Methyl isocyanate: The Bhopal gas

Handbook of Toxicology of Chemical Warfare Agents

Volumn , Issue , 2009, Pages 293-312

  Varma, Daya R ^a   Mulay, Shree ^b  

^a MCGILL UNIVERSITY   (Canada)

^b MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84884757383     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-374484-5.00021-3     Document Type: Chapter

References (215)

1. Acquilla S.D., Cullinan P., Dhara V.R. Long-term morbidity in survivors of the 1984 Bhopal gas leak. Natl Med. J. India. 1996, 9:5-10.
2. Adams W.G.F. Lung function of men engaged on the manufacture of toluene diisocyanate. Proc. R. Soc. Med 1970, 63:378-379.
3. Adkins B., O'Conner R.W., Dement J.M. Inhalation exposure system used for acute and repeated-dose methyl isocyanate exposure of laboratory animals. Environ. Health Perspect 1987, 72:45-51.
4. Alarie Y., Ferguson J.S., Stock M.F., Weyel D.A., Schaper M. Sensory and pulmonary irritation of methyl isocyanate and pulmonary irritation and possible cyanide-like effects of methyl isocyanate in guinea pigs. Environ. Health Perspect 1987, 72:159-167.
5. Anderson D., Goyle S., Phillips B.J., Tee A., Beech L., Butler W.H. Effects of methyl isocyanate on rat muscle cells in culture. Br. J. Ind. Med. 1988, 45:269-274.
6. Anderson D., Goyle S., Phillips B.J., Tee A., Beech L., Butler W.H. Effects of methyl isocyanate on rat brain cells in culture. Br. J. Ind. Med. 1990, 47:596-601.
7. Andersson N., Muir M.K., Mehra V. Bhopal eye. Lancet 1984, ii: 1481.
8. Andersson N., Muir M.K., Salmon A.G., Wells C.J., Brown R.B., Purnell C.J., Mittal P.C., Mehra V. eye follow-up and analytical chemistry. Lancet 1985, 761-762. Bhopal disasteri.
9. Andersson N., Muir M.K., Ajwani M.K., Mahashabde S., Salmon A., Vaidyanathan K. Persistent eye watering among Bhopal survivors. Lancet 1986, ii: 1152.
10. Andersson N., Muir M.K., Mehra V., Salmon A.G. Exposure and response to methyl isocyanate: results of community-based survey in Bhopal. Br. J. Ind. Med 1988, 45:469-475.
11. Andersson N., Ajwani M.K., Mahashabde S., Tiwari M.K., Muir M.K., Mehra V., Ashiru K., Mackenzie C.D. Delayed eye and other consequences from exposure to methyl isocyanate: 93% follow up of exposed and unexposed cohorts in Bhopal. Br. J. Ind. Med 1990, 47:553-558.
12. Avashia B., Battigelli M.C., Morgan W.K.C., Reger R.B. Effects of prolonged low exposure to methyl isocyanate. J. Occup. Environ. Med 1996, 38:625-630.
13. Axford A.T., McKerrow C.B., Parry J.A., Le Quesne P.M. Accidental exposure to isocyanate fumes in a group of firemen. Br. J. Ind. Med. 1976, 33:65-71.
14. Axness M.E., Fleeker J.R. Metabolism of the butylcarbamoyl moiety of benomyl in rats. Pestic. Biochem. Physiol. 1979, 11:1-12.
15. Baader E.W. Lungenschaden durch isozynate [Lung injury by isocyanate]. Med. Sachverstaend. 1956, 52:128.
16. Baillie, T.A., Slatter, J.G. (1991). GSH: a vehicle for the transport of chemically reactive metabolites in vivo. Accounts Chem. Res.24: 264-70.
17. Ballantyne, B., Marrs, T.C. (1987). Clinical and Experimental Toxicology of Cyanides. Wright, Bristol. 512 pp.
18. Ballantyne B., Bright J.E., Williams P. The post-mortem rate of transformation of cyanide. Forensic Sci. 1974, 3:71-76.
19. Baxter P.J. From Flixborough to Bhopal: is legislation enough?. Br. J. Ind. Med. 1986, 43:1-5.
20. Bhandari N.R., Syal A.K., Kambo I., Nair A., Beohar V., Saxena N.C., Dabke A.T., Agarwal S.S., Saxena B.N. Pregnancy outcome in women exposed to toxic gas at Bhopal. Indian J. Med. Res. 1990, 92:28-33.
21. Bhargava D.K., Varma A., Batni G., Misra N.P., Tiwari U.C., Vijayan V.K., Jain S.K. Early observations on lung function studies in symptomatic "gas'-exposed population of Bhopal. Indian J. Med. Res. 1987, 86(Suppl.):1-10.
22. Bharucha E.P., Bharucha N.E. Neurological manifestations among those exposed to toxic gas at Bhopal. Indian J. Med. Res. 1987, 86(Suppl.):59-62.
23. 14C]methyl isocyanate to various tissue proteins. Biochem. Pharmacol. 1988, 37:2489-2493.
24. Blake P.G., Ijadi-Maghsoodi S. Kinetics and mechanism of the thermal decomposition of methyl isocyanate. Int. J. Chem. Kinet 1982, 14:945-952.
25. Boorman G.A., Uraih L.C., Gupta B.N., Bucher J.R. Two-hour methyl isocyanate inhalation and 90-day recovery study in B6C3F1 mice. Environ. Health Perspect 1987, 72:63-69.
26. Brooks S.M., Weiss M.A., Bernstein I.L. Reactive airways dysfunction syndrome (RADS): persistent asthma syndrome after high level irritant exposures. Chest 1985, 88:376-384.
