Paralemmin-1 is expressed in lymphatic endothelial cells and modulates cell migration, cell maturation and tumor lymphangiogenesis

Angiogenesis

Volumn 16, Issue 4, 2013, Pages 795-807

  Albrecht, Imke ^a,b   Bieri, Raphael ^a,c   Leu, Angela ^a   Granacher, Philipp ^a   Hagmann, Jörg ^a   Kilimann, Manfred W ^d,e   Christofori, Gerhard ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b ACTELION PHARMACEUTICALS LTD   (Switzerland)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^e MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Angiogenesis; Cancer; Cell migration; Lymphangiogenesis; Paralemmin

Indexed keywords

MEMBRANE PROTEIN; PARALEMMIN 1; UNCLASSIFIED DRUG;

ADULT ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; FILOPODIUM; IN VITRO STUDY; INSULINOMA; LYMPHANGIOGENESIS; LYMPHATIC ENDOTHELIAL CELL; MEMBRANE BIOLOGY; MOUSE; NEWBORN; NONHUMAN; PANCREAS ISLET; PANCREAS TUMOR; PLASMA MEMBRANE BLEBBING; PRIORITY JOURNAL; PROTEIN EXPRESSION;

MUS;

ACTIN CYTOSKELETON; ANIMALS; CELL ADHESION; CELL MOVEMENT; CELL SURFACE EXTENSIONS; ENDOTHELIAL CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; INSULINOMA; ISLETS OF LANGERHANS; LYMPHANGIOGENESIS; LYMPHATIC METASTASIS; LYMPHATIC VESSELS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NEOPLASM PROTEINS; PANCREATIC NEOPLASMS; PHOSPHOPROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; VASCULAR ENDOTHELIAL GROWTH FACTOR C;

EID: 84884816124     PISSN: 09696970     EISSN: 15737209     Source Type: Journal    
DOI: 10.1007/s10456-013-9356-7     Document Type: Article

References (30)

1. Alitalo A, Detmar M (2012) Interaction of tumor cells and lymphatic vessels in cancer progression. Oncogene 31:4499-4508
2. Albrecht I, Christofori G (2011) Molecular mechanisms of lymphangiogenesis in development and cancer. Int J Dev Biol 55:483-494
3. Duong T, Koopman P, Francois M (2012) Tumor lymphangiogenesis as a potential therapeutic target. J Oncol 2012:204946
4. Hirakawa S (2011) Regulation of pathological lymphangiogenesis requires factors distinct from those governing physiological lymphangiogenesis. J Dermatol Sci 61:85-93
5. Stacker SA, Caesar C, Baldwin ME, Thornton GE, Williams RA, Prevo R, et al. (2001) VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat Med 7:186-191
6. Cao R, Bjorndahl MA, Religa P, Clasper S, Garvin S, Galter D, et al. (2004) PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis. Cancer Cell 6:333-345
7. Baluk P, Yao LC, Feng J, Romano T, Jung SS, Schreiter JL, et al. (2009) TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice. J Clin Invest 119:2954-2964
8. Maruyama K, Ii M, Cursiefen C, Jackson DG, Keino H, Tomita M, et al. (2005) Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. J Clin Invest 115:2363-2372
9. Kerjaschki D, Huttary N, Raab I, Regele H, Bojarski-Nagy K, Bartel G, et al. (2006) Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants. Nat Med 12:230-234
10. Zumsteg A, Baeriswyl V, Imaizumi N, Schwendener R, Ruegg C, Christofori G (2009) Myeloid cells contribute to tumor lymphangiogenesis. PLoS ONE 4:e7067
11. Hultqvist G, Ocampo Daza D, Larhammar D, Kilimann MW (2012) Evolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. PLoS ONE 7:e41850
12. Kutzleb C, Sanders G, Yamamoto R, Wang X, Lichte B, Petrasch-Parwez E, et al. (1998) Paralemmin, a prenyl-palmitoyl-anchored phosphoprotein abundant in neurons and implicated in plasma membrane dynamics and cell process formation. J Cell Biol 143:795-813
13. Arstikaitis P, Gauthier-Campbell C, Carolina Gutierrez Herrera R, Huang K, Levinson JN, Murphy TH, et al. (2008) Paralemmin-1, a modulator of filopodia induction is required for spine maturation. Mol Biol Cell 19:2026-2038
14. Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini A-D (2004) Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. Mol Biol Cell 15:2205-2217
15. Hanahan D (1985) Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315:115-122
16. Mandriota SJ, Jussila L, Jeltsch M, Compagni A, Baetens D, Prevo R, et al. (2001) Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J 20:672-682
17. Ando T, Jordan P, Joh T, Wang Y, Jennings MH, Houghton J, et al. (2005) Isolation and characterization of a novel mouse lymphatic endothelial cell line: SV-LEC. Lymphat Res Biol 3:105-115
18. Sironi M, Conti A, Bernasconi S, Fra AM, Pasqualini F, Nebuloni M, et al. (2006) Generation and characterization of a mouse lymphatic endothelial cell line. Cell Tissue Res 325:91-100
19. Giannone G, Dubin-Thaler BJ, Dobereiner HG, Kieffer N, Bresnick AR, Sheetz MP (2004) Periodic lamellipodial contractions correlate with rearward actin waves. Cell 116:431-443
20. DiMilla PA, Stone JA, Quinn JA, Albelda SM, Lauffenburger DA (1993) Maximal migration of human smooth muscle cells on fibronectin and type IV collagen occurs at an intermediate attachment strength. J Cell Biol 122:729-737
21. Palecek SP, Loftus JC, Ginsberg MH, Lauffenburger DA, Horwitz AF (1997) Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Nature 385:537-540
22. Petrie RJ, Doyle AD, Yamada KM (2009) Random versus directionally persistent cell migration. Nat Rev Mol Cell Biol 10:538-549
23. Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, et al. (2010) Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. J Cell Biol 188:115-130
24. Kutzleb C, Petrasch-Parwez E, Kilimann MW (2007) Cellular and subcellular localization of paralemmin-1, a protein involved in cell shape control, in the rat brain, adrenal gland and kidney. Histochem Cell Biol 127:13-30
25. Turk CM, Fagan-Solis KD, Williams KE, Gozgit JM, Smith-Schneider S, Marconi SA, et al. (2012) Paralemmin-1 is over-expressed in estrogen-receptor positive breast cancers. Cancer Cell Int 12:17
26. Fackler OT, Grosse R (2008) Cell motility through plasma membrane blebbing. J Cell Biol 181:879-884
27. Zaidel-Bar R, Cohen M, Addadi L, Geiger B (2004) Hierarchical assembly of cell-matrix adhesion complexes. Biochem Soc Trans 32:416-420
28. Basile M, Lin R, Kabbani N, Karpa K, Kilimann M, Simpson I, et al. (2006) Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling. Arch Biochem Biophys 446:60-68
29. Chen X, Wu X, Zhao Y, Wang G, Feng J, Li Q, et al. (2011) A novel binding protein of single immunoglobulin IL-1 receptor-related molecule: paralemmin-3. Biochem Biophys Res Commun 404:1029-1033
30. Hultqvist G, Ocampo Daza D, Larhammar D, Kilimann MW (2012) Evolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. PLoS ONE 7:e41850