-
1
-
-
17744368482
-
Selective estrogenic effects of a novel triphenylethylene compound, FC1271a, on bone, cholesterol level, and reproductive tissues in intact and ovariectomized rats
-
Qu Q, Zheng H, Dahllund J, et al. Selective estrogenic effects of a novel triphenylethylene compound, FC1271a, on bone, cholesterol level, and reproductive tissues in intact and ovariectomized rats. Endocrinology. 2000;141(2):809-820.
-
(2000)
Endocrinology.
, vol.141
, Issue.2
, pp. 809-820
-
-
Qu, Q.1
Zheng, H.2
Dahllund, J.3
-
2
-
-
84884822270
-
-
Inventor; Hormos Medical Ltd, Turku (FI), assignee. US patent 8,470,890 B2. June 25
-
Anttila M, Inventor; Hormos Medical Ltd, Turku (FI), assignee. Method for enhancing the bioavailability of ospemifene. US patent 8,470,890 B2. June 25, 2013.
-
(2013)
Method for enhancing the bioavailability of ospemifene
-
-
Anttila, M.1
-
3
-
-
67649595194
-
Ospemifene use in postmenopausal women
-
Gennari L, Merlotti D, Valleggi F, Nuti R. Ospemifene use in postmenopausal women. Expert Opin Investig Drugs. 2009;18(6):839-849.
-
(2009)
Expert Opin Investig Drugs.
, vol.18
, Issue.6
, pp. 839-849
-
-
Gennari, L.1
Merlotti, D.2
Valleggi, F.3
Nuti, R.4
-
6
-
-
61549129012
-
The use of estrogen therapy in women's sexual functioning (CME)
-
Nappi RE, Polatti F. The use of estrogen therapy in women's sexual functioning (CME). J Sex Med. 2009;6(3):603-616.
-
(2009)
J Sex Med.
, vol.6
, Issue.3
, pp. 603-616
-
-
Nappi, R.E.1
Polatti, F.2
-
7
-
-
68349155731
-
Prevalence and impact of vaginal symptoms among postmenopausal women
-
Santoro N, Komi J. Prevalence and impact of vaginal symptoms among postmenopausal women. J Sex Med. 2009;6(8):2133-2142.
-
(2009)
J Sex Med.
, vol.6
, Issue.8
, pp. 2133-2142
-
-
Santoro, N.1
Komi, J.2
-
8
-
-
0344255781
-
Predictors of difficulty when discontinuing postmenopausal hormone therapy
-
Grady D, Ettinger B, Tosteson AN, Pressman A, Macer JL. Predictors of difficulty when discontinuing postmenopausal hormone therapy. Obstet Gynecol. 2003;102(6):1233-1239.
-
(2003)
Obstet Gynecol.
, vol.102
, Issue.6
, pp. 1233-1239
-
-
Grady, D.1
Ettinger, B.2
Tosteson, A.N.3
Pressman, A.4
Macer, J.L.5
-
9
-
-
0037125379
-
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial
-
Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA. 2002;288(3):321-333.
-
(2002)
JAMA.
, vol.288
, Issue.3
, pp. 321-333
-
-
Rossouw, J.E.1
Anderson, G.L.2
Prentice, R.L.3
-
10
-
-
73349115224
-
Intravaginal dehydroepiandrosterone (Prasterone), a physiological and highly efficient treatment of vaginal atrophy
-
Labrie F, Archer D, Bouchard C, et al. Intravaginal dehydroepiandrosterone (Prasterone), a physiological and highly efficient treatment of vaginal atrophy. Menopause. 2009;16(5):907-922.
-
(2009)
Menopause.
, vol.16
, Issue.5
, pp. 907-922
-
-
Labrie, F.1
Archer, D.2
Bouchard, C.3
-
11
-
-
69649108864
-
The role of local vaginal estrogen for treatment of vaginal atrophy in postmenopausal women: 2007 position statement of The North American Menopause Society
-
North American Menopause Society
-
North American Menopause Society. The role of local vaginal estrogen for treatment of vaginal atrophy in postmenopausal women: 2007 position statement of The North American Menopause Society. Menopause. 2007;14(3 Pt 1):355-369.
