Patient Activation through Counseling and Exercise - Acute Leukemia (PACE-AL) - a randomized controlled trial

BMC Cancer

Volumn 13, Issue , 2013, Pages

  Jarden, Mary ^a,b   Møller, Tom ^a,b   Kjeldsen, Lars ^a,b   Birgens, Henrik ^b,c   Christensen, Jesper F ^a,b   Bang Christensen, Karl ^b,d   Diderichsen, Finn ^b,d   Hendriksen, Carsten ^b,d   Adamsen, Lis ^a,b,d  

^a University of Copenhagen   (Denmark)

^b Centre for Integrated Rehabilitation of Cancer Patients (CIRE)   (Denmark)

^c GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Acute leukemia; Cancer; Chemotherapy; Exercise; Health counseling; Outpatient management; Physical and functional capacity; Qualitative evaluation; Quality of life; Randomised controlled trial; Symptoms

Indexed keywords

ACUTE LEUKEMIA; AEROBIC EXERCISE; ARTICLE; BICYCLE ERGOMETER; BODY MASS; CANCER PATIENT; CANCER RECURRENCE; CANCER REHABILITATION; CANCER SURVIVAL; CLINICAL PRACTICE; CONSOLIDATION CHEMOTHERAPY; CONTROLLED STUDY; DIET; EXERCISE; FEMALE; FUNCTIONAL STATUS; HEALTH BEHAVIOR; HEALTH PROGRAM; HEALTH PROMOTION; HUMAN; INDUCTION CHEMOTHERAPY; INTERVENTION STUDY; MAJOR CLINICAL STUDY; MOTIVATION; MULTICENTER STUDY; MUSCLE STRENGTH; NONHUMAN; OUTCOME ASSESSMENT; PATIENT COUNSELING; PERSONAL EXPERIENCE; PHYSICAL ACTIVITY; PRACTICE GUIDELINE; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RELAXATION TRAINING; RISK FACTOR; SOCIAL NETWORK; WALKING SPEED; WEIGHT LIFTING;

CASE-CONTROL STUDIES; CLINICAL PROTOCOLS; DIRECTIVE COUNSELING; EXERCISE; EXERCISE THERAPY; HUMANS; LEUKEMIA, MYELOID, ACUTE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA;

EID: 84884897585     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-446     Document Type: Article

References (76)

