Administration of E2 and NS1 siRNAs Inhibit Chikungunya Virus Replication In Vitro and Protects Mice Infected with the Virus

PLoS Neglected Tropical Diseases

Volumn 7, Issue 9, 2013, Pages

  Parashar, Deepti ^a   Paingankar, Mandar S ^a   Kumar, Satyendra ^a   Gokhale, Mangesh D ^a   Sudeep, A B ^a   Shinde, Sapana B ^a   Arankalle, V A ^a  

^a NATIONAL INSTITUTE OF VIROLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN E2; NONSTRUCTURAL PROTEIN 1; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CHIKUNGUNYA; CHIKUNGUNYA ALPHAVIRUS; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOFLUORESCENCE TEST; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS CULTURE; VIRUS INHIBITION; VIRUS LOAD; VIRUS REPLICATION;

ALPHAVIRUS INFECTIONS; ANIMALS; BIOLOGICAL PRODUCTS; BIOLOGICAL THERAPY; CERCOPITHECUS AETHIOPS; CHIKUNGUNYA VIRUS; DISEASE MODELS, ANIMAL; MICE; MICE, INBRED C57BL; RNA, SMALL INTERFERING; TREATMENT OUTCOME; VERO CELLS; VIRAL PROTEINS;

EID: 84884684000     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0002405     Document Type: Article

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