Antibacterial activity of head-to-head bis-benzimidazoles

International Journal of Antimicrobial Agents

Volumn 42, Issue 4, 2013, Pages 361-366

  Moreira, Joao B ^a   Mann, John ^a   Neidle, Stephen ^a   McHugh, Timothy D ^a   Taylor, Peter W ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Antibacterial bis benzimidazoles; Gram positive pathogens; Mycobacterium tuberculosis; Staphylococcus aureus

Indexed keywords

BENZIMIDAZOLE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIOSTASIS; BACTERIUM ISOLATE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; EMBRYO; FIBROBLAST; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LISTERIA MONOCYTOGENES; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS; TOXICITY TESTING; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ANTIBACTERIAL BIS-BENZIMIDAZOLES; GRAM-POSITIVE PATHOGENS; MYCOBACTERIUM TUBERCULOSIS; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BENZIMIDAZOLES; CELL LINE; CELL SURVIVAL; FIBROBLASTS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; MICROBIAL SENSITIVITY TESTS;

EID: 84884704237     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2013.04.033     Document Type: Article

References (14)

1. E. Lacey Mode of action of benzimidazoles Parasitol Today 6 1990 112 115
2. L. Hu, M.L. Kully, D.W. Boykin, and N. Abood Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents Bioorg Med Chem Lett 19 2009 3374 3377
3. N. Mani, C.H. Gross, J.D. Parsons, B. Hanzelka, U. Müh, and S. Mullin In vitro characterization of the antibacterial spectrum of novel bacterial type II topoisomerase inhibitors of the aminobenzimidazole class Antimicrob Agents Chemother 50 2006 1228 1237
4. A.G. Dale, J. Hinds, J. Mann, P.W. Taylor, and S. Neidle Symmetric bis-benzimidazoles are potent anti-staphylococcal agents with dual inhibitory mechanisms against DNA gyrase Biochemistry 51 2012 5860 5871
5. M.K. Teng, N. Usman, C.A. Frederick, and A.H. Wang The molecular structure of the complex of Hoechst 33258 and the DNA dodecamer d(CGCGAATTCGCG) Nucleic Acids Res 16 1988 2671 2690
6. J. Mann, A. Baron, Y. Opoku-Boahen, E. Johansson, G. Parkinson, and L.R. Kelland A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity J Med Chem 44 2001 138 144
7. V. Seidel, and P.W. Taylor In vitro activity of extracts and constituents of Pelargonium against rapidly growing mycobacteria Int J Antimicrob Agents 23 2004 613 619
8. S. Bhakta, G.S. Besra, A.M. Upton, T. Parish, C. Sholto-Douglas-Vernon, and K.J. Gibson Arylamine N-acetyltransferase is required for synthesis of mycolic acids and complex lipids in Mycobacterium bovis BCG and represents a novel drug target J Exp Med 199 2004 1191 1199
9. Y. Hu, A.R. Coates, and D.A. Mitchison Sterilising action of pyrazinamide in models of dormant and rifampicin-tolerant Mycobacterium tuberculosis Int J Tuberc Lung Dis 10 2006 317 322
10. T. Hadjivassileva, P.D. Stapleton, D.E. Thurston, and P.W. Taylor Interactions of pyrrolobenzodiazepine dimers and duplex DNA from methicillin-resistant Staphylococcus aureus Int J Antimicrob Agents 290 2007 672 678
11. P. Skehan, R. Storeng, D. Scudiero, A. Monks, J. McMahon, and D. Vistica New colorimetric cytotoxicity assay for anticancer-drug screening J Natl Cancer Inst 82 1990 1107 1112
12. G.A. Chung, Z. Aktar, S. Jackson, and K. Duncan High-throughput screen for detecting antimycobacterial agents Antimicrob Agents Chemother 39 1995 2235 2238
13. S. Neidle, E.L. Rayner, I.J. Simpson, N.J. Smith, J. Mann, and A. Baron Symmetric bis-benzimidazoles: new sequence-selective DNA-binding molecules Chem Commun 1999 929 930
14. A.K. Jain, A. Paul, B. Maji, K. Muniyappa, and S. Bhattacharya Dimeric 1,3-phenylene-bis(piperazinyl benzimidazole)s: synthesis and structure-activity investigations on their binding with human telomeric G-quadruplex DNA and telomerase inhibition properties J Med Chem 55 2012 2981 2993