Physical exercise induces specific adaptations resulting in reduced organ injury and mortality during severe polymicrobial sepsis

Critical Care Medicine

Volumn 41, Issue 10, 2013, Pages

  Sossdorf, Maik ^a   Fischer, Jacqueline ^a   Meyer, Stefan ^a   Dahlke, Katja ^a   Wissuwa, Bianka ^a   Seidel, Carolin ^a   Schrepper, Andrea ^a   Bockmeyer, Clemens L ^b   Lupp, Amelie ^a   Neugebauer, Sophie ^a   Schmerler, Diana ^a   Rödel, Jürgen ^a   Claus, Ralf A ^a   Otto, Gordon P ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

host response; inflammation; metabolism; organ failure; physical training; physiological adaptation

Indexed keywords

CARNITINE DERIVATIVE; INTERLEUKIN 10; INTERLEUKIN 6; LYSOPHOSPHATIDYLCHOLINE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; TRYPTOPHAN;

ACUTE KIDNEY FAILURE; ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL CLEARANCE; BLOOD SAMPLING; CLINICAL CHEMISTRY; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; EXERCISE; HISTOPATHOLOGY; IMMUNE RESPONSE; KIDNEY TUBULE DAMAGE; MALE; METABOLISM; MORPHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RUNNING; SEPSIS; SURVIVAL RATE; TREADMILL EXERCISE;

ACUTE KIDNEY INJURY; ADAPTATION, PHYSIOLOGICAL; ANIMALS; COINFECTION; CYTOKINES; HEPATIC INSUFFICIENCY; LUNG INJURY; MALE; MICE; MICE, INBRED C57BL; PHYSICAL CONDITIONING, ANIMAL; RANDOM ALLOCATION; SEPSIS; SURVIVAL ANALYSIS;

EID: 84884884117     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31828a2ae3     Document Type: Article

References (46)

