Imageable fluorescent metastasis resulting in transgenic GFP mice orthotopically implanted with human-patient primary pancreatic cancer specimens

Anticancer Research

Volumn 32, Issue 4, 2012, Pages 1175-1180

  Suetsugu, Atsushi ^a,b,d   Katz, Matthew ^c   Fleming, Jason ^c   Truty, Mark ^c   Thomas, Ryan ^c   Saji, Shigetoyo ^d   Moriwaki, Hisataka ^d   Bouvet, Michael ^b   Hoffman, Robert M ^a,b  

^a Anti Cancer Inc   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

GFP; Human patient pancreatic cancer; Imaging; Metastasis; Microenvironment; Nude mice; Stroma; Tumor

Indexed keywords

GREEN FLUORESCENT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER PATIENT; FIBROBLAST; HUMAN; HUMAN TISSUE; LIVER METASTASIS; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; NUDE MOUSE; ORTHOTOPIC TRANSPLANTATION; PANCREAS CANCER; PERITONEUM METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCID MOUSE; STROMA; TUMOR ASSOCIATED LEUKOCYTE; UBIQUITINATION;

ANIMALS; GREEN FLUORESCENT PROTEINS; HUMANS; MICE; MICE, TRANSGENIC; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS;

EID: 84859952919     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Fu X, Guadagni F and Hoffman RM: A metastatic nude-mouse model of human pancreatic cancer constructed orthotopically with histologically intact patient specimens. Proc Natl Acad Sci USA 89: 5645-5649, 1992.
2. Fu X, Besterman JM, Monosov A and Hoffman RM: Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically intact patient specimens. Proc Natl Acad Sci USA 88: 9345-9349, 1991. (Pubitemid 21915628)
3. Rygaard J and Povlsen CO: Heterotransplantation of a human malignant tumour to "Nude" mice. Acta Pathol Microbiol Scand 77: 758-760, 1969.
4. Fiebig HH, Widmer K-H, Fiedler L, Wittekind C and Lohr GW: Development and characterization of 51 human tumor models for large bowel, stomach and esophageal cancer. Digestive Surgery 1: 225-235, 1984. (Pubitemid 15127012)
5. Fiebig HH, Schmid JR, Bieser W, Henss H and Lohr GW: Colony assay with human tumor xenografts, murine tumors and human bone marrow. Potential for anticancer drug development. Eur J Cancer Clin Oncol 23: 937-948, 1987. (Pubitemid 17120013)
6. Steel GG: Therapeutic response of human tumour xenografts in immune-suppressed mice. In: Immune-Deficient Animals. 4th Int. Workshop on Immune-Deficient Animals in Exp Res Chexbres 1982. Karger, Basel pp. 395-404, 1984.
7. Nowak K, Peckham MJ and Steel GG: Variation in response of xenografts of colo-rectal carcinoma to chemotherapy. Br J Cancer 37: 576-584, 1978. (Pubitemid 8332997)
8. Pickard RG, Cobb LM and Steel GG: The growth kinetics of xenografts of human colorectal tumours in immune deprived mice. Br J Cancer 31: 36-45, 1975.
9. Selby PJ, Courtenay VD, McElwain TJ, Peckham MJ and Steel GG: Colony growth and clonogenic cell survival in human melanoma xenografts treated with chemotherapy. Br. J Cancer 42: 438-447, 1980. (Pubitemid 10024636)
10. Sharkey FE and Fogh J: Consideration in the use of nude mice for cancer research. Cancer Metastasis Rev 3: 341-360, 1984.
11. Giovanella BC, Stehlin JS Jr, Williams LJ Jr., Lee S-S and Shepard RC: Heterotransplantation of human cancers into nude mice: a model system for human cancer chemotherapy. Cancer 42: 2269-2281, 1978. (Pubitemid 9125885)
12. Bailey MJ, Gazet JC and Peckham MJ: Human breast-cancer xenografts in immune-suppressed mice. Br J Cancer 42: 524-529, 1980. (Pubitemid 11240531)