1. Dohner H, Estey E, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010, 115:453-474. 10.1182/blood-2009-07-235358, 19880497.
2. Rubinitz JE, Gibson B, Smith FO. Acute myeloid leukemia. Hematol Oncol Clin North Am 2010, 24:35-63. 10.1016/j.hoc.2009.11.008, 20113895.
3. The Danish National Acute Leukemia Registry Annual Report 2000-2011 https://www.sundhed.dk/content/cms/64/1864_algrapport2011.pdf.
4. Grigoropoulos N, Petter R, Van t Veer M, Scott M, Follows G. Leukaemia update. Part 2: managing patients with leukaemia in the community. BMJ 2013, 346:f1932. published 9 April 2013, 10.1136/bmj.f1932, 23571739.
5. Malihi Z, Kandiah M, Chan YM, Hosseinzadeh M, Sohanaki Azad M, Zarif Yeganeh M. Nutritional status and quality of life in patients with acute leukemia prior to and after induction chemotherapy in three hospitals in Tehran, Iran: a prospective study. J Hum Nutr Diet 2013, doi:10.1111/jhn.12043. Epub ahead of print.
6. Johnsen A, Tholstrup D, Petersen M, Pedersen L, Groenvold M. Health related quality of life in a nationally representative sample of haematological patients. Euro J Haematol 2009, 83:139-148.
7. Zimmermann C, Yuen D, Mischitelle A, Minden MD, Brandwein JM, Schimmer A, Gagliese L, Lo C, Rydall A, Rodin G. Symptom burden and supportive care in patients with acute leukemia. Leuk Res 2013, doi:10.1016/j.leukres.2013.02.009. Epub ahead of print.
8. Deschler B, Ihorst G, Platzbecker U, Germing U, Marz E, de FM, et al. Parameters detected by geriatric and quality of life assessments in 195 older patients with myeloplastic syndromes and acute myelodysplastic syndromes and acute myeloid leukemia are highly predictive for outcome. Haematologica 2013, 98:208-216. 10.3324/haematol.2012.067892, 3561427, 22875615.
9. Jarden M, Kjeldsen L, Birgins H, Stensen M, Sørensen V, Christiansen J, Tolver A, Adamsen L, Møller T. The emerging role of exercise and health counseling in patients with acute leukemia during outpatient management. Leuk Res 2013, 37(2):155-161. 10.1016/j.leukres.2012.09.001. Epub 2012 Sep 27, 10.1016/j.leukres.2012.09.001, 23021021.
10. Santos FR, Kozasa EH, Chauffaille Mde L, Colleoni GW, Leite JR. Psychosocial adaptation and quality of life among Brazilian patients with different hematological malignancies. J Psychosom Res 2006, 60:505-511. 10.1016/j.jpsychores.2005.08.017, 16650591.
11. Pamuk GE, Harmandar F, Ermantaş N, Harmandar O, Turgut B, Demir M, Vural O. EORTC QLQ-C30 assessment in Turkish patients with hematological malignancies: association with anxiety and depression. Ann Hematol 2008, 87:305-310. 10.1007/s00277-008-0445-4, 18219486.
12. Møller T, Adamsen L, Appel C, Welinder P, Stage M, Jarden M, Hjerming M, Kjeldsen L. Health related quality of life and impact of infectious comorbidity in outpatient management of patients with acute leukemia. Leuk Lymphoma 2012, Epub ahead of print.
13. Savoie ML, Nevil TJ, Song KW, Forrest DL, Hogge DE, Nantel SH, Shepherd JD, Smith CA, Sutherland HJ, Toze CL, Lavoie JC. Shifting to outpatient management of acute myeloid leukemia: a prospective experience. Ann Oncol 2006, 17:763-768. 10.1093/annonc/mdl011, 16497826.
14. Møller T, Nielsen OJ, Welinder P, Dünweber A, Hjerming M, Moser C, Kjeldsen L. Safe and feasible outpatient treatment following induction and consolidation chemotherapy for patients with acute leukaemia. Eur J Haematol 2009, 84:316-322.
15. Greene J, Hibbard J. Why does parient activation matter? an examination of the relationships between patient activation and health-related outcomes. j gen intern med 2011, 27(5):520-526.
16. Foster C, Fenlon D. Recovery and self-management support following primary cancer treatment. Br J Cancer 2011, 105(Suppl 1):S21-S28. 3251956, 22048029.
17. Hibbard J, Greene J, Tusler M. Improving the outcomes of disease management by tailoring care to the patient's level of activation. Am J Manag Care 2009, 15(6):353-360.
