The impact of renal tubular damage, as assessed by urinary β2-microglobulin-creatinine ratio, on cardiac prognosis in patients with chronic heart failure

Circulation: Heart Failure

Volumn 6, Issue 4, 2013, Pages 662-668

  Otaki, Yoichiro ^a   Watanabe, Tetsu ^a   Shishido, Tetsuro ^a   Takahashi, Hiroki ^a   Funayama, Akira ^a   Narumi, Taro ^a   Kadowaki, Shinpei ^a   Hasegawa, Hiromasa ^a   Honda, Shintaro ^a   Netsu, Shunsuke ^a   Ishino, Mitsunori ^a   Arimoto, Takanori ^a   Miyashita, Takehiko ^a   Miyamoto, Takuya ^a   Konta, Tsuneo ^a   Kubota, Isao ^a  

^a YAMAGATA UNIVERSITY   (Japan)

Author keywords

Heart failure; Renal tubular damage; Urinary 2 microglobulin

Indexed keywords

BETA 2 MICROGLOBULIN; CREATININE;

ADULT; AGED; ARTICLE; BETA 2 MICROGLOBULIN URINE LEVEL; CARDIOVASCULAR RISK; CHRONIC KIDNEY DISEASE; COMORBIDITY; CONTROLLED STUDY; CREATININE URINE LEVEL; FEMALE; FOLLOW UP; HEART DEATH; HEART DISEASE; HEART FAILURE; HUMAN; KIDNEY TUBULE DISORDER; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NEW YORK HEART ASSOCIATION CLASS; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; RENAL TUBULAR DAMAGE; ALBUMINURIA; CHRONIC DISEASE; KAPLAN MEIER METHOD; KIDNEY DISEASE; KIDNEY TUBULE; MIDDLE AGED; MORTALITY; PATHOPHYSIOLOGY; URINARY Β2-MICROGLOBULIN; URINE; VERY ELDERLY;

HEART FAILURE; RENAL TUBULAR DAMAGE; URINARY Β2-MICROGLOBULIN;

AGED; AGED, 80 AND OVER; ALBUMINURIA; BETA 2-MICROGLOBULIN; CHRONIC DISEASE; CREATININE; FEMALE; HEART FAILURE; HUMANS; KAPLAN-MEIER ESTIMATE; KIDNEY DISEASES; KIDNEY TUBULES; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES;

EID: 84884728826     PISSN: 19413289     EISSN: 19413297     Source Type: Journal    
DOI: 10.1161/CIRCHEARTFAILURE.112.000089     Document Type: Article

References (32)