27. Brown W.E., Green A.H., Cedel T.E., Cairns J. Biochemistry of protein-isocyanate interactions: a comparison of the effects of aryl vs. alkyl isocyanates. Environ. Health Perspect 1987, 72:5-11.
28. Bruckner H.C., Avery S.B., Stetson D.M., Dodson V.N. Clinical and immunologic appraisal of workers exposed to diisocyanates. Arch. Environ. Health 1968, 16:619-625.
29. Bruggeman I.M., Temmink J.H.M., Bladeren P.J. Glutathione-and cysteine-mediated cytotoxicity of allyl and benzyl isothiocyanate. Toxicol. Appl. Pharmacol. 1986, 83:349-359.
30. Brugsch H.G., Elkins H.B. Toluene diisocyanate (TDI) toxicity. N. Engl. J. Med. 1963, 268:353-357.
31. Brusewitz G., Cameron B.D., Chasseaud L.F., Gorler K., Hawkins D.R., Koch H., Mennicke W.H. The metabolism of benzyl isothiocyanate and its cysteine conjugate. Biochem. J. 1977, 162:99-107.
32. Bucher J.R. Methyl isocyanate: a review of health effects research since Bhopal. Fundam. Appl. Toxicol 1987, 9:367-379.
33. Bucher, J.R., Boorman, G.A., Gupta, B.N., Uraih, L.C., Hall, L.B., Stefanski, S.A. (1987a). Two-hour methyl isocyanate inhalation exposure and 91-day recovery: a preliminary description of pathologic changes in F344 rats. Environ. Health Perspect.72: 71-5.
34. Bucher, J.R., Gupta, B.N., Adkins, B., Thompson, M., Jameson, C.W., Thigpen, J.E., Schwetz, B.A. (1987b). Toxicity of inhaled methyl isocyanate in F344/N rats and B6C3F1 mice. I. Acute exposure and recovery studies. Environ. Health Perspect.72: 53-61.
35. Budiansky S. Bhopal aftermath -legal complications mount. Nature 1985, 314:663.
36. Cailleux A., Subra J.F., Riberi P., Tuchais E., Premel-Cabic A., Allain P. Cyanide and thiocyanate blood levels in patients with renal failure or respiratory disease. J. Med. 1988, 19:345-351.
37. Carney I.F. Toxicology of isocyanates. Eur. J. Cell. Plastics 1980, 3:78-81.
38. Caspary W.J., Myhr B. Mutagenicity of methylisocyanate and its reaction products to cultured mammalian cells. Mutat. Res. 1986, 174:285-293.
39. Chandra H., Rao G.J., Saraf A.K., Sharma V.K., Jadhav R.K., Sriramachari S. GC-MS identification of MIC trimer: a constituent of tank residue in preserved autopsy blood of Bhopal gas victims. Med. Sci. Law 1991, 31:194-198.
40. Chandra H., Saraf A.K., Jadhav R.K., Rao R.K., Sharma V.K., Sriramachari S., Vairamani M. Isolation of an unknown compound from both blood of Bhopal aerosol disaster victims and residue of Tank E-610 of Union Carbide India Limited -chemical characterization of the structure. Med. Sci. Law 1994, 34:106-110.
41. Charles L., Bernstein A., Jones B., Jones D.J., Edwards J.H., Seal R.M.E., Seaton A. Hypersensitivity pneumonitis after exposure to isocyanates. Thorax 1976, 31:127-136.
42. Chemical & Engineering News (1985). A C&EN Special Issue -Bhopal the continuing story, 63: no. 6.
43. Chen K.K., Rose C.L. Treatment of acute cyanide poisoning. JAMA 1956, 162:1154-1155.
44. CliffJ., Martelli A., Molin A., Rosling H. Mantakassa: an epidemic of spastic paraparesis associated with chronic cyanide intoxication in a cassava staple area of Mozambique. 1. Epidemiology and clinical and laboratory findings in patients. Bull. World Health Org. 1984, 62:477-484.
45. Conner M.K., Rubinson H.F., Ferguson J.S., Stock M.F., Alarie Y. Evaluation of sister chromatid exchange and cytotoxicity in murine tissues in vivo and lymphocytes in vitro following methyl isocyanate exposure. Environ. Health Perspect. 1987, 72:177-182.
46. Crabb C. Revisiting the Bhopal tragedy. Science 2004, 306:1670-1671.
47. Cullinan P., Acquilla S.D., Dhara V.R. Long term morbidity in survivors of the 1984 Bhopal gas leak. Natl Med. J. India 1996, 9:5-10.
48. Cullinan P., Acquilla S.D., Dhara V.R. Respiratory morbidity 10 years after the Union Carbide gas leak at Bhopal: a cross sectional survey. Br. Med. J. 1997, 314:338-342.
49. Curry A.S. Cyanide poisoning. Acta Pharmacol. Toxicol. 1963, 20:291-294.
50. Daniel, C.S., Singh, A.K., Siddiqui, P., Mathur, B.B.L., Das, S.K., Agarwal, S.S. (1987). Preliminary report on spermatogenic function of male subjects exposed to gas at Bhopal. Indian J. Med. Res.86 (Suppl.): 83-6.
51. Deo, M.G., Gangal, S., Bhisey, A.N., Somasundaram, R., Balsara, B., Gulwani, B., Darbari, B.S., Bhide, S., Maru, G.B. (1987). Immunological, mutagenic and genotoxic investigation in gas exposed population of Bhopal. Indian J. Med. Res.86 (Suppl.): 63-76.