18. Courneya KS, Friedenreich CM. Physical activity and cancer: an introduction. Recent Results Cancer Res 2011, 186:1-10.
19. Speck R, Courneya K, Mass L, Duval S, Schmitz KH. An update of controlled physical activity trials in cancer survivors: a systematic and meta-analysis. J Cancer Surviv 2010, 4:87-100. 10.1007/s11764-009-0110-5, 20052559.
20. Brown J, Huedo-Medina T, Pescatello L, Pescatello S, Ferrer R, Johnson B. Efficacy of exercise interventions in modulating cancer-related fatigue among adult cancer survivors: a meta-analysis. Cancer Epidemiol Biomarkers Prev 2011, 20:123-133. 10.1158/1055-9965.EPI-10-0988, 21051654.
21. Adamsen L, Quist M, Andersen C, et al. Effect of a multimodal high intensity exercise intervention in cancer patients undergoing chemotherapy. A randomized controlled trial. BMJ 2009, 339:b3410. 10.1136/bmj.b3410, 2762035, 19826172.
22. Battaglini CL. Physical activity and hematological cancer survivorship. Recent Results Cancer Res 2011, 186:275-304.
23. Chang PH, Lai YH, Shun SC, Lin LY, Chen ML, Yang Y, Tsai JC, Huang GS, Cheng SY. Effects of a walking intervention on fatigue-related experiences of hospitalized acute mylogenous leukemia patients undergoing chemotherapy: randomized controlled trial. J PainSymptom Manage 2008, 35:524-534.
24. Battaglini CL, Hackney AC, Garcia R, Groff D, Evans E, Shea T. The effects of an exercise program in leukemia patients. Integr Cancer Ther 2009, 8:130-138. 10.1177/1534735409334266, 19679621.
25. Alibhai S, O'Neill S, Fisher-Schlombs K, Breunis H, Brandwein JM, Timilshina N, Tomlinson G, Klepin H, Culos-Reed SN. A clinical trial of supervised exercise for adult inpatients with acute myeloid leukemia (AML) undergoing induction chemotherapy. Leuk Res 2012, 36:1255-1261. 10.1016/j.leukres.2012.05.016, 3767429, 22726923.
26. Elter T, Stipanov M, Heuser E, von Bergwelt-Baildon M, Bloch W, Hallek M, Baumann F. Is physical exercise possible in patients with critical cytopenia undergoing intensive chemotherapy for acute leukaemia or aggressive lymphoma?. Int J Hematol 2009, 90:199-204. 10.1007/s12185-009-0376-4, 19629631.
27. Thorhauge C. Danish data protection agency open up for sensitive data on the Internet http://www.computerworld.dk/art/64111/registertilsynet-aabner-for-foelsomme-data-paa-internet.
28. Humphries B, Dugan EL, Doyle TLA. Muscular fitness. American College of Sports Medicine. ACSM's Resource Manual For Guidelines For Exercise Testing and Prescription 2006, 206-224. Philadelphia: Lippincott Williams & Wilkins, 5.
29. Bandura A. Health promotion by social cognitive means. Health Educ Behav 2004, 31:143-164. 10.1177/1090198104263660, 15090118.
30. Aizen I. The theory of planned behaviour. Organ Behav Hum Decis Process 1991, 50:179-211.
31. Jonas S. On clinician engagement and counseling. ACSM's Exercise Is Medicine: A Clinician's Guide to Exercise Prescription 2009, 13-19. Philadelphia: Lippincott Williams & Wilkins, Jonas S, Phillips E.
32. Jonas S. Mobilizing motivation: the wellness pathway and Behavior Change Pyramid. ACSM's Exercise Is Medicine: A Clinician's Guide to Exercise Prescription 2009, 61-69. Philadelphia: Lippincott Williams & Wilkins, Jonas S, Phillips E.
33. Jonas S. Mobilizing motivation: behavior change pyramid. ACSM's Exercise Is Medicine: A Clinician's Guide to Exercise Prescription 2009, 70-83. Philadelphia: Lippincott Williams & Wilkins, Jonas S, Phillips E.
34. Rollnick S, Miller WR, Butler C. Motivational interviewing in health care: helping patients change behavior 2008, New York: Guilford Press.
35. Phillips E, Capell J. The exercise prescription. ACSM's Exercise Is Medicine: A Clinician's Guide to Exercise Prescription 2009, 99-133. Philadelphia: Lippincott Williams & Wilkins, Jonas S, Phillips E.
36. Borg G. Borg's Perceived Exertion and Pain scales 1998, Champaign, IL: Human Kinetics.
37. Ainsworth BE, Haskell WL, Whitt MC, et al. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 2000, 498-516.