-
(2007)
Menopause.
, vol.14
, Issue.3 PART 1
, pp. 355-369
-
-
-
13
-
-
0642367765
-
Effects of ospemifene, a novel SERM, on hormones, genital tract, climacteric symptoms, and quality of life in postmenopausal women: A double-blind, randomized trial
-
Rutanen EM, Heikkinen J, Halonen K, Komi J, Lammintausta R, Ylikorkala O. Effects of ospemifene, a novel SERM, on hormones, genital tract, climacteric symptoms, and quality of life in postmenopausal women: a double-blind, randomized trial. Menopause. 2003;10(5): 433-439.
-
(2003)
Menopause.
, vol.10
, Issue.5
, pp. 433-439
-
-
Rutanen, E.M.1
Heikkinen, J.2
Halonen, K.3
Komi, J.4
Lammintausta, R.5
Ylikorkala, O.6
-
14
-
-
20144388972
-
Effects of ospemifene and raloxifene on hormonal status, lipids, genital tract, and tolerability in postmenopausal women
-
Komi J, Lankinen KS, Harkonen P, et al. Effects of ospemifene and raloxifene on hormonal status, lipids, genital tract, and tolerability in postmenopausal women. Menopause. 2005;12(2):202-209.
-
(2005)
Menopause.
, vol.12
, Issue.2
, pp. 202-209
-
-
Komi, J.1
Lankinen, K.S.2
Harkonen, P.3
-
15
-
-
77952270259
-
Ospemifene effectively treats vulvovaginal atrophy in postmenopausal women: Results from a pivotal phase 3 study
-
Bachmann GA, Komi JO. Ospemifene effectively treats vulvovaginal atrophy in postmenopausal women: results from a pivotal phase 3 study. Menopause. 2010;17(3):480-486.
-
(2010)
Menopause.
, vol.17
, Issue.3
, pp. 480-486
-
-
Bachmann, G.A.1
Komi, J.O.2
-
16
-
-
84879172530
-
Ospemifene, a novel selective estrogen receptor modulator for treating dyspareunia associated with postmenopausal vulvar and vaginal atrophy
-
Portman DJ, Bachmann GA, Simon JA. Ospemifene, a novel selective estrogen receptor modulator for treating dyspareunia associated with postmenopausal vulvar and vaginal atrophy. Menopause. 2013;20(6): 623-630.
-
(2013)
Menopause.
, vol.20
, Issue.6
, pp. 623-630
-
-
Portman, D.J.1
Bachmann, G.A.2
Simon, J.A.3
-
17
-
-
0037145885
-
Effects of ospemifene (FC-1271a) on uterine endometrium, vaginal maturation index, and hormonal status in healthy postmenopausal women
-
Voipio SK, Komi J, Kangas L, Halonen K, DeGregorio MW, Erkkola RU. Effects of ospemifene (FC-1271a) on uterine endometrium, vaginal maturation index, and hormonal status in healthy postmenopausal women. Maturitas. 2002;43(3):207-214.
-
(2002)
Maturitas.
, vol.43
, Issue.3
, pp. 207-214
-
-
Voipio, S.K.1
Komi, J.2
Kangas, L.3
Halonen, K.4
DeGregorio, M.W.5
Erkkola, R.U.6
-
18
-
-
85028098042
-
One-year long-term safety extension study of ospemifene for the treatment of vulvar and vaginal atrophy in postmenopausal women with a uterus
-
Simon JA, Lin VH, Radovich C, Bachmann GA. One-year long-term safety extension study of ospemifene for the treatment of vulvar and vaginal atrophy in postmenopausal women with a uterus. Menopause. 2013;20(4):418-427.
-
(2013)
Menopause.
