A proof-of-concept study of the effect of a novel H3-receptor antagonist in allergen-induced nasal congestion

Journal of Allergy and Clinical Immunology

Volumn 132, Issue 4, 2013, Pages

  Barchuk, William T ^a   Salapatek, Anne Marie ^b   Ge, Tingting ^a   D'Angelo, Pina ^c   Liu, Xuejun ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^b MCMASTER UNIVERSITY   (Canada)

^c Cetero Research   (Canada)

Author keywords

acoustic rhinometry; Allergic rhinitis; environmental exposure chamber; JNJ 39220675; pseudoephedrine; total nasal symptom scores

Indexed keywords

HISTAMINE H3 RECEPTOR ANTAGONIST; JNJ 39220675; PLACEBO; PSEUDOEPHEDRINE; RAGWEED ANTIGEN; UNCLASSIFIED DRUG;

ACOUSTIC RHINOMETRY; ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; CROSSOVER PROCEDURE; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FATALITY; DRUG INDUCED HEADACHE; DRUG SAFETY; ELECTROCARDIOGRAPHY; FEMALE; HUMAN; INSOMNIA; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; NASAL PATENCY; NAUSEA; NOSE; NOSE ALLERGY; NOSE CAVITY; NOSE OBSTRUCTION; PHASE 2 CLINICAL TRIAL; POLLEN ALLERGY; PRIORITY JOURNAL; RAGWEED; RAGWEED ALLERGY; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SIDE EFFECT; SINGLE BLIND PROCEDURE; SINGLE DRUG DOSE; SYMPTOM; TOTAL NASAL SYMPTOM SCORE; TREATMENT OUTCOME; VITAL SIGN;

EID: 84884900745     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.05.001     Document Type: Article

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