1. Engel C, Brunkhorst FM, Bone HG, et al: Epidemiology of sepsis in Germany: Results from a national prospective multicenter study. Intensive Care Med 2007; 33:606-618 (Pubitemid 46474888)
2. Martin GS, Mannino DM, Eaton S, et al: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003; 348:1546-1554 (Pubitemid 36437931)
3. Bosmann M, Ward PA. The inflammatory response in sepsis. Trends Immunol 2013; 34:129-136
4. Cinel I, Opal SM: Molecular biology of inflammation and sepsis: A primer. Crit Care Med 2009; 37:291-304
5. Powers S, Howley E: Exercise Physiology: Theory and Application to Fitness and Performance. Eighth Edition. Australia and New Zealand, McGraw-Hill Humanities, Social Sciences, and World Languages, 2011
6. Blair SN: Physical inactivity: The biggest public health problem of the 21st century. Br J Sports Med 2009; 43:1-2
7. Gleeson M, Bishop NC, Stensel DJ, et al: The anti-inflammatory effects of exercise: Mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol 2011; 11:607-615
8. Löllgen H, Böckenhoff A, Knapp G: Physical activity and all-cause mortality: An updated meta-analysis with different intensity categories. Int J Sports Med 2009; 30:213-224
9. Lee DC, Sui X, Artero EG, et al: Long-term effects of changes in cardiorespiratory fitness and body mass index on all-cause and cardiovascular disease mortality in men: The Aerobics Center Longitudinal Study. Circulation 2011; 124:2483-2490
10. Folsom RW, Littlefield-Chabaud MA, French DD, et al: Exercise alters the immune response to equine influenza virus and increases susceptibility to infection. Equine Vet J 2001; 33:664-669 (Pubitemid 33640025)
11. Friman G, Ilbäck NG, Crawford DJ, et al: Metabolic responses to swimming exercise in Streptococcus pneumoniae infected rats. Med Sci Sports Exerc 1991; 23:415-421
12. Kohut ML, Davis JM, Jackson DA, et al: Exercise effects on IFN-beta expression and viral replication in lung macrophages after HSV-1 infection. Am J Physiol 1998; 275(6, Part 1):L1089-L1094
13. Murphy EA, Davis JM, Carmichael MD, et al: Exercise stress increases susceptibility to influenza infection. Brain Behav Immun 2008; 22:1152-1155
14. Sim YJ, Yu S, Yoon KJ, et al: Chronic exercise reduces illness severity, decreases viral load, and results in greater anti-inflammatory effects than acute exercise during influenza infection. J Infect Dis 2009; 200:1434-1442
15. Cannon JG, Kluger MJ: Exercise enhances survival rate in mice infected with Salmonella typhimurium. Proc Soc Exp Biol Med 1984; 175:518-521 (Pubitemid 14023753)
16. Chen HI, Hsieh SY, Yang FL, et al: Exercise training attenuates septic responses in conscious rats. Med Sci Sports Exerc 2007; 39:435-442 (Pubitemid 46667942)
17. de Araújo CC, Silva JD, Samary CS, et al: Regular and moderate exercise before experimental sepsis reduces the risk of lung and distal organ injury. J Appl Physiol 2012; 112:1206-1214
18. Gonnert FA, Recknagel P, Seidel M, et al: Characteristics of clinical sepsis reflected in a reliable and reproducible rodent sepsis model. J Surg Res 2011; 170:e123-e134
19. Kemi OJ, Loennechen JP, Wisløff U, et al: Intensity-controlled treadmill running in mice: Cardiac and skeletal muscle hypertrophy. J Appl Physiol 2002; 93:1301-1309
20. Teichholz LE, Kreulen T, Herman MV, et al: Problems in echocardiographic volume determinations: Echocardiographic-angiographic correlations in the presence of absence of asynergy. Am J Cardiol 1976; 37:7-11
21. Perlini S: Determinants of left ventricular mass in hypertensive heart disease: A complex interplay between volume, pressure, systolic function and genes. J Hypertens 2007; 25:1341-1342 (Pubitemid 46918816)
22. Bockmeyer CL, Reuken PA, Simon TP, et al: ADAMTS13 activity is decreased in a septic porcine model. Significance for glomerular thrombus deposition. Thromb Haemost 2011; 105:145-153
23. Xia J, Wishart DS: Metabolomic data processing, analysis, and interpretation using MetaboAnalyst. Curr Protoc Bioinformatics 2011; Chapter 14:Unit 14.10
24. Wen CP, Wai JP, Tsai MK, et al: Minimum amount of physical activity for reduced mortality and extended life expectancy: A prospective cohort study. Lancet 2011; 378:1244-1253
25. Nieman DC: Special feature for the Olympics: Effects of exercise on the immune system: Exercise effects on systemic immunity. Immunol Cell Biol 2000; 78:496-501
26. Gleeson M, McFarlin B, Flynn M: Exercise and Toll-like receptors. Exerc Immunol Rev 2006; 12:34-53
27. Walsh NP, Gleeson M, Shephard RJ, et al: Position statement. Part one: Immune function and exercise. Exerc Immunol Rev 2011; 17:6-63
28. Andaluz-Ojeda D, Bobillo F, Iglesias V, et al: A combined score of pro- and anti-inflammatory interleukins improves mortality prediction in severe sepsis. Cytokine 2012; 57:332-336
29. Heper Y, Akalin EH, Mistik R, et al: Evaluation of serum C-reactive protein, procalcitonin, tumor necrosis factor alpha, and interleukin-10 levels as diagnostic and prognostic parameters in patients with community- acquired sepsis, severe sepsis, and septic shock. Eur J Clin Microbiol Infect Dis 2006; 25:481-491
30. Lichtenstern C, Brenner T, Bardenheuer HJ, et al: Predictors of survival in sepsis: What is the best inflammatory marker to measure? Curr Opin Infect Dis 2012; 25:328-336
31. Gustot T: Multiple organ failure in sepsis: Prognosis and role of systemic inflammatory response. Curr Opin Crit Care 2011; 17:153-159
32. Bonventre JV, Yang L: Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest 2011; 121:4210-4221
33. Honore PM, Jacobs R, Joannes-Boyau O, et al: Septic AKI in ICU patients. Diagnosis, pathophysiology, and treatment type, dosing, and timing: A comprehensive review of recent and future developments. Ann Intensive Care 2011; 1:32
34. Hoste EA, Schurgers M: Epidemiology of acute kidney injury: How big is the problem? Crit Care Med 2008; 36(4 Suppl):S146-S151 (Pubitemid 351483044)
35. Davis JS, Anstey NM: Is plasma arginine concentration decreased in patients with sepsis? A systematic review and meta-analysis. Crit Care Med 2011; 39:380-385
36. Otto GP, Neugebauer S, Claus RA, et al: Arginine metabolism is markedly impaired in polymicrobial infected mice. Crit Care 2012; 16:412
37. Levillain O: Expression and function of arginine-producing and consuming- enzymes in the kidney. Amino Acids 2012; 42:1237-1252
38. Luiking YC, Poeze M, Ramsay G, et al: The role of arginine in infection and sepsis. JPEN J Parenter Enteral Nutr 2005; 29(1 Suppl):S70-S74
39. Hammad SM: Blood sphingolipids in homeostasis and pathobiology. Adv Exp Med Biol 2011; 721:57-66
40. Matsumoto T, Kobayashi T, Kamata K: Role of lysophosphatidylcholine (LPC) in atherosclerosis. Curr Med Chem 2007; 14: 3209-3220
41. Engelmann B, Zieseniss S, Brand K, et al: Tissue factor expression of human monocytes is suppressed by lysophosphatidylcholine. Arterioscler Thromb Vasc Biol 1999; 19:47-53 (Pubitemid 29031911)
42. Zembowicz A, Tang JL, Wu KK: Transcriptional induction of endothelial nitric oxide synthase type III by lysophosphatidylcholine. J Biol Chem 1995; 270:17006-17010
43. Drobnik W, Liebisch G, Audebert FX, et al: Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patients. J Lipid Res 2003; 44:754-761 (Pubitemid 37279677)
44. Yan JJ, Jung JS, Lee JE, et al: Therapeutic effects of lysophosphatidylcholine in experimental sepsis. Nat Med 2004; 10:161-167
45. Chen G, Li J, Qiang X, et al: Suppression of HMGB1 release by stearoyl lysophosphatidylcholine: An additional mechanism for its therapeutic effects in experimental sepsis. J Lipid Res 2005; 46:623-627 (Pubitemid 43073271)
46. Murch O, Collin M, Sepodes B, et al: Lysophosphatidylcholine reduces the organ injury and dysfunction in rodent models of gram-negative and gram-positive shock. Br J Pharmacol 2006; 148:769-777 (Pubitemid 44079406)