1. McAlister FA, Ezekowitz J, Tonelli M, Armstrong PW. Renal insufficiency and heart failure: prognostic and therapeutic implications from a prospective cohort study. Circulation. 2004;109:1004-1009.
2. Mahon NG, Blackstone EH, Francis GS, Starling RC III, Young JB, Lauer MS. The prognostic value of estimated creatinine clearance alongside functional capacity in ambulatory patients with chronic congestive heart failure. J Am Coll Cardiol. 2002;40:1106-1113.
3. Nakhoul N, Batuman V. Role of proximal tubules in the pathogenesis of kidney disease. Contrib Nephrol. 2011;169:37-50.
4. Kudo K, Konta T, Mashima Y, Ichikawa K, Takasaki S, Ikeda A, Hoshikawa M, Suzuki K, Shibata Y, Watanabe T, Kato T, Kawata S, Kubota I. The association between renal tubular damage and rapid renal deterioration in the Japanese population: the Takahata study. Clin Exp Nephrol. 2011;15:235-241.
5. Nishijo M, Morikawa Y, Nakagawa H, Tawara K, Miura K, Kido T, Ikawa A, Kobayashi E, Nogawa K. Causes of death and renal tubular dysfunction in residents exposed to cadmium in the environment. Occup Environ Med. 2006;63:545-550.
6. Nishijo M, Nakagawa H, Morikawa Y, Kuriwaki J, Katsuyuki M, Kido T, Nogawa K. Mortality in a cadmium polluted area in Japan. Biometals. 2004;17:535-538.
7. Harris HW, Gill TJ III. Expression of class I transplantation antigens. Transplantation. 1986;42:109-117.
8. Bernier GM, Conrad ME. Catabolism of human beta-2-microglobulin by the rat kidney. Am J Physiol. 1969;217:1359-1362.
9. Miyata T, Jadoul M, Kurokawa K, Van Ypersele de Strihou C. Beta-2 microglobulin in renal disease. J Am Soc Nephrol. 1998;9:1723-1735.
10. Vesely DL, Perez-Lamboy GI, Schocken DD. Long-acting natriuretic peptide, vessel dilator, and kaliuretic peptide enhance urinary excretion rate of albumin, total protein, and beta(2)-microglobulin in patients with congestive heart failure. J Card Fail. 2001;7:55-63.
11. Ikeda A, Konta T, Takasaki S, Hao Z, Suzuki K, Sato H, Shibata Y, Takeishi Y, Kato T, Kawata S, Kubota I. In a non-diabetic Japanese population, the combination of macroalbuminuria and increased urine beta 2-microglobulin predicts a decline of renal function: the Takahata study. Nephrol Dial Transplant. 2009;24:841-847.
12. McKee PA, Castelli WP, McNamara PM, Kannel WB. The natural history of congestive heart failure: the Framingham study. N Engl J Med. 1971;285:1441-1446.
13. Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, Yamagata K, Tomino Y, Yokoyama H, Hishida A; Collaborators developing the Japanese equation for estimated GFR. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 2009;53:982-992.
14. Eckardt KU, Berns JS, Rocco MV, Kasiske BL. Definition and classification of CKD: the debate should be about patient prognosis-a position statement from KDOQI and KDIGO. Am J Kidney Dis. 2009;53:915-920.
15. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002;39:S1-S266.
16. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology. 1982;143:29-36.
17. Ronco C, Haapio M, House AA, Anavekar N, Bellomo R. Cardiorenal syndrome. J Am Coll Cardiol. 2008;52:1527-1539.
18. Goh CY, Vizzi G, De Cal M, Ronco C. Cardiorenal syndrome: a complex series of combined heart/kidney disorders. Contrib Nephrol. 2011;174:33-45.
19. Martinez-Santos P, Vilacosta I. Cardiorenal syndrome: an unsolved clinical problem. Int J Nephrol. 2011;913029:1-6.
20. Legrand M, Mik EG, Johannes T, Payen D, Ince C. Renal hypoxia and dysoxia after reperfusion of the ischemic kidney. Mol Med. 2008;14:502-516.
21. Nangaku M. Hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. Nephron Exp Nephrol. 2004;98:e8-e12.
22. Nangaku M. Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol. 2006;17:17-25.
23. Heyman SN, Khamaisi M, Rosen S, Rosenberger C. Renal parenchymal hypoxia, hypoxia response and the progression of chronic kidney disease. Am J Nephrol. 2008;28:998-1006.
24. Obara N, Suzuki N, Kim K, Nagasawa T, Imagawa S, Yamamoto M. Repression via the GATA box is essential for tissue-specific erythropoietin gene expression. Blood. 2008;111:5223-5232.
25. Westhuyzen J, Endre ZH, Reece G, Reith DM, Saltissi D, Morgan TJ. Measurement of tubular enzymuria facilitates early detection of acute renal impairment in the intensive care unit. Nephrol Dial Transplant. 2003;18:543-551.
26. Price RG. Measurement of N-acetyl-beta-glucosaminidase and its isoenzymes in urine methods and clinical applications. Eur J Clin Chem Clin Biochem. 1992;30:693-705.
27. Hofstra JM, Deegens JK, Willems HL, Wetzels JF. Beta-2-microglobulin is superior to N-acetyl-beta-glucosaminidase in predicting prognosis in idiopathic membranous nephropathy. Nephrol Dial Transplant. 2008;23:2546-2551.
28. Damman K, Van Veldhuisen DJ, Navis G, Vaidya VS, Smilde TD, Westenbrink BD, Bonventre JV, Voors AA, Hillege HL. Tubular damage in chronic systolic heart failure is associated with reduced survival independent of glomerular filtration rate. Heart. 2010;96:1297-1302.
29. Nieminen MS, Brutsaert D, Dickstein K, Drexler H, Follath F, Harjola VP, Hochadel M, Komajda M, Lassus J, Lopez-Sendon JL, Ponikowski P, Tavazzi L; EuroHeart Survey Investigators; Heart Failure Association, European Society of Cardiology. EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population. Eur Heart J. 2006;27:2725-2736.
30. Ho KK, Anderson KM, Kannel WB, Grossman W, Levy D. Survival after the onset of congestive heart failure in Framingham Heart Study subjects. Circulation. 1993;88:107-115.
31. Shiba N, Shimokawa H. Chronic heart failure in Japan: implications of the CHART studies. Vasc Health Risk Manag. 2008;4:103-113.
32. Shiba N, Nochioka K, Miura M, Kohno H, Shimokawa H; CHART-2 Investigators. Trend of westernization of etiology and clinical characteristics of heart failure patients in Japan-first report from the CHART-2 study. Circ J. 2011;75:823-833.