Elevated Serum Ferritin Level Is Associated with the Incident Type 2 Diabetes in Healthy Korean Men: A 4 Year Longitudinal Study

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Jung, Chang Hee ^a   Lee, Min Jung ^a   Hwang, Jenie Yoonoo ^a   Jang, Jung Eun ^a   Leem, Jaechan ^a   Park, Joong Yeol ^a   Lee, JungBok ^a   Kim, Hong Kyu ^a   Lee, Woo Je ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN;

ADULT; ARTICLE; ASIAN; CHEMILUMINESCENCE IMMUNOASSAY; CONTROLLED STUDY; DISEASE ASSOCIATION; FERRITIN BLOOD LEVEL; FOLLOW UP; HUMAN; INCIDENCE; INSULIN RESISTANCE; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MEDICAL EXAMINATION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBSERVATIONAL STUDY; SOUTH KOREA;

COHORT STUDIES; DIABETES MELLITUS, TYPE 2; FERRITINS; HUMANS; IMMUNOASSAY; LONGITUDINAL STUDIES; MALE; REPUBLIC OF KOREA; STATISTICS, NONPARAMETRIC;

EID: 84884797324     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075250     Document Type: Article

References (42)

1. Rajpathak SN, Crandall JP, Wylie-Rosett J, Kabat GC, Rohan TE, et al. (2009) The role of iron in type 2 diabetes in humans. Biochim Biophys Acta 1790: 671-681.
2. Piperno A, Trombini P, Gelosa M, Mauri V, Pecci V, et al. (2002) Increased serum ferritin is common in men with essential hypertension. J Hypertens 20: 1513-1518.
3. Sheu WH, Chen YT, Lee WJ, Wang CW, Lin LY, (2003) A relationship between serum ferritin and the insulin resistance syndrome is present in non-diabetic women but not in non-diabetic men. Clin Endocrinol (Oxf) 58: 380-385.
4. Ma J, Stampfer MJ, (2002) Body iron stores and coronary heart disease. Clin Chem 48: 601-603.
5. Opara EC, (2004) Role of oxidative stress in the etiology of type 2 diabetes and the effect of antioxidant supplementation on glycemic control. J Investig Med 52: 19-23.
6. Jiang R, Manson JE, Meigs JB, Ma J, Rifai N, et al. (2004) Body iron stores in relation to risk of type 2 diabetes in apparently healthy women. JAMA 291: 711-717.
7. Salonen JT, Tuomainen TP, Nyyssonen K, Lakka HM, Punnonen K, (1998) Relation between iron stores and non-insulin dependent diabetes in men: case-control study. BMJ 317: 727.
8. Forouhi NG, Harding AH, Allison M, Sandhu MS, Welch A, et al. (2007) Elevated serum ferritin levels predict new-onset type 2 diabetes: results from the EPIC-Norfolk prospective study. Diabetologia 50: 949-956.
9. Rajpathak SN, Wylie-Rosett J, Gunter MJ, Negassa A, Kabat GC, et al. (2009) Biomarkers of body iron stores and risk of developing type 2 diabetes. Diabetes Obes Metab 11: 472-479.
10. Jehn ML, Guallar E, Clark JM, Couper D, Duncan BB, et al. (2007) A prospective study of plasma ferritin level and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Epidemiol 165: 1047-1054.
11. Fumeron F, Pean F, Driss F, Balkau B, Tichet J, et al. (2006) Ferritin and transferrin are both predictive of the onset of hyperglycemia in men and women over 3 years: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study. Diabetes Care 29: 2090-2094.
12. Montonen J, Boeing H, Steffen A, Lehmann R, Fritsche A, et al. (2012) Body iron stores and risk of type 2 diabetes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study. Diabetologia 55: 2613-2621.
13. Zhao Z, Li S, Liu G, Yan F, Ma X, et al. (2012) Body iron stores and heme-iron intake in relation to risk of type 2 diabetes: a systematic review and meta-analysis. PLoS One 7: e41641.
14. Bao W, Rong Y, Rong S, Liu L, (2012) Dietary iron intake, body iron stores, and the risk of type 2 diabetes: a systematic review and meta-analysis. BMC Med 10: 119.
15. Kunutsor SK, Apekey TA, Walley J, Kain K, (2013) Ferritin levels and risk of type 2 diabetes mellitus: an updated systematic review and meta-analysis of prospective evidence. Diabetes Metab Res Rev 29: 308-318.
16. Shi Z, Hu X, Yuan B, Pan X, Meyer HE, et al. (2006) Association between serum ferritin, hemoglobin, iron intake, and diabetes in adults in Jiangsu, China. Diabetes Care 29: 1878-1883.
17. Kim CH, Kim HK, Bae SJ, Park JY, Lee KU, (2011) Association of elevated serum ferritin concentration with insulin resistance and impaired glucose metabolism in Korean men and women. Metabolism 60: 414-420.
18. Lee BK, Kim Y, Kim YI, (2011) Association of serum ferritin with metabolic syndrome and diabetes mellitus in the South Korean general population according to the Korean National Health and Nutrition Examination Survey 2008. Metabolism 60: 1416-1424.
