Tissue-infiltrating lymphocytes analysis reveals large modifications of the duodenal "immunological niche" in coeliac disease after gluten-free diet

Clinical and Translational Gastroenterology

Volumn 3, Issue , 2012, Pages

  Cianci, Rossella ^a   Cammarota, Giovanni ^a   Frisullo, Giovanni ^a   Pagliari, Danilo ^a   Ianiro, Gianluca ^a   Martini, Maurizio ^a   Frosali, Simona ^a   Plantone, Domenico ^a   Damato, Valentina ^a   Casciano, Fabio ^a   Landolfi, Raffaele ^a   Batocchi, Anna Paola ^a   Pandolfi, Franco ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BLOOD; CD62L+ T LYMPHOCYTE; CELIAC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DUODENUM MUCOSA; FEMALE; GLUTEN FREE DIET; HUMAN; HUMAN TISSUE; IMMUNOPATHOGENESIS; INFLAMMATION; MALE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TISSUE INFILTRATING LYMPHOCYTE;

EID: 84884710837     PISSN: None     EISSN: 2155384X     Source Type: Journal    
DOI: 10.1038/ctg.2012.22     Document Type: Article

References (45)

1. Sollid LM, Thorsby E. HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis. Gastroenterology 1993; 105: 910-922.
2. Green PH, Jabri B. Coeliac disease. Lancet 2003; 362: 383-391.
3. Giambra V, Cianci R, Lolli S et al. Allele *1 of HS1.2 enhancer associates with selective IgA deficiency and IgM concentration. J Immunol 2009; 183: 8280-8285.
4. Green PH, Cellier C. Celiac disease. N Engl J Med 2007; 357: 1731-1743.
5. Ludvigsson JF, Green PH. Clinical management of coeliac disease. J Intern Med 2011; 269: 560-571.
6. Ciccocioppo R, Finamore A, Mengheri E et al. Isolation and characterization of circulating tissue transglutaminase-specific T cells in coeliac disease. Int J Immunopathol Pharmacol 2010; 23: 179-191.
7. Olaussen RW, Johansen FE, Lundin KE et al. Interferon-gamma-secreting T cells localize to the epithelium in coeliac disease. Scand J Immunol 2002; 56: 652-664.
8. Ciccocioppo R, D'Alo S, Di Sabatino A et al. Mechanisms of villous atrophy in autoimmune enteropathy and coeliac disease. Clin Exp Immunol 2002; 128: 88-93.
9. Giovannetti A, Pierdominici M, Di Iorio A et al. Apoptosis in the homeostasis of the immune system and in human immune mediated diseases. Curr Pharm Des 2008; 14: 253-268.
10. Sollid LM. Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol 2002; 2: 647-655.
11. Jabri B, Sollid LM. Tissue-mediated control of immunopathology in coeliac disease. Nat Rev Immunol 2009; 9: 858-870.
12. Frisullo G, Nociti V, Iorio R et al. T-bet and pSTAT-1 expression in PBMC from coeliac disease patients: new markers of disease activity. Clin Exp Immunol 2009; 158: 106-114.
13. Nilsen EM, Lundin KE, Krajci P et al. Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma. Gut 1995; 37: 766-776.
14. Pandolfi F, Corte G, Quinti I et al. Defect of T helper lymphocytes, as identified by the 5/9 monoclonal antibody, in patients with common variable hypogammaglobulinaemia. Clin Exp Immunol 1983; 51: 470-474.
15. Hishii M, Kurnick JT, Ramirez-Montagut T et al. Studies of the mechanism of cytolysis by tumour-infiltrating lymphocytes. Clin Exp Immunol 1999; 116: 388-394.
16. Pandolfi F, Cianci R, Pagliari D et al. Cellular mediators of inflammation: tregs and TH17 cells in gastrointestinal diseases. Mediators Inflamm 2009; 2009: 132028.
17. Liu W, Putnam AL, Xu-Yu Z et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006; 203: 1701-1711.
18. Sakaguchi S, Miyara M, Costantino CM et al. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol 2010; 10: 490-500.
19. Brazowski E, Cohen S, Yaron A et al. FOXP3 expression in duodenal mucosa in pediatric patients with celiac disease. Pathobiology 2010; 77: 328-334.
20. Delabie J, Holte H, Vose JM et al. Enteropathy-associated T-cell lymphoma: clinical and histological findings from the international peripheral T-cell lymphoma project. Blood 2011; 118: 148-155.
21. Monteleone I, Sarra M, Del Vecchio Blanco G et al. Characterization of IL-17A-producing cells in celiac disease mucosa. J Immunol 2010; 184: 2211-2218.
