Neural correlates of the automatic processing of threat facial signals J Neurosci 23 2003 5627 5633 (Pubitemid 36807840)
53. T. Canli, Z. Zhao, J. Brewer, J.D. Gabrieli, and L. Cahill Event-related activation in the human amygdala associates with later memory for individual emotional experience J Neurosci 20 2000 RC99
54. S.L. Rauch, L.M. Shin, and C.I. Wright Neuroimaging studies of amygdala function in anxiety disorders Ann NY Acad Sci 985 2003 389 410 (Pubitemid 36521129)
55. R.D. Lane, E.M. Reiman, G.L. Ahern, G.E. Schwartz, and R.J. Davidson Neuroanatomical correlates of happiness, sadness, and disgust Am J Psychiatry 154 1997 926 933 (Pubitemid 27274534)
56. K. Park, J.J. Seo, H.K. Kang, S.B. Ryu, H.J. Kim, and G.W. Jeong A new potential of blood oxygenation level dependent (BOLD) functional MRI for evaluating cerebral centers of penile erection Int J Impot Res 13 2001 73 81 (Pubitemid 32506075)
57. T. Sundaram, G.W. Jeong, T.H. Kim, G.W. Kim, H.S. Baek, and H.K. Kang Time-course analysis of the neuroanatomical correlates of sexual arousal evoked by erotic video stimuli in healthy males Korean J Radiol 11 2010 278 285
58. J.C. Yang, K. Park, S.J. Eun, M.S. Lee, J.S. Yoon, and I.S. Shin Assessment of cerebrocortical areas associated with sexual arousal in depressive women using functional MR imaging J Sex Med 5 2008 602 609 (Pubitemid 351337886)
59. B.N. Lundstrom, K.M. Petersson, J. Andersson, M. Johansson, P. Fransson, and M. Ingvar Isolating the retrieval of imagined pictures during episodic memory: activation of the left precuneus and left prefrontal cortex Neuroimage 20 2003 1934 1943 (Pubitemid 37543612)
60. H.C. Lou, B. Luber, M. Crupain, J.P. Keenan, M. Nowak, and T.W. Kjaer Parietal cortex and representation of the mental Self Proc Natl Acad Sci USA 101 2004 6827 6832 (Pubitemid 38586059)
61. B.N. Lundstrom, M. Ingvar, and K.M. Petersson The role of precuneus and left inferior frontal cortex during source memory episodic retrieval Neuroimage 27 2005 824 834 (Pubitemid 41317252)
62. X. Zhu, X. Wang, C. Parkinson, C. Cai, S. Gao, and P. Hu Brain activation evoked by erotic films varies with different menstrual phases: an fMRI study Behav Brain Res 206 2010 279 285
63. H.A. Rupp, T.W. James, E.D. Ketterson, D.R. Sengelaub, E. Janssen, and J.R. Heiman Neural activation in the orbitofrontal cortex in response to male faces increases during the follicular phase Horm Behav 56 2009 66 72
64. B. Abler, D. Kumpfmuller, G. Gron, M. Walter, J. Stingl, and A. Seeringer Neural correlates of erotic stimulation under different levels of female sexual hormones PloS one 8 2013 e54447
65. S.R. Davis, S.L. Davison, S. Donath, and R.J. Bell Circulating androgen levels and self-reported sexual function in women JAMA 294 2005 91 96 (Pubitemid 41002843)