52. Dhara R., Dhara V.R. Bhopal -a case study of international disaster. Int. J. Occup. Environ. Health 1995, 1:58-69.
53. Dhara V.R., Dhara R. The Union Carbide disaster in Bhopal: a review of health effects. Arch. Environ. Health 2002, 57:391-404.
54. Dhara V.R., Gassert T.H. The Bhopal syndrome: persistent questions about acute toxicity and management of gas victims. Int. J. Occup. Environ. Health 2002, 8:380-386.
55. Dhara V.R., Kriebel D. The Bhopal gas disaster: it's not too late for sound epidemiology. Arch. Environ. Health 1993, 48:436-437.
56. Dhara V.R., Dhara R., Acquilla S.D., Cullinan P. Personal exposure and long-term health effects in survivors of the Union Carbide disaster at Bhopal. Environ. Health Perspect. 2002, 110:487-500.
57. Dikshit R.P., Kanhere S. Cancer patterns of lung, oropharynx and oral cavity cancer in relation to gas exposure at Bhopal. Cancer Causes Control 1999, 10:627-636.
58. Dodd D.E., Fowler E.H., Snellings W.M., Pritts I.M., Baron R.L. Acute inhalation studies with methyl isocyanate vapor. Fundam. Appl. Toxicol. 1986, 6:747-755.
59. Dodd D.E., Frank F.R., Fowler E.H., Troup C.M., Milton R.M. Biological effects of short-term, high concentration exposure to methyl isocyanate. I. Study objectives and inhalation exposure design. Environ. Health Perspect 1987, 72:13-19.
60. D'Silva T.D.J., Lopes A., Jones R.L., Singhawangcha S., Chan J.K. Studies of methyl isocyanate chemistry in the Bhopal incident. J. Org. Chem. 1986, 51:3781-3788.
61. Dureja G.P., Saxena R.S. The methyl isocyanate (MIC) gas tragedy in Bhopal (India). Indian J. Anaesth. 1987, 35:264-268.
62. Dutta K.K., Gupta G.S.D., Mishra A., Joshi A., Tandon G.S., Ray P.K. Inhalation toxicity studies of methyl isocyanate (MIC) in rats. Part I: Pulmonary pathology and genotoxicity evaluation. Indian J. Exp. Biol. 1988, 26:177-182.
63. Dwivedi P.C., Raizada J.K., Saini V.K., Mittal P.C. Ocular lesions following methyl isocyanate contamination. Arch. Ophthalmol. 1985, 103:1627.
64. Dwivedi P.D., Mishra A., Gupta G.S.D., Dutta K.K., Das S.N., Ray P.K. Inhalation toxicity studies of methyl isocyanate (MIC) in rats. IV. Immunologic response of rats one week after exposure: effect on body and organ weights, phagocytic and DTH response. Indian J. Exp. Biol. 1988, 26:191-194.
65. Eckerman, I. (2005). The Bhopal Saga. Universities Press, Hyderabad.
66. Editorial Hazards of di-isocyanates. Lancet 1966, 32-33. i.
67. Editorial (1984). Calamity at Bhopal. Lancetii: 1378-9.
68. Ennever F.K., Rosenkranz H.S. Evaluating the potential for genotoxic carcinogenicity of methyl isocyanate. Toxicol. Appl. Pharmacol. 1987, 91:502-505.
69. European Economic Council Directive Official Journal of the European Communities 1982, 25. L230/1-L230/18.
70. Everest, L. (1985). Behind The Poison Cloud. Banner Press, Chicago.
71. Fedde M.R., Dodd D.E., Troup C.M., Fowler E.H. Biological effects of short-term, high-concentration exposure to methyl isocyanate. III. Influence on gas exchange in the guinea pig lung. Environ. Health Perspect 1987, 72:29-33.
72. Ferguson J.S., Alarie Y. Long term pulmonary impairment following a single exposure to methyl isocyanate. Toxicol. Appl. Pharmacol 1991, 107:253-268.
73. Ferguson J.S., Schaper M., Stock M.F., Weyel D.A., Alarie Y. Sensory and pulmonary irritation with exposure to methyl isocyanate. Toxicol. Appl. Pharmacol 1986, 82:329-335.
74. 14C]methyl isocyanate. Toxicol. Appl. Pharmacol 1988, 94:104-117.
75. Fowler, E.H., Dodd, D.E. (1987a). Respiratory tract changes in guinea pigs, rats, and mice following a single six-hour exposure to methyl isocyanate vapor. Environ. Health Perspect. 72: 109-16.
76. Fowler, E.H., Dodd, D.E. (1987b). Eighty-five day post exposure follow-up study in Fisher 344 rats after repeated exposure to methyl isocyanate vapor. Environ. Health Perspect. 72: 125-32.
77. Fowler E.H., Dodd D.E., Troup C.M. Biological effects of short-term, high concentration exposure to methyl isocyanate. V. Morphologic evaluation of rat and guinea pig lungs. Environ. Health Perspect 1987, 72:39-44.
78. Fuchs S., Valade P. Etude clinique et experimentale sur quelques cas d'intoxication par le Desmodur T (diisocyanate de toluylene 1-2-4 et 1-2-6). Arch. Mal. Prof. 1951, 12:191-196.
79. Ghosh B.B., Sengupta S., Roy A., Maity S., Ghosh S., Talukder G., Sharma A. Cytogenetic studies in human population exposed to gas leak at Bhopal, India. Environ. Health Perspect 1990, 86:323-326.
80. Gibson B.B., Hickman J.A. The role of isocyanates in the toxicity of antitumor haloalkylnitrosoureas. Biochem. Pharmacol. 1982, 31:2795-2800.
81. Goldstein A., Rieders F. Formation of cyanide in dog and man following administration of thiocyanate. Am. J. Physiol. 1951, 167:47-51.
