The prostate cancer-up-regulated long noncoding RNA PlncRNA-1 modulates apoptosis and proliferation through reciprocal regulation of androgen receptor

Urologic Oncology: Seminars and Original Investigations

Volumn 31, Issue 7, 2013, Pages 1117-1123

  Cui, Zilian ^a   Ren, Shancheng ^a   Lu, Ji ^a   Wang, Fubo ^a   Xu, Weidong ^a   Sun, Yi ^a   Wei, Min ^a   Chen, Junyi ^a   Gao, Xu ^a   Xu, Chuanliang ^a   Mao, Jian Hua ^b   Sun, Yinghao ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Androgen receptor; Long noncoding RNA; Prostate cancer

Indexed keywords

ANDROGEN RECEPTOR; CHOLECYSTOKININ OCTAPEPTIDE; DNA NUCLEOTIDYLEXOTRANSFERASE; LONG UNTRANSLATED RNA; PLNCRNA 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER TISSUE; CELL PROLIFERATION; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; NICK END LABELING; PATHOGENESIS; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE EPITHELIUM; PROSTATE HYPERTROPHY; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANDROGEN RECEPTOR; LONG NONCODING RNA; PROSTATE CANCER;

APOPTOSIS; BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MOLECULAR SEQUENCE DATA; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, LONG NONCODING; UP-REGULATION;

EID: 84884673330     PISSN: 10781439     EISSN: 18732496     Source Type: Journal    
DOI: 10.1016/j.urolonc.2011.11.030     Document Type: Article

References (20)

1. Jemal A., Siegel R., Xu J., et al. Cancer statistics. CA Cancer J Clin 2010, 60:277-300.
2. Molina A., Belldegrun A. Novel therapeutic strategies for castration resistant prostate cancer: Inhibition of persistent androgen production and androgen receptor mediated signaling. J Urol 2011, 185:787-794.
3. Yamaoka M., Hara T., Kusaka M. Overcoming persistent dependency on androgen signaling after progression to castration-resistant prostate cancer. Clin Cancer Res 2010, 16:4319-4324.
4. Heemers H.V., Tindall D.J. Unraveling the complexities of androgen receptor signaling in prostate cancer cells. Cancer Cell 2009, 15:245-247.
5. Cai C., Chen S., Ng P., et al. Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is up-regulated by treatment with CYP17A1 inhibitors. Cancer Res 2011, 71:6503-6513.
6. Chang G.T., Steenbeek M., Schippers E., et al. A novel gene on human chromosome 2p24 is differentially expressed between androgen-dependent and androgen-independent prostate cancer cells. Eur J Cancer 2001, 37:2129-2134.
7. Guttman M., Amit I., Garber M., et al. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 2009, 458:223-227.
8. Mattick J.S. The genetic signatures of noncoding RNAs. PLoS Genet 2009, 5:e1000459.
9. Bernstein E., Allis C.D. RNA meets chromatin. Genes Dev 2005, 19:1635-1655.
10. Rinn J.L., Kertesz M., Wang J.K., et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 2007, 129:1311-1323.
11. Pibouin L., Villaudy J., Ferbus D., et al. Cloning of the mRNA of overexpression in colon carcinoma-1: A sequence overexpressed in a subset of colon carcinomas. Cancer Genet Cytogenet 2002, 133:55-60.
12. Fu X., Ravindranath L., Tran N., et al. Regulation of apoptosis by a prostate-specific and prostate cancer-associated noncoding gene, PCGEM1. DNA Cell Biol 2006, 25:135-141.
13. Calin G.A., Liu C.G., Ferracin M., et al. Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell 2007, 12:215-229.
14. Lin R., Maeda S., Liu C., et al. A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas. Oncogene 2007, 26:851-858.
15. Gupta R.A., Shah N., Wang K.C., et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 2010, 464:1071-1076.
16. Li L., Feng T., Lian Y., et al. Role of human noncoding RNAs in the control of tumorigenesis. Proc Natl Acad Sci USA 2009, 106:12956-12961.
17. Yu W., Gius D., Onyango P., et al. Epigenetic silencing of tumor suppressor gene p15 by its antisense RNA. Nature 2008, 451:202-206.
18. Massard C., Fizazi K. Targeting continued androgen receptor signaling in prostate cancer. Clin Cancer Res 2011, 17:3876-3883.
19. Heemers H.V., Tindall D.J. Androgen receptor (AR) coregulators: A diversity of functions converging on and regulating the AR transcriptional complex. Endocr Rev 2007, 28:778-808.
20. Messeguer X., Escudero R., Farré D., et al. PROMO: detection of known transcription regulatory elements using species-tailored searches. Bioinformatics 2002, 18(2):333-334.