, vol.20
, Issue.4
, pp. 418-427
-
-
Simon, J.A.1
Lin, V.H.2
Radovich, C.3
Bachmann, G.A.4
-
20
-
-
0642306447
-
Effects of ospemifene, a novel SERM, on vascular markers and function in healthy, postmenopausal women
-
Ylikorkala O, Cacciatore B, Halonen K, et al. Effects of ospemifene, a novel SERM, on vascular markers and function in healthy, postmenopausal women. Menopause. 2003;10(5):440-447.
-
(2003)
Menopause.
, vol.10
, Issue.5
, pp. 440-447
-
-
Ylikorkala, O.1
Cacciatore, B.2
Halonen, K.3
-
21
-
-
0344142469
-
Comparative effects of estrogen and antiestrogens on differentiation of osteoblasts in mouse bone marrow culture
-
Qu Q, Harkonen PL, Vaananen HK. Comparative effects of estrogen and antiestrogens on differentiation of osteoblasts in mouse bone marrow culture. J Cell Biochem. 1999;73(4):500-507.
-
(1999)
J Cell Biochem.
, vol.73
, Issue.4
, pp. 500-507
-
-
Qu, Q.1
Harkonen, P.L.2
Vaananen, H.K.3
-
22
-
-
1542267719
-
Effects of ospemifene, a novel SERM, on biochemical markers of bone turnover in healthy postmenopausal women
-
Komi J, Heikkinen J, Rutanen EM, Halonen K, Lammintausta R, Ylikorkala O. Effects of ospemifene, a novel SERM, on biochemical markers of bone turnover in healthy postmenopausal women. Gynecol Endocrinol. 2004;18(3):152-158.
-
(2004)
Gynecol Endocrinol.
, vol.18
, Issue.3
, pp. 152-158
-
-
Komi, J.1
Heikkinen, J.2
Rutanen, E.M.3
Halonen, K.4
Lammintausta, R.5
Ylikorkala, O.6
-
23
-
-
33745603721
-
Effects of ospemifene and raloxifene on biochemical markers of bone turnover in postmenopausal women
-
Komi J, Lankinen KS, DeGregorio M, et al. Effects of ospemifene and raloxifene on biochemical markers of bone turnover in postmenopausal women. J Bone Miner Metab. 2006;24(4):314-318.
-
(2006)
J Bone Miner Metab.
, vol.24
, Issue.4
, pp. 314-318
-
-
Komi, J.1
Lankinen, K.S.2
DeGregorio, M.3
-
25
-
-
84875434415
-
Ospemifene, vulvovaginal atrophy, and breast cancer
-
Wurz GT, Soe LH, Degregorio MW. Ospemifene, vulvovaginal atrophy, and breast cancer. Maturitas. 2013;74(3):220-225.
-
(2013)
Maturitas.
, vol.74
, Issue.3
, pp. 220-225
-
-
Wurz, G.T.1
Soe, L.H.2
Degregorio, M.W.3
-
26
-
-
0034907007
-
In vitro and in vivo biologic effects of ospemifene (FC-1271a) in breast cancer
-
Taras TL, Wurz GT, DeGregorio MW. In vitro and in vivo biologic effects of ospemifene (FC-1271a) in breast cancer. J Steroid Biochem Mol Biol. 2001;77(4-5):271-279.
-
(2001)
J Steroid Biochem Mol Biol.
, vol.77
, Issue.4-5
, pp. 271-279
-
-
Taras, T.L.1
Wurz, G.T.2
DeGregorio, M.W.3
-
27
-
-
27744590563
-
Ospemifene inhibits the growth of dimethylbenzanthracene-induced mammary tumors in Sencar mice
-
Wurz GT, Read KC, Marchisano-Karpman C, et al. Ospemifene inhibits the growth of dimethylbenzanthracene-induced mammary tumors in Sencar mice. J Steroid Biochem Mol Biol. 2005;97(3):230-240.
-
(2005)
J Steroid Biochem Mol Biol.
