Serum Ghrelin; A New Surrogate Marker of Gastric Mucosal Alterations in Upper Gastrointestinal Carcinogenesis

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Sadjadi, Alireza ^a,b   Yazdanbod, Abbas ^c   Lee, Yeong Yeh ^d,e   Boreiri, Majid ^a   Samadi, Fatemeh ^c   Alizadeh, Behrooz Z ^a,b   Islami, Farhad ^f   Fyfe, Valerie ^d   Babaei, Masoud ^c   Namazi, Mohammad J ^d,g   Going, James J ^d   Sotoudeh, Masoud ^a   de Bock, Geertruida H ^b   Malekzadeh, Reza ^a   Derakhshan, Mohammad H ^a,d  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c ARDABIL UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e SCHOOL OF MEDICAL SCIENCES   (Malaysia)

^f MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^g SABZEVAR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM ANTIBODY; GHRELIN; HELICOBACTER PYLORI ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; PEPSINOGEN I; PEPSINOGEN II; UNCLASSIFIED DRUG;

ADULT; AGE; AGED; ARTICLE; ATROPHIC GASTRITIS; CARCINOGENESIS; CARDIA; CONTROLLED STUDY; DIGESTIVE SYSTEM CANCER; DISEASE ASSOCIATION; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; GASTROESOPHAGEAL CANCER; GASTROINTESTINAL ENDOSCOPY; GENDER; GHRELIN BLOOD LEVEL; HISTOPATHOLOGY; HORMONE BLOOD LEVEL; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; POPULATION BASED CASE CONTROL STUDY; POPULATION RESEARCH; SMOKING; STOMACH CANCER; STOMACH MUCOSA LESION; UPPER GASTROINTESTINAL TRACT;

ESOPHAGEAL NEOPLASMS; GASTRIC MUCOSA; GHRELIN; HUMANS; IMMUNOGLOBULIN G; LOGISTIC MODELS; ODDS RATIO; PEPSINOGEN A; PEPSINOGEN C; STATISTICS, NONPARAMETRIC; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84884805016     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074440     Document Type: Article