82. Goldstein A., Aronow L., Kalman S.M. Principles of Drug Action 1968, Harper & Row, New York, pp. 399-402.
83. Goswami H.K. Cytogenetic effects of methyl isocyanate exposure in Bhopal. Hum. Genet. 1986, 74:81-84.
84. Goswami H.K., Guron C., Jain N., Goswami I. Genetic assessment of Union Carbide gas tragedy in Bhopal. I. Effects on somatic chromosomes and haemoglobin. Bionature 1985, 4:88-90.
85. Goswami H.K., Chandorkar M., Bhattacharya K., Vidyanath G., Parmar D., Sengupta S., Patidar S.L., Sengupta L.K., Goswami R., Sharma P.N. Search for chromosomal variations among gas-exposed persons in Bhopal. Hum. Genet. 1990, 84:172-176.
86. Guest I., Varma D.R. Developmental toxicity of methylamines in mice. J. Toxicol. Environ. Health 1991, 32:319-330.
87. Guest I., Varma D.R. Teratogenic and macromolecular synthesis inhibitory effects of trimethylamine on mouse embryos in culture. J. Toxicol. Environ. Health 1992, 36:27-41.
88. Guest I., Varma D.R. Selective growth inhibition of the male progeny of mice treated with trimethylamine during pregnancy. Can. J. Physiol. Pharmacol 1993, 71:85-87.
89. Guest I., Varma D.R. Inhibition of mouse embryonic, yolk sac, and limb-bud functions by the methyl isocyanate metabolite S-(N-methylcarbamoyl) glutathione. Can. J. Physiol. Pharmacol. 1994, 72:50-56.
90. Guest I., Baillie T.A., Varma D.R. Toxicity of the methyl isocyanate metabolite S-(N-methylcarbamoyl)GSH on mouse embryos in culture. Teratology 1992, 46:61-67.
91. Guest I., Cyr D.G., Varma D.R. Mechanism of trimethylamine-induced inhibition of macromolecular synthesis by mouse embryos in culture. Food Chem. Toxicol. 1994, 32:365-371.
92. Gupta B.N., Stefanski S.A., Bucher J.R., Hall L.B. Effect of methyl isocyanate (MIC) gas on the eyes of Fischer 344 rats. Environ. Health Perspect 1987, 72:105-108.
93. Gupta B.N., Rastogi S.K., Chandra H., Mathur A.K., Mathur N., Mahendra P.N., Pangtey B.S., Kumar S., Kumar P., Seth R.K., Dwivedi R.S., Ray P.K. Effect of exposure to toxic gas on the population of Bhopal: 1. Epidemiological, clinical, radiological and behavioral studies. Indian J. Exp. Biol. 1988, 26:149-160.
94. Harding J.J., Rixon K.C. Lens opacities induced in rat lenses by methyl isocyanate. Lancet 1985, i: 762.
95. Henneken H., Lindahl R., Ostin A., Vogel M., Levin J.-O., Karst U. Diffusive sampling of methyl isocyanate using 4-nitro-7-piperazinobenzo-2-oxa-1,3-diazole (NBDPZ) as derivatizing agent. J. Environ. Monit. 2003, 5:100-105.
96. Henschler D., Assmann W., Meyers K.O. Zur Toxikologie der toluylen-diisocyanate. Arch. Toxicol. 1962, 19:364-387.
97. Hill R.N. controlled study of workers handling organic diisocyanates. Proc. R. Soc. Med. 1970, 63:375. A.
98. Hong H.L., Bucher J.R., Canipe J., Boorman G.A. Myelotoxicity induced in female B6C3F1 mice by inhalation of methyl isocyanate. Environ. Health Perspect 1987, 72:143-148.
99. ICMR (1985). Health effects of exposure to toxic gas at Bhopal: an update on ICMR sponsored researches. Indian Council of Medical Research (December), New Delhi.
100. ICMR (1986). Health effects of the Bhopal gas tragedy. Indian Council of Medical Research (April), New Delhi.
101. ICMR (2004). Health effects of the toxic gas leak from the Union Carbide methyl isocyanate plant in Bhopal. Indian Council of Medical Research, Technical report based on population based long term epidemiological studies (1985-1994), New Delhi.
102. Irani S.F., Mahashur A.A. A survey of Bhopal children affected by methyl isocyanate gas. J. Postgrad. Med. (India) 1986, 32:195-198.
103. Jayaraman K.S. Pesticide plant leak wreaks disaster in India. Nature 1984, 312:581.
104. Jeevaratnam K., Vaidyanathan C.S. Acute toxicity of methyl isocyanate in rabbit: in vitro and in vivo effects on erythrocyte membrane. Arch. Environ. Contam. Toxicol. 1992, 22:300-304.
105. Jeevarathinam K., Selvamurthy W.S., Ray U.S., Mukhopadhyay S., Thakur L. Acute toxicity of methyl isocyanate, administered subcutaneously in rabbits: changes in physiological, clinico-chemical and histological parameters. Toxicology 1988, 51:223-240.
106. Jeevaratnam K., Bhattacharya R., Sugendran K., Vaidyanathan C.S. Acute toxicity of methyl isocyanate in mammals. IV. Biochemical and haematological changes in rabbits. Biomed. Environ. Sci. 1991, 4:384-391.
107. Jeevaratnam, K., Sugendran, K., Vaidyanathan, C.S. (1992a). Influence of methylamine and N, N0-dimethylurea, the hydrolysis products of methyl isocyanate, on its systemic toxicity. J. Appl. Toxicol.13: 15-18.
