Quantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood-brain barrier disruption

BMC Genomics

Volumn 14, Issue 1, 2013, Pages

  Johnson, Holly L ^a,b   Hanson, Lisa M ^b   Chen, Yi ^c   Bieber, Allan J ^a   Buono, Russell J ^d   Ferraro, Thomas N ^e   Pirko, Istvan ^a   Johnson, Aaron J ^a,b  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d Cooper Medical School of Rowan University ^*  (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Blood brain barrier (BBB); CD8 T cell; CNS vascular permeability; Peptide induced fatal syndrome (PIFS); Quantitative trait loci (QTL); Single nucleotide polymorphism (SNP); Theiler's murine encephalomyelitis virus (TMEV)

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CENTRAL NERVOUS SYSTEM; CHROMOSOME 12; CHROMOSOME 17; CONTROLLED STUDY; FEMALE; FUNCTIONAL DISEASE; GENE; GENE CONTROL; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENE TARGETING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC MARKER; GENETIC TRAIT; HEREDITY; LIMIT OF DETECTION; MALE; MEMBRANE DAMAGE; MOTOR DYSFUNCTION; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PHENOTYPE; PIFS1 GENE; PIFS2 GENE; PROGENY; PROTEIN EXPRESSION; QUANTITATIVE TRAIT; QUANTITATIVE TRAIT LOCUS; ROTAROD TEST; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; C57BL MOUSE; CAPILLARY PERMEABILITY; CHI SQUARE DISTRIBUTION; GENETICS; IMMUNOLOGY; MOTOR ACTIVITY; PATHOLOGY; PATHOPHYSIOLOGY; SYNDROME;

MUS; THEILER'S ENCEPHALOMYELITIS VIRUS;

ANIMALS; ASTROCYTES; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CD8-POSITIVE T-LYMPHOCYTES; CHI-SQUARE DISTRIBUTION; GENETIC ASSOCIATION STUDIES; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; QUANTITATIVE TRAIT LOCI; QUANTITATIVE TRAIT, HERITABLE; SYNDROME;

EID: 84884857013     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-14-678     Document Type: Article

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