References (41)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, et al. (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127: 2893-917.
2. Correa P, (1992) Human gastric carcinogenesis: a multistep and multifactorial process-First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 52: 6735-40.
3. McColl KE, El-Omar E, (2002) How does H. pylori infection cause gastric cancer? Keio J Med 51Suppl 2: 53-6.
4. Derakhshan MH, El-Omar E, Oien K, Gillen D, Fyfe V, et al. (2006) Gastric histology, serological markers and age as predictors of gastric acid secretion in patients infected with Helicobacter pylori. J Clin Pathol 59: 1293-9.
5. Ohata H, Oka M, Yanaoka K, Shimizu Y, Mukoubayashi C, et al. (2005) Gastric cancer screening of a high-risk population in Japan using serum pepsinogen and barium digital radiography. Cancer Sci 96: 713-20.
6. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, et al. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402: 656-660.
7. Rindi G, Necchi V, Savio A, Torsello A, Zoli M, et al. (2002) Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues. Histochem Cell Biol 117: 511-99.
8. Atalayer D, Gibson C, Konopacka A, Geliebter A, (2013) Ghrelin and eating disorders. Prog Neuropsychopharmacol Biol Psychiatry 40: 70-82.
9. Komarowska H, Jaskula M, Stangierski A, Wasko R, Sowinski J, et al. (2012) Influence of ghrelin on energy balance and endocrine physiology.Neuro Endocrinol Lett. 33: 749-56.
10. Hansen S, Vollset SE, Derakhshan MH, Fyfe V, Melby KK, et al. (2007) Two distinct aetiologies of cardia cancer; evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status. Gut 56: 918-25.
11. Derakhshan MH, Malekzadeh R, Watabe H, Yazdanbod A, Fyfe V, et al. (2008) Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer. Gut 57: 298-305.
12. Chopin L, Walpole C, Seim I, Cunningham P, Murray R, et al. (2011) Ghrelin and cancer. Mol Cell Endocrinol 340: 65-9.
13. Murphy G, Kamangar F, Albanes D, Stanczyk FZ, Weinstein SJ, et al. (2012) Serum ghrelin is inversely associated with risk of subsequent oesophageal squamous cell carcinoma. Gut 61: 1533-7.
14. de Martel C, Haggerty TD, Corley DA, Vogelman JH, Orentreich N, et al. (2007) Serum ghrelin levels and risk of subsequent adenocarcinoma of the oesophagus. Am J Gastroenterol 102: 1166-72.
15. Murphy G, Kamangar F, Dawsey SM, Stanczyk FZ, Weinstein SJ, et al. (2011) The relationship between serum ghrelin and the risk of gastric and esophagogastric junctional adenocarcinomas. J Natl Cancer Inst 103: 1123-9.
16. Sadjadi A, Malekzadeh R, Derakhshan MH, Sepehr A, Nouraie M, et al. (2003) Cancer occurrence in Ardabil: results of a population-based cancer registry from Iran. Int J Cancer 107: 113-8.
17. Derakhshan MH, Yazdanbod A, Sadjadi AR, Shokoohi B, McColl KE, et al. (2004) High incidence of adenocarcinoma arising from the right side of the gastric cardia in NW Iran. Gut 53: 1262-6.
18. Percy CA, Fritz AJ, Shanmugarathan S, Sobin L, Parkin DM, et al. (2000) International classification of disease for oncology. 3 rd edition. Geneva: World Health Organization.
19. Lauren P, (1965) The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 64: 31-49.
20. Dixon MF, Genta RM, Yardley JH, Correa P, (1996) Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol 20: 1161-81.
21. Hosoda H, Doi K, Nagaya N, Okumura H, Nakagawa E, et al. (2004) Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples. Clinical Chemistry 50: 1077-1080.
22. Zub-Pokrowiecka A, Rembiasz K, Konturek PC, Budzynski A, Konturek SJ, et al. (2011) Ghrelin and gastrin in advanced gastric cancer before and after gastrectomy. World J Gastroenterol 17: 449-58.
23. Tanaka-Shintani M, Watanabe M, (2005) Distribution of ghrelin-immunoreactive cells in human gastric mucosa: comparison with that of parietal cells. J Gastroenterol 4: 345-349.
24. Zub-Pokrowiecka A, Rembiasz K, Konturek SJ, Budzynski A, Konturek PC, et al. (2010) Ghrelin in diseases of the gastric mucosa associated with Helicobacter pylori infection. Med Sci Monit 16: CR493-500.
25. Kawashima J, Ohno S, Sakurada T, Takabayashi H, Kudo M, et al. (2009) Circulating acylated ghrelin level decreases in accordance with the extent of atrophic gastritis. J Gastroenterol 44: 1046-54.
26. Carrasco F, Rojas P, Csendes A, Codoceo J, Inostroza J, et al. (2012) Changes in ghrelin concentrations one year after resective and non-resective gastric bypass: associations with weight loss and energy and macronutrient intakes. Nutrition 28: 757-61.
27. Isomoto H, Ueno H, Saenko VA, Mondal MS, Nishi Y, et al. (2005) Impact of Helicobacter pylori infection on gastric and plasma ghrelin dynamics in humans. Am J Gastroenterol 100: 1711-20.
28. Strickertsson JA, Døssing KB, Aabakke AJ, Nilsson HO, Hansen TV, et al. (2011) Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism. World J Gastroenterol 17: 3117-25.
29. Kerem M, Ferahkose Z, Yilmaz UT, Pasaoglu H, Ofluoglu E, et al. (2008) Adipokines and ghrelin in gastric cancer cachexia.World J. Gastroenterol (14): 3633-41.
30. McColl KE, Watabe H, Derakhshan MH, (2008) Role of gastric atrophy in mediating negative association between Helicobacter pylori infection and reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma. Gut 57: 721-3.
31. Ye W, Held M, Lagergren J, Lagergren J, Engstrand L, et al. (2004) Helicobacter pylori infection and gastric atrophy: risk of adenocarcinoma and squamous-cell carcinoma of the oesophagus and adenocarcinoma of the gastric cardia. J Natl Cancer Inst 96: 388-96.
32. Derakhshan MH, Malekzadeh R, Fyfe V, Yazdanbod A, Kazemi A, et al. (2007) Chronic atrophic gastritis is a major risk factor for oesophageal squamous cell carcinoma. Gut 56: A68-69.
33. Kamangar F, Diaw L, Wei WQ, Abnet CC, Wang GQ, et al. (2009) Serum pepsinogens and risk of oesophageal squamous dysplasia. Int J Cancer 124: 456-60.
34. de Vries AC, Capelle LG, Looman CW, van Blankenstein M, van Grieken NC, et al. (2009) Increased risk of oesophageal squamous cell carcinoma in patients with gastric atrophy: independent of the severity of atrophic changes. Int J Cancer 124: 2135-8.
35. Cook MB, Dawsey SM, Diaw L, Blaser MJ, Perez-Perez GI, et al. (2010) Serum pepsinogens and Helicobacter pylori in relation to the risk of oesophageal squamous cell carcinoma in the alpha-tocopherol, beta-carotene cancer prevention study. Cancer Epidemiol Biomarkers Prev 19: 1966-75.
36. Islami F, Sheikhattari P, Ren JS, Kamangar F, (2011) Gastric atrophy and risk of oesophageal cancer and gastric cardia adenocarcinoma - a systematic review and meta-analysis. Ann Oncol 22: 754-60.
37. Iijima K, Koike T, Abe Y, Inomata Y, Sekine H, et al. (2007) Extensive gastric atrophy: an increased risk factor for superficial oesophageal squamous cell carcinoma in Japan. Am J Gastroenterol 102: 1603-9.
38. Akiyama T, Inamori M, Iida H, Endo H, Hosono K, et al. (2009) Macroscopic extent of gastric mucosal atrophy: increased risk factor for oesophageal squamous cell carcinoma in Japan. BMC Gastroenterol 9: 34.
39. Wu Y, Chen J, Ohshima H, Pignatelli B, Boreham J, et al. (1993) Geographic association between urinary excretion of N-nitroso compounds and oesophageal cancer mortality in China. Int J Cancer 54: 713-19.
40. Sadjadi A, Derakhshan MH, Yazdanbod A, Boreiri M, Parsaeian M, et al. (2013) Neglected role of hookah and opium in gastric carcinogenesis: A cohort study on risk factors and attributable fractions. Int J Cancer. doi:10.1002/ijc.28344.
41. Sadeghi-Bazargani H, Jafarzadeh H, Fallah M, Hekmat S, Bashiri J, et al. (2011) Risk factor investigation for cardiovascular health through WHO STEPS approach in Ardabil, Iran. Vasc Health Risk Manag 7: 417-24.