In vivo serial selection of human pancreatic cancer cells in orthotopic mouse models produces high metastatic variants irrespective of Kras status

Journal of Surgical Research

Volumn 184, Issue 1, 2013, Pages 290-298

  Metildi, Cristina A ^a   Kaushal, Sharmeela ^a   Hoffman, Robert M ^a,b   Bouvet, Michael ^a,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b ANTICANCER INC   (United States)

^c VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

In vivo selection; Kras; Metastasis; Orthotopic mouse models; Pancreatic cancer; Survival; Variants

Indexed keywords

GREEN FLUORESCENT PROTEIN; K RAS PROTEIN; RED FLUORESCENT PROTEIN; KRAS PROTEIN, HUMAN; ONCOPROTEIN; PHOTOPROTEIN; RAS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER GROWTH; CELL LINE; CONTROLLED STUDY; DISTANT METASTASIS; FEMALE; GENE MUTATION; IMAGING SYSTEM; IN VIVO STUDY; LIFESPAN; MOUSE; NONHUMAN; NUDE MOUSE; ORTHOTOPIC TRANSPLANTATION; OVERALL SURVIVAL; PANCREAS CANCER; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL TIME; VIRUS CULTURE; WILD TYPE; ANIMAL; CANCER TRANSPLANTATION; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IN VIVO SELECTION; KAPLAN MEIER METHOD; KRAS; METASTASIS; MORTALITY; ORTHOTOPIC MOUSE MODELS; PANCREAS TUMOR; SURVIVAL; TUMOR CELL LINE; VARIANTS;

IN VIVO SELECTION; KRAS; METASTASIS; ORTHOTOPIC MOUSE MODELS; PANCREATIC CANCER; SURVIVAL; VARIANTS;

ANIMALS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GREEN FLUORESCENT PROTEINS; HUMANS; KAPLAN-MEIER ESTIMATE; LUMINESCENT PROTEINS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS; RAS PROTEINS;

EID: 84884669424     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2013.03.049     Document Type: Article

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