Human amniotic epithelial cell feeder layers maintain iPS cell pluripotency by inhibiting endogenous DNA methyltransferase 1

Experimental and Therapeutic Medicine

Volumn 6, Issue 5, 2013, Pages 1145-1154

  Chen, Qing ^a   Qiu, Chaolin ^a   Huang, Yongyi ^b   Jiang, Lizhen ^b,c   Huang, Qin ^b,c   Guo, Lihe ^b,d   Liu, Te ^d  

^a Shanghai Pudong New Area Gongli Hospital   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^c Sino America United Stem Cell Research Center   (China)

^d SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

DNA methyltransferase 1; Human amniotic epithelial cells; Human induced pluripotent stem cells; Pluripotency maintenance

Indexed keywords

DNA METHYLTRANSFERASE 1; GENOMIC DNA;

AMNIOTIC FLUID CELL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; COCULTURE; CPG ISLAND; ENZYME INHIBITION; FEEDER CELL; FIBROBLAST; FIBROBLAST CULTURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; POLYMERASE CHAIN REACTION; RNA INTERFERENCE;

EID: 84884736225     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2013.1279     Document Type: Article

References (44)

1. Takahashi K and Yamanaka S: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663-676, 2006.
2. Takahashi K, Tanabe K, Ohnuki M, et al: Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861-872, 2007.
3. Galach M and Utikal J: From skin to the treatment of diseases-the possibilities of iPS cell research in dermatology.Exp Dermatol 20: 523-528, 2011.
4. Maherali N, Sridharan R, Xie W, et al: Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell 1: 55-70, 2007.
5. Okita K, Ichisa ka T and Yamana ka S: Generation of germline-competent induced pluripotent stem cells. Nature 448: 313-317, 2007.
6. Hanna J, Markoulaki S, Schorderet P, et al: Direct repro gramming of terminally differentiated mature B lymphocytes to pluripotency. Cell 133: 250-264, 2008.
7. Wernig M, Meissner A, Foreman R, et al: In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448: 318-324, 2007.
8. Liu H, Zhu F, Yong J, et al: Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts. Cell Stem Cell 3: 587-590, 2008.
9. Yu J, Vodyanik MA, Smuga-Otto K, et al: Induced pluripotent stem cell lines derived from human somatic cells. Science 318: 1917-1920, 2007.
10. Thier M, Munst B and Edenhofer F: Exploring refined conditions for reprogramming cells by recombinant Oct4 protein. Int J Dev Biol 54: 1713-1721, 2010.
11. Zhong B, Watts KL, Gori JL, et al: Safeguarding nonhuman primate iPS cells with suicide genes. Mol Ther 19: 1667-1675, 2011.
12. Ye Z, Zhan H, Mali P, et al: Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood 114: 5473-5480, 2009.
13. Ezashi T, Telugu BP, Alexenko AP, Sachdev S, Sinha S and Roberts RM: Derivation of induced pluripotent stem cells from pig somatic cells. Proc Natl Acad Sci USA 106: 10993-10998, 2009.
14. Gonzalez F, Barragan Monasterio M, Tiscornia G, et al: Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector. Proc Natl Acad Sci USA 106: 8918-8922, 2009.
15. Kaji K, Norrby K, Paca A, Mileikovsky M, Mohseni P and Woltjen K: Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 458: 771-775, 2009.
16. Zhou H, Wu S, Joo JY, et al: Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 4: 381-384, 2009.
17. Yakubov E, Rechavi G, Rozenblatt S and Givol D: Reprogramming of human fibroblasts to pluripotent stem cells using mRNA of four transcription factors. Biochem Biophys Res Commun 394: 189-193, 2010.
18. Liu T, Cheng W, Liu T, et al: Human amniotic epithelial cell feeder layers maintain mouse embryonic stem cell pluripotency via epigenetic regulation of the c-Myc promoter. Acta Biochim Biophys Sin (Shanghai) 42: 109-115, 2010.
19. Liu T, Guo L, Liu Z and Cheng W: Human amniotic epithelial cells maintain mouse spermatogonial stem cells in an undifferentiated state due to high leukemia inhibitor factor (LIF) expression. In Vitro Cell Dev Biol Anim 47: 318-326, 2011.