13. Rubio-Viqueira B, Jimeno A, Cusatis G, Zhang X, Iacobuzio-Donahue C, Karikari C, Shi C, Danenberg K, Danenberg PV, Kuramochi H, Tanaka K, Singh S, Salimi-Moosavi H, Bouraoud N, Amador ML, Altiok S, Kulesza P, Yeo C, Messersmith W, Eshleman J, Hruban RH, Maitra A and Hidalgo M: An in vivo platform for translational drug development in pancreatic cancer. CHn Cancer Res 12: 4652-4661, 2006. (Pubitemid 44297818)
14. Embuscado EE, Laheru D, Ricci F, Yun KJ, de Boom Witzel S, Seigel A, Flickinger K, Hidalgo M, Bova GS and Iacobuzio-Donahue CA: Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy. Cancer Biol Ther 4: 548-554, 2005. (Pubitemid 41351229)
15. Talmadge JE, Singh RK, Fidler IJ and Raz A: Murine models to evaluate novel and conventional therapeutic strategies for cancer. Am J Pathol 170: 793-804, 2007. (Pubitemid 47339349)
16. Hwang RF, Yokoi K, Bucana CD, Tsan R, Killion JJ, Evans DB and Fidler IJ: Inhibition of platelet-derived growth factor receptor phosphorylation by STI571 (Gleevec) reduces growth and metastasis of human pancreatic carcinoma in an orthotopic nude mouse model. Clin Cancer Res 9: 6534-6544, 2003. (Pubitemid 38031842)
17. Yokoi K, Kim S-J, Thaker P, Yazici S, Nam D-H, He J, Sasaki T, Chiao PJ, Sclabas GM, Abbruzzesez JL, Hamilton SR and Fidler IJ: Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice. Neoplasia 7: 696-704, 2005. (Pubitemid 41099423)
18. Kim MP, Truty MJ, Choi W, Kang Y, Chopin-Lally X, Gallick GE, Wang H, McConkey DJ, Hwang R, Logsdon C, Abbruzzesse J and Fleming JB: Molecular profiling of direct xenograft tumors established from human pancreatic adenocarcinoma after neoadjuvant therapy. Ann Surg Oncol, 2011 [Epub ahead of print] (DOI: 10.1245/s10434-011-1839-4).
19. Kim MP, Evans DB, Wang H, Abbruzzese JL, Fleming JB and Gallick GE: Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice. Nat Protol 4: 1670-1680, 2009.
20. Garber K: Personal mouse colonies give hope for pancreatic cancer patients. J Natl Cancer Inst 99: 105-107, 2007.
21. Bertotti A, Migliardi G, Galimi F, Sassi F, Totti D, Isella C, Cora D, Di Nicolantonio F, Buscarino M, Petti C, Ribero D, Russolillo N, Muratore A, Massucco P, Pisacane A, Molinaro L, Valtorta E, Sartore-Bianchi A, Risio M, Capussotti L, Gambacorta M, Siena S, Medico E, Sapino A, Marsoni S, Comoglio PM, Bardelli A and Trusolino L: A molecularly annotated platform of patient-derived xenografts ("Xenopatients") identified HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. Cancer Disc 1: 509-523, 2011.
22. Suetsugu A, Katz M, Fleming J, Moriwaki H, Bouvet M, Saji S and Hoffman RM: Multi-color pallete of fluorescent proteins for imaging the tumor microenvironment of orthotopic tumorgraft mouse models of clinical pancreatic cancer specimens. J Cell Biochem, in press, 2012.
23. Okabe M, Ikawa M, Kominami K, Nakanishi T and Nishimune Y: 'Green mice' as a source of ubiquitous green cells. FEBS Lett 407: 313-319, 1997. (Pubitemid 27199450)
24. Yang M, Reynoso J, Jiang P, Li L, Moossa AR and Hoffman RM: Transgenic nude mouse with ubiquitous green fluorescent protein expression as a host for human tumors. Cancer Res 64: 8651-8656, 2004. (Pubitemid 39552079)
25. Tran Cao HS, Reynoso J, Yang M, Kimura H, Kaushal S, Snyder CS Hoffman RM and Bouvet M. Development of the transgenic cyan fluorescent protein (CFP)-expressing nude mouse for "Technicolor" cancer imaging. J Cell Biochem 107: 328-334, 2009.
26. Kuo T-H, Kubota T, Watanabe M, Furukawa T, Kase S, Tanino H, Saikawa Y, Ishibiki K, Kitajima M and Hoffman RM: Site-specific chemosensitivity of human small-cell lung carcinoma growing orthotopically compared to subcutaneously in SCID mice: the importance of orthotopic models to obtain relevant drug evaluation data. Anticancer Res 13: 627-630, 1993. (Pubitemid 23216957)