Neural Correlates of Erotic Stimulation under Different Levels of Female Sexual Hormones

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Abler, Birgit ^a   Kumpfmüller, Daniela ^a   Grön, Georg ^a   Walter, Martin ^b   Stingl, Julia ^a   Seeringer, Angela ^a  

^a UNIVERSITY OF ULM   (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORMADINONE ACETATE PLUS ETHINYLESTRADIOL; DESOGESTREL PLUS ETHINYLESTRADIOL; DIENOGEST PLUS ETHINYLESTRADIOL; DROSPIRENONE PLUS ETHINYLESTRADIOL; ESTROGEN; ETHINYLESTRADIOL PLUS LEVONORGESTREL; PLACEBO; PROGESTERONE; SEX HORMONE;

ADULT; ARTICLE; BRAIN FUNCTION; BRAIN REGION; CONTROLLED STUDY; CORRELATIONAL STUDY; EROTISM; ESTROGEN BLOOD LEVEL; EXECUTIVE FUNCTION; FEMALE; FOLLICULAR PHASE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEMODYNAMICS; HORMONAL CONTRACEPTION; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; IMAGE ANALYSIS; LUTEAL PHASE; NERVE STIMULATION; NEUROMODULATION; NORMAL HUMAN; PHOTOGRAPHY; PRIMARY MOTOR CORTEX; PROGESTERONE BLOOD LEVEL; SEXUAL AROUSAL; SEXUAL BEHAVIOR; STIMULUS RESPONSE; TASK PERFORMANCE; VIDEORECORDING; VISUAL STIMULATION;

ADULT; BRAIN; BRAIN MAPPING; CONTRACEPTIVES, ORAL, HORMONAL; EROTICA; ESTROGENS; FEMALE; FUNCTIONAL NEUROIMAGING; HUMANS; MAGNETIC RESONANCE IMAGING; PHOTIC STIMULATION; PROGESTERONE; SEXUAL BEHAVIOR;

EID: 84873920518     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054447     Document Type: Article

References (52)