19. Luan de C, Li H, Li SJ, Zhao Z, Li X, et al. (2008) Body iron stores and dietary iron intake in relation to diabetes in adults in North China. Diabetes Care 31: 285-286.
20. Sun L, Franco OH, Hu FB, Cai L, Yu Z, et al. (2008) Ferritin concentrations, metabolic syndrome, and type 2 diabetes in middle-aged and elderly chinese. J Clin Endocrinol Metab 93: 4690-4696.
21. Carlson MD, Morrison RS, (2009) Study design, precision, and validity in observational studies. J Palliat Med 12: 77-82.
22. Harris EL, McLaren CE, Reboussin DM, Gordeuk VR, Barton JC, et al. (2007) Serum ferritin and transferrin saturation in Asians and Pacific Islanders. Arch Intern Med 167: 722-726.
23. Merkel PA, Simonson DC, Amiel SA, Plewe G, Sherwin RS, et al. (1988) Insulin resistance and hyperinsulinemia in patients with thalassemia major treated by hypertransfusion. N Engl J Med 318: 809-814.
24. Dekker LH, Nicolaou M, van der AD, Busschers WB, Brewster LM, et al. (2013) Sex Differences in the Association Between Serum Ferritin and Fasting Glucose in Type 2 Diabetes Among South Asian Surinamese, African Surinamese, and Ethnic Dutch: The population-based SUNSET study. Diabetes Care 36: 965-971.
25. Park SK, Ryoo JH, Kim MG, Shin JY, (2012) Association of serum ferritin and the development of metabolic syndrome in middle-aged Korean men: a 5-year follow-up study. Diabetes Care 35: 2521-2526.
26. Kim BJ, Ahn SH, Bae SJ, Kim EH, Lee SH, et al. (2012) Iron overload accelerates bone loss in healthy postmenopausal women and middle-aged men: a 3-year retrospective longitudinal study. J Bone Miner Res 27: 2279-2290.
27. Jung CH, Lee WJ, Hwang JY, Yu JH, Shin MS, et al. (2013) Assessment of the fatty liver index as an indicator of hepatic steatosis for predicting incident diabetes independently of insulin resistance in a Korean population. Diabet Med 30: 428-435.
28. Standards of medical care in diabetes-2013. Diabetes Care 36: S11-66.
29. Furusyo N, Koga T, Ai M, Otokozawa S, Kohzuma T, et al. (2011) Utility of glycated albumin for the diagnosis of diabetes mellitus in a Japanese population study: results from the Kyushu and Okinawa Population Study (KOPS). Diabetologia 54: 3028-3036.
30. Shi Z, Zhou M, Yuan B, Qi L, Dai Y, et al. (2010) Iron intake and body iron stores, anaemia and risk of hyperglycaemia among Chinese adults: the prospective Jiangsu Nutrition Study (JIN). Public Health Nutr 13: 1319-1327.
31. Warnecke RB, Oh A, Breen N, Gehlert S, Paskett E, et al. (2008) Approaching Health Disparities From a Population Perspective: The National Institutes of Health Centers for Population Health and Health Disparities. Am J Public Health 98: 1608-1615.
32. Niederau C, Berger M, Stremmel W, Starke A, Strohmeyer G, et al. (1984) Hyperinsulinaemia in non-cirrhotic haemochromatosis: impaired hepatic insulin degradation? Diabetologia 26: 441-444.
33. Fernandez-Real JM, Ricart-Engel W, Arroyo E, Balanca R, Casamitjana-Abella R, et al. (1998) Serum ferritin as a component of the insulin resistance syndrome. Diabetes Care 21: 62-68.
34. Trombini P, Piperno A, (2007) Ferritin, metabolic syndrome and NAFLD: elective attractions and dangerous liaisons. J Hepatol 46: 549-552.
35. Williams KH, Shackel NA, Gorrell MD, McLennan SV, Twigg SM, (2012) Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo. Endocr Rev 13: 13.
36. Oberley LW, (1988) Free radicals and diabetes. Free Radic Biol Med 5: 113-124.
37. Wilson JG, Lindquist JH, Grambow SC, Crook ED, Maher JF, (2003) Potential role of increased iron stores in diabetes. Am J Med Sci 325: 332-339.
38. Gabay C, Kushner I, (1999) Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 340: 448-454.
39. Haffner SM, (2006) The metabolic syndrome: inflammation, diabetes mellitus, and cardiovascular disease. Am J Cardiol 97: 3A-11A.
40. Rushton DH, Dover R, Sainsbury AW, Norris MJ, Gilkes JJ, et al. (2001) Why should women have lower reference limits for haemoglobin and ferritin concentrations than men? BMJ 322: 1355-1357.
41. Malczewska J, Stupnicki R, Blach W, Turek-Lepa E, (2004) The effects of physical exercise on the concentrations of ferritin and transferrin receptor in plasma of male judoists. Int J Sports Med 25: 516-521.
42. Whitfield JB, Zhu G, Heath AC, Powell Lw, et al. (2001) Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers. Alcohol Clin Exp Res 25: 1037-1045.