108. Jeevaratnam, K., Vidya, S., Vaidyanathan, C.S. (1992b). In vitro and in vivo effect of methyl isocyanate on rat liver mitochondrial respiration. Toxicol. Appl. Pharmacol.117: 172-9.
109. Jeevaratnam K., Vijayraghavan R., Kaushik M.P., Vaidyanathan C.S. Acute toxicity of methyl isocyanate in mammals. II. Induction of hyperglycemia, lactic acidosis, uraemia and hypothermia in rats. Arch. Environ. Contam. Toxicol. 1992, 19:314-318.
110. Kamat S.R., Mahashur A.A., Tiwari A.K.B., Potdar P.V., Gaur M., Kolhatkar V.P., Vaidya P.R., Parmar D., Rupwate R., Chaterjee T.S., Jain K., Kelkar M.D., Kinare S.G. Early observations on pulmonary changes and clinical morbidity due to the isocyanate gas leak at Bhopal. J. Postgrad. Med. (India) 1985, 31:63-72.
111. Kamat, S.R., Patel, M.H., Kolhatkar, V.P., Dave, A.A., Mahashur, A.A. (1987). Sequential respiratory changes in those exposed to the gas leak in Bhopal. Indian J. Med. Res.86 (Suppl.): 20-38.
112. Kamat S.R., Patel M.H., Pradhan P.V., Taskar S.P., Vaidya P.R., Kolhatkar V.P., Gopalani J.P., Chaandarana J.P., Dalal N., Naik M. Sequential respiratory, psychologic, and immunologic studies in relation to methyl isocyanate exposure over two years with model development. Environ. Health Perspect. 1992, 97:241-253.
113. Kanhere S., Darbari B.S., Shrivastava A.K. Morphological study of expectant mothers exposed to gas leak at Bhopal. Indian J. Med. Res. 1987, 86(Suppl.):77-82.
114. Karol M.H. Survey of industrial workers for antibodies to toluene diisocyanate. J. Occup. Med. 1981, 23:741-747.
115. Karol M.H. Concentration-dependent immunologic response to toluene diisocyanate (TDI) following inhalation exposure. Toxicol. Appl. Pharmacol. 1983, 68:229-241.
116. Karol M.H., Kamat S.R. The antibody response to methyl isocyanate: experimental and clinical findings. Bull. Eur. Physiopathol. Respir. 1988, 23:591-597.
117. Karol M.H., Taskar S., Gangal S., RubanoffB.F., Kamat S.R. The antibody response to methyl isocyanate: experimental and clinical findings. Environ. Health Perspect 1987, 72:169-175.
118. Khurrum M.A., Ahmad H.S. Long-term follow up of ocular lesions of methyl isocyanate gas disaster in Bhopal. Indian J. Ophthalmol. 1987, 35:136-137.
119. Kimmerle G., Eben A. Zur toxicitat von methylisocyanat und dessen quantitativer bestimung in der luft. [Toxicity of methyl isocyanate and its quantitation in the air]. Archiv. Toxikol. 1964, 20:235-241.
120. Kolb W.P., Savary J.R., Troup C.M., Dodd D.E., Tamerius J.D. Biological effects of short-term, high concentration exposure to methyl isocyanate. VI. In vitro and in vivo complement activation studies. Environ. Health Perspect 1987, 72:189-195.
121. Lapierre, D., Moro, J. (2001). It Was Five Past Midnight in Bhopal. Full Circle Publishing, Delhi.
122. Le Quesne P.M., Axford A.T., McKerrow C.B., Parry J.A. Neurological complications after a single severe exposure to toluene diisocyanate. Br. J. Ind. Med. 1976, 33:72-78.
123. Lee C.K. Methylisocyanate as an antisickling agent and its reaction with hemoglobin S. J. Biol. Chem. 1976, 251:6226-6231.
124. Lepkowski W. Special report -Bhopal. Chem. Eng. News 1985, 63:18-32.
125. Lowe A. The chemistry of isocyanates. Proc. R. Soc. Med. 1970, 63:367-368.
126. Luster M.I., Tucker A.N., Germolec D.R., Silver M.T., Thomas P.T., Vore S.J., Bucher J.R. Immunotoxicity studies on mice exposed to methyl isocyanate. Toxicol. Appl. Pharmacol. 1986, 86:140-144.
127. Maginniss L.A., Szewczak J.M., Troup C.M. Biological effects of short-term, high-concentration exposure to methyl isocyanate. IV. Influence on the oxygen-binding properties of guinea pig blood. Environ. Health Perspect 1987, 72:35-38.
128. Mangla B. Long-term effects of methyl isocyanate. Lancet 1989, ii: 103.
129. Marwick C. Bhopal tragedy's repercussions may reach American physicians. J. Am. Med. Assoc. 1985, 253:2001-2013.
130. Maskati Q.B. Ophthalmic survey of Bhopal victims 104 days after the tragedy. J. Postgrad. Med. (India) 1986, 32:199-202.
131. Mason J.M., Zeiger N., Haworth S., Ivett J., Valencia R. Genotoxicity studies of MIC in Salmonella, Drosophila and cultured Chinese hamster ovary cells. Environ. Mutagen. 1987, 9:19-20.
132. Mehta P.S., Mehta A.S., Mehta S.J., Makhijani A.B. Bhopal tragedy's health effects: a review of methyl isocyanate toxicity. J. Am. Med. Assoc. 1990, 264:2781-2787.
133. Mennicke W.H., Gorler K., Krumbiegel G. Metabolism of some naturally occurring isothiocyanates in the rat. Xenobiotica 1983, 13:203-207.
134. Meshram G.P., Rao K.M. Cytogenetic activity of methyl isocyanate in vivo in the mouse micronucleus test. Toxicol. Lett. 1988, 42:65-71.