38. Kim SD, Kim HS. Effects of a relaxation breathing exercise on fatigue in haemopoietic stem cell transplantation patients. J Clin Nurs 2005, 14:51-55. 10.1111/j.1365-2702.2004.00938.x, 15656848.
39. Jacobsen E. Progressive relaxation: a physiological and clinical investigation of muscular states and their significance in psychology and medical practice 1938, Chicago: University of Chicago Press.
40. Sang-Dol Effects of a relaxation breathing exercise on fatigue in haemopoietic stem cell transplantation patients. J Clin Nurs 2005, 14(1):51-55. 10.1111/j.1365-2702.2004.00938.x, 15656848, Sang-Dol.
41. Suzuki M. Glycemic carbohydrates consumed with amino acids or protein right after exercise enhance muscle formation. Nutr Rev 2003, 61:588-594.
42. Koopman R, Saris WH, Wagenmakers AJ, van Loon LJ. Nutritional interventions to promote post-exericse muscle protein synthesis. Sports Med 2007, 37(10):895-906. 10.2165/00007256-200737100-00005, 17887813.
43. Prochaska JO, DiClemente CC, Norcross JC. In search of how people change: applications to addictive behaviors. Am Psychol 1992, 47(9):1102-1114.
44. Bravata DM, Smith-Spangler C, Sundaram V, Gienger AL, Lin N, Lewis R, Stave CD, Olkin I, Sirard JR. Using pedometers to increase physical activity and improve health: a systematic review. JAMA 2007, 298:2296-2304. 10.1001/jama.298.19.2296, 18029834.
45. Crapo R, Casaburi R, Coates A, et al. ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002, 166:111-117.
46. ATS statement: guidelines for the six-minute walk test. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. Am J Respir Crit Care Med 2002, 166(1):111.
47. Enright P. The six minute walk test. Respir Care 2003, 48(8):783-785.
48. Aastrand PO, Rodahl K, Dahl HA, Strømme SB. Evaluation of physical performance on the basis of tests. Textbook of work physiology: physiological bases of exercise 2003, 273-297. Champaign: Human Kinetics, 4, 333-364.
49. Jones CJ, Rikli RE, Beam W. A 30-s chair-stand test as a measure of lower body strength in community-residing older adults. Res Q Exerc Sport 1999, 70:113-119. 10.1080/02701367.1999.10608028, 10380242.
50. Osness WH, Adrian M, Clark B, Hoeger W, Raab D, Wisnell R. Functional fitness assessment for adults over 60 years (a field based assessment) 1990, Reston, VA: American Alliance for Health. Physical Education Recreation and Dance (AAHPRED).
51. Yellen SB, Cella DF, Webster K, Blendowski C, Kaplan E. Measuring fatigue and other anemia-related symptoms with the Functional assessment of Cancer Therapy (FACT) measurement system. J Pain Symptom Manage 1997, 13:63-74.
52. Ware JE JR, Sherbourne CD. The MOS 36-item short-form health survey (SF-36) I: conceptual framework and item selection. Med Care 1992, 30:473-483. 10.1097/00005650-199206000-00002, 1593914.
53. Aaronson NK, Ahmedzai S, Bergman B, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: quality-og-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993, 85:365-376. 10.1093/jnci/85.5.365, 8433390.
54. Grønvold M, Klee M, Sprangers MAG, Aaronson NK. Validation of the EORTC QLQ-C30 quality of life questionnaire through combined qualitative and quantitative assessment of patient-observer agreement. J Clin Epidemiol 1997, 50:441-450EORTC.
55. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983, 67:361-370. 10.1111/j.1600-0447.1983.tb09716.x, 6880820.
56. Cleeland CS, Mendoza TR, Wang XS, Chou C, Harle MT, Morrissey M, Engstrom MC. Assessing symptom distress in cancer: the M.D. Anderson Symptoms Inventory. Cancer 2000, 89:1634-1646. 10.1002/1097-0142(20001001)89:7<1634::AID-CNCR29>3.0.CO;2-V, 11013380.
57. Mendoza TR, Wang XS, Cleeland CS, Morrissey M, Johnson BA, Wendt JK, Huber SL. The rapid assessment of fatigue severity in cancer patients: use of the Brief Fatigue Inventory. Cancer 1999, 85(5):1186-1196. 10.1002/(SICI)1097-0142(19990301)85:5<1186::AID-CNCR24>3.0.CO;2-N, 10091805.
