Age-related changes in cellular electrophysiology and calcium handling for atrial fibrillation

Journal of Cellular and Molecular Medicine

Volumn 17, Issue 9, 2013, Pages 1109-1118

  Xu, Guo Jun ^a   Gan, Tian Yi ^a   Tang, Bao Peng ^a   Chen, Zu Heng ^a   Jiang, Tao ^a   Song, Jian Guo ^a   Guo, Xia ^a   Li, Jin xin ^a  

^a XINJIANG MEDICAL UNIVERSITY   (China)

Author keywords

Ageing; Atrial fibrillation; Ca2+ handling proteins; Cellular electrophysiology; L type Ca2+ current

Indexed keywords

CANIS FAMILIARIS;

CALCIUM; CALCIUM CHANNEL L TYPE; MESSENGER RNA;

ACTION POTENTIAL; AGING; ANIMAL; ARTICLE; CA2+ HANDLING PROTEINS; CELLULAR ELECTROPHYSIOLOGY; DOG; ECHOGRAPHY; ELECTROPHYSIOLOGY; GENETICS; HEART ATRIUM; HEART ATRIUM FIBRILLATION; HEART MUSCLE; HEART MUSCLE CELL; HOMEOSTASIS; L-TYPE CA2+ CURRENT; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

AGEING; ATRIAL FIBRILLATION; CA2+ HANDLING PROTEINS; CELLULAR ELECTROPHYSIOLOGY; L-TYPE CA2+ CURRENT;

ACTION POTENTIALS; AGING; ANIMALS; ATRIAL FIBRILLATION; CALCIUM; CALCIUM CHANNELS, L-TYPE; DOGS; ELECTROPHYSIOLOGICAL PHENOMENA; HEART ATRIA; HOMEOSTASIS; MYOCARDIUM; MYOCYTES, CARDIAC; RNA, MESSENGER;

EID: 84884816520     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12084     Document Type: Article

References (30)

1. Allessie MA, Boyden PA, Camm AJ, et al. Pathophysiology and prevention of atrial fibrillation. Circulation. 2001; 103: 769-77.
2. Chen LY, Shen W-K. Epidemiology of atrial fibrillation: a current perspective. Heart Rhythm. 2007; 4(3 Suppl): S1-6.
3. Dun W, Yagi T, Rosen MR, et al. Calcium and potassium currents in cells from adult and aged canine right atria. Cardiovasc Res. 2003; 58: 526-34.
4. Anyukhovsky EP, Sosunov EA, Plotnikov A, et al. Cellular electrophysiologic properties of old canine atria provide a substrate for arrhythmogenesis. Cardiovasc Res. 2002; 54: 462-9.
5. Anyukhovsky EP, Sosunov EA, Chandra P, et al. Age-associated changes in electrophysiologic remodeling: a potential contributor to initiation of atrial fibrillation. Cardiovasc Res. 2005; 66: 353-63.
6. Chou CC, Nihei M, Zhou S, et al. Intracellular calcium dynamics and anisotropic reentry in isolated canine pulmonary veins and left atrium. Circulation. 2005; 111: 2889-97.
7. 2+ channels in aging heart. J Mol Cell Cardiol. 2002; 34: 297-308.
8. Sosunov EA, Anyukhovsky EP, Rosen MR. The adrenergic-cholinergic interaction that modulates repolarization in the atrium is altered with aging. J Cardiovasc Electrophysiol. 2002; 13: 374-9.
9. Nattel S, Maguy A, Le Bouter S, et al. Arrhythmogenic ion-channel remodelling in the heart: heart failure, myocardial infarction, and atrial fibrillation. Physiol Rev. 2007; 87: 425-56.
10. Van Gelder IC, Brundel BJ, Henning RH, et al. Alterations in gene expression of proteins involved in the calcium handling in patients with atrial fibrillation. J Cardiovasc Electrophysiol. 1999; 10: 552-60.
11. Brundel BJ, Van Gelder IC, Henning RH, et al. Gene expression of proteins influencing the calcium homeostasis in patients with persistent and paroxysmal atrial fibrillation. Cardiovasc Res. 1999; 42: 443-54.
12. Vest JA, Wehrens XH, Reiken SR, et al. Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation. 2005; 111: 2025-32.
13. 2+ handling in human chronic atrial fibrillation. Circulation. 2006; 114: 670-80.
14. 2+ levels in right atrial myocardium of patients with atrial fibrillation. Circ Res. 2010; 106: 1134-44.
15. Yue L, Feng J, Gaspo R, et al. Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation. Circ Res. 1997; 81: 512-25.
16. Bosch RF, Nattel S. Cellular electrophysiology of atrial fibrillation. Cardiovasc Res. 2002; 54: 259-69.
17. Verheule S, Wilson E, Banthia S, et al. Direction-dependent conduction abnormalities in a canine model of atrial fibrillation due to chronic atrial dilatation. Am J Physiol Heart Circ Physiol. 2004; 287: H634-44.
18. Spach MS, Heidlage JF, Dolber PC, et al. Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study. Heart Rhythm. 2007; 4: 175-85.
19. Wijffels MC, Kirchhof CJ, Dorland R, et al. Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation. 1995; 92: 1954-68.
20. Willems R, Holemans P, Ector H, et al. Mind the model: effect of instrumentation on inducibility of atrial fibrillation in a sheep model. J Cardiovasc Electrophysiol. 2002; 13: 62-7.
21. Nattel S, Khairy P, Schram G. Arrhythmogenic ionic remodelling: adaptive responses with maladaptive consequences. Trends Cardiovasc Med. 2001; 11: 295-301.
22. Baba S, Dun W, Hirose M, et al. Sodium current function in adult and aged canine atrial cells. Am J Physiol Heart Circ Physiol. 2006; 291: H756-61.
23. King LM, Opie LH. Glucose and glycogen utilisation in myocardial ischemia- changes in metabolism and consequences for the myocyte. Mol Cell Biochem. 1998; 180: 3-26.
24. O'Rourke B, Ramza BM, Marban E. Oscillations of membrane current and excitability driven by metabolic oscillations in heart cells. Science. 1994; 265: 962-6.
25. Depre C, Rider M, Hue L. Mechanisms of control of heart glycolysis. Eur J Biochem. 1998; 258: 277-90.
26. Cortassa S, Aon MA, Marban E, et al. An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics. Biophys J. 2003; 84: 2734-55.
27. Mihm MJ, Yu F, Carnes CA, et al. Impaired myofibrillar energetics and oxidative injury during human atrial fibrillation. Circulation. 2001; 104: 174-80.
28. Strand MA, Louis CF, Mickelson JR. Phosphorylation of porcine skeletal and cardiac muscle sarcoplasmic reticulum ryanodine receptor. Biochim Biophys Acta. 1993; 1175: 319-26.
29. Witcher DR, Kovacs RJ, Schulman H, et al. Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity. J Biol Chem. 1991; 266: 11144-52.
30. Hain J, Onoue H, Mayrleitner M, et al. Phosphorylation modulates the function of the calcium release channel of sarcoplasmic reticulum from cardiac muscle. J Biol Chem. 1995; 270: 2074-81.