135. Mishra A., Dwivedi P.D., Verma A.S., Mishra J., Sinha M. Modulation of microsomal membrane associated detoxification enzyme activity my methyl isocyanate (MIC) exposure. Bull. Environ. Contam. Toxicol. 1991, 47:675-681.
136. Misra U.K., Kalita J. A study of cognitive functions in methyl isocyanate victims one year after Bhopal accident. Neurotoxicology 1997, 18:381-386.
137. Misra U.K., Nag D. clinical study of toxic gas poisoning in Bhopal. India. Indian J. Exp. Biol. 1988, 26:201-204. A.
138. Misra N.P., Pathak R., Gaur K.J.B.S., Jain S.C., Yesikar S.S., Manoria P.C., Sharma K.N., Tripathi B.M., Asthana B.S., Trivedi H.H., Sharma V.K., Malhotra Y., Verma A., Bhargava D.K., Batni G. Clinical profile of gas leak victims in acute phase after Bhopal episode. Indian J. Med. Res. 1987, 86(Suppl.):11-19.
139. Morehouse, W., Subramaniam, M.A. (1986). The Bhopal Tragedy: What Really Happened and What it Means for American Workers and Communities at Risk. Council of International & Public Affairs, New York.
140. Murthy, S.R., Isaac, M.K. (1987). Mental health needs of Bhopal disaster victims and training of medical officers in mental health aspects. Indian J. Med. Res.86 (Suppl.): 51-8.
141. Nemery B. Late consequences of accidental exposure to inhaled irritants: RADS and the Bhopal disaster. Eur. Respir. J. 1996, 9:1973-1976.
142. Nemery, B., Dinsdale, D., Sparrow, S., Ray, D.E. (1985a). Effects of methyl isocyanate on the respiratory tract of rats. Br. J. Ind. Med. 42: 799-805.
143. Nemery, B., Sparrow, S., Dinsdale, D. (1985b). Methyl isocyanate: thiosulphate does not protect. Lancetii: 1245-6.
144. Nemery B., Dinsdale D., Sparrow S. Toxicity of inhaled methyl isocyanate in experimental animals, a review of studies published less than two years after the Bhopal disaster. Bull. Eur. Physiopathol. Respir. 1987, 23:315-322.
145. Newman R.A., Farquhar D. Release of methyl isocyanate from the antitumor agent caracemide. Invest. New Drugs 1987, 5:267-271.
146. NIOSH Recommended standard for occupational exposure to diisocyanates. Pub. U.S. Department of Health 1978, Education and Welfare, Washington, DC, 78-215.
147. Opinion Helping out in Bhopal. Nature 1984, 312:579-580.
148. Padma T.V. Long-delayed report on Bhopal disaster offers little new information. Nat. Med. 2005, 11:5.
149. Patel M.H., Kolhatkar V.P., Potdar V.P., Shekhavat K.L., Shah H.N., Kamat S.R. Methyl isocyanate survivors of Bhopal: sequential flow volume loop changes observed in eighteen month follow-up. Lung (India) 1987, 2:59-65.
150. Pearson P.G., Slatter J.G., Rashed M.S., Han D.H., Grillo M.P., Baillie T.A. S-(N-methylcarbamoyl)glutathione: a reactive S-linked metabolite of methyl isocyanate. Biochem. Biophys. Res. Commun. 1990, 166:245-250.
151. Pearson P.G., Slatter J.G., Rashed M.S., Han D.H., Baillie T.A. Carbamoylation of peptides and proteins in vitro by S-(N-methylcarbamoyl)GSH and S-(N-methylcarbamoyl)cysteine, two electrophilic S-linked conjugates of methyl isocyanate. Chem. Res. Toxicol. 1991, 4:436-444.
152. Raizada J.K., Dwivedi P.C. Chronic ocular lesions in Bhopal gas tragedy. Indian J. Ophthalmol 1987, 35:453-455.
153. Ramachandran P.K., Gandhi B.R., Venkateswaran K.S., Kaushik M.P., Vijayraghavan R., Agarwal G.S., Gopalan N., Suryanarayana M.V.S., Shinde S.K., Sriramachari S. Gas chromatographic studies of the carbamoylation of haemoglobin by methyl isocyanate in rats and rabbits. J. Chromat. 1988, 426:239-247.
154. Ranjan N., Sarangi S., Padmanabhan V.T., Holliman S., Ramakrishnan R., Varma D.R. Methyl isocyanate exposure and growth patterns of adolescents in Bhopal. J. Am. Med. Assoc. 2003, 290:1856-1857.
155. Raphael B., Middleton W. After the horror. Br. Med. J 1988, 296:1142-1144.
156. Rye W.A. Human responses to isocyanate exposure. J. Occup. Med 1973, 15:306-307.
157. Salmon A.G. Does acute toxicity testing tell us anything useful? Methyl isocyanate as a test case. Br. J. Ind. Med. 1985, 42:577-578.
158. Salmon A.G. Bright red blood of Bhopal victims: cyanide or MIC?. Br. J. Ind. Med. 1986, 43:503.
159. Salmon A.G., Kerr Muir M., Andersson N. Acute toxicity of methyl isocyanate: a preliminary study of the dose-response for eye and other effects. Br. J. Ind. Med. 1985, 42:795-798.
160. Sangha G.K., Alarie Y. Sensory irritation by toluene diisocyanate in single and repeated exposures. Toxicol. Appl. Pharmacol. 1979, 50:533-547.
161. Sangha G.K., Matijak M., Alarie Y. Comparison of some mono-and diisocyanates as sensory irritants. Toxicol. Appl. Pharmacol. 1982, 57:241-246.