1. Stuckey BG, (2008) Female sexual function and dysfunction in the reproductive years: the influence of endogenous and exogenous sex hormones. J Sex Med 5: 2282-2290.
2. Pillsworth EG, Haselton MG, Buss DM, (2004) Ovulatory shifts in female sexual desire. J Sex Res 41: 55-65.
3. Wilcox AJ, Baird DD, Dunson DB, McConnaughey DR, Kesner JS, et al. (2004) On the frequency of intercourse around ovulation: evidence for biological influences. Hum Reprod 19: 1539-1543.
4. Bancroft J, Sanders D, Davidson D, Warner P, (1983) Mood, sexuality, hormones, and the menstrual cycle. III. Sexuality and the role of androgens. Psychosom Med 45: 509-516.
5. Schaffir J, (2006) Hormonal contraception and sexual desire: a critical review. J Sex Marital Ther 32: 305-314.
6. Trussell J, Westoff CF, (1980) Contraceptive practice and trends in coital frequency. Fam Plann Perspect 12: 246-249.
7. Dennerstein L, Burrows G, (1976) Oral contraception and sexuality. Med J Aust 1: 796-798.
8. Davis AR, Castano PM, (2004) Oral contraceptives and libido in women. Annu Rev Sex Res 15: 297-320.
9. Bancroft J, Sherwin BB, Alexander GM, Davidson DW, Walker A, (1991) Oral contraceptives, androgens, and the sexuality of young women: II. The role of androgens. Arch Sex Behav 20: 121-135.
10. Hamann S, Herman RA, Nolan CL, Wallen K, (2004) Men and women differ in amygdala response to visual sexual stimuli. Nat Neurosci 7: 411-416.
11. Karama S, Lecours AR, Leroux JM, Bourgouin P, Beaudoin G, et al. (2002) Areas of brain activation in males and females during viewing of erotic film excerpts. Hum Brain Mapp 16: 1-13.
12. Pfaus JG, (2009) Pathways of sexual desire. J Sex Med 6: 1506-1533.
13. Kuhn S, Gallinat J, (2011) A quantitative meta-analysis on cue-induced male sexual arousal. J Sex Med 8: 2269-2275.
14. Gizewski ER, Krause E, Karama S, Baars A, Senf W, et al. (2006) There are differences in cerebral activation between females in distinct menstrual phases during viewing of erotic stimuli: A fMRI study. Exp Brain Res 174: 101-108.
15. Archer JS, Love-Geffen TE, Herbst-Damm KL, Swinney DA, Chang JR, (2006) Effect of estradiol versus estradiol and testosterone on brain-activation patterns in postmenopausal women. Menopause 13: 528-537.
16. Zhu X, Wang X, Parkinson C, Cai C, Gao S, et al. (2010) Brain activation evoked by erotic films varies with different menstrual phases: an fMRI study. Behav Brain Res 206: 279-285.
17. Goldstein JM, Jerram M, Poldrack R, Ahern T, Kennedy DN, et al. (2005) Hormonal cycle modulates arousal circuitry in women using functional magnetic resonance imaging. J Neurosci 25: 9309-9316.
18. Dreher JC, Schmidt PJ, Kohn P, Furman D, Rubinow D, et al. (2007) Menstrual cycle phase modulates reward-related neural function in women. Proc Natl Acad Sci U S A 104: 2465-2470.
19. Abler B, Seeringer A, Hartmann A, Gron G, Metzger C, et al. (2011) Neural correlates of antidepressant-related sexual dysfunction: a placebo-controlled FMRI study on healthy males under subchronic paroxetine and bupropion. Neuropsychopharmacology 36: 1837-1847.
20. Kessler RC, Berglund P, Demler O, Jin R, Koretz D, et al. (2003) The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). Jama 289: 3095-3105.
21. Walter M, Stadler J, Tempelmann C, Speck O, Northoff G, (2008) High resolution fMRI of subcortical regions during visual erotic stimulation at 7 T. Magma. 21: 103-111.
22. Georgiadis JR, Kringelbach ML, (2012) The human sexual response cycle: brain imaging evidence linking sex to other pleasures. Prog Neurobiol 98: 49-81.
23. Klucken T, Schweckendiek J, Merz CJ, Tabbert K, Walter B, et al. (2009) Neural activations of the acquisition of conditioned sexual arousal: effects of contingency awareness and sex. J Sex Med 6: 3071-3085.
24. Reinecke A, Schöps D, Hoyer J, (2006) Sexuelle Dysfunktionen bei Patienten einer verhaltenstherapeutischen Hochschulambulanz: Häufigkeit, Erkennen, Behandlung. Verhaltenstherapie 16: 166-172.
25. Labbate LA, Lare SB, (2001) Sexual Dysfunction in Male Psychiatric Outpatients: Validity of the Massachusetts General Hospital Sexual Functioning Questionnaire. Psychotherapy and Psychosomatics 70: 221-225.
26. Radloff LS, (1977) The CES-D scale: A self-report depression scale for research in the general population. Appl Psychol Measurement 1: 385-401.
27. Hautzinger M, Bailer M (1993) Allgemeine Depressionsskala (ADS). Weinheim: Beltz.