20. Liu T, Wu J, Huang Q, et al: Human amniotic epithelial cells ameliorate behavioral dysfunction and reduce infarct size in the rat middle cerebral artery occlusion model. Shock 29: 603-611, 2008.
21. Liu T, Cheng W, Huang Y, Huang Q, Jiang L and Guo L: Human amniotic epithelial cell feeder layers maintain human iPS cell pluripotency via inhibited endogenous microRNA-145 and increased Sox2 expression. Exp Cell Res 318: 424-434, 2012.
22. Hattori N, Imao Y, Nishino K, et al: Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells. Genes Cells 12: 387-396, 2007.
23. Cowan CA, Atienza J, Melton DA and Eggan K: Nuclear repro gramming of somatic cells after fusion with human embryonic stem cells. Science 309: 1369-1373, 2005.
24. Freberg CT, Dahl JA, Timoskainen S and Collas P: Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract. Mol Biol Cell 18: 1543-1553, 2007.
25. Simonsson S and Gurdon J: DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei. Nat Cell Biol 6: 984-990, 2004.
26. Tada M, Tada T, Lefebvre L, Barton SC and Surani MA: Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells. EMBO J 16: 6510-6520, 1997.
27. Bibikova M, Chudin E, Wu B, et al: Human embryonic stem cells have a unique epigenetic signature. Genome Res 16: 1075-1083, 2006.
28. Li JY, Pu MT, Hirasawa R, et al: Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol Cell Biol 27: 8748-8759, 2007.
29. Delgado-Olguin P and Recillas-Targa F: Chromatin structure of pluripotent stem cells and induced pluripotent stem cells. Brief Funct Genomics 10: 37-49, 2011.
30. Athanasiadou R, de Sousa D, Myant K, Merusi C, Stancheva I and Bird A: Targeting of de novo DNA methylation throughout the Oct-4 gene regulatory region in differentiating embryonic stem cells. PLoS One 5: e9937, 2010.
31. Tsumura A, Hayakawa T, Kumaki Y, et al: Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b. Genes Cells 11: 805-814, 2006.
32. Fatemi M, Hermann A, Pradhan S and Jeltsch A: The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA. J Mol Biol 309: 1189-1199, 2001.
33. Sen GL, Reuter JA, Webster DE, Zhu L and Khavari PA: DNMT1 maintains progenitor function in self-renewing somatic tissue. Nature 463: 563-567, 2010.
34. Mikkelsen TS, Hanna J, Zhang X, et al: Dissecting direct repro gramming through integrative genomic analysis. Nature 454: 49-55, 2008.
35. Datta J, Ghoshal K, Sharma SM, Tajima S and Jacob ST: Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1. J Cell Biochem 88: 855-864, 2003.
36. Ohi Y, Qin H, Hong C, et al: Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells. Nat Cell Biol 13: 541-549, 2011.
37. + cells derived from human amniotic fluid into induced pluripotent stem cells with Oct4. Stem Cells Dev 21: 2322-2332, 2012.
38. Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C and Kahn M: Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc Natl Acad Sci USA 104: 5668-5673, 2007.
39. Lai D, Cheng W, Liu T, Jiang L, Huang Q and Liu T: Use of human amnion epithelial cells as a feeder layer to support undifferentiated growth of mouse embryonic stem cells. Cloning Stem Cells 11: 331-340, 2009.
40. Lai D, Cheng W, Liu T, Jiang L, Liu T, Huang Q and Guo L: Optimization of culture conditions to support undifferentiated growth of human embryonic stem cells. Cell Reprogram 12: 305-314, 2010.
41. Guo Y, Liu S, Wang P, et al: Expression profile of embryonic stem cell-associated genes Oct4, Sox2 and Nanog in human gliomas. Histopathology 59: 763-775, 2011.
42. Robertson KD, Uzvolgyi E, Liang G, et al: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate Mrna expression in normal tissues and overexpression in tumors. Nucleic Acids Res 27: 2291-2298, 1999.
43. Liu T, Chen Q, Huang Y, Huang Q, Jiang L and Guo L: Low microRNA-199a expression in human amniotic epithelial cell feeder layers maintains human-induced pluripotent stem cell pluripotency via increased leukemia inhibitory factor expression. Acta Biochim Biophys Sin (Shanghai) 44: 197-206, 2012.
44. Miki T, Lehmann T, Cai H, Stolz DB and Strom SC: Stem cell characteristics of amniotic epithelial cells. Stem Cells 23: 1549-1559, 2005.