, vol.97
, Issue.3
, pp. 230-240
-
-
Wurz, G.T.1
Read, K.C.2
Marchisano-Karpman, C.3
-
28
-
-
4444238684
-
Polyomavirus middle T-induced mammary intraepithelial neoplasia outgrowths: Single origin, divergent evolution, and multiple outcomes
-
Maglione JE, McGoldrick ET, Young LJ, et al. Polyomavirus middle T-induced mammary intraepithelial neoplasia outgrowths: single origin, divergent evolution, and multiple outcomes. Mol Cancer Ther. 2004;3(8):941-953.
-
(2004)
Mol Cancer Ther.
, vol.3
, Issue.8
, pp. 941-953
-
-
Maglione, J.E.1
McGoldrick, E.T.2
Young, L.J.3
-
29
-
-
0035890383
-
Transgenic polyoma middle-T mice model premalignant mammary disease
-
Maglione JE, Moghanaki D, Young LJ, et al. Transgenic polyoma middle-T mice model premalignant mammary disease. Cancer Res. 2001;61(22):8298-8305.
-
(2001)
Cancer Res.
, vol.61
, Issue.22
, pp. 8298-8305
-
-
Maglione, J.E.1
Moghanaki, D.2
Young, L.J.3
-
30
-
-
34447637387
-
Selective estrogen receptor modulators inhibit growth and progression of premalignant lesions in a mouse model of ductal carcinoma in situ
-
Namba R, Young LJ, Maglione JE, et al. Selective estrogen receptor modulators inhibit growth and progression of premalignant lesions in a mouse model of ductal carcinoma in situ. Breast Cancer Res. 2005;7(6): R881-R889.
-
(2005)
Breast Cancer Res.
, vol.7
, Issue.6
-
-
Namba, R.1
Young, L.J.2
Maglione, J.E.3
-
31
-
-
84655163386
-
Ospemifene and 4-hydroxyospemifene effectively prevent and treat breast cancer in the MTag. Tg transgenic mouse model
-
Burich RA, Mehta NR, Wurz GT, et al. Ospemifene and 4-hydroxyospemifene effectively prevent and treat breast cancer in the MTag. Tg transgenic mouse model. Menopause. 2012;19(1): 96-103.
-
(2012)
Menopause.
, vol.19
, Issue.1
, pp. 96-103
-
-
Burich, R.A.1
Mehta, N.R.2
Wurz, G.T.3
-
32
-
-
0026587657
-
Induction of mammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease
-
Guy CT, Cardiff RD, Muller WJ. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol. 1992;12(3):954-961.
-
(1992)
Mol Cell Biol.
, vol.12
, Issue.3
, pp. 954-961
-
-
Guy, C.T.1
Cardiff, R.D.2
Muller, W.J.3
-
33
-
-
0142244181
-
Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases
-
Lin EY, Jones JG, Li P, et al. Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol. 2003;163(5):2113-2126.
-
(2003)
Am J Pathol.
, vol.163
, Issue.5
, pp. 2113-2126
-
-
Lin, E.Y.1
Jones, J.G.2
Li, P.3
-
34
-
-
79952959860
-
Current treatment options for vulvovaginal atrophy
-
Burich R, DeGregorio M. Current treatment options for vulvovaginal atrophy. Expert Rev Obstet Gynecol. 2011;6(2):141-151.
-
(2011)
Expert Rev Obstet Gynecol.
, vol.6
, Issue.2
, pp. 141-151
-
-
Burich, R.1
DeGregorio, M.2
-
36
-
-
77958138780
-
Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women
-
Chlebowski RT, Anderson GL, Gass M, et al. Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women. JAMA. 2010;304(15):1684-1692.
-
(2010)
JAMA.
, vol.304
, Issue.15
, pp. 1684-1692
-
-
Chlebowski, R.T.1
Anderson, G.L.2
Gass, M.3
-
37
-
-
77954522752
-
Vaginal atrophy and sexual dysfunction in current users of systemic postmenopausal hormone therapy
-
Indhavivadhana S, Leerasiri P, Rattanachaiyanont M, et al. Vaginal atrophy and sexual dysfunction in current users of systemic postmenopausal hormone therapy. J Med Assoc Thai. 2010;93(6):667-675.
