The effects of quercetin protect cardiomyocytes from A/R injury is related to its capability to increasing expression and activity of PKCε protein

Molecular and Cellular Biochemistry

Volumn 382, Issue 1-2, 2013, Pages 145-152

  Tang, Lei ^a   Peng, Yian ^a   Xu, Tiantian ^a   Yi, Xiaoqing ^a   Liu, Ying ^a   Luo, Yuchao ^a   Yin, Dong ^a   He, Ming ^a  

^a NANCHANG UNIVERSITY   (China)

Author keywords

Anoxia reoxygenation; Cardioprotection; PKC ; Quercetin

Indexed keywords

PROTEIN KINASE C EPSILON; PROTEIN KINASE C INHIBITOR; QUERCETIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANOXIA REOXYGENATION INJURY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL LEVEL; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; HEART MUSCLE CELL; HEART PROTECTION; MITOCHONDRIAL MEMBRANE POTENTIAL; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; REPERFUSION INJURY; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALIA; RATTUS;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CARDIOTONIC AGENTS; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; CYTOPROTECTION; GLUTATHIONE PEROXIDASE; L-LACTATE DEHYDROGENASE; MALONDIALDEHYDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; OXIDATIVE STRESS; OXYGEN; PROTEIN KINASE C-EPSILON; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

EID: 84884669031     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1729-0     Document Type: Article

References (26)

1. Kelly GS (2011) Quercetin. Monograph. Altern Med Rev 16(2):172-194
2. Hwang IK, Lee CH, Yoo KY, Choi JH, Park OK, Lim SS, Kang IJ, Kwon DY, Park J, Yi JS, Bae YS, Won MH (2009) Neuroprotective effects of onion extract and quercetin against ischemic neuronal damage in the gerbil hippocampus. J Med Food 12(5):990-995. doi: 10.1089/jmf.2008.1400
3. Annapurna A, Reddy CS, Akondi RB, Rao SR (2009) Cardioprotective actions of two bioflavonoids, quercetin and rutin, in experimental myocardial infarction in both normal and streptozotocin-induced type I diabetic rats. J Pharm Pharmacol 61(10):1365-1374. doi: 10.1211/jpp/61.10.0014
4. Huk I, Brovkovych V, Nanobash Vili J, Weigel G, Neumayer C, Partyka L, Patton S, Malinski T (1998) Bioflavonoid quercetin scavenges superoxide and increases nitric oxide concentration in ischemia-reperfusion injury: an experimental study. Br J Surg 85(8):1080-1085. doi: 10.1046/j.1365-2168.1998. 00787.x
5. Mojzis J, Hviscova K, Germanova D, Bukovicova D, Mirossay L (2001) Protective effect of quercetin on ischemia/reperfusion-induced gastric mucosal injury in rats. Physiol Res 50(5):501-506
6. Kahraman A, Erkasap N, Serteser M, Koken T (2003) Protective effect of quercetin on renal ischemia/reperfusion injury in rats. J Nephrol 16(2):219-224
7. Su JF, Guo CJ, Wei JY, Yang JJ, Jiang YG, Li YF (2003) Protection against hepatic ischemia-reperfusion injury in rats by oral pretreatment with quercetin. Biomed Environ Sci 16(1):1-8
8. Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D (1993) Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342(8878):1007-1011
9. Knekt P, Jarvinen R, Reunanen A, Maatela J (1996) Flavonoid intake and coronary mortality in Finland: a cohort study. BMJ 312(7029):478-481
10. Kinaci MK, Erkasap N, Kucuk A, Koken T, Tosun M (2012) Effects of quercetin on apoptosis, NF-kappaB and NOS gene expression in renal ischemia/reperfusion injury. Exp Ther Med 3(2):249-254
11. Wan LL, Xia J, Ye D, Liu J, Chen J, Wang G (2009) Effects of quercetin on gene and protein expression of NOX and NOS after myocardial ischemia and reperfusion in rabbit. Cardiovasc Ther 27(1):28-33
12. Jin HB, Yang YB, Song YL, Zhang YC, Li YR (2012) Protective roles of quercetin in acute myocardial ischemia and reperfusion injury in rats. Mol Biol Rep 39(12):11005-11009
13. Zhang N, Pei F, Wei H, Zhang T, Yang C, Ma G (2011) Isorhamnetin protects rat ventricular myocytes from ischemia and reperfusion injury. Exp Toxicol Pathol 63(1-2):33-38
14. Ikizler M, Erkasap N, Dernek S, Kural T, Kaygisiz Z (2007) Dietary polyphenol quercetin protects rat hearts during reperfusion: enhanced antioxidant capacity with chronic treatment. Anadolu Kardiyol Derg 7(4):404-410
15. Watkins SJ, Borthwick GM, Arthur HM (2010) The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro. In Vitro Cell Dev Biol Anim 47(2):125-131. doi: 10.1007/s11626-010-9368-1
16. Murphy E, Steenbergen C (2008) Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol Rev 88(2):581-609. doi: 10.1152/physrev.00024.2007
17. Pandey AK, Verma S, Bhattacharya P, Paul S, Mishra A, Patnaik R (2012) An in silico strategy to explore neuroprotection by quercetin in cerebral ischemia: a novel hypothesis based on inhibition of matrix metalloproteinase (MMPs) and acid sensing ion channel 1a (ASIC1a). Med Hypotheses 79(1):76-81
18. Yao RQ, Qi DS, Yu HL, Liu J, Yang LH, Wu XX (2012) Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway. Neurochem Res 37(12):2777-2786
19. Gruber JV, Holtz R (2010) Examining the genomic influence of skin antioxidants in vitro. Mediators Inflamm. doi: 10.1155/2010/ 230450
20. Miura T, Tanno M, Sato T (2010) Mitochondrial kinase signalling pathways in myocardial protection from ischemia/reperfusion-induced necrosis. Cardiovasc Res 88(1):7-15. doi: 10.1093/cvr/cvq206
21. Kim JA, Jung YS, Kim MY, Yang SY, Lee S, Kim YH (2011) Protective effect of components isolated from Lindera erythrocarpa against oxidative stress-induced apoptosis of H9c2 cardiomyocytes. Phytother Res 25(11):1612-1617. doi: 10.1002/ptr.3465
22. Lu N, Zhang Y, Gao Z (2009) Nitrite-glucose-glucose oxidase system directly induces rat heart homogenate oxidation and tyrosine nitration: effects of some flavonoids. Toxicol In Vitro 23(4):627-633. doi: 10.1016/j.tiv.2009.02. 013
23. Griffiths EJ (2012) Mitochondria and heart disease. Adv Exp Med Biol 942:249-267. doi: 10.1007/978-94-007-2869-1-11
24. Angst E, Park JL, Moro A, Lu QY, Lu X, Li G, King J, Chen M, Reber HA, Go VL, Eibl G, Hines OJ (2012) The flavonoid quercetin inhibits pancreatic cancer growth in vitro and in vivo. Pancreas 20:20
25. Castillo-Pichardo L, Dharmawardhane SF (2012) Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer. Nutr Cancer 64(7):1058-1069
26. Chuang-Xin L, Wen-Yu W, Yao C, Xiao-Yan L, Yun Z (2012) Quercetin enhances the effects of 5-fluorouracil-mediated growth inhibition and apoptosis of esophageal cancer cells by inhibiting NF-kappaB. Oncol Lett 4(4):775-778