58. Saltin B, Grimby G. Physiological analysis of middle-aged and old former athletes: comparison with still active athletes of the same ages. Circulation 1968, 38:1104-1115. 10.1161/01.CIR.38.6.1104, 5721960.
59. Andersen L, Groenvold M, Jørgensen T, Aadahl M. Construct validity of a revised Physical Activity Scale and testing by cognitive interviewing. Scand J Public Health 2010, 38(7):707-714. 10.1177/1403494810380099, 20823047.
60. Zimet GD, Dahlem NW, Zimet SG, Farley GK. The Multidimensional Scale of Perceived Social Support. J Pers Assess 1988, 52:30-41.
61. Hibbard JH, Stockard J, Mahoney ER, Tusler M. Development of the Patient Activation Measure (PAM): conceptualizing and measuring activation in patients and consumers. Health Serv Res 2004, 39(4 Pt 1):1005-1026. 1361049, 15230939.
62. Schwarzer R, Jerusalem M. Generalized self-efficacy scale. Measures in health psychology: A user's portfolio. Causal and control beliefs 1995, 35-37. Windsor, UK: NFER-NELSON, Weinman J, Wrigh S, Johnston M, 3473319, 22726578.
63. Thielen K, Nygaard E, Andersen I, Diderichsen F. Employment consequences of depressive symptoms and work demands individually and combined 2013, Health: Eur J Publ.
64. OpenClinica https://www.openclinica.com/product-features.
65. Büchele G, Och B, Bolte G, Weiland S. Single vs. double data entry. Epidemiology 2005, 16(1):130-131. 10.1097/01.ede.0000147166.24478.f4, 15613958.
66. Skorkjaer Binderkrantz A, Bøge AL. Guide til NVivo 9 2011, Copenhagen: Hans Reitzels Forlag.
67. Braun V, Clarke V. Using thematic analysis in psychology. Qual Res Psychol 2006, 3:77-101.
68. Malterud K. The art and science of clinical knowledge: evidence beyond measures and numbers. Lancet 2001, 358:397-400. 10.1016/S0140-6736(01)05548-9, 11502338.
69. Cannas G, Pautas C, Raffoux E, Quesnel B, et al. Infectious complications in adult acute myeloid leukemia: analysis of the Acute Leukemia French Association-9802 prospective multicenter clinical trial. Leuk Lymphoma 2012, 53(6):1068-1076. doi:10.3109/10428194.2011.636812. Epub 2012 Jan 31, 10.3109/10428194.2011.636812, 22145959.
70. Gupta A, Singh M, Singh H, Kumar L, Sharma A, Bakhshi S. Infections in acute myeloid leukemia: an analysis of 382 febrile episodes. Med Oncol 2010, 27(4):1037-1045. doi:10.1007/s12032-009-9330-9. Epub 2009 Oct 15, 10.1007/s12032-009-9330-9, 19830601.
71. Courneya KS, Keats MR, Turner AR. Physical exercise and quality of life in cancer patients following high dose chemotherapy and autologous bone marrow transplantation. Psychooncology 2009, 9:127-136.
72. Jarden M, Baadsgaard MT, Hovgaard DJ, Boesen E, Adamsen L. A randomized trial on the effect of a multimodal intervention on physical capacity, functional performance and quality of life in adult patients undergoing allogeneic SCT. Bone Marrow Transplant 2009, 43(9):725-737. 10.1038/bmt.2009.27, 19234513.
73. Baumann FT, Kraut L, Schule K, et al. A controlled randomized study examining the effects of exercise therapy on patients undergoing haematopoietic stem cell transplantation. Bone Marrow Transplant 2009, 45(2):355-362.
74. Wiskemann J, Dreger P, Schwerdtfeger R, Bondong A, Huber G, Kleindienst N, Ulrich CM, Bohus M. Effects of a partly self-administered exercise program before, during and after allogeneic stem cell transplantation. Blood 2010, 117(9):2604-2613.
75. Jarden M. A systematic review of nonpharmacological exercise-based rehabilitative interventions in adults undergoing allogeneic hematopoietic stem cell transplantation. New advances in stem cell transplantation 2012, 558-582. Rijeka: InTech, Demirer T.
76. Dimeo F, Schwartz S, Fietz T, Wanjura T, Boning D, Thiel E. Effects of endurance training on the physical performance of patients with hematological malignancies during chemotherapy. Support Care Cancer 2003, 11:623-628. 10.1007/s00520-003-0512-2, 12942360.