162. Saraf A.K., Rao G.J., Chandra H. GC-MS evidence of dimethyl isocyanurate and 2,4 dione of methyl isocyanate in the viscera of Bhopal victims. Curr. Sci. 1995, 68:500-501.
163. Saxena A.K., Singh K.P., Nagle S.L., Gupta B.N., Ray P.K., Srivastav R.K., Tewari S.P., Singh R. Effect of exposure to toxic gas on the population of Bhopal. IV. Immunological and chromosomal studies. Indian J. Exp. Biol. 1988, 26:173-176.
164. Saxena A.K., Paul B.N., Sinha M., Dutta K.K., Das S.N., Rap P.K. A study on the B cell activity in protein deficient rats exposed to methyl isocyanate vapour. Immunopharmacol. Immunotoxicol. 1991, 13:413-424.
165. Scheel L.D., Killens R., Josephson A. Immunochemical aspects of toluene diisocyanate (T.D.I.) toxicity. Am. Ind. Hyg. Assoc. J. 1964, 25:179-181.
166. Schmidt-Nowara W.W., Murphy R.L.H., Atkinson J.D. Lung function after acute toluene diisocyanate inhalation. Chest 1973, 63:1039-1040.
167. Schwetz B.A., Adkins B., Harris M., Moorman M., Sloane R. Methyl isocyanate: reproductive and developmental toxicology studies in Swiss mice. Environ. Health Perspect 1987, 72:149-152.
168. Segal A., Solomon J.J., Li F. Isolation of the methylcarbamoyl-adducts of adenine and cytosine following in vitro reaction of methyl isocyanate with calf thymus DNA. Chem. Biol. Interact 1989, 69:359-372.
169. Sethi, B.B., Sharma, M., Trivedi, J.K., Singh, H. (1987). Psychiatric morbidity in patients attending clinics in gas affected areas of Bhopal. Indian J. Med. Res.86 (Suppl.): 45-50.
170. Sharma D.C. Bhopal: 20 years on. Lancet 2005, 365:111-112.
171. Sharma P.N., Gaur K.J.B.S. Radiological spectrum of lung changes in gas-exposed victims. Indian J. Med. Res. 1987, 86(Suppl.):39-44.
172. Shelby M.D., Allen J.W., Caspary W.J., Haworth S., Ivett J., Kligerman A., Luke C.A., Mason J.M., Myhr B., Tice R.T., Valencia R., Zeiger E. Results of in vitro and in vivo genetic toxicity tests on methyl isocyanate. Environ. Health Perspect 1987, 72:183-187.
173. Sinha, I. (2007). Animal's People. Simon & Schuster, London.
174. Slatter J.G., Rashed M.S., Pearson P.G., Han D.H., Baillie T.A. Biotransformation of methyl isocyanate in the rat: evidence of GSH conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicities. Chem. Res. Toxicol 1991, 4:157-161.
175. Slotta K.H., Tschesche R. Uber isocyanate, V: Kondensationen mit methylisocyanat, im besonderen mit blausaure. Berichte 1927, 60:1021-1025.
176. Sriramachari S. The Bhopal gas tragedy: an environmental disaster. Curr. Sci. 2004, 86:905-920.
177. Sriramachari S., Chandra H. The lessons of Bhopal [toxic] MIC gas disaster scope for expanding global biomonitoring and environmental specimen banking. Chemosphere 1997, 34:2237-2250.
178. Sriramachari S., Rao G.J., Sharma V.K., Jadhav R.K., Saraf A.K., Chandra H. GC-NPD and GC-MS analysis of preserved tissue of Bhopal gas disaster: evidence of methyl carbamoylation in post-mortem blood. Med. Sci. Law 1991, 31:289-293.
179. Stevens M.A., Fitzgerald S., Ménache M.G., Costa D.L., Bucher J.R. Functional evidence of persistent airway obstruction in rats following a two-hour inhalation exposure to methyl isocyanate. Environ. Health Perspect. 1987, 72:89-94.
180. Sufrin, S.C. (1985). Bhopal: Its Setting, Responsibility and Challenge. Ajanta, New Delhi.
181. Sutcliffe M. My student elective: an eyewitness in Bhopal. Br. Med. J 1985, 290:1883-1884.
182. Taylor P. Anticholineesterase agents. Goodman and Gilman's The Pharmacological Basis of Therapeutics 1980, 100-119. Macmillan, New York. 6th edition. A. Goodman Gilman, L.S. Goodman, A. Gilman (Eds.).
183. Tepper J.S., Wiester M.J., Costa D.L., Watkinson W.P., Weber M.F. Cardiopulmonary effects in awake rats four and six months after exposure to methyl isocyanate. Environ. Health Perspect. 1987, 72:95-103.
184. Tice R.R., Luke C.A., Shelby M.D. Methyl isocyanate: an evaluation of in vivo cytogenic activity. Environ. Mutagen. 1987, 9:37-50.
185. Troup C.M., Dodd D.E., Fowler E.H., Frank F.R. Biological effects of short-term, high-concentration exposure to methyl isocyanate. II. Blood chemistry and hematologic evaluation. Environ. Health Perspect. 1987, 72:21-28.
186. Tse C.S.T., Pesce A.J. Chemical characterization of isocyanate-protein conjugates. Toxicol. Appl. Pharmacol. 1978, 51:39-46.
187. Tucker A.N., Bucher J.R., Germolec D.R., Silver M.T., Vore S.J., Luster M.I. Immunological studies on mice exposed subacutely to methyl isocyanate. Environ. Health Perspect 1987, 72:139-141.