22. Zanzi D, Stefanile R, Santagata S et al. IL-15 interferes with suppressive activity of intestinal regulatory T cells expanded in Celiac disease. Am J Gastroenterol 2011; 106: 1308-1317.
23. Frisullo G, Nociti V, Iorio R et al. Increased CD4+CD25+Foxp3+ T cells in peripheral blood of celiac disease patients: correlation with dietary treatment. Hum Immunol 2009; 70: 430-435.
24. Hmida NB, Ben Ahmed M, Moussa A et al. Impaired control of effector T cells by regulatory T cells: a clue to loss of oral tolerance and autoimmunity in celiac disease? Am J Gastroenterol 2012; 107: 604-611.
25. Castellanos-Rubio A, Santin I, Irastorza I et al. TH17 (and TH1) signatures of intestinal biopsies of CD patients in response to gliadin. Autoimmunity 2009; 42: 69-73.
26. Fernandez S, Molina IJ, Romero P et al. Characterization of gliadin-specific Th17 cells from the mucosa of celiac disease patients. Am J Gastroenterol 2011; 106: 528-538.
27. Sapone A, Lammers KM, Mazzarella G et al. Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. Int Arch Allergy Immunol 2010; 152: 75-80.
28. Kivling A, Nilsson L, Falth-Magnusson K et al. Diverse foxp3 expression in children with type 1 diabetes and celiac disease. Ann N Y Acad Sci 2008; 1150: 273-277.
29. Cianci R, Pagliari D, Landolfi R et al. New Insights on the role of T-cells in the pathogenesis of Celiac disease. J Biol Regul Homeost Agents 2012; 26: 171-179.
30. Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 1978; 4: 7-25.
31. Scadden DT. The stem-cell niche as an entity of action. Nature 2006; 441: 1075-1079.
32. Rostom A, Murray JA, Kagnoff MF. American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease. Gastroenterology 2006; 131: 1981-2002.
33. Cianci R, Cammarota G, Lolli S et al. Abnormal synthesis of IgA in coeliac disease and related disorders. J Biol Regul Homeost Agents 2008; 22: 99-104.
34. Cianci R, Iacopini F, Petruzziello L et al. Involvement of central immunity in uncomplicated diverticular disease. Scand J Gastroenterol 2009; 44: 108-115.
35. Pandolfi F, Boyle LA, Trentin L et al. Expression of HLA-A2 antigen in human melanoma cell lines and its role in T-cell recognition. Cancer Res 1991; 51: 3164-3170.
36. Kolkowski EC, Fernandez MA, Pujol-Borrell R et al. Human intestinal alphabeta IEL clones in celiac disease show reduced IL-10 synthesis and enhanced IL-2 production. Cell Immunol 2006; 244: 1-9.
37. Sanchez-Munoz LB, Santon A, Cano A et al. Flow cytometric analysis of intestinal intraepithelial lymphocytes in the diagnosis of refractory celiac sprue. Eur J Gastroenterol Hepatol 2008; 20: 478-487.
38. Woodberry T, Suscovich TJ, Henry LM et al. Alpha E beta 7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population. J Immunol 2005; 175: 4355-4362.
39. Lionetti P, Pazzaglia A, Moriondo M et al. Differing patterns of transforming growth factor-beta expression in normal intestinal mucosa and in active celiac disease. J Pediatr Gastroenterol Nutr 1999; 29: 308-313.
40. Benahmed M, Meresse B, Arnulf B et al. Inhibition of TGF-beta signaling by IL-15: a new role for IL-15 in the loss of immune homeostasis in celiac disease. Gastroenterology 2007; 132: 994-1008.
41. Cianci R, Pagliari D, Pietroni V et al. Tissue infiltrating lymphocytes: the role of cytokines in their growth and differentiation. J Biol Regul Homeost Agents 2010; 24: 239-249.
42. Hu MC, Crowe DT, Weissman IL et al. Cloning and expression of mouse integrin beta p(beta 7): a functional role in Peyer's patch-specific lymphocyte homing. Proc Natl Acad Sci USA 1992; 89: 8254-8258.
43. Wagner N, Lohler J, Kunkel EJ et al. Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue. Nature 1996; 382: 366-370.
44. Schon MP, Arya A, Murphy EA et al. Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice. J Immunol 1999; 162: 6641-6649.
45. Allez M, Brimnes J, Dotan I et al. Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells. Gastroenterology 2002; 123: 1516-1526.