-
(2010)
J Med Assoc Thai.
, vol.93
, Issue.6
, pp. 667-675
-
-
Indhavivadhana, S.1
Leerasiri, P.2
Rattanachaiyanont, M.3
-
38
-
-
8644234310
-
Self-reported urogenital symptoms in postmenopausal women: Women's Health Initiative
-
Pastore LM, Carter RA, Hulka BS, Wells E. Self-reported urogenital symptoms in postmenopausal women: Women's Health Initiative. Maturitas. 2004;49(4):292-303.
-
(2004)
Maturitas.
, vol.49
, Issue.4
, pp. 292-303
-
-
Pastore, L.M.1
Carter, R.A.2
Hulka, B.S.3
Wells, E.4
-
39
-
-
64049083020
-
Effect of one-week treatment with vaginal estrogen preparations on serum estrogen levels in postmenopausal women
-
Labrie F, Cusan L, Gomez JL, et al. Effect of one-week treatment with vaginal estrogen preparations on serum estrogen levels in postmenopausal women. Menopause. 2009;16(1):30-36.
-
(2009)
Menopause.
, vol.16
, Issue.1
, pp. 30-36
-
-
Labrie, F.1
Cusan, L.2
Gomez, J.L.3
-
40
-
-
77249172217
-
Effects of bazedoxifene/conjugated estrogens on quality of life in postmenopausal women with symptoms of vulvar/vaginal atrophy
-
Bachmann G, Bobula J, Mirkin S. Effects of bazedoxifene/conjugated estrogens on quality of life in postmenopausal women with symptoms of vulvar/vaginal atrophy. Climacteric. 2010;13(2):132-140.
-
(2010)
Climacteric.
, vol.13
, Issue.2
, pp. 132-140
-
-
Bachmann, G.1
Bobula, J.2
Mirkin, S.3
-
41
-
-
84887467281
-
Tissue-selective estrogen complexes for postmenopausal women
-
July 10, [Epub ahead of print.]
-
Mirkin S, Komm BS. Tissue-selective estrogen complexes for postmenopausal women. Maturitas. July 10, 2013. [Epub ahead of print.]
-
(2013)
Maturitas
-
-
Mirkin, S.1
Komm, B.S.2
-
42
-
-
0041887216
-
Estrogens and menopause: Pharmacology of conjugated equine estrogens and their potential role in the prevention of neurodegenerative diseases such as Alzheimer's
-
Bhavnani BR. Estrogens and menopause: pharmacology of conjugated equine estrogens and their potential role in the prevention of neurodegenerative diseases such as Alzheimer's. J Steroid Biochem Mol Biol. 2003;85(2-5):473-482.
-
(2003)
J Steroid Biochem Mol Biol.
, vol.85
, Issue.2-5
, pp. 473-482
-
-
Bhavnani, B.R.1
-
43
-
-
77950112868
-
Aprela, a single tablet formulation of bazedoxifene and conjugated equine estrogens (Premarin) for the potential treatment of menopausal symptoms
-
Stovall DW. Aprela, a single tablet formulation of bazedoxifene and conjugated equine estrogens (Premarin) for the potential treatment of menopausal symptoms. Curr Opin Investig Drugs. 2010;11(4): 464-471.
-
(2010)
Curr Opin Investig Drugs.
, vol.11
, Issue.4
, pp. 464-471
-
-
Stovall, D.W.1
-
44
-
-
84884889049
-
-
Florham Park, NJ: Shionogi Inc; Available from: Accessed August 22, 2013
-
Osphena™ (ospemifene) prescribing information. Florham Park, NJ: Shionogi Inc; 2013. Available from: http://www.shionogi.com/pdf/PI/Osphena-PI.pdf. Accessed August 22, 2013.
-
(2013)
Osphena™ (ospemifene) prescribing information
-
-
|