188. Twu J.S., Wold F. Butyl isocyanate and active site specific reagent for yeast alcohol dehydrogenase. Biochemistry 1973, 12:381-386.
189. Union Carbide (1978). U.S. Department of Labor: OSHA document on: Occupational health guideline for methyl isocyanate. September.
190. Uraih L.C., Talley F.A., Mitsumori K., Gupta B.N., Bucher J.R., Boorman G.A. Ultrastructural changes in the nasal mucosa of F344/N rats and B6C3F1 mice following an acute exposure to methyl isocyanate. Environ. Health Perspect 1987, 72:77-88.
191. Varadarajan S., Doraiswamy L.K., Ayyangar N.R., Iyer C.S.P., Khan A.A., Lahiri A.K., Muzumdar K.V., Mashelkar R.A., Mitra R.B., Nambiar O.G.B., Ramachandran V., Sahasrabudhe V.D., Sivaram S., Sriram M., Thyagarajan G., Venkataraman R.S. A scientific enquiry into the methyl isocyanate leak in Bhopal. Council of Scientific and Industrial Research 1985, Publication, New Delhi.
192. Varma D. Anatomy of the methyl isocyanate leak in Bhopal. Hazard Assessment of Chemicals 1986, 233-289. Hemisphere, Washington, DC. J. Saxena (Ed.).
193. Varma D.R. Epidemiological and experimental studies on the effects of methyl isocyanate on the course of pregnancy. Environ. Health Perspect. 1987, 72:153-157.
194. Varma D.R. Hydrogen cyanide and Bhopal. Lancet 1989, 557-558. ii.
195. Varma D.R. Pregnancy complications in Bhopal women exposed to methyl isocyanate vapor. J. Environ. Sci. Health 1991, A26:1437-1447.
196. Varma D., Guest I. The Bhopal accident and methyl isocyanate toxicity. J. Toxicol. Environ. Health 1993, 40:513-529.
197. Varma D.R., Mulay S. The Bhopal accident and methyl isocyanate toxicity. Toxicology of Organophosphate and Carbamate Compounds 2006, 79-88. Elsevier, San Diego. R.C. Gupta (Ed.).
198. Varma R., Varma D.R. The Bhopal disaster of 1984. Bull. Sci. Technol. Soc. 2005, 25:37-45.
199. Varma D.R., Ferguson J.S., Alarie Y. Reproductive toxicity of methyl isocyanate in mice. J. Toxicol. Environ. Health 1987, 21:265-275.
200. Varma D.R., Ferguson J.S., Alarie Y. Inhibition of methyl isocyanate toxicity in mice by starvation and dexamethasone but not by sodium thiosulfate, atropine and ethanol. J. Toxicol. Environ. Health 1988, 24:93-101.
201. Varma D.R., Guest I., Smith S., Mulay S. Dissociation between maternal and fetal toxicity of methyl isocyanate in mice and rats. J. Toxicol. Environ. Health 1990, 30:1-14.
202. Vijayan V.K., Kuppurao K.V. Early clinical, pulmonary function and blood gas studies in victims of Bhopal tragedy. Biomedicine 1993, 13:36-42.
203. Vijayan V.K., Sankaran K. Relationship between lung inflammation, changes in lung function and severity of methyl isocyanate exposure in victims of the Bhopal tragedy. Eur. Respir. J 1996, 9:1982-1997.
204. Vijayan V.K., Pandey V.P., Sankaran K., Mehrotra Y., Darbari B.S., Misra N.P. Bronchoalveolar lavage study in victims of toxic gas leak at Bhopal. Indian J. Med. Res. 1989, 90:407-414.
205. Vijayan V.K., Sankaran K., Sharma S.K., Misra N.P. Chronic lung inflammation in victims of toxic gas leak at Bhopal. Respir. Med. 1995, 89:105-111.
206. Von Zweigbergk P., Lindahl R., Ostin A., Ekman J., Levin J.-O. Development of a diffusive sampling method for determination of methyl isocyanate in air. J. Environ. Monit. 2002, 4:663-666.
207. Way J.L. Cyanide intoxication and its mechanism of antagonism. Annu. Rev. Pharmacol. Toxicol. 1984, 24:451-481.
208. Westcott N.D. Chemistry of methyl isocyanate. Proceedings of Symposium on Highly Toxic Chemical; Detection and Protection Methods 1985, 41-45. University of Saskatchewan, Saskatoon. H.B. Schiefer (Ed.).
209. Weyel D.A., Schaffer R.B. Pulmonary and sensory irritation of diphenylmethane-4,40-and dicyclohexylmethane-4,40-diisocyanate. Toxicol. Appl. Pharmacol. 1985, 77:427-433.
210. Weyel D.A., Rodney B.S., Alarie Y. Sensory irritation, pulmonary irritation and acute lethality of polymeric isocyanate and sensory irritation of 2,6-toluene diisocyanate. Toxicol. Appl. Pharmacol 1982, 64:423-430.
211. Williamson K.S. Studies of diisocyanate workers. Trans. Assoc. Ind. Med. Offrs 1965, 15:29-35.
212. Wilson R.H., Wilson G.L. Toxicology of diisocyanates. J. Occup. Med. 1959, 1:448-450.
213. 2 challenges to evaluate the pulmonary performance of guinea pigs exposed to toluene diisocyanate. J. Toxicol. Environ. Health 1985, 15:137-148.
214. Worthy W. Bhopal report -methyl isocyanate: chemistry of a hazard. Chem. Eng. News 1985, 63(6):27-36.
215. Zapp J.A. Hazards of isocyanates in polyurethane foam plastic production. Arch. Ind. Health 1957, 15:324-330.