28. Lang PJ, Bradley MM, Cuthbert BN (2008) International affective picture system (IAPS): Affective ratings of pictures and instruction manual. Technical Report A-8. University of Florida, Gainesville, FL.
29. Naidich TP, Duvernoy HM, Delman BN, Sorensen AG, Kollias SS, et al. (2008) Duvernoy's Atlas of the Human Brain Stem and Cerebellum: High-Field MRI, Surface Anatomy, Internal Structure, Vascularization and 3 D Sectional Anatomy: Springer.
30. Talairach J, Tournoux P (1988) Co-planar stereotaxic atlas of the human brain. Stuttgart: Thieme.
31. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH, (2003) An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 19: 1233-1239.
32. Friston KJ, Penny WD, Glaser DE, (2005) Conjunction revisited. Neuroimage 25: 661-667.
33. Ferretti A, Caulo M, Del Gratta C, Di Matteo R, Merla A, et al. (2005) Dynamics of male sexual arousal: distinct components of brain activation revealed by fMRI. Neuroimage 26: 1086-1096.
34. Mouras H, Stoleru S, Bittoun J, Glutron D, Pelegrini-Issac M, et al. (2003) Brain processing of visual sexual stimuli in healthy men: a functional magnetic resonance imaging study. Neuroimage 20: 855-869.
35. Redoute J, Stoleru S, Gregoire MC, Costes N, Cinotti L, et al. (2000) Brain processing of visual sexual stimuli in human males. Hum Brain Mapp 11: 162-177.
36. Walter M, Bermpohl F, Mouras H, Schiltz K, Tempelmann C, et al. (2008) Distinguishing specific sexual and general emotional effects in fMRI-subcortical and cortical arousal during erotic picture viewing. Neuroimage 40: 1482-1494.
37. Rupp HA, Wallen K, (2009) Sex-specific content preferences for visual sexual stimuli. Arch Sex Behav 38: 417-426.
38. Wallen K, Rupp HA, (2010) Women's exposure in visual sexual stimuli varies with menstrual cycle phase at first exposure and predicts later interest. Horm Behav 57: 263-268.
39. Rupp HA, Wallen K, (2007) Sex differences in viewing sexual stimuli: an eye-tracking study in men and women. Horm Behav 51: 524-533.
40. Rumberg B, Baars A, Fiebach J, Ladd ME, Forsting M, et al. (2010) Cycle and gender-specific cerebral activation during a verb generation task using fMRI: comparison of women in different cycle phases, under oral contraception, and men. Neurosci Res 66: 366-371.
41. MacLusky NJ, Clark AS, Naftolin F, Goldman-Rakic PS, (1987) Estrogen formation in the mammalian brain: possible role of aromatase in sexual differentiation of the hippocampus and neocortex. Steroids 50: 459-474.
42. Goldstein JM, Seidman LJ, Horton NJ, Makris N, Kennedy DN, et al. (2001) Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging. Cereb Cortex 11: 490-497.
43. Arnow BA, Desmond JE, Banner LL, Glover GH, Solomon A, et al. (2002) Brain activation and sexual arousal in healthy, heterosexual males. Brain 125: 1014-1023.
44. Rupp HA, James TW, Ketterson ED, Sengelaub DR, Janssen E, et al. (2009) Neural Activation in Women in Response to Masculinized Male Faces: Mediation by Hormones and Psychosexual Factors. Evol Hum Behav 30: 1-10.
45. Ruby P, Decety J, (2001) Effect of subjective perspective taking during simulation of action: a PET investigation of agency. Nat Neurosci 4: 546-550.
46. Sugiura M, Sassa Y, Jeong H, Horie K, Sato S, et al. (2008) Face-specific and domain-general characteristics of cortical responses during self-recognition. Neuroimage 42: 414-422.
47. Bianchi-Demicheli F, Ortigue S, (2009) Mental representation of subjective pleasure of partnered experiences in women's brain conveyed through event-related fMRI. Med Sci Monit 15: CR545-550.
48. Walter M, Matthia C, Wiebking C, Rotte M, Tempelmann C, et al. (2009) Preceding attention and the dorsomedial prefrontal cortex: process specificity versus domain dependence. Hum Brain Mapp 30: 312-326.
49. Gusnard DA, Akbudak E, Shulman GL, Raichle ME, (2001) Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc Natl Acad Sci U S A 98: 4259-4264.
50. Phan KL, Taylor SF, Welsh RC, Ho SH, Britton JC, et al. (2004) Neural correlates of individual ratings of emotional salience: a trial-related fMRI study. Neuroimage 21: 768-780.
51. Moulier V, Mouras H, Pelegrini-Issac M, Glutron D, Rouxel R, et al. (2006) Neuroanatomical correlates of penile erection evoked by photographic stimuli in human males. Neuroimage 33: 689-699.
52. Georgiadis JR, Farrell MJ, Boessen R, Denton DA, Gavrilescu M, et al. (2010) Dynamic subcortical blood flow during male sexual activity with ecological validity: a perfusion fMRI study. Neuroimage 50: 208-216.