Changes in expression of four molecular marker proteins and one microRNA in mesothelial cells of the peritoneal dialysate effluent fluid of peritoneal dialysis patients

Experimental and Therapeutic Medicine

Volumn 6, Issue 5, 2013, Pages 1189-1193

  Zhang, Lin ^a,b   Liu, Fuyou ^a   Peng, Youming ^a   Sun, Lin ^a,c   Chen, Guochun ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b Fourth Hospital of Changsha   (China)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

MicroRNA 200c; Peritoneal dialysis; Peritoneal fibrosis

Indexed keywords

COLLAGEN TYPE 1; FIBRONECTIN; MICRORNA 200C; MOLECULAR MARKER; UVOMORULIN; VIMENTIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTINUOUS AMBULATORY PERITONEAL DIALYSIS; CONTROLLED STUDY; DIALYSATE; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MALE; MESOTHELIUM CELL; PERITONEAL DIALYSIS; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

EID: 84884735907     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm_2013.1281     Document Type: Article

References (24)

1. Smit W, Schouten N, van den Berg N, Langedijk MJ, Struijk DG and Krediet RT; Netherlands Ultrafiltration Failure Study Group: Analysis of the prevalence and causes of ultrafiltration failure during long-term peritoneal dialysis: a cross-sectional study. Perit Dial Int 24: 562-570, 2004.
2. Kim YL: Update on mechanisms of ultrafiltration failure. Perit Dial Int 29 (Suppl 2): S123-S127, 2009.
3. Selgas R, Bajo A, Jiménez-Heffernan JA, Sánchez-Tomero JA, Del Peso G, Aguilera A and López-Cabrera M: Epithelial-to-mesenchymal transition of the mesothelial cell its role in the response of the peritoneum to dialysis. Nephrol Dial Transplant 21 (SUPPL 2): 112-117, 2006.
4. Aroeira LS, Aguilera A, Sánchez-Tomero JA, et al: Epithelial to mesenchymal transition and peritoneal membrane failure in peritoneal dialysis patients: pathologic significance and potential therapeutic interventions. J Am Soc Nephrol 18: 2004-2013, 2007.
5. Elsurer R, Afsar B, Sezer S and Ozdemir FN: Peritoneal cells at admission: do they have prognostic significance in peritonitis? Ren Fail 32: 335-342, 2010.
6. Wienholds E, Kloosterman WP, Miska E, et al: MicroRNA expression in zebrafish embryonic development. Science 309: 310-311, 2005.
7. Chen CZ, Li L, Lodish HF and Bartel DP: MicroRNAs modulate hematopoietic lineage differentiation. Science 303: 83-86, 2004.
8. Kato M, Zhang J, Wang M, et al: MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc Natl Acad Sci USA 104: 3432-3437, 2007.
9. Ogawa T, Iizuka M, Sekiya Y, et al: Suppression of type I collagen production by microRNA-29b in cultured human stellate cells. Biochem Biophys Res Commun 391: 316-321, 2010.
10. Kong D, Li Y, Wang Z, et al: Mir-200 regulates PDGF-D-mediated epithelial-mesenchymal transition, adhesion, and invasion of prostate cancer cells. Stem Cells 27: 1712-1721, 2009.
11. Sabatel C, Cornet AM, Tabruyn SP, et al: Sprouty1, a new target of the angiostatic agent 16K prolactin, negatively regulates angiogenesis. Mol Cancer 9: 231, 2010.
12. Jeffrey SS: Cancer biomarker profiling with microRNAs. Nat Biotechnol 26: 400-401, 2008.
13. Cortez MA, Bueso-Ramos C, Ferdin J, et al: MicroRNAs in body fluids the mix of hormones and biomarkers. Nat Rev Clin Oncol 8: 467-477, 2011.
14. Ge Y, Xiao L, Chen X, et al: MicroRNAs in peritoneal dialysis effluent are promising biomarkers for peritoneal fibrosis in peritoneal dialysis patients. Med Hypotheses 78: 155-156, 2012.
15. Wang B, Koh P, Winbanks C, et al: Mir-200a prevents renal fibrogenesis through repression of TGF-β2 expression. Diabetes 60: 280-287, 2011.
16. Yang S, Banerjee S, de Freitas A, et al: Participation of miR-200 in pulmonary fibrosis. Am J Pathol 180: 484-493, 2012.
17. Iwano M, Plieth D, Danoff TM, et al: Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 110: 341-350, 2002.
18. Williams JD, Craig KJ, Topley N and Williams GT: Peritoneal dialysis: changes to the structure of the peritoneal membrane and potential for biocompatible solutions. Kidney Int Suppl 84: S158-S161, 2003.
19. Williams JD, Craig KJ, Topley N, et al: Peritoneal Biopsy Study Group: Morphologic changes in the peritoneal membrane of patients with renal disease. J Am Soc Nephrol 13: 470-479, 2002.
20. Yáñez-Mó M, Lara-Pezzi E, Selgas R, et al: Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells. N Engl J Med 348: 403-413, 2003.
21. Jiménez-Heffernan JA, Aguilera A, Aroeira LS, et al: Immunohistochemical characterization of fibroblast subpopulations in normal peritoneal tissue and in peritoneal dialysis-induced fibrosis. Virchows Arch 444: 247-256, 2004.
22. Schilte MN, Loureiro J, Keuning ED, ter Wee PM, Celie JW, Beelen RH and van den Born J: Long-term intervention with heparins in a rat model of peritoneal dialysis. Perit Dial Int 29: 26-35, 2009.
23. Margetts PJ, Bonniaud P, Liu L, Hoff CM, Holmes CJ, West-Mays JA and Kelly MM: Transient overexpression of TGF-{beta}1 induces epithelial mesenchymal transition in the rodent peritoneum. J Am Soc Nephrol 16: 425-436, 2005.
24. Del Peso G, Jiménez-Heffernan JA, Bajo MA, et al: Epithelial-to-mesenchymal transition of mesothelial cells is an early event during peritoneal dialysis and is associated with high peritoneal transport. Kidney Int Suppl